Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YGL012W
Length:
473
Number of sequences:
5887
Description:
YGL012W ERG4 SGDID:S000002980, Chr VII from 472855-474276, Genome Release 64-1-1, Verified ORF, "C-24(28) sterol reductase, catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
1P25340    473   ERG4_YEAST Delta(24(24(1)))-sterol reductase ...4730     981     100     100GO:0005783; C:endoplasmic reticulum; IDA:SGD.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0000246; F:delta24(24-1) sterol reductase activity; IDA:SGD.
GO:0006696; P:ergosterol biosynthetic process; IMP:SGD.
2P36209    453   STS1_SCHPO Delta(24(24(1)))-sterol reductase ...4425e-173     501     54     70GO:0005789; C:endoplasmic reticulum membrane; ISS:PomBase.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0000246; F:delta24(24-1) sterol reductase activity; ISS:PomBase.
GO:0030437; P:ascospore formation; IMP:PomBase.::GO:0071473; P:cellular response to cation stress; IMP:PomBase.::GO:0006696; P:ergosterol biosynthetic process; IMP:PomBase.::GO:0090002; P:establishment of protein localization in plasma membrane; IMP:PomBase.::GO:0071210; P:protein insertion into membrane raft; IMP:PomBase.::GO:0042493; P:response to drug; IMP:PomBase.
3Q54PP1    462   ERG24_DICDI Delta(14)-sterol reductase OS=Dic...4721e-64     221     30     48GO:0005789; C:endoplasmic reticulum membrane; ISS:dictyBase.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0050613; F:delta14-sterol reductase activity; ISS:dictyBase.
GO:0006696; P:ergosterol biosynthetic process; IC:dictyBase.
4O08984    620   LBR_RAT Lamin-B receptor OS=Rattus norvegicus...4775e-58     207     31     49GO:0005637; C:nuclear inner membrane; IEA:UniProtKB-SubCell.::GO:0005643; C:nuclear pore; IDA:RGD.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0016628; F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor; IEA:InterPro.::GO:0004872; F:receptor activity; IEA:UniProtKB-KW.
5Q5R7H4    615   LBR_PONAB Lamin-B receptor OS=Pongo abelii (S...4433e-57     205     31     49GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005637; C:nuclear inner membrane; IEA:UniProtKB-SubCell.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0016628; F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor; IEA:InterPro.::GO:0004872; F:receptor activity; IEA:UniProtKB-KW.
6Q14739    615   LBR_HUMAN Lamin-B receptor OS=Homo sapiens (H...4431e-56     203     31     49GO:0005639; C:integral to nuclear inner membrane; TAS:ProtInc.
GO:0070087; F:chromo shadow domain binding; IPI:BHF-UCL.::GO:0003677; F:DNA binding; TAS:ProtInc.::GO:0005521; F:lamin binding; TAS:ProtInc.::GO:0016628; F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor; IEA:InterPro.::GO:0004872; F:receptor activity; IEA:UniProtKB-KW.
GO:0006695; P:cholesterol biosynthetic process; TAS:Reactome.
7Q3U9G9    626   LBR_MOUSE Lamin-B receptor OS=Mus musculus (M...4888e-54     196     29     47GO:0005637; C:nuclear inner membrane; TAS:MGI.::GO:0005652; C:nuclear lamina; TAS:MGI.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0016628; F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor; IEA:InterPro.::GO:0004872; F:receptor activity; IEA:UniProtKB-KW.
8Q71KT5    418   ERG24_MOUSE Delta(14)-sterol reductase OS=Mus...4483e-51     184     30     47GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005792; C:microsome; IEA:UniProtKB-SubCell.
GO:0050613; F:delta14-sterol reductase activity; IEA:EC.
GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.
9P23913    637   LBR_CHICK Lamin-B receptor OS=Gallus gallus (...4391e-50     187     30     47GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005637; C:nuclear inner membrane; IEA:UniProtKB-SubCell.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0016628; F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor; IEA:InterPro.::GO:0004872; F:receptor activity; IEA:UniProtKB-KW.
10Q09195    424   ERG24_SCHPO Delta(14)-sterol reductase OS=Sch...4533e-48     176     29     48GO:0005789; C:endoplasmic reticulum membrane; ISS:PomBase.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0050613; F:delta14-sterol reductase activity; ISS:PomBase.
GO:0006696; P:ergosterol biosynthetic process; ISS:PomBase.
11P32462    438   ERG24_YEAST Delta(14)-sterol reductase OS=Sac...4752e-47     174     29     47GO:0005783; C:endoplasmic reticulum; IDA:SGD.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0050613; F:delta14-sterol reductase activity; IDA:SGD.
GO:0006696; P:ergosterol biosynthetic process; IMP:SGD.
12P78575    430   ERG24_ASCIM Delta(14)-sterol reductase OS=Asc...4563e-46     171     30     46GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0050613; F:delta14-sterol reductase activity; IEA:EC.
GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW.
13P38670    490   ERG24_NEUCR Delta(14)-sterol reductase OS=125...5028e-46     171     28     44GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0050613; F:delta14-sterol reductase activity; IEA:EC.
GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW.
14O76062    418   ERG24_HUMAN Delta(14)-sterol reductase OS=Hom...3492e-43     163     31     48GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.::GO:0005887; C:integral to plasma membrane; TAS:ProtInc.::GO:0005792; C:microsome; IEA:UniProtKB-SubCell.
GO:0050613; F:delta14-sterol reductase activity; IEA:EC.
GO:0006695; P:cholesterol biosynthetic process; TAS:Reactome.
15Q8WMV1    418   ERG24_BOVIN Delta(14)-sterol reductase OS=Bos...2719e-43     161     34     53GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005792; C:microsome; IEA:UniProtKB-SubCell.
GO:0050613; F:delta14-sterol reductase activity; IEA:EC.
GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.
16Q5UQI4    447   DHCR7_MIMIV Probable 7-dehydrocholesterol red...4454e-40     154     29     47GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0047598; F:7-dehydrocholesterol reductase activity; IEA:EC.
GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.
17Q7ZXH1    473   DHCR7_XENLA 7-dehydrocholesterol reductase OS...4802e-39     153     28     46GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0047598; F:7-dehydrocholesterol reductase activity; IEA:EC.
GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.
18Q6P4M0    473   DHCR7_XENTR 7-dehydrocholesterol reductase OS...4932e-39     153     28     44GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0047598; F:7-dehydrocholesterol reductase activity; IEA:EC.
GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.
19Q01447    485   ERG24_FUSSO Delta(14)-sterol reductase OS=Fus...5061e-38     150     27     42GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0050613; F:delta14-sterol reductase activity; IEA:EC.
GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW.
20Q7SXF1    478   DHCR7_DANRE 7-dehydrocholesterol reductase OS...4991e-37     147     27     44GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0047598; F:7-dehydrocholesterol reductase activity; IEA:EC.
GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.
21Q5E9J5    475   DHCR7_BOVIN 7-dehydrocholesterol reductase OS...4952e-35     141     27     43GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0047598; F:7-dehydrocholesterol reductase activity; IEA:EC.
GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.
22O13597    512   ERG24_SEPLY Delta(14)-sterol reductase OS=Sep...5124e-34     137     25     42GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0050613; F:delta14-sterol reductase activity; IEA:EC.
GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW.
23O88455    471   DHCR7_MOUSE 7-dehydrocholesterol reductase OS...4856e-34     136     27     43GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0047598; F:7-dehydrocholesterol reductase activity; IDA:MGI.
GO:0001568; P:blood vessel development; IMP:MGI.::GO:0030154; P:cell differentiation; IMP:MGI.::GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.::GO:0030324; P:lung development; IMP:MGI.::GO:0035264; P:multicellular organism growth; IMP:MGI.::GO:0009791; P:post-embryonic development; IMP:MGI.::GO:0042127; P:regulation of cell proliferation; IMP:MGI.
24Q9Z2Z8    471   DHCR7_RAT 7-dehydrocholesterol reductase OS=R...4861e-33     135     27     43GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005792; C:microsome; IDA:RGD.
GO:0047598; F:7-dehydrocholesterol reductase activity; IMP:RGD.
GO:0006695; P:cholesterol biosynthetic process; IDA:RGD.::GO:0045540; P:regulation of cholesterol biosynthetic process; IDA:RGD.
25Q9UBM7    475   DHCR7_HUMAN 7-dehydrocholesterol reductase OS...4713e-33     134     28     44GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0016020; C:membrane; IEA:InterPro.::GO:0005640; C:nuclear outer membrane; IDA:UniProtKB.
GO:0047598; F:7-dehydrocholesterol reductase activity; IDA:UniProtKB.::GO:0016628; F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor; IEA:InterPro.
GO:0006695; P:cholesterol biosynthetic process; IMP:UniProtKB.
26Q9LDR4    369   ERG24_ARATH Delta(14)-sterol reductase OS=Ara...3765e-32     129     28     48GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0050613; F:delta14-sterol reductase activity; IMP:TAIR.
GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW.
27Q9LDU6    432   ST7R_ARATH 7-dehydrocholesterol reductase OS=...3961e-31     129     28     44GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0005794; C:Golgi apparatus; IDA:TAIR.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IDA:TAIR.
GO:0047598; F:7-dehydrocholesterol reductase activity; IEA:EC.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0009918; F:sterol delta7 reductase activity; IMP:TAIR.
GO:0016132; P:brassinosteroid biosynthetic process; IMP:TAIR.::GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.
28Q8MLV1    741   LBR_DROME Lamin-B receptor OS=Drosophila mela...3180.092     38.9     24     37GO:0005639; C:integral to nuclear inner membrane; IDA:UniProtKB.
GO:0003682; F:chromatin binding; IDA:UniProtKB.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0005521; F:lamin binding; IPI:UniProtKB.::GO:0004872; F:receptor activity; IEA:UniProtKB-KW.
GO:0006997; P:nucleus organization; IC:UniProtKB.
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