UniProt_SwissProt BLAST: Single locus

Species:

Saccharomyces cerevisiae S288C

Locus:

YGL011C

Length:

252

Number of sequences:

5887

Description:

YGL011C SCL1 SGDID:S000002979, Chr VII from 475247-474489, Genome Release 64-1-1, reverse complement, Verified ORF, "Alpha 1 subunit of the 20S proteasome involved in the degradation of ubiquitinated substrates; 20S proteasome is the core complex of the 26S proteasome; essential for growth; detected in the mitochondria"

rec.	Subject	Hit Length	Description	Align.Len	E value	Bit score	% ident.	% pos.	GO associations
1	P21243	252	PSA6_YEAST Proteasome component C7-alpha OS=S...	252	0	525	100	100	GO:0005739; C:mitochondrion; IDA:SGD.::GO:0042175; C:nuclear outer membrane-endoplasmic reticulum membrane network; IC:SGD.::GO:0005634; C:nucleus; IC:SGD.::GO:0019773; C:proteasome core complex, alpha-subunit complex; IDA:SGD.::GO:0034515; C:proteasome storage granule; IC:SGD.
									GO:0005515; F:protein binding; IPI:IntAct.::GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW.
									GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; IDA:SGD.::GO:0010499; P:proteasomal ubiquitin-independent protein catabolic process; IDA:SGD.
2	O94517	244	PSA6_SCHPO Probable proteasome subunit alpha ...	247	3e-94	283	56	71	GO:0005829; C:cytosol; IDA:PomBase.::GO:0005634; C:nucleus; IDA:PomBase.::GO:0019773; C:proteasome core complex, alpha-subunit complex; ISS:PomBase.
									GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW.
									GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; ISS:PomBase.::GO:0007346; P:regulation of mitotic cell cycle; IC:PomBase.
3	Q9QUM9	246	PSA6_MOUSE Proteasome subunit alpha type-6 OS...	248	5e-91	275	54	73	GO:0016363; C:nuclear matrix; IDA:BHF-UCL.::GO:0005844; C:polysome; ISS:BHF-UCL.::GO:0019773; C:proteasome core complex, alpha-subunit complex; ISS:BHF-UCL.::GO:0030017; C:sarcomere; ISS:BHF-UCL.
									GO:0003723; F:RNA binding; IDA:BHF-UCL.::GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW.
									GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISS:BHF-UCL.::GO:0007519; P:skeletal muscle tissue development; NAS:BHF-UCL.::GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
4	P60901	246	PSA6_RAT Proteasome subunit alpha type-6 OS=R...	248	1e-90	275	54	72	GO:0016363; C:nuclear matrix; ISS:BHF-UCL.::GO:0005844; C:polysome; ISS:BHF-UCL.::GO:0019773; C:proteasome core complex, alpha-subunit complex; ISS:BHF-UCL.::GO:0030017; C:sarcomere; IDA:BHF-UCL.
									GO:0003723; F:RNA binding; ISS:BHF-UCL.::GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW.
									GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISS:BHF-UCL.::GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
5	P60900	246	PSA6_HUMAN Proteasome subunit alpha type-6 OS...	248	1e-90	275	54	72	GO:0005829; C:cytosol; TAS:Reactome.::GO:0005739; C:mitochondrion; IDA:HPA.::GO:0016363; C:nuclear matrix; ISS:BHF-UCL.::GO:0005654; C:nucleoplasm; TAS:Reactome.::GO:0005844; C:polysome; IDA:BHF-UCL.::GO:0019773; C:proteasome core complex, alpha-subunit complex; IDA:BHF-UCL.::GO:0030017; C:sarcomere; ISS:BHF-UCL.
									GO:0051059; F:NF-kappaB binding; IPI:BHF-UCL.::GO:0035639; F:purine ribonucleoside triphosphate binding; NAS:BHF-UCL.::GO:0003723; F:RNA binding; NAS:UniProtKB.::GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW.
									GO:0031145; P:anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; TAS:Reactome.::GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome.::GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0006977; P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; TAS:Reactome.::GO:0000082; P:G1/S transition of mitotic cell cycle; TAS:Reactome.::GO:0010467; P:gene expression; TAS:Reactome.::GO:0000216; P:M/G1 transition of mitotic cell cycle; TAS:Reactome.::GO:0016071; P:mRNA metabolic process; TAS:Reactome.::GO:0051436; P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; TAS:Reactome.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IMP:BHF-UCL.::GO:0051437; P:positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; TAS:Reactome.::GO:0000209; P:protein polyubiquitination; TAS:Reactome.::GO:0042981; P:regulation of apoptotic process; TAS:Reactome.::GO:0006521; P:regulation of cellular amino acid metabolic process; TAS:Reactome.::GO:0050727; P:regulation of inflammatory response; IC:BHF-UCL.::GO:0000084; P:S phase of mitotic cell cycle; TAS:Reactome.::GO:0044281; P:small molecule metabolic process; TAS:Reactome.::GO:0016032; P:viral reproduction; TAS:Reactome.
6	Q2YDE4	246	PSA6_BOVIN Proteasome subunit alpha type-6 OS...	248	1e-90	275	54	72
									GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW.
									GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
7	Q9XG77	246	PSA6_TOBAC Proteasome subunit alpha type-6 OS...	248	2e-84	259	52	70	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0019773; C:proteasome core complex, alpha-subunit complex; IEA:InterPro.
									GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW.
									GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
8	O81146	246	PSA6A_ARATH Proteasome subunit alpha type-6-A...	248	9e-83	254	51	69	GO:0005829; C:cytosol; IDA:TAIR.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0019773; C:proteasome core complex, alpha-subunit complex; IEA:InterPro.::GO:0005774; C:vacuolar membrane; IDA:TAIR.
									GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW.
									GO:0010043; P:response to zinc ion; IEP:TAIR.::GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
9	O81147	246	PSA6B_ARATH Proteasome subunit alpha type-6-B...	248	2e-82	253	49	69	GO:0022626; C:cytosolic ribosome; IDA:TAIR.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0019773; C:proteasome core complex, alpha-subunit complex; IEA:InterPro.
									GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW.
									GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
10	Q9LSU3	246	PSA6_ORYSJ Proteasome subunit alpha type-6 OS...	248	6e-82	252	51	69	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0019773; C:proteasome core complex, alpha-subunit complex; IEA:InterPro.
									GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW.
									GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
11	O48551	246	PSA6_SOYBN Proteasome subunit alpha type-6 OS...	248	2e-81	251	51	69	GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0019773; C:proteasome core complex, alpha-subunit complex; IEA:InterPro.
									GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW.
									GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
12	Q9XZJ4	244	PSA6_DROME Proteasome subunit alpha type-6 OS...	248	4e-80	248	49	67	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0019773; C:proteasome core complex, alpha-subunit complex; IEA:InterPro.
									GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW.
									GO:0006974; P:response to DNA damage stimulus; IMP:FlyBase.::GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
13	O17586	246	PSA6_CAEEL Proteasome subunit alpha type-6 OS...	248	6e-78	242	49	67	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0019773; C:proteasome core complex, alpha-subunit complex; IEA:InterPro.
									GO:0005515; F:protein binding; IPI:IntAct.::GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW.
									GO:0008340; P:determination of adult lifespan; IMP:WormBase.::GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.::GO:0040007; P:growth; IMP:WormBase.::GO:0040011; P:locomotion; IMP:WormBase.::GO:0018996; P:molting cycle, collagen and cuticulin-based cuticle; IMP:WormBase.::GO:0040015; P:negative regulation of multicellular organism growth; IMP:WormBase.::GO:0002119; P:nematode larval development; IMP:WormBase.::GO:0000003; P:reproduction; IMP:WormBase.::GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
14	Q54XM7	250	PSA6_DICDI Proteasome subunit alpha type-6 OS...	248	3e-76	238	46	67	GO:0005737; C:cytoplasm; IPI:dictyBase.::GO:0005634; C:nucleus; IPI:dictyBase.::GO:0019773; C:proteasome core complex, alpha-subunit complex; IEA:InterPro.
									GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW.
									GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
15	Q9GU37	266	PSA1_TRYBB Proteasome subunit alpha type-1 OS...	250	2e-47	164	38	58	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0019773; C:proteasome core complex, alpha-subunit complex; IEA:InterPro.
									GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW.
									GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
16	Q8TYB7	246	PSA_METKA Proteasome subunit alpha OS=100938)...	232	2e-40	145	34	55	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0019773; C:proteasome core complex, alpha-subunit complex; IEA:InterPro.
									GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW.
									GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
17	O24733	260	PSA_THEK1 Proteasome subunit alpha OS=Thermoc...	238	4e-35	131	34	54	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0019773; C:proteasome core complex, alpha-subunit complex; IEA:InterPro.
									GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW.
									GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
18	C6A459	260	PSA_THESM Proteasome subunit alpha OS=Thermoc...	234	6e-35	131	34	55	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0019773; C:proteasome core complex, alpha-subunit complex; IEA:InterPro.
									GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW.
									GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
19	Q9V122	260	PSA_PYRAB Proteasome subunit alpha OS=Pyrococ...	238	6e-35	131	35	54	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0019773; C:proteasome core complex, alpha-subunit complex; IEA:HAMAP.
									GO:0004298; F:threonine-type endopeptidase activity; IEA:HAMAP.
									GO:0010498; P:proteasomal protein catabolic process; IEA:HAMAP.::GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
20	Q5JIU9	260	PSA_PYRKO Proteasome subunit alpha OS=(Thermo...	236	9e-35	130	34	54	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0019773; C:proteasome core complex, alpha-subunit complex; IEA:InterPro.
									GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW.
									GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
21	O59219	260	PSA_PYRHO Proteasome subunit alpha OS=NBRC 10...	238	1e-34	130	35	54	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0019773; C:proteasome core complex, alpha-subunit complex; IEA:InterPro.
									GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW.
									GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
22	Q469M6	249	PSA_METBF Proteasome subunit alpha OS=Methano...	247	6e-34	128	31	53	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0019773; C:proteasome core complex, alpha-subunit complex; IEA:InterPro.
									GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW.
									GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
23	C5A2C2	260	PSA_THEGJ Proteasome subunit alpha OS=Thermoc...	223	9e-34	128	35	53	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0019773; C:proteasome core complex, alpha-subunit complex; IEA:InterPro.
									GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW.
									GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
24	Q8TPX5	247	PSA_METAC Proteasome subunit alpha OS=C2A). G...	247	1e-33	127	31	52	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0019773; C:proteasome core complex, alpha-subunit complex; IEA:InterPro.
									GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW.
									GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
25	B6YSH9	260	PSA_THEON Proteasome subunit alpha OS=Thermoc...	224	1e-33	127	34	54	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0019773; C:proteasome core complex, alpha-subunit complex; IEA:InterPro.
									GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW.
									GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
26	Q8U0L6	260	PSA_PYRFU Proteasome subunit alpha OS=Pyrococ...	238	2e-33	127	34	54	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0019773; C:proteasome core complex, alpha-subunit complex; IEA:InterPro.
									GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW.
									GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
27	O29760	246	PSA_ARCFU Proteasome subunit alpha OS=9628 / ...	225	4e-33	126	34	54	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0019773; C:proteasome core complex, alpha-subunit complex; IEA:InterPro.
									GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW.
									GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
28	Q8PTU1	249	PSA_METMA Proteasome subunit alpha OS=JCM 118...	247	6e-33	125	31	52	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0019773; C:proteasome core complex, alpha-subunit complex; IEA:InterPro.
									GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW.
									GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
29	Q59565	247	PSA_METTE Proteasome subunit alpha OS=Methano...	229	1e-32	124	32	53	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0019773; C:proteasome core complex, alpha-subunit complex; IEA:InterPro.
									GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW.
									GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
30	Q9N599	250	PSA4_CAEEL Proteasome subunit alpha type-4 OS...	223	2e-32	124	33	50	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0019773; C:proteasome core complex, alpha-subunit complex; IEA:InterPro.
									GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW.
									GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.::GO:0040007; P:growth; IMP:WormBase.::GO:0040035; P:hermaphrodite genitalia development; IMP:WormBase.::GO:0040011; P:locomotion; IMP:WormBase.::GO:0002009; P:morphogenesis of an epithelium; IMP:WormBase.::GO:0002119; P:nematode larval development; IMP:WormBase.::GO:0040010; P:positive regulation of growth rate; IMP:WormBase.::GO:0006898; P:receptor-mediated endocytosis; IMP:WormBase.::GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
31	O26782	248	PSA_METTH Proteasome subunit alpha OS=thermoa...	239	3e-32	124	32	53	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0019773; C:proteasome core complex, alpha-subunit complex; IEA:InterPro.
									GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW.
									GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.

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