UniProt_SwissProt BLAST: Single locus

Species:

Saccharomyces cerevisiae S288C

Locus:

YGL001C

Length:

349

Number of sequences:

5887

Description:

YGL001C ERG26 SGDID:S000002969, Chr VII from 496502-495453, Genome Release 64-1-1, reverse complement, Verified ORF, "C-3 sterol dehydrogenase, catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis"

rec.	Subject	Hit Length	Description	Align.Len	E value	Bit score	% ident.	% pos.	GO associations
1	P53199	349	ERG26_YEAST Sterol-4-alpha-carboxylate 3-dehy...	349	0	724	100	100	GO:0005789; C:endoplasmic reticulum membrane; IDA:SGD.
									GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.::GO:0000252; F:C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity; IDA:SGD.::GO:0000166; F:nucleotide binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0047012; F:sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity; IEA:EC.
									GO:0006696; P:ergosterol biosynthetic process; IDA:SGD.
2	O43050	340	ERG26_SCHPO Sterol-4-alpha-carboxylate 3-dehy...	348	8e-107	323	50	63	GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0005794; C:Golgi apparatus; IDA:PomBase.
									GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.::GO:0000252; F:C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity; ISS:PomBase.::GO:0000166; F:nucleotide binding; IEA:InterPro.::GO:0047012; F:sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity; IEA:EC.
									GO:0006696; P:ergosterol biosynthetic process; ISS:PomBase.
3	Q3ZBE9	356	NSDHL_BOVIN Sterol-4-alpha-carboxylate 3-dehy...	346	1e-69	228	39	55	GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
									GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.::GO:0000166; F:nucleotide binding; IEA:InterPro.::GO:0047012; F:sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity; IEA:EC.
									GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.
4	Q9R1J0	362	NSDHL_MOUSE Sterol-4-alpha-carboxylate 3-dehy...	346	7e-68	223	38	55	GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
									GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.::GO:0000166; F:nucleotide binding; IEA:InterPro.::GO:0047012; F:sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity; IEA:EC.
									GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.::GO:0001942; P:hair follicle development; IMP:MGI.::GO:0060716; P:labyrinthine layer blood vessel development; IMP:MGI.::GO:0007224; P:smoothened signaling pathway; IGI:MGI.
5	Q5PPL3	362	NSDHL_RAT Sterol-4-alpha-carboxylate 3-dehydr...	347	5e-66	218	38	56	GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
									GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.::GO:0000166; F:nucleotide binding; IEA:InterPro.::GO:0047012; F:sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity; IEA:EC.
									GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.
6	Q15738	373	NSDHL_HUMAN Sterol-4-alpha-carboxylate 3-dehy...	338	9e-65	216	38	56	GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005811; C:lipid particle; IDA:UniProtKB.
									GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; TAS:ProtInc.::GO:0000166; F:nucleotide binding; IEA:InterPro.::GO:0047012; F:sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity; IEA:EC.
									GO:0006695; P:cholesterol biosynthetic process; TAS:Reactome.
7	Q9FX01	439	HSDD1_ARATH 3beta-hydroxysteroid-dehydrogenas...	354	6e-54	189	37	53	GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
									GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.::GO:0000166; F:nucleotide binding; IEA:InterPro.::GO:0047012; F:sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity; IDA:TAIR.
									GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW.
8	Q67ZE1	564	HSDD2_ARATH 3beta-hydroxysteroid-dehydrogenas...	351	1e-51	185	36	51	GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
									GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.::GO:0000166; F:nucleotide binding; IEA:InterPro.::GO:0047012; F:sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity; IDA:TAIR.
									GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW.
9	Q8WUS8	393	D42E1_HUMAN Short-chain dehydrogenase/reducta...	346	2e-43	160	34	52	GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
									GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.::GO:0000166; F:nucleotide binding; IEA:InterPro.
									GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
10	Q4R7R1	393	D42E1_MACFA Short-chain dehydrogenase/reducta...	346	8e-43	158	34	52	GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
									GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.::GO:0000166; F:nucleotide binding; IEA:InterPro.
									GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
11	A8DZE7	387	D42E1_DANRE Short-chain dehydrogenase/reducta...	353	6e-40	150	32	52	GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
									GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.::GO:0000166; F:nucleotide binding; IEA:InterPro.
									GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
12	Q32L94	393	D42E1_BOVIN Short-chain dehydrogenase/reducta...	346	7e-39	147	32	50	GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
									GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.::GO:0000166; F:nucleotide binding; IEA:InterPro.
									GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
13	A9X4U2	561	HSDD3_ARATH 3beta-hydroxysteroid-dehydrogenas...	365	7e-38	146	30	48	GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IDA:TAIR.::GO:0009506; C:plasmodesma; IDA:TAIR.
									GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.::GO:0000166; F:nucleotide binding; IEA:InterPro.::GO:0047012; F:sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity; IEA:EC.
									GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW.
14	Q9D665	394	D42E1_MOUSE Short-chain dehydrogenase/reducta...	346	1e-37	144	32	51	GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
									GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.::GO:0000166; F:nucleotide binding; IEA:InterPro.
									GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
15	Q0IH73	386	D42E1_XENLA Short-chain dehydrogenase/reducta...	360	5e-34	134	31	49	GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
									GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.::GO:0000166; F:nucleotide binding; IEA:InterPro.
									GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
16	O53454	370	3BHS_MYCTU 3 beta-hydroxysteroid dehydrogenas...	361	3e-29	119	29	45	GO:0005829; C:cytosol; IDA:MTBBASE.::GO:0005886; C:plasma membrane; IDA:MTBBASE.
									GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IDA:MTBBASE.::GO:0070403; F:NAD+ binding; IDA:MTBBASE.::GO:0004769; F:steroid delta-isomerase activity; IDA:MTBBASE.::GO:0030283; F:testosterone dehydrogenase [NAD(P) activity; IDA:UniProtKB.
									GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.::GO:0006694; P:steroid biosynthetic process; IEA:InterPro.]
17	Q9EQC1	369	3BHS7_MOUSE 3 beta-hydroxysteroid dehydrogena...	359	1e-26	112	28	45	GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
									GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.::GO:0047016; F:cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity; IEA:EC.::GO:0000166; F:nucleotide binding; IEA:InterPro.
									GO:0006694; P:steroid biosynthetic process; IEA:UniProtKB-KW.
18	P14060	373	3BHS1_HUMAN 3 beta-hydroxysteroid dehydrogena...	370	2e-26	112	29	45	GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005792; C:microsome; IDA:UniProtKB.::GO:0005743; C:mitochondrial inner membrane; IDA:UniProtKB.::GO:0005758; C:mitochondrial intermembrane space; IDA:UniProtKB.::GO:0030868; C:smooth endoplasmic reticulum membrane; ISS:UniProtKB.
									GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; ISS:UniProtKB.::GO:0000166; F:nucleotide binding; IEA:InterPro.::GO:0004769; F:steroid delta-isomerase activity; ISS:UniProtKB.
									GO:0006702; P:androgen biosynthetic process; TAS:UniProtKB.::GO:0006703; P:estrogen biosynthetic process; TAS:UniProtKB.::GO:0006704; P:glucocorticoid biosynthetic process; TAS:Reactome.::GO:0006705; P:mineralocorticoid biosynthetic process; TAS:Reactome.::GO:0044281; P:small molecule metabolic process; TAS:Reactome.
19	O46516	373	3BHS_HORSE 3 beta-hydroxysteroid dehydrogenas...	367	2e-26	112	28	45	GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
									GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:EC.::GO:0000166; F:nucleotide binding; IEA:InterPro.::GO:0004769; F:steroid delta-isomerase activity; IEA:EC.
									GO:0006694; P:steroid biosynthetic process; IEA:UniProtKB-KW.
20	A6NKP2	422	D42E2_HUMAN Putative short-chain dehydrogenas...	341	2e-26	112	28	44
									GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.::GO:0000166; F:nucleotide binding; IEA:InterPro.
									GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
21	Q62878	373	3BHS4_RAT 3 beta-hydroxysteroid dehydrogenase...	365	2e-26	111	29	44	GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.::GO:0005625; C:soluble fraction; IDA:RGD.
									GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IDA:RGD.::GO:0000166; F:nucleotide binding; IEA:InterPro.::GO:0004769; F:steroid delta-isomerase activity; IDA:RGD.::GO:0030283; F:testosterone dehydrogenase [NAD(P) activity; TAS:RGD.
									GO:0006702; P:androgen biosynthetic process; IDA:RGD.::GO:0006700; P:C21-steroid hormone biosynthetic process; IDA:RGD.::GO:0021766; P:hippocampus development; IEP:RGD.::GO:0033327; P:Leydig cell differentiation; IEP:RGD.::GO:0034757; P:negative regulation of iron ion transport; IMP:RGD.::GO:0046686; P:response to cadmium ion; IEP:RGD.::GO:0051412; P:response to corticosterone stimulus; IEP:RGD.::GO:0034698; P:response to gonadotropin stimulus; IEP:RGD.::GO:0010288; P:response to lead ion; IEP:RGD.]
22	P27364	373	3BHS5_RAT 3 beta-hydroxysteroid dehydrogenase...	365	5e-26	110	29	45	GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005792; C:microsome; IDA:RGD.::GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.::GO:0005625; C:soluble fraction; IDA:RGD.
									GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IDA:RGD.::GO:0051287; F:NAD binding; IDA:RGD.::GO:0005496; F:steroid binding; IDA:RGD.
									GO:0042448; P:progesterone metabolic process; IDA:RGD.::GO:0050810; P:regulation of steroid biosynthetic process; IDA:RGD.::GO:0006694; P:steroid biosynthetic process; IDA:RGD.
23	P26150	373	3BHS3_MOUSE 3 beta-hydroxysteroid dehydrogena...	365	7e-26	110	29	44	GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005743; C:mitochondrial inner membrane; IDA:MGI.
									GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:EC.::GO:0000166; F:nucleotide binding; IEA:InterPro.::GO:0004769; F:steroid delta-isomerase activity; IEA:EC.
									GO:0006694; P:steroid biosynthetic process; IEA:UniProtKB-KW.
24	P27365	373	3BHS1_MACMU 3 beta-hydroxysteroid dehydrogena...	368	1e-25	109	28	45	GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
									GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:EC.::GO:0000166; F:nucleotide binding; IEA:InterPro.::GO:0004769; F:steroid delta-isomerase activity; IEA:EC.
									GO:0006694; P:steroid biosynthetic process; IEA:UniProtKB-KW.
25	Q67477	370	3BHS_FOWPN 3 beta-hydroxysteroid dehydrogenas...	363	1e-25	109	29	45
									GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:EC.::GO:0000166; F:nucleotide binding; IEA:InterPro.::GO:0004769; F:steroid delta-isomerase activity; IEA:EC.
									GO:0006694; P:steroid biosynthetic process; IEA:UniProtKB-KW.
26	O35469	373	3BHS6_MOUSE 3 beta-hydroxysteroid dehydrogena...	370	2e-25	108	29	44	GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
									GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:EC.::GO:0000166; F:nucleotide binding; IEA:InterPro.::GO:0004769; F:steroid delta-isomerase activity; IEA:EC.
									GO:0006694; P:steroid biosynthetic process; IEA:UniProtKB-KW.
27	Q64421	373	3BHS2_MESAU 3 beta-hydroxysteroid dehydrogena...	369	2e-25	108	28	44	GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
									GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:EC.::GO:0000166; F:nucleotide binding; IEA:InterPro.::GO:0004769; F:steroid delta-isomerase activity; IEA:EC.
									GO:0006694; P:steroid biosynthetic process; IEA:UniProtKB-KW.
28	P26149	373	3BHS2_MOUSE 3 beta-hydroxysteroid dehydrogena...	363	4e-25	108	29	44	GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
									GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:EC.::GO:0000166; F:nucleotide binding; IEA:InterPro.::GO:0004769; F:steroid delta-isomerase activity; IEA:EC.
									GO:0006694; P:steroid biosynthetic process; IEA:UniProtKB-KW.
29	P26439	372	3BHS2_HUMAN 3 beta-hydroxysteroid dehydrogena...	368	1e-24	106	28	44	GO:0016021; C:integral to membrane; NAS:UniProtKB.::GO:0005792; C:microsome; ISS:UniProtKB.::GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.::GO:0005758; C:mitochondrial intermembrane space; ISS:UniProtKB.::GO:0030868; C:smooth endoplasmic reticulum membrane; ISS:UniProtKB.
									GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IDA:UniProtKB.::GO:0000166; F:nucleotide binding; IEA:InterPro.::GO:0004769; F:steroid delta-isomerase activity; IDA:UniProtKB.
									GO:0006702; P:androgen biosynthetic process; TAS:Reactome.::GO:0006704; P:glucocorticoid biosynthetic process; TAS:Reactome.::GO:0006705; P:mineralocorticoid biosynthetic process; TAS:Reactome.::GO:0044281; P:small molecule metabolic process; TAS:Reactome.
30	O57245	346	3BHS_VACCA 3 beta-hydroxysteroid dehydrogenas...	363	8e-24	103	25	45
									GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:EC.::GO:0000166; F:nucleotide binding; IEA:InterPro.::GO:0004769; F:steroid delta-isomerase activity; IEA:EC.
									GO:0006694; P:steroid biosynthetic process; IEA:UniProtKB-KW.
31	Q61767	373	3BHS4_MOUSE 3 beta-hydroxysteroid dehydrogena...	364	8e-24	103	28	44	GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
									GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.::GO:0000166; F:nucleotide binding; IEA:InterPro.
									GO:0035634; P:response to stilbenoid; IEP:UniProtKB.::GO:0006694; P:steroid biosynthetic process; IEA:UniProtKB-KW.

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