UniProt_SwissProt BLAST: Single locus

Species:

Saccharomyces cerevisiae S288C

Locus:

YFR055W

Length:

340

Number of sequences:

5887

Description:

YFR055W IRC7 SGDID:S000001952, Chr VI from 264204-265226, Genome Release 64-1-1, Uncharacterized ORF, "Beta-lyase involved in the production of thiols; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner and by copper levels in a Mac1-dependent manner"

rec.	Subject	Hit Length	Description	Align.Len	E value	Bit score	% ident.	% pos.	GO associations
1	P43623	340	METC_YEAST Putative cystathionine beta-lyase ...	340	0	697	100	100	GO:0005737; C:cytoplasm; IEA:InterPro.
									GO:0004121; F:cystathionine beta-lyase activity; IEA:EC.::GO:0047804; F:cysteine-S-conjugate beta-lyase activity; IDA:SGD.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0019450; P:L-cysteine catabolic process to pyruvate; IMP:SGD.::GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
2	Q52811	396	METC_RHIL3 Putative cystathionine beta-lyase ...	338	1e-102	314	45	62	GO:0005737; C:cytoplasm; IEA:InterPro.
									GO:0004121; F:cystathionine beta-lyase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
3	P44527	396	METC_HAEIN Cystathionine beta-lyase OS=Haemop...	341	5e-87	274	40	60	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004121; F:cystathionine beta-lyase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
4	P18949	395	METC_SALTY Cystathionine beta-lyase OS=Salmon...	335	1e-84	267	41	59	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004121; F:cystathionine beta-lyase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
5	P06721	395	METC_ECOLI Cystathionine beta-lyase metC OS=E...	337	8e-83	263	40	58	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004121; F:cystathionine beta-lyase activity; IDA:EcoCyc.::GO:0080146; F:L-cysteine desulfhydrase activity; IMP:EcoCyc.::GO:0030170; F:pyridoxal phosphate binding; IDA:EcoCyc.
									GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
6	Q07703	396	METC_BORAV Cystathionine beta-lyase OS=Bordet...	329	5e-65	217	38	55	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004121; F:cystathionine beta-lyase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
7	Q1M0P5	380	METB_HELPX Cystathionine gamma-synthase OS=He...	330	1e-53	186	36	55	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0003962; F:cystathionine gamma-synthase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
8	P56069	380	METB_HELPY Cystathionine gamma-synthase OS=py...	330	3e-53	185	36	55	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0003962; F:cystathionine gamma-synthase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
9	Q9ZMW7	380	METB_HELPJ Cystathionine gamma-synthase OS=He...	333	9e-53	184	36	53	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0003962; F:cystathionine gamma-synthase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
10	P24601	319	METB_HERAU Probable cystathionine gamma-synth...	308	2e-51	179	34	56	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0003962; F:cystathionine gamma-synthase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
11	O31632	390	METC_BACSU Cystathionine beta-lyase metC OS=B...	338	1e-50	179	33	54	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004121; F:cystathionine beta-lyase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
12	O05394	379	MCCB_BACSU Cystathionine gamma-lyase OS=Bacil...	288	6e-47	168	33	57
									GO:0004123; F:cystathionine gamma-lyase activity; IEA:EC.::GO:0047982; F:homocysteine desulfhydrase activity; IEA:EC.::GO:0080146; F:L-cysteine desulfhydrase activity; IEA:EC.::GO:0044540; F:L-cystine L-cysteine-lyase (deaminating); IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0006520; P:cellular amino acid metabolic process; IEA:InterPro.
13	P55216	392	CGL2_CAEEL Putative cystathionine gamma-lyase...	327	1e-46	168	34	53	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004123; F:cystathionine gamma-lyase activity; IEA:EC.::GO:0080146; F:L-cysteine desulfhydrase activity; IEA:EC.::GO:0044540; F:L-cystine L-cysteine-lyase (deaminating); IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0019344; P:cysteine biosynthetic process; IEA:UniProtKB-KW.::GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.
14	P32929	405	CGL_HUMAN Cystathionine gamma-lyase OS=Homo s...	332	5e-46	166	33	53	GO:0005829; C:cytosol; TAS:Reactome.::GO:0005634; C:nucleus; IDA:HPA.
									GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0004123; F:cystathionine gamma-lyase activity; IDA:UniProtKB.::GO:0047982; F:homocysteine desulfhydrase activity; TAS:Reactome.::GO:0080146; F:L-cysteine desulfhydrase activity; TAS:Reactome.::GO:0044540; F:L-cystine L-cysteine-lyase (deaminating); IMP:UniProtKB.::GO:0030170; F:pyridoxal phosphate binding; IDA:UniProtKB.
									GO:0019344; P:cysteine biosynthetic process; IDA:UniProtKB.::GO:0030968; P:endoplasmic reticulum unfolded protein response; TAS:UniProtKB.::GO:0070814; P:hydrogen sulfide biosynthetic process; IDA:UniProtKB.::GO:0051289; P:protein homotetramerization; IPI:UniProtKB.::GO:0044524; P:protein sulfhydration; IMP:UniProtKB.::GO:0018272; P:protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine; IDA:UniProtKB.::GO:0000098; P:sulfur amino acid catabolic process; TAS:Reactome.::GO:0019346; P:transsulfuration; TAS:Reactome.
15	A2RM21	380	METC_LACLM Cystathionine beta-lyase OS=Lactoc...	322	4e-45	164	34	51	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004121; F:cystathionine beta-lyase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
16	P0A4K2	380	METC_LACLA Cystathionine beta-lyase OS=lactis...	322	4e-45	164	34	51	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004121; F:cystathionine beta-lyase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
17	Q60HG7	405	CGL_MACFA Cystathionine gamma-lyase OS=Macaca...	331	5e-44	161	31	52	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0004123; F:cystathionine gamma-lyase activity; ISS:UniProtKB.::GO:0080146; F:L-cysteine desulfhydrase activity; IEA:EC.::GO:0044540; F:L-cystine L-cysteine-lyase (deaminating); ISS:UniProtKB.::GO:0030170; F:pyridoxal phosphate binding; ISS:UniProtKB.
									GO:0006916; P:anti-apoptosis; ISS:UniProtKB.::GO:0019344; P:cysteine biosynthetic process; ISS:UniProtKB.::GO:0070814; P:hydrogen sulfide biosynthetic process; ISS:UniProtKB.::GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; ISS:UniProtKB.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.::GO:0044524; P:protein sulfhydration; ISS:UniProtKB.::GO:0018272; P:protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine; ISS:UniProtKB.
18	P0C2T9	380	METC_LACLC Cystathionine beta-lyase OS=Lactoc...	322	3e-43	159	34	51	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004121; F:cystathionine beta-lyase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
19	Q19QT7	405	CGL_PIG Cystathionine gamma-lyase OS=Sus scro...	332	1e-42	157	32	51	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0004123; F:cystathionine gamma-lyase activity; ISS:UniProtKB.::GO:0080146; F:L-cysteine desulfhydrase activity; IEA:EC.::GO:0044540; F:L-cystine L-cysteine-lyase (deaminating); ISS:UniProtKB.::GO:0030170; F:pyridoxal phosphate binding; ISS:UniProtKB.
									GO:0006916; P:anti-apoptosis; ISS:UniProtKB.::GO:0019344; P:cysteine biosynthetic process; ISS:UniProtKB.::GO:0070814; P:hydrogen sulfide biosynthetic process; ISS:UniProtKB.::GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; ISS:UniProtKB.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.::GO:0044524; P:protein sulfhydration; ISS:UniProtKB.::GO:0018272; P:protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine; ISS:UniProtKB.
20	Q58DW2	405	CGL_BOVIN Cystathionine gamma-lyase OS=Bos ta...	332	3e-42	156	31	52	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0004123; F:cystathionine gamma-lyase activity; ISS:UniProtKB.::GO:0080146; F:L-cysteine desulfhydrase activity; IEA:EC.::GO:0044540; F:L-cystine L-cysteine-lyase (deaminating); ISS:UniProtKB.::GO:0030170; F:pyridoxal phosphate binding; ISS:UniProtKB.
									GO:0006916; P:anti-apoptosis; ISS:UniProtKB.::GO:0019344; P:cysteine biosynthetic process; ISS:UniProtKB.::GO:0070814; P:hydrogen sulfide biosynthetic process; ISS:UniProtKB.::GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; ISS:UniProtKB.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.::GO:0044524; P:protein sulfhydration; ISS:UniProtKB.::GO:0018272; P:protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine; ISS:UniProtKB.
21	Q8VCN5	398	CGL_MOUSE Cystathionine gamma-lyase OS=Mus mu...	332	9e-42	155	31	52	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0004123; F:cystathionine gamma-lyase activity; ISS:UniProtKB.::GO:0080146; F:L-cysteine desulfhydrase activity; IEA:EC.::GO:0044540; F:L-cystine L-cysteine-lyase (deaminating); IDA:UniProtKB.::GO:0030170; F:pyridoxal phosphate binding; ISS:UniProtKB.
									GO:0006916; P:anti-apoptosis; IMP:UniProtKB.::GO:0019344; P:cysteine biosynthetic process; ISS:UniProtKB.::GO:0070814; P:hydrogen sulfide biosynthetic process; ISS:UniProtKB.::GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IMP:UniProtKB.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IMP:UniProtKB.::GO:0044524; P:protein sulfhydration; IDA:UniProtKB.::GO:0018272; P:protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine; ISS:UniProtKB.
22	P46807	388	METB_MYCLE Cystathionine gamma-synthase OS=My...	334	3e-41	153	30	49	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0003962; F:cystathionine gamma-synthase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
23	P66875	388	METB_MYCTU Cystathionine gamma-synthase OS=My...	334	5e-41	152	30	49	GO:0005829; C:cytosol; TAS:Reactome.::GO:0005886; C:plasma membrane; IDA:MTBBASE.
									GO:0004123; F:cystathionine gamma-lyase activity; IDA:MTBBASE.::GO:0003962; F:cystathionine gamma-synthase activity; IDA:MTBBASE.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0019343; P:cysteine biosynthetic process via cystathionine; IMP:MTBBASE.::GO:0019279; P:L-methionine biosynthetic process from L-homoserine via cystathionine; IMP:MTBBASE.
24	P66876	388	METB_MYCBO Cystathionine gamma-synthase OS=My...	334	5e-41	152	30	49	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0003962; F:cystathionine gamma-synthase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
25	P18757	398	CGL_RAT Cystathionine gamma-lyase OS=Rattus n...	332	1e-40	152	30	51	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0004121; F:cystathionine beta-lyase activity; IDA:RGD.::GO:0004123; F:cystathionine gamma-lyase activity; ISS:UniProtKB.::GO:0080146; F:L-cysteine desulfhydrase activity; IEA:EC.::GO:0044540; F:L-cystine L-cysteine-lyase (deaminating); ISS:UniProtKB.::GO:0030170; F:pyridoxal phosphate binding; ISS:UniProtKB.
									GO:0006916; P:anti-apoptosis; ISS:UniProtKB.::GO:0019344; P:cysteine biosynthetic process; ISS:UniProtKB.::GO:0006749; P:glutathione metabolic process; IMP:RGD.::GO:0070814; P:hydrogen sulfide biosynthetic process; ISS:UniProtKB.::GO:0030308; P:negative regulation of cell growth; IMP:RGD.::GO:0008285; P:negative regulation of cell proliferation; IMP:RGD.::GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; ISS:UniProtKB.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.::GO:0044524; P:protein sulfhydration; ISS:UniProtKB.::GO:0018272; P:protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine; ISS:UniProtKB.::GO:0019346; P:transsulfuration; TAS:RGD.
26	Q55DV9	387	CGL_DICDI Cystathionine gamma-lyase OS=Dictyo...	337	2e-40	151	28	50	GO:0005737; C:cytoplasm; ISS:dictyBase.::GO:0005615; C:extracellular space; IDA:dictyBase.
									GO:0004123; F:cystathionine gamma-lyase activity; ISS:dictyBase.::GO:0080146; F:L-cysteine desulfhydrase activity; IEA:EC.::GO:0044540; F:L-cystine L-cysteine-lyase (deaminating); IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0019344; P:cysteine biosynthetic process; IEA:UniProtKB-KW.
27	P55217	563	METB_ARATH Cystathionine gamma-synthase, chlo...	317	7e-38	146	31	49	GO:0009570; C:chloroplast stroma; IDA:TAIR.
									GO:0003962; F:cystathionine gamma-synthase activity; IDA:TAIR.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0009086; P:methionine biosynthetic process; IMP:TAIR.::GO:0001887; P:selenium compound metabolic process; IDA:TAIR.
28	O31631	373	METI_BACSU Cystathionine gamma-synthase/O-ace...	278	9e-38	144	32	55	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.::GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
									GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
29	P13254	398	MEGL_PSEPU Methionine gamma-lyase OS=Pseudomo...	314	2e-37	143	28	48
									GO:0018826; F:methionine gamma-lyase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0006520; P:cellular amino acid metabolic process; IEA:InterPro.
30	P00935	386	METB_ECOLI Cystathionine gamma-synthase OS=Es...	322	2e-35	137	29	48	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0003962; F:cystathionine gamma-synthase activity; IDA:EcoCyc.::GO:0042802; F:identical protein binding; IPI:EcoCyc.::GO:0030170; F:pyridoxal phosphate binding; IDA:EcoCyc.
									GO:0009086; P:methionine biosynthetic process; IMP:EcoCyc.
31	Q83A83	387	METC_COXBU Cystathionine beta-lyase OS=Coxiel...	335	1e-33	132	27	48	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004121; F:cystathionine beta-lyase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.

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