UniProt_SwissProt BLAST: Single locus

Species:

Saccharomyces cerevisiae S288C

Locus:

YFR053C

Length:

485

Number of sequences:

5887

Description:

YFR053C HXK1 SGDID:S000001949, Chr VI from 255049-253592, Genome Release 64-1-1, reverse complement, Verified ORF, "Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p"

rec.	Subject	Hit Length	Description	Align.Len	E value	Bit score	% ident.	% pos.	GO associations
1	P04806	485	HXKA_YEAST Hexokinase-1 OS=Saccharomyces cere...	485	0	999	100	100	GO:0005829; C:cytosol; IDA:SGD.::GO:0005739; C:mitochondrion; IDA:SGD.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004396; F:hexokinase activity; IDA:SGD.
									GO:0032445; P:fructose import; IGI:SGD.::GO:0006000; P:fructose metabolic process; IMP:SGD.::GO:0006096; P:glycolysis; IDA:SGD.::GO:0006013; P:mannose metabolic process; IDA:SGD.
2	P04807	486	HXKB_YEAST Hexokinase-2 OS=Saccharomyces cere...	486	0	777	77	89	GO:0005829; C:cytosol; IDA:SGD.::GO:0005739; C:mitochondrion; IDA:SGD.::GO:0005634; C:nucleus; IDA:SGD.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004396; F:hexokinase activity; IDA:SGD.
									GO:0032445; P:fructose import; IGI:SGD.::GO:0006000; P:fructose metabolic process; IMP:SGD.::GO:0006096; P:glycolysis; IDA:SGD.::GO:0006013; P:mannose metabolic process; IDA:SGD.::GO:0008361; P:regulation of cell size; IMP:SGD.::GO:0046015; P:regulation of transcription by glucose; IDA:SGD.::GO:0001302; P:replicative cell aging; IMP:SGD.
3	P33284	485	HXK_KLULA Hexokinase OS=1267 / NRRL Y-1140 / ...	485	0	731	71	85
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004396; F:hexokinase activity; IEA:EC.
									GO:0006096; P:glycolysis; IEA:UniProtKB-KW.
4	P83776	484	HXKB_CANAL Hexokinase-2 OS=Candida albicans (...	486	0	695	69	81	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004396; F:hexokinase activity; IEA:EC.
									GO:0006096; P:glycolysis; IEA:UniProtKB-KW.
5	P50506	478	HXK_SCHOC Hexokinase OS=Schwanniomyces occide...	481	0	691	71	83
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004396; F:hexokinase activity; IEA:EC.
									GO:0006096; P:glycolysis; IEA:UniProtKB-KW.
6	P80581	490	HXK_EMENI Hexokinase OS=194 / M139) (Aspergil...	485	0	547	55	73
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004396; F:hexokinase activity; IEA:EC.
									GO:0006096; P:glycolysis; IEA:UniProtKB-KW.
7	Q09756	484	HXK1_SCHPO Hexokinase-1 OS=Schizosaccharomyce...	476	2e-152	450	48	66	GO:0005829; C:cytosol; IDA:PomBase.::GO:0005634; C:nucleus; IDA:PomBase.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008865; F:fructokinase activity; IDA:PomBase.::GO:0004340; F:glucokinase activity; IDA:PomBase.::GO:0019158; F:mannokinase activity; IDA:PomBase.
									GO:0006002; P:fructose 6-phosphate metabolic process; IDA:PomBase.::GO:0006096; P:glycolysis; IC:PomBase.::GO:0006013; P:mannose metabolic process; IDA:PomBase.::GO:0009051; P:pentose-phosphate shunt, oxidative branch; TAS:PomBase.
8	Q92407	495	HXKG_ASPNG Glucokinase OS=Aspergillus niger. ...	491	2e-88	285	37	53
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004340; F:glucokinase activity; IEA:EC.
									GO:0006096; P:glycolysis; IEA:UniProtKB-KW.
9	Q9NFT7	486	HXK2_DROME Hexokinase type 2 OS=Drosophila me...	460	2e-87	283	36	54
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004396; F:hexokinase activity; NAS:UniProtKB.
									GO:0006096; P:glycolysis; NAS:UniProtKB.
10	P17709	500	HXKG_YEAST Glucokinase-1 OS=Saccharomyces cer...	491	6e-87	282	38	54	GO:0005829; C:cytosol; IDA:SGD.::GO:0001950; C:plasma membrane enriched fraction; IDA:SGD.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004340; F:glucokinase activity; IDA:SGD.
									GO:0006096; P:glycolysis; IDA:SGD.::GO:0006013; P:mannose metabolic process; IDA:SGD.
11	Q04409	500	EMI2_YEAST Putative glucokinase-2 OS=Saccharo...	489	1e-83	273	38	52	GO:0005737; C:cytoplasm; IDA:SGD.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004340; F:glucokinase activity; IEA:EC.
									GO:0030437; P:ascospore formation; IMP:SGD.::GO:0006096; P:glycolysis; IEA:UniProtKB-KW.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:SGD.
12	Q6CUZ3	481	HXKG_KLULA Glucokinase-1 OS=1267 / NRRL Y-114...	482	9e-82	268	38	53
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004340; F:glucokinase activity; IEA:EC.
									GO:0006096; P:glycolysis; IEA:UniProtKB-KW.
13	A2PYL6	917	HXK2_HORSE Hexokinase-2 OS=Equus caballus (Ho...	451	3e-70	245	35	53
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004396; F:hexokinase activity; IEA:EC.
									GO:0006096; P:glycolysis; IEA:UniProtKB-KW.
14	A2PYL7	917	HXK2_EQUZE Hexokinase-2 OS=Equus zebra (Mount...	451	3e-70	245	35	53
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004396; F:hexokinase activity; IEA:EC.
									GO:0006096; P:glycolysis; IEA:UniProtKB-KW.
15	A2PYL8	917	HXK2_EQUGR Hexokinase-2 OS=Equus grevyi (Grev...	451	3e-70	245	35	53
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004396; F:hexokinase activity; IEA:EC.
									GO:0006096; P:glycolysis; IEA:UniProtKB-KW.
16	P52790	923	HXK3_HUMAN Hexokinase-3 OS=Homo sapiens (Huma...	476	3e-45	174	28	48	GO:0005829; C:cytosol; TAS:Reactome.::GO:0016020; C:membrane; NAS:UniProtKB.
									GO:0005524; F:ATP binding; NAS:UniProtKB.::GO:0004396; F:hexokinase activity; NAS:UniProtKB.
									GO:0015758; P:glucose transport; TAS:Reactome.::GO:0006096; P:glycolysis; NAS:UniProtKB.::GO:0055085; P:transmembrane transport; TAS:Reactome.
17	Q2TB90	917	HKDC1_HUMAN Putative hexokinase HKDC1 OS=Homo...	458	1e-60	218	33	55	GO:0005739; C:mitochondrion; IDA:HPA.::GO:0005634; C:nucleus; IDA:HPA.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004396; F:hexokinase activity; IEA:EC.
									GO:0006096; P:glycolysis; IEA:UniProtKB-KW.
18	O08528	917	HXK2_MOUSE Hexokinase-2 OS=Mus musculus (Mous...	452	2e-70	246	35	54
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004396; F:hexokinase activity; IDA:MGI.
									GO:0006096; P:glycolysis; IEA:UniProtKB-KW.::GO:0046324; P:regulation of glucose import; IMP:MGI.
19	P52792	465	HXK4_MOUSE Glucokinase OS=Mus musculus (Mouse...	464	1e-78	259	33	57	GO:0005829; C:cytosol; TAS:Reactome.::GO:0005739; C:mitochondrion; IDA:MGI.::GO:0005625; C:soluble fraction; IDA:MGI.
									GO:0005524; F:ATP binding; ISS:UniProtKB.::GO:0004340; F:glucokinase activity; ISS:UniProtKB.::GO:0005536; F:glucose binding; ISS:UniProtKB.
									GO:0070509; P:calcium ion import; IMP:UniProtKB.::GO:0001678; P:cellular glucose homeostasis; IMP:MGI.::GO:0051594; P:detection of glucose; ISS:UniProtKB.::GO:0031018; P:endocrine pancreas development; TAS:Reactome.::GO:0006096; P:glycolysis; IEA:UniProtKB-KW.::GO:0006739; P:NADP metabolic process; IMP:MGI.::GO:0045721; P:negative regulation of gluconeogenesis; ISS:UniProtKB.::GO:0045725; P:positive regulation of glycogen biosynthetic process; ISS:UniProtKB.::GO:0032024; P:positive regulation of insulin secretion; IMP:UniProtKB.::GO:0043266; P:regulation of potassium ion transport; IMP:MGI.
20	P27881	917	HXK2_RAT Hexokinase-2 OS=Rattus norvegicus (R...	446	3e-70	245	35	54	GO:0005741; C:mitochondrial outer membrane; TAS:RGD.
									GO:0005524; F:ATP binding; IDA:RGD.::GO:0005536; F:glucose binding; IDA:RGD.::GO:0004396; F:hexokinase activity; IDA:RGD.
									GO:0006096; P:glycolysis; IEA:UniProtKB-KW.::GO:0007595; P:lactation; IEP:RGD.
21	Q9SEK2	497	HXK1_TOBAC Hexokinase-1 OS=Nicotiana tabacum ...	463	3e-78	259	35	52	GO:0009707; C:chloroplast outer membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004396; F:hexokinase activity; IEA:EC.
									GO:0006096; P:glycolysis; IEA:UniProtKB-KW.
22	P35557	465	HXK4_HUMAN Glucokinase OS=Homo sapiens (Human...	466	3e-78	258	33	56	GO:0005829; C:cytosol; TAS:Reactome.::GO:0005654; C:nucleoplasm; TAS:Reactome.
									GO:0005524; F:ATP binding; IDA:UniProtKB.::GO:0004340; F:glucokinase activity; IDA:UniProtKB.::GO:0005536; F:glucose binding; IDA:UniProtKB.::GO:0005515; F:protein binding; IPI:UniProtKB.
									GO:0032869; P:cellular response to insulin stimulus; ISS:BHF-UCL.::GO:0044320; P:cellular response to leptin stimulus; ISS:BHF-UCL.::GO:0051594; P:detection of glucose; IMP:UniProtKB.::GO:0031018; P:endocrine pancreas development; TAS:Reactome.::GO:0042593; P:glucose homeostasis; IMP:UniProtKB.::GO:0015758; P:glucose transport; TAS:Reactome.::GO:0006096; P:glycolysis; IEA:UniProtKB-KW.::GO:0045721; P:negative regulation of gluconeogenesis; IMP:UniProtKB.::GO:0045725; P:positive regulation of glycogen biosynthetic process; IMP:UniProtKB.::GO:0032024; P:positive regulation of insulin secretion; IMP:UniProtKB.::GO:0010827; P:regulation of glucose transport; TAS:Reactome.::GO:0006110; P:regulation of glycolysis; NAS:BHF-UCL.::GO:0055085; P:transmembrane transport; TAS:Reactome.
23	Q42525	496	HXK1_ARATH Hexokinase-1 OS=Arabidopsis thalia...	444	3e-78	259	37	53	GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IDA:TAIR.::GO:0009536; C:plastid; IDA:TAIR.::GO:0005774; C:vacuolar membrane; IDA:TAIR.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008865; F:fructokinase activity; IDA:TAIR.::GO:0004340; F:glucokinase activity; IDA:TAIR.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0008270; F:zinc ion binding; IDA:TAIR.
									GO:0010255; P:glucose mediated signaling pathway; IMP:TAIR.::GO:0006096; P:glycolysis; IEA:UniProtKB-KW.::GO:0012501; P:programmed cell death; IMP:TAIR.
24	Q9SEK3	498	HXK1_SPIOL Hexokinase-1 OS=Spinacia oleracea ...	472	6e-78	258	35	54	GO:0009707; C:chloroplast outer membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004396; F:hexokinase activity; IEA:EC.
									GO:0006096; P:glycolysis; IEA:UniProtKB-KW.
25	P52789	917	HXK2_HUMAN Hexokinase-2 OS=Homo sapiens (Huma...	454	8e-72	250	36	54	GO:0005829; C:cytosol; TAS:Reactome.::GO:0005741; C:mitochondrial outer membrane; IDA:MGI.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004396; F:hexokinase activity; TAS:ProtInc.
									GO:0008637; P:apoptotic mitochondrial changes; IDA:MGI.::GO:0015758; P:glucose transport; TAS:Reactome.::GO:0006096; P:glycolysis; IEA:UniProtKB-KW.::GO:0055085; P:transmembrane transport; TAS:Reactome.
26	P17712	465	HXK4_RAT Glucokinase OS=Rattus norvegicus (Ra...	464	1e-77	256	33	57	GO:0044448; C:cell cortex part; IDA:RGD.::GO:0005829; C:cytosol; IDA:RGD.::GO:0005739; C:mitochondrion; IDA:RGD.::GO:0005654; C:nucleoplasm; IDA:RGD.::GO:0030141; C:secretory granule; IDA:RGD.
									GO:0043531; F:ADP binding; IDA:RGD.::GO:0005524; F:ATP binding; ISS:UniProtKB.::GO:0004340; F:glucokinase activity; ISS:UniProtKB.::GO:0005536; F:glucose binding; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; IDA:RGD.::GO:0019903; F:protein phosphatase binding; IPI:RGD.
									GO:0001678; P:cellular glucose homeostasis; IMP:RGD.::GO:0042149; P:cellular response to glucose starvation; IMP:RGD.::GO:0032869; P:cellular response to insulin stimulus; IDA:BHF-UCL.::GO:0044320; P:cellular response to leptin stimulus; IDA:BHF-UCL.::GO:0051594; P:detection of glucose; ISS:UniProtKB.::GO:0007204; P:elevation of cytosolic calcium ion concentration; IDA:RGD.::GO:0006003; P:fructose 2,6-bisphosphate metabolic process; IDA:RGD.::GO:0005978; P:glycogen biosynthetic process; IDA:RGD.::GO:0006096; P:glycolysis; IDA:RGD.::GO:0032811; P:negative regulation of epinephrine secretion; IMP:RGD.::GO:0045721; P:negative regulation of gluconeogenesis; ISS:UniProtKB.::GO:0045725; P:positive regulation of glycogen biosynthetic process; ISS:UniProtKB.::GO:0045821; P:positive regulation of glycolysis; IDA:RGD.::GO:0032024; P:positive regulation of insulin secretion; ISS:UniProtKB.::GO:0042327; P:positive regulation of phosphorylation; IDA:RGD.::GO:0019932; P:second-messenger-mediated signaling; IDA:RGD.
27	Q1W674	917	HXK2_PIG Hexokinase-2 OS=Sus scrofa (Pig). GN...	446	2e-70	246	35	55
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004396; F:hexokinase activity; IEA:EC.
									GO:0006096; P:glycolysis; IEA:UniProtKB-KW.
28	Q3TRM8	922	HXK3_MOUSE Hexokinase-3 OS=Mus musculus (Mous...	462	2e-44	171	28	48	GO:0005739; C:mitochondrion; IDA:MGI.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004396; F:hexokinase activity; IEA:EC.
									GO:0006096; P:glycolysis; IEA:UniProtKB-KW.
29	Q2KNB7	502	HXK9_ORYSJ Hexokinase-9 OS=Oryza sativa subsp...	457	7e-77	255	36	52	GO:0009707; C:chloroplast outer membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004396; F:hexokinase activity; IEA:EC.
									GO:0006096; P:glycolysis; IEA:UniProtKB-KW.
30	P05708	918	HXK1_RAT Hexokinase-1 OS=Rattus norvegicus (R...	451	2e-63	226	32	53	GO:0005901; C:caveola; IDA:RGD.::GO:0005829; C:cytosol; IDA:RGD.::GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.::GO:0043234; C:protein complex; IDA:RGD.
									GO:0005524; F:ATP binding; IDA:RGD.::GO:0016887; F:ATPase activity; IC:RGD.::GO:0004340; F:glucokinase activity; IDA:RGD.::GO:0005536; F:glucose binding; IDA:RGD.::GO:0032403; F:protein complex binding; IDA:RGD.::GO:0042803; F:protein homodimerization activity; IDA:RGD.::GO:0004672; F:protein kinase activity; IDA:RGD.
									GO:0006096; P:glycolysis; IDA:RGD.::GO:0043066; P:negative regulation of apoptotic process; IMP:RGD.::GO:0018105; P:peptidyl-serine phosphorylation; IDA:RGD.::GO:0018107; P:peptidyl-threonine phosphorylation; IDA:RGD.::GO:0018108; P:peptidyl-tyrosine phosphorylation; IDA:RGD.::GO:0046777; P:protein autophosphorylation; IDA:RGD.::GO:0010359; P:regulation of anion channel activity; IDA:RGD.
31	P27926	924	HXK3_RAT Hexokinase-3 OS=Rattus norvegicus (R...	454	2e-53	197	29	51	GO:0043234; C:protein complex; IDA:RGD.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0019899; F:enzyme binding; IPI:RGD.::GO:0004396; F:hexokinase activity; IDA:RGD.::GO:0042562; F:hormone binding; IPI:RGD.
									GO:0006096; P:glycolysis; IEA:UniProtKB-KW.

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