Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YFR028C
Length:
551
Number of sequences:
5887
Description:
YFR028C CDC14 SGDID:S000001924, Chr VI from 210068-208413, Genome Release 64-1-1, reverse complement, Verified ORF, "Protein phosphatase required for mitotic exit; located in the nucleolus until liberated by the FEAR and Mitotic Exit Network in anaphase, enabling it to act on key substrates to effect a decrease in CDK/B-cyclin activity and mitotic exit; required for meiosis I spindle disassembly; released from nucleolus upon entry into anaphase I of meiosis, resequestered in metaphase II, then released again upon entry into anaphase II; maintained in nucleolus by Cdc55p in early meiosis"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
1Q00684    551   CDC14_YEAST Tyrosine-protein phosphatase CDC1...5510     1154     100     100GO:0030869; C:RENT complex; IDA:SGD.::GO:0005816; C:spindle pole body; IDA:SGD.
GO:0005515; F:protein binding; IPI:IntAct.::GO:0004725; F:protein tyrosine phosphatase activity; IEA:EC.::GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; IEA:InterPro.
GO:0000278; P:mitotic cell cycle; IMP:SGD.::GO:0007096; P:regulation of exit from mitosis; IGI:SGD.
2Q9P7H1    537   FLP1_SCHPO Tyrosine-protein phosphatase CDC14...4921e-127     391     44     59GO:0000777; C:condensed chromosome kinetochore; IDA:PomBase.::GO:0031097; C:medial cortex; IDA:PomBase.::GO:0005730; C:nucleolus; IDA:PomBase.::GO:0005816; C:spindle pole body; IDA:PomBase.
GO:0005515; F:protein binding; IPI:IntAct.::GO:0004864; F:protein phosphatase inhibitor activity; IGI:PomBase.::GO:0004725; F:protein tyrosine phosphatase activity; IEA:EC.::GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; IEA:InterPro.
GO:0008608; P:attachment of spindle microtubules to kinetochore; IGI:PomBase.::GO:0071937; P:barrier septum assembly involved in cell cycle cytokinesis; IMP:PomBase.::GO:0035853; P:chromosome passenger complex localization to spindle midzone; IMP:PomBase.::GO:0031566; P:contractile ring maintenance involved in cell cycle cytokinesis; IMP:PomBase.::GO:0031565; P:cytokinesis checkpoint; IMP:PomBase.::GO:0045736; P:negative regulation of cyclin-dependent protein kinase activity; IGI:PomBase.::GO:0031031; P:positive regulation of septation initiation signaling cascade; TAS:PomBase.::GO:0007096; P:regulation of exit from mitosis; IMP:PomBase.::GO:0010389; P:regulation of G2/M transition of mitotic cell cycle; IMP:PomBase.::GO:0031134; P:sister chromatid biorientation; IMP:PomBase.
3Q6GQT0    603   CC14A_MOUSE Dual specificity protein phosphat...3894e-74     253     35     56GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
GO:0004725; F:protein tyrosine phosphatase activity; IEA:EC.::GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; IEA:InterPro.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0051301; P:cell division; IEA:UniProtKB-KW.
4Q9UNH5    594   CC14A_HUMAN Dual specificity protein phosphat...3252e-70     243     37     58GO:0005813; C:centrosome; IDA:UniProtKB.::GO:0005634; C:nucleus; IDA:HPA.::GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
GO:0005515; F:protein binding; IPI:HGNC.::GO:0004725; F:protein tyrosine phosphatase activity; IEA:EC.::GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; IEA:InterPro.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0008283; P:cell proliferation; TAS:ProtInc.
5O60729    498   CC14B_HUMAN Dual specificity protein phosphat...3334e-70     239     37     57GO:0005730; C:nucleolus; IDA:UniProtKB.::GO:0005654; C:nucleoplasm; IDA:UniProtKB.
GO:0004722; F:protein serine/threonine phosphatase activity; IDA:UniProtKB.::GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.::GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; IEA:InterPro.
GO:0051488; P:activation of anaphase-promoting complex activity; IMP:UniProtKB.::GO:0006281; P:DNA repair; IEA:UniProtKB-KW.::GO:0031572; P:G2/M transition DNA damage checkpoint; IDA:UniProtKB.
6A4D256    554   CC14C_HUMAN Dual specificity protein phosphat...3116e-69     238     38     59GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
GO:0004725; F:protein tyrosine phosphatase activity; IEA:EC.::GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; IEA:InterPro.
7Q6PFY9    485   CC14B_MOUSE Dual specificity protein phosphat...3978e-69     236     35     53GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.::GO:0005654; C:nucleoplasm; ISS:UniProtKB.
GO:0004722; F:protein serine/threonine phosphatase activity; ISS:UniProtKB.::GO:0004725; F:protein tyrosine phosphatase activity; IEA:EC.::GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; IEA:InterPro.
GO:0051488; P:activation of anaphase-promoting complex activity; ISS:UniProtKB.::GO:0006281; P:DNA repair; IEA:UniProtKB-KW.::GO:0031572; P:G2/M transition DNA damage checkpoint; ISS:UniProtKB.
8A6N3Q4    483   CC14C_HYLSY Dual specificity protein phosphat...3311e-68     235     38     57GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
GO:0004725; F:protein tyrosine phosphatase activity; IEA:EC.::GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; IEA:InterPro.
9P81299    1063   CDC14_CAEEL Probable tyrosine-protein phospha...3514e-52     196     33     51GO:0000235; C:astral microtubule; IDA:WormBase.::GO:0005813; C:centrosome; IDA:WormBase.::GO:0030496; C:midbody; IDA:WormBase.::GO:0005730; C:nucleolus; IDA:WormBase.::GO:0051233; C:spindle midzone; IDA:WormBase.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0003676; F:nucleic acid binding; IEA:InterPro.::GO:0004725; F:protein tyrosine phosphatase activity; TAS:UniProtKB.::GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; IEA:InterPro.
GO:0000910; P:cytokinesis; IMP:UniProtKB.::GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.::GO:0071850; P:mitotic cell cycle arrest; IMP:WormBase.::GO:0040010; P:positive regulation of growth rate; IMP:WormBase.::GO:0060284; P:regulation of cell development; IMP:UniProtKB.::GO:0006974; P:response to DNA damage stimulus; IMP:WormBase.
10A1L1R5    713   PTPC1_DANRE Protein tyrosine phosphatase doma...880.00000009     58.5     35     55
GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.::GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; IEA:InterPro.
11Q6NZK8    747   PTPC1_MOUSE Protein tyrosine phosphatase doma...880.0000002     57.8     35     55
GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.::GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; IEA:InterPro.
12A2A3K4    754   PTPC1_HUMAN Protein tyrosine phosphatase doma...880.0000002     57.8     34     55
GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.::GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; IEA:InterPro.
13A7E379    796   PTPC1_BOVIN Protein tyrosine phosphatase doma...880.0000002     57.8     34     55
GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.::GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; IEA:InterPro.
14Q9BVJ7    150   DUS23_HUMAN Dual specificity protein phosphat...1060.0000004     53.5     28     46GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IDA:HPA.
GO:0004725; F:protein tyrosine phosphatase activity; IEA:EC.::GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; IEA:InterPro.
15Q6P9X4    167   TP4A2_RAT Protein tyrosine phosphatase type I...1360.0000006     53.1     31     45GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0004725; F:protein tyrosine phosphatase activity; IEA:EC.
16O70274    167   TP4A2_MOUSE Protein tyrosine phosphatase type...1360.0000006     53.1     31     45GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0004725; F:protein tyrosine phosphatase activity; IEA:EC.
17Q12974    167   TP4A2_HUMAN Protein tyrosine phosphatase type...1360.0000006     53.1     31     45GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0004727; F:prenylated protein tyrosine phosphatase activity; TAS:ProtInc.
18Q9D658    173   TP4A3_MOUSE Protein tyrosine phosphatase type...1060.0000007     53.1     34     50GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0004725; F:protein tyrosine phosphatase activity; IEA:EC.
19Q54DU9    166   TP4AA_DICDI Probable protein tyrosine phospha...1470.0000009     52.8     29     44GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0004725; F:protein tyrosine phosphatase activity; IEA:EC.::GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; IEA:InterPro.
20A2VDT1    173   TP4A3_BOVIN Protein tyrosine phosphatase type...1240.0000009     52.8     30     44GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0004725; F:protein tyrosine phosphatase activity; IEA:EC.
21Q78EG7    173   TP4A1_RAT Protein tyrosine phosphatase type I...1340.000002     51.6     31     43GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.::GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IDA:RGD.::GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
GO:0004725; F:protein tyrosine phosphatase activity; IDA:RGD.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
22Q63739    173   TP4A1_MOUSE Protein tyrosine phosphatase type...1340.000002     51.6     31     43GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.::GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.::GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
GO:0004727; F:prenylated protein tyrosine phosphatase activity; TAS:UniProtKB.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.::GO:0030335; P:positive regulation of cell migration; IDA:UniProtKB.
23Q9TSM6    173   TP4A1_MACFA Protein tyrosine phosphatase type...1340.000002     51.6     31     43GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.::GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
GO:0004725; F:protein tyrosine phosphatase activity; IEA:EC.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
24Q93096    173   TP4A1_HUMAN Protein tyrosine phosphatase type...1340.000002     51.6     31     43GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.::GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.::GO:0009898; C:internal side of plasma membrane; IDA:UniProtKB.::GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
GO:0004725; F:protein tyrosine phosphatase activity; NAS:UniProtKB.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
25O75365    173   TP4A3_HUMAN Protein tyrosine phosphatase type...1060.000003     51.2     34     50GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0004727; F:prenylated protein tyrosine phosphatase activity; TAS:ProtInc.
26Q5R7J8    173   TP4A1_PONAB Protein tyrosine phosphatase type...1340.000003     50.8     31     43GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.::GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
GO:0004725; F:protein tyrosine phosphatase activity; IEA:EC.::GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; IEA:InterPro.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
27Q6NT99    150   DUS23_MOUSE Dual specificity protein phosphat...1060.000007     49.7     27     44GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0004725; F:protein tyrosine phosphatase activity; IEA:EC.::GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; IEA:InterPro.
28Q9PUT6    402   PTEN_XENLA Phosphatidylinositol 3,4,5-trispho...880.00001     51.2     32     53GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0016605; C:PML body; IEA:UniProtKB-SubCell.
GO:0051717; F:inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity; ISS:UniProtKB.::GO:0008289; F:lipid binding; IEA:UniProtKB-KW.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0030165; F:PDZ domain binding; ISS:UniProtKB.::GO:0016314; F:phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity; ISS:UniProtKB.::GO:0051800; F:phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity; ISS:UniProtKB.::GO:0004438; F:phosphatidylinositol-3-phosphatase activity; ISS:UniProtKB.::GO:0004722; F:protein serine/threonine phosphatase activity; ISS:UniProtKB.::GO:0004725; F:protein tyrosine phosphatase activity; ISS:UniProtKB.::GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; IEA:InterPro.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0046855; P:inositol phosphate dephosphorylation; ISS:UniProtKB.::GO:0030336; P:negative regulation of cell migration; ISS:UniProtKB.::GO:0008285; P:negative regulation of cell proliferation; ISS:UniProtKB.::GO:0051895; P:negative regulation of focal adhesion assembly; ISS:UniProtKB.::GO:0051898; P:negative regulation of protein kinase B signaling cascade; ISS:UniProtKB.::GO:0046856; P:phosphatidylinositol dephosphorylation; ISS:UniProtKB.::GO:0043491; P:protein kinase B signaling cascade; ISS:UniProtKB.::GO:0010975; P:regulation of neuron projection development; ISS:UniProtKB.::GO:0031647; P:regulation of protein stability; ISS:UniProtKB.
29Q9D700    211   DUS26_MOUSE Dual specificity protein phosphat...1060.00006     47.8     33     50GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0005739; C:mitochondrion; IDA:MGI.::GO:0005634; C:nucleus; ISS:MGI.
GO:0004725; F:protein tyrosine phosphatase activity; IEA:EC.::GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; IBA:RefGenome.
30O08586    403   PTEN_MOUSE Phosphatidylinositol 3,4,5-trispho...890.0001     48.1     31     51GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0035749; C:myelin sheath adaxonal region; IDA:BHF-UCL.::GO:0016605; C:PML body; IEA:UniProtKB-SubCell.::GO:0043220; C:Schmidt-Lanterman incisure; IDA:BHF-UCL.::GO:0019717; C:synaptosome; IDA:BHF-UCL.
GO:0051717; F:inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0030165; F:PDZ domain binding; ISS:UniProtKB.::GO:0016314; F:phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity; ISS:UniProtKB.::GO:0051800; F:phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity; ISS:UniProtKB.::GO:0004438; F:phosphatidylinositol-3-phosphatase activity; ISS:UniProtKB.::GO:0019901; F:protein kinase binding; IPI:UniProtKB.::GO:0004722; F:protein serine/threonine phosphatase activity; ISS:UniProtKB.::GO:0004725; F:protein tyrosine phosphatase activity; ISS:UniProtKB.::GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; IEA:InterPro.
GO:0007092; P:activation of mitotic anaphase-promoting complex activity; IMP:BHF-UCL.::GO:0001525; P:angiogenesis; IMP:MGI.::GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0048738; P:cardiac muscle tissue development; IMP:MGI.::GO:0032286; P:central nervous system myelin maintenance; IMP:BHF-UCL.::GO:0021955; P:central nervous system neuron axonogenesis; IMP:BHF-UCL.::GO:0060997; P:dendritic spine morphogenesis; IMP:BHF-UCL.::GO:0021542; P:dentate gyrus development; IMP:BHF-UCL.::GO:0043542; P:endothelial cell migration; IMP:MGI.::GO:0048853; P:forebrain morphogenesis; IMP:BHF-UCL.::GO:0006917; P:induction of apoptosis; IMP:MGI.::GO:0046855; P:inositol phosphate dephosphorylation; ISS:UniProtKB.::GO:0007611; P:learning or memory; IMP:BHF-UCL.::GO:0045475; P:locomotor rhythm; IMP:BHF-UCL.::GO:0060291; P:long-term synaptic potentiation; IMP:BHF-UCL.::GO:0060179; P:male mating behavior; IMP:BHF-UCL.::GO:0042711; P:maternal behavior; IMP:BHF-UCL.::GO:0033555; P:multicellular organismal response to stress; IMP:BHF-UCL.::GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB.::GO:0050771; P:negative regulation of axonogenesis; IMP:BHF-UCL.::GO:0090344; P:negative regulation of cell aging; IMP:BHF-UCL.::GO:0030336; P:negative regulation of cell migration; ISS:UniProtKB.::GO:0045792; P:negative regulation of cell size; IMP:BHF-UCL.::GO:0061002; P:negative regulation of dendritic spine morphogenesis; IMP:BHF-UCL.::GO:0050680; P:negative regulation of epithelial cell proliferation; IMP:MGI.::GO:0090394; P:negative regulation of excitatory postsynaptic membrane potential; IMP:BHF-UCL.::GO:0051895; P:negative regulation of focal adhesion assembly; ISS:UniProtKB.::GO:0031642; P:negative regulation of myelination; IMP:MGI.::GO:0046621; P:negative regulation of organ growth; IMP:BHF-UCL.::GO:0051898; P:negative regulation of protein kinase B signaling cascade; IMP:UniProtKB.::GO:0090071; P:negative regulation of ribosome biogenesis; IMP:BHF-UCL.::GO:2000808; P:negative regulation of synaptic vesicle clustering; IMP:BHF-UCL.::GO:0007270; P:neuron-neuron synaptic transmission; IMP:BHF-UCL.::GO:0046856; P:phosphatidylinositol dephosphorylation; ISS:UniProtKB.::GO:0008284; P:positive regulation of cell proliferation; IMP:BHF-UCL.::GO:2000463; P:positive regulation of excitatory postsynaptic membrane potential; IMP:BHF-UCL.::GO:0097107; P:postsynaptic density assembly; IMP:BHF-UCL.::GO:0060134; P:prepulse inhibition; IMP:BHF-UCL.::GO:0097105; P:presynaptic membrane assembly; IMP:BHF-UCL.::GO:0060736; P:prostate gland growth; IMP:MGI.::GO:0043491; P:protein kinase B signaling cascade; IMP:UniProtKB.::GO:0002902; P:regulation of B cell apoptotic process; IMP:MGI.::GO:0033032; P:regulation of myeloid cell apoptotic process; IMP:MGI.::GO:0060024; P:rhythmic synaptic transmission; IMP:BHF-UCL.::GO:0035176; P:social behavior; IMP:BHF-UCL.::GO:0060074; P:synapse maturation; IMP:BHF-UCL.
31P60484    403   PTEN_HUMAN Phosphatidylinositol 3,4,5-trispho...890.0001     48.1     31     51GO:0042995; C:cell projection; IDA:UniProtKB.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0009898; C:internal side of plasma membrane; IDA:UniProtKB.::GO:0035749; C:myelin sheath adaxonal region; ISS:BHF-UCL.::GO:0016605; C:PML body; IEA:UniProtKB-SubCell.::GO:0043220; C:Schmidt-Lanterman incisure; ISS:BHF-UCL.::GO:0019717; C:synaptosome; ISS:BHF-UCL.
GO:0010997; F:anaphase-promoting complex binding; IPI:BHF-UCL.::GO:0051717; F:inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity; IDA:UniProtKB.::GO:0008289; F:lipid binding; IEA:UniProtKB-KW.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0030165; F:PDZ domain binding; IPI:UniProtKB.::GO:0016314; F:phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity; IDA:UniProtKB.::GO:0051800; F:phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity; IDA:UniProtKB.::GO:0004438; F:phosphatidylinositol-3-phosphatase activity; IDA:UniProtKB.::GO:0004722; F:protein serine/threonine phosphatase activity; IDA:UniProtKB.::GO:0004725; F:protein tyrosine phosphatase activity; IDA:UniProtKB.::GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; IEA:InterPro.
GO:0007092; P:activation of mitotic anaphase-promoting complex activity; IDA:BHF-UCL.::GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0060070; P:canonical Wnt receptor signaling pathway; IDA:BHF-UCL.::GO:0008283; P:cell proliferation; TAS:UniProtKB.::GO:0032286; P:central nervous system myelin maintenance; ISS:BHF-UCL.::GO:0021955; P:central nervous system neuron axonogenesis; ISS:BHF-UCL.::GO:0060997; P:dendritic spine morphogenesis; ISS:BHF-UCL.::GO:0021542; P:dentate gyrus development; ISS:BHF-UCL.::GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome.::GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:Reactome.::GO:0048853; P:forebrain morphogenesis; ISS:BHF-UCL.::GO:0006917; P:induction of apoptosis; ISS:UniProtKB.::GO:0046855; P:inositol phosphate dephosphorylation; IDA:UniProtKB.::GO:0007611; P:learning or memory; ISS:BHF-UCL.::GO:0045475; P:locomotor rhythm; ISS:BHF-UCL.::GO:0033555; P:multicellular organismal response to stress; ISS:BHF-UCL.::GO:0050771; P:negative regulation of axonogenesis; ISS:BHF-UCL.::GO:0030336; P:negative regulation of cell migration; IMP:UniProtKB.::GO:0045792; P:negative regulation of cell size; ISS:BHF-UCL.::GO:0031658; P:negative regulation of cyclin-dependent protein kinase activity involved in G1/S; IDA:BHF-UCL.::GO:0061002; P:negative regulation of dendritic spine morphogenesis; ISS:BHF-UCL.::GO:0090394; P:negative regulation of excitatory postsynaptic membrane potential; ISS:BHF-UCL.::GO:0051895; P:negative regulation of focal adhesion assembly; IMP:UniProtKB.::GO:2000134; P:negative regulation of G1/S transition of mitotic cell cycle; IDA:BHF-UCL.::GO:0046621; P:negative regulation of organ growth; ISS:BHF-UCL.::GO:0014067; P:negative regulation of phosphatidylinositol 3-kinase cascade; TAS:BHF-UCL.::GO:0051898; P:negative regulation of protein kinase B signaling cascade; IMP:UniProtKB.::GO:0001933; P:negative regulation of protein phosphorylation; IDA:BHF-UCL.::GO:2000808; P:negative regulation of synaptic vesicle clustering; ISS:BHF-UCL.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0007270; P:neuron-neuron synaptic transmission; ISS:BHF-UCL.::GO:0046856; P:phosphatidylinositol dephosphorylation; IDA:UniProtKB.::GO:0048015; P:phosphatidylinositol-mediated signaling; TAS:Reactome.::GO:0008284; P:positive regulation of cell proliferation; ISS:BHF-UCL.::GO:2000463; P:positive regulation of excitatory postsynaptic membrane potential; ISS:BHF-UCL.::GO:2000060; P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IDA:BHF-UCL.::GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; IMP:BHF-UCL.::GO:0097107; P:postsynaptic density assembly; ISS:BHF-UCL.::GO:0060134; P:prepulse inhibition; ISS:BHF-UCL.::GO:0097105; P:presynaptic membrane assembly; ISS:BHF-UCL.::GO:0043491; P:protein kinase B signaling cascade; ISS:UniProtKB.::GO:0050821; P:protein stabilization; IDA:BHF-UCL.::GO:0060024; P:rhythmic synaptic transmission; ISS:BHF-UCL.::GO:0035176; P:social behavior; ISS:BHF-UCL.::GO:0060074; P:synapse maturation; ISS:BHF-UCL.::GO:0050852; P:T cell receptor signaling pathway; TAS:Reactome.
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