UniProt_SwissProt BLAST: Single locus

Species:

Saccharomyces cerevisiae S288C

Locus:

YFR019W

Length:

2278

Number of sequences:

5887

Description:

YFR019W FAB1 SGDID:S000001915, Chr VI from 184502-191338, Genome Release 64-1-1, Verified ORF, "1-phosphatidylinositol-3-phosphate 5-kinase; vacuolar membrane kinase that generates phosphatidylinositol (3,5)P2, which is involved in vacuolar sorting and homeostasis"

rec.	Subject	Hit Length	Description	Align.Len	E value	Bit score	% ident.	% pos.	GO associations
91	Q91ZT5	766	FGD4_MOUSE FYVE, RhoGEF and PH domain-contain...	85	0.00000004	62.4	31	51	GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0030175; C:filopodium; IDA:MGI.::GO:0030027; C:lamellipodium; IDA:MGI.
									GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
									GO:0030032; P:lamellipodium assembly; IDA:MGI.::GO:0030035; P:microspike assembly; IDA:MGI.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
92	O60331	668	PI51C_HUMAN Phosphatidylinositol 4-phosphate ...	170	0.00000004	62.4	31	46	GO:0005829; C:cytosol; TAS:Reactome.::GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.::GO:0005925; C:focal adhesion; TAS:UniProtKB.::GO:0001891; C:phagocytic cup; IEA:UniProtKB-SubCell.::GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell.::GO:0001931; C:uropod; TAS:UniProtKB.
									GO:0016308; F:1-phosphatidylinositol-4-phosphate 5-kinase activity; IEA:EC.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
									GO:0030036; P:actin cytoskeleton organization; TAS:UniProtKB.::GO:0034333; P:adherens junction assembly; TAS:UniProtKB.::GO:0007411; P:axon guidance; TAS:Reactome.::GO:0016337; P:cell-cell adhesion; TAS:UniProtKB.::GO:0072583; P:clathrin-mediated endocytosis; TAS:UniProtKB.::GO:0030593; P:neutrophil chemotaxis; TAS:UniProtKB.::GO:0006909; P:phagocytosis; TAS:UniProtKB.::GO:0048488; P:synaptic vesicle endocytosis; TAS:UniProtKB.::GO:0016079; P:synaptic vesicle exocytosis; TAS:UniProtKB.
93	B4JHI7	1115	LST2_DROGR Lateral signaling target protein 2...	65	0.00000005	62.4	35	51
									GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
94	Q8K296	1196	MTMR3_MOUSE Myotubularin-related protein 3 OS...	135	0.00000006	62.4	31	43
									GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004438; F:phosphatidylinositol-3-phosphatase activity; ISS:UniProtKB.::GO:0004725; F:protein tyrosine phosphatase activity; IEA:EC.
									GO:0046856; P:phosphatidylinositol dephosphorylation; ISS:UniProtKB.
95	O88370	420	PI42C_RAT Phosphatidylinositol 5-phosphate 4-...	195	0.00000006	61.2	26	49	GO:0005783; C:endoplasmic reticulum; IDA:RGD.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
									GO:0016308; F:1-phosphatidylinositol-4-phosphate 5-kinase activity; IDA:RGD.::GO:0016309; F:1-phosphatidylinositol-5-phosphate 4-kinase activity; IEA:EC.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
									GO:0006661; P:phosphatidylinositol biosynthetic process; NAS:RGD.
96	O24731	549	THSA_THEK8 Thermosome subunit alpha OS=Thermo...	251	0.00000006	61.6	24	43
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0051082; F:unfolded protein binding; IEA:InterPro.
									GO:0006457; P:protein folding; IEA:InterPro.
97	Q5PQ01	419	PI42C_XENLA Phosphatidylinositol 5-phosphate ...	180	0.00000006	61.2	28	49	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
									GO:0016309; F:1-phosphatidylinositol-5-phosphate 4-kinase activity; IEA:EC.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
98	Q5F356	405	PI42A_CHICK Phosphatidylinositol 5-phosphate ...	183	0.00000007	60.8	26	50	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
									GO:0016309; F:1-phosphatidylinositol-5-phosphate 4-kinase activity; IEA:EC.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
99	Q5PQT2	1194	MTMR3_RAT Myotubularin-related protein 3 OS=R...	135	0.00000008	61.6	31	43	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
									GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004438; F:phosphatidylinositol-3-phosphatase activity; ISS:UniProtKB.::GO:0004725; F:protein tyrosine phosphatase activity; IEA:EC.
									GO:0046856; P:phosphatidylinositol dephosphorylation; ISS:UniProtKB.
100	Q8BL66	1411	EEA1_MOUSE Early endosome antigen 1 OS=Mus mu...	61	0.00000008	61.6	39	56	GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.::GO:0019897; C:extrinsic to plasma membrane; ISS:UniProtKB.::GO:0005969; C:serine-pyruvate aminotransferase complex; IDA:MGI.
									GO:0005545; F:1-phosphatidylinositol binding; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
									GO:0006897; P:endocytosis; ISS:UniProtKB.
101	Q13615	1198	MTMR3_HUMAN Myotubularin-related protein 3 OS...	135	0.00000009	61.6	31	43	GO:0005737; C:cytoplasm; IDA:UniProtKB.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.::GO:0005624; C:membrane fraction; IDA:UniProtKB.::GO:0005634; C:nucleus; IDA:HPA.
									GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004438; F:phosphatidylinositol-3-phosphatase activity; IDA:UniProtKB.::GO:0004722; F:protein serine/threonine phosphatase activity; IDA:UniProtKB.::GO:0004725; F:protein tyrosine phosphatase activity; IDA:UniProtKB.
									GO:0046856; P:phosphatidylinositol dephosphorylation; IDA:UniProtKB.
102	Q6GL14	419	PI42C_XENTR Phosphatidylinositol 5-phosphate ...	180	0.00000009	60.5	27	49	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
									GO:0016309; F:1-phosphatidylinositol-5-phosphate 4-kinase activity; IEA:EC.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
103	Q91XU3	421	PI42C_MOUSE Phosphatidylinositol 5-phosphate ...	195	0.0000001	60.5	26	49	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
									GO:0016309; F:1-phosphatidylinositol-5-phosphate 4-kinase activity; IEA:EC.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
104	P48425	543	THSB_THEAC Thermosome subunit beta OS=NBRC 15...	188	0.0000001	60.8	25	52
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0051082; F:unfolded protein binding; IEA:InterPro.
									GO:0006457; P:protein folding; IEA:InterPro.
105	Q15075	1411	EEA1_HUMAN Early endosome antigen 1 OS=Homo s...	61	0.0000001	61.2	38	56	GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.::GO:0019897; C:extrinsic to plasma membrane; IDA:UniProtKB.::GO:0005624; C:membrane fraction; TAS:ProtInc.
									GO:0005545; F:1-phosphatidylinositol binding; IDA:UniProtKB.::GO:0005516; F:calmodulin binding; NAS:UniProtKB.::GO:0030742; F:GTP-dependent protein binding; IDA:UniProtKB.::GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.::GO:0008270; F:zinc ion binding; TAS:UniProtKB.
									GO:0045022; P:early endosome to late endosome transport; NAS:UniProtKB.::GO:0016189; P:synaptic vesicle to endosome fusion; TAS:UniProtKB.::GO:0006906; P:vesicle fusion; IMP:UniProtKB.
106	B4PRU6	984	LST2_DROYA Lateral signaling target protein 2...	124	0.0000001	61.2	26	44
									GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
107	A2A3N6	862	PIPSL_HUMAN Putative PIP5K1A and PSMD4-like p...	192	0.0000001	61.2	28	42	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0016307; F:phosphatidylinositol phosphate kinase activity; IEA:InterPro.
108	Q6IQE1	416	PI42C_DANRE Phosphatidylinositol 5-phosphate ...	180	0.0000001	60.5	28	48	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
									GO:0016309; F:1-phosphatidylinositol-5-phosphate 4-kinase activity; IEA:EC.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
109	Q4P7Q1	916	VPS27_USTMA Vacuolar protein sorting-associat...	51	0.0000001	60.8	45	53	GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
									GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0006886; P:intracellular protein transport; IEA:InterPro.
110	O88387	766	FGD4_RAT FYVE, RhoGEF and PH domain-containin...	85	0.0000001	60.8	29	51	GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0030175; C:filopodium; IEA:UniProtKB-SubCell.
									GO:0051015; F:actin filament binding; IMP:RGD.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
									GO:0007257; P:activation of JUN kinase activity; IDA:MGI.::GO:0008360; P:regulation of cell shape; IMP:RGD.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
111	Q9SLG9	772	PI5K5_ARATH Phosphatidylinositol 4-phosphate ...	173	0.0000001	60.8	31	50	GO:0016324; C:apical plasma membrane; IDA:TAIR.::GO:0044445; C:cytosolic part; IDA:TAIR.::GO:0090406; C:pollen tube; IDA:TAIR.
									GO:0016308; F:1-phosphatidylinositol-4-phosphate 5-kinase activity; IDA:TAIR.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
									GO:0009827; P:plant-type cell wall modification; IMP:TAIR.::GO:0009846; P:pollen germination; IGI:TAIR.::GO:0009860; P:pollen tube growth; IGI:TAIR.
112	B4IC49	975	LST2_DROSE Lateral signaling target protein 2...	124	0.0000002	60.5	26	44
									GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
113	Q54LD5	785	ADCD_DICDI Arrestin domain-containing protein...	70	0.0000002	60.1	41	57
									GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
114	A8QCE4	619	LST2_BRUMA Lateral signaling target protein 2...	60	0.0000003	59.7	40	57
									GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
115	Q96M96	766	FGD4_HUMAN FYVE, RhoGEF and PH domain-contain...	85	0.0000003	59.7	29	49	GO:0015629; C:actin cytoskeleton; IDA:HPA.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0030175; C:filopodium; IEA:UniProtKB-SubCell.::GO:0005794; C:Golgi apparatus; ISS:UniProtKB.::GO:0030027; C:lamellipodium; ISS:UniProtKB.::GO:0001726; C:ruffle; ISS:UniProtKB.
									GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.::GO:0031267; F:small GTPase binding; ISS:UniProtKB.
									GO:0030036; P:actin cytoskeleton organization; ISS:UniProtKB.::GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0046847; P:filopodium assembly; ISS:UniProtKB.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0043088; P:regulation of Cdc42 GTPase activity; ISS:UniProtKB.::GO:0008360; P:regulation of cell shape; ISS:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.
116	Q80U44	1528	ZFY16_MOUSE Zinc finger FYVE domain-containin...	238	0.0000003	60.1	24	39	GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
									GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
117	Q9BQS8	1478	FYCO1_HUMAN FYVE and coiled-coil domain-conta...	90	0.0000004	59.7	33	46	GO:0005776; C:autophagic vacuole; IDA:UniProtKB.::GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.::GO:0016021; C:integral to membrane; IEA:InterPro.::GO:0005770; C:late endosome; IDA:UniProtKB.::GO:0005764; C:lysosome; IDA:UniProtKB.
									GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB.
									GO:0072383; P:plus-end-directed vesicle transport along microtubule; IMP:UniProtKB.
118	P34657	266	YOTB_CAEEL Uncharacterized protein ZK632.12 O...	81	0.0000004	57.4	36	53
									GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0032266; F:phosphatidylinositol-3-phosphate binding; ISS:WormBase.::GO:0005515; F:protein binding; IPI:IntAct.
119	Q96T51	708	RUFY1_HUMAN RUN and FYVE domain-containing pr...	54	0.0000004	59.3	43	59	GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
									GO:0008289; F:lipid binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0008270; F:zinc ion binding; IEA:InterPro.
									GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0015031; P:protein transport; IEA:UniProtKB-KW.
120	Q9LMN1	427	PI5KA_ARATH Phosphatidylinositol 4-phosphate ...	166	0.0000004	58.5	25	51
									GO:0016308; F:1-phosphatidylinositol-4-phosphate 5-kinase activity; IEA:EC.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
121	Q06651	286	PIB1_YEAST E3 ubiquitin-protein ligase PIB1 O...	38	0.0000005	57.4	55	66	GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.::GO:0000329; C:fungal-type vacuole membrane; IDA:SGD.::GO:0005770; C:late endosome; IDA:SGD.
									GO:0032266; F:phosphatidylinositol-3-phosphate binding; IDA:SGD.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:SGD.::GO:0008270; F:zinc ion binding; IEA:InterPro.

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