Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YFR010W
Length:
499
Number of sequences:
5887
Description:
YFR010W UBP6 SGDID:S000001906, Chr VI from 165067-166566, Genome Release 64-1-1, Verified ORF, "Ubiquitin-specific protease situated in the base subcomplex of the 26S proteasome, releases free ubiquitin from branched polyubiquitin chains; works in opposition to Hul5p polyubiquitin elongation activity; mutant has aneuploidy tolerance"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
1P43593    499   UBP6_YEAST Ubiquitin carboxyl-terminal hydrol...4990     1034     100     100GO:0005838; C:proteasome regulatory particle; IPI:SGD.
GO:0004221; F:ubiquitin thiolesterase activity; IEA:InterPro.::GO:0004843; F:ubiquitin-specific protease activity; IDA:SGD.
GO:0016579; P:protein deubiquitination; IMP:SGD.::GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
2Q92353    468   UBP6_SCHPO Ubiquitin carboxyl-terminal hydrol...4962e-101     319     39     57GO:0005654; C:nucleoplasm; IDA:PomBase.::GO:0000502; C:proteasome complex; IDA:PomBase.
GO:0004221; F:ubiquitin thiolesterase activity; IEA:InterPro.::GO:0004843; F:ubiquitin-specific protease activity; IDA:PomBase.
GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; IC:PomBase.::GO:0071947; P:protein deubiquitination involved in ubiquitin-dependent protein catabolic process; IC:PomBase.
3P40826    493   UBP14_RABIT Ubiquitin carboxyl-terminal hydro...5021e-72     244     32     52GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0000502; C:proteasome complex; IEA:UniProtKB-KW.
GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
4Q0IIF7    494   UBP14_BOVIN Ubiquitin carboxyl-terminal hydro...5032e-72     244     33     52GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0000502; C:proteasome complex; IEA:UniProtKB-KW.
GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.::GO:0070628; F:proteasome binding; IDA:UniProtKB.::GO:0004221; F:ubiquitin thiolesterase activity; IDA:UniProtKB.
GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
5Q9JMA1    493   UBP14_MOUSE Ubiquitin carboxyl-terminal hydro...5043e-72     243     33     52GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0000502; C:proteasome complex; IEA:UniProtKB-KW.::GO:0005625; C:soluble fraction; IDA:MGI.::GO:0019717; C:synaptosome; IDA:MGI.
GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
GO:0007268; P:synaptic transmission; IMP:MGI.::GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
6P54578    494   UBP14_HUMAN Ubiquitin carboxyl-terminal hydro...5036e-72     243     32     52GO:0009986; C:cell surface; IDA:UniProtKB.::GO:0016023; C:cytoplasmic membrane-bounded vesicle; IDA:UniProtKB.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0000502; C:proteasome complex; IEA:UniProtKB-KW.
GO:0004197; F:cysteine-type endopeptidase activity; TAS:ProtInc.::GO:0004866; F:endopeptidase inhibitor activity; IMP:UniProtKB.::GO:0070628; F:proteasome binding; IDA:UniProtKB.::GO:0008193; F:tRNA guanylyltransferase activity; TAS:ProtInc.::GO:0004221; F:ubiquitin thiolesterase activity; IDA:UniProtKB.::GO:0004843; F:ubiquitin-specific protease activity; TAS:ProtInc.
GO:0050920; P:regulation of chemotaxis; IMP:UniProtKB.::GO:0061136; P:regulation of proteasomal protein catabolic process; IMP:UniProtKB.::GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
7P60051    493   UBP14_PANTR Ubiquitin carboxyl-terminal hydro...5037e-72     243     32     52GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0000502; C:proteasome complex; IEA:UniProtKB-KW.
GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
8Q949Y0    482   UBP6_ARATH Ubiquitin carboxyl-terminal hydrol...4792e-69     236     33     52GO:0009506; C:plasmodesma; IDA:TAIR.
GO:0005516; F:calmodulin binding; IDA:TAIR.::GO:0004221; F:ubiquitin thiolesterase activity; IEA:InterPro.::GO:0004843; F:ubiquitin-specific protease activity; IGI:TAIR.
GO:0016579; P:protein deubiquitination; TAS:TAIR.::GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
9Q84WC6    477   UBP7_ARATH Ubiquitin carboxyl-terminal hydrol...4762e-69     236     34     54
GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.::GO:0004221; F:ubiquitin thiolesterase activity; IEA:InterPro.
GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
10Q17361    489   UBP14_CAEEL Ubiquitin carboxyl-terminal hydro...5036e-57     202     29     50GO:0000502; C:proteasome complex; IEA:UniProtKB-KW.
GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.::GO:0004221; F:ubiquitin thiolesterase activity; IEA:InterPro.
GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
11Q70CQ2    3546   UBP34_HUMAN Ubiquitin carboxyl-terminal hydro...4140.0000000000001     77.8     23     39
GO:0004197; F:cysteine-type endopeptidase activity; IMP:UniProtKB.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004221; F:ubiquitin thiolesterase activity; IDA:UniProtKB.::GO:0004843; F:ubiquitin-specific protease activity; IDA:UniProtKB.
GO:0090263; P:positive regulation of canonical Wnt receptor signaling pathway; IDA:UniProtKB.::GO:0071108; P:protein K48-linked deubiquitination; IDA:UniProtKB.::GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.::GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW.
12Q6ZQ93    3582   UBP34_MOUSE Ubiquitin carboxyl-terminal hydro...4140.000000000001     74.3     23     39
GO:0005488; F:binding; IEA:InterPro.::GO:0004197; F:cysteine-type endopeptidase activity; ISS:UniProtKB.::GO:0004221; F:ubiquitin thiolesterase activity; ISS:UniProtKB.::GO:0004843; F:ubiquitin-specific protease activity; ISS:UniProtKB.
GO:0090263; P:positive regulation of canonical Wnt receptor signaling pathway; ISS:UniProtKB.::GO:0071108; P:protein K48-linked deubiquitination; ISS:UniProtKB.::GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.::GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW.
13Q5ZID5    1047   UBP28_CHICK Ubiquitin carboxyl-terminal hydro...660.002     44.7     39     58GO:0005654; C:nucleoplasm; ISS:UniProtKB.
GO:0004221; F:ubiquitin thiolesterase activity; ISS:UniProtKB.::GO:0004843; F:ubiquitin-specific protease activity; ISS:UniProtKB.
GO:0008283; P:cell proliferation; ISS:UniProtKB.::GO:0000077; P:DNA damage checkpoint; ISS:UniProtKB.::GO:0042771; P:DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; ISS:UniProtKB.::GO:0006281; P:DNA repair; IEA:UniProtKB-KW.::GO:0016579; P:protein deubiquitination; ISS:UniProtKB.::GO:0010212; P:response to ionizing radiation; ISS:UniProtKB.::GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
14Q24574    1556   UBPE_DROME Ubiquitin carboxyl-terminal hydrol...3970.000000002     63.9     22     40GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.::GO:0004221; F:ubiquitin thiolesterase activity; IEA:InterPro.
GO:0031935; P:regulation of chromatin silencing; IMP:FlyBase.::GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
15Q8BY87    1376   UBP47_MOUSE Ubiquitin carboxyl-terminal hydro...3890.000000002     63.5     21     40GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0019005; C:SCF ubiquitin ligase complex; ISS:UniProtKB.
GO:0004221; F:ubiquitin thiolesterase activity; IEA:InterPro.::GO:0004843; F:ubiquitin-specific protease activity; ISS:UniProtKB.
GO:0006284; P:base-excision repair; ISS:UniProtKB.::GO:0034644; P:cellular response to UV; IMP:UniProtKB.::GO:0035520; P:monoubiquitinated protein deubiquitination; ISS:UniProtKB.::GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB.::GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; ISS:UniProtKB.::GO:0010972; P:negative regulation of G2/M transition of mitotic cell cycle; ISS:UniProtKB.::GO:0045892; P:negative regulation of transcription, DNA-dependent; ISS:UniProtKB.::GO:0030307; P:positive regulation of cell growth; ISS:UniProtKB.::GO:0042493; P:response to drug; ISS:UniProtKB.::GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
16Q5I043    1051   UBP28_MOUSE Ubiquitin carboxyl-terminal hydro...660.023     41.2     38     56GO:0005654; C:nucleoplasm; ISS:UniProtKB.
GO:0004221; F:ubiquitin thiolesterase activity; ISS:UniProtKB.::GO:0004843; F:ubiquitin-specific protease activity; ISS:UniProtKB.
GO:0008283; P:cell proliferation; ISS:UniProtKB.::GO:0000077; P:DNA damage checkpoint; ISS:UniProtKB.::GO:0042771; P:DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; ISS:UniProtKB.::GO:0006281; P:DNA repair; IEA:UniProtKB-KW.::GO:0016579; P:protein deubiquitination; ISS:UniProtKB.::GO:0010212; P:response to ionizing radiation; ISS:UniProtKB.::GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
17Q9UPU5    2620   UBP24_HUMAN Ubiquitin carboxyl-terminal hydro...4000.000000005     63.2     24     38
GO:0005488; F:binding; IEA:InterPro.::GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.::GO:0004221; F:ubiquitin thiolesterase activity; IEA:InterPro.
GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
18Q96RU2    1077   UBP28_HUMAN Ubiquitin carboxyl-terminal hydro...660.02     41.2     36     56GO:0005730; C:nucleolus; IDA:HPA.::GO:0005654; C:nucleoplasm; IDA:UniProtKB.::GO:0043234; C:protein complex; IDA:UniProtKB.
GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004221; F:ubiquitin thiolesterase activity; IMP:UniProtKB.::GO:0004843; F:ubiquitin-specific protease activity; IDA:UniProtKB.
GO:0008283; P:cell proliferation; IMP:UniProtKB.::GO:0034644; P:cellular response to UV; IDA:UniProtKB.::GO:0000077; P:DNA damage checkpoint; IMP:UniProtKB.::GO:0042771; P:DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; IDA:UniProtKB.::GO:0006281; P:DNA repair; IEA:UniProtKB-KW.::GO:0016579; P:protein deubiquitination; IDA:UniProtKB.::GO:0010212; P:response to ionizing radiation; IDA:UniProtKB.::GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
19A1A5G2    1354   UBP47_XENTR Ubiquitin carboxyl-terminal hydro...4220.000000005     62.8     21     40GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO:0004221; F:ubiquitin thiolesterase activity; IEA:InterPro.::GO:0004843; F:ubiquitin-specific protease activity; ISS:UniProtKB.
GO:0006284; P:base-excision repair; ISS:UniProtKB.::GO:0035520; P:monoubiquitinated protein deubiquitination; ISS:UniProtKB.::GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
20Q5U252    1350   UBP47_XENLA Ubiquitin carboxyl-terminal hydro...4220.000000009     62     21     40GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO:0004221; F:ubiquitin thiolesterase activity; IEA:InterPro.::GO:0004843; F:ubiquitin-specific protease activity; ISS:UniProtKB.
GO:0006284; P:base-excision repair; ISS:UniProtKB.::GO:0035520; P:monoubiquitinated protein deubiquitination; ISS:UniProtKB.::GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
21B1AY13    2617   UBP24_MOUSE Ubiquitin carboxyl-terminal hydro...4020.00000001     62     24     37
GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.::GO:0004221; F:ubiquitin thiolesterase activity; IEA:InterPro.
GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
22D3ZJ96    1083   UBP28_RAT Ubiquitin carboxyl-terminal hydrola...660.038     40.4     38     56GO:0005654; C:nucleoplasm; ISS:UniProtKB.
GO:0004221; F:ubiquitin thiolesterase activity; ISS:UniProtKB.::GO:0004843; F:ubiquitin-specific protease activity; ISS:UniProtKB.
GO:0008283; P:cell proliferation; ISS:UniProtKB.::GO:0000077; P:DNA damage checkpoint; ISS:UniProtKB.::GO:0042771; P:DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; ISS:UniProtKB.::GO:0006281; P:DNA repair; IEA:UniProtKB-KW.::GO:0016579; P:protein deubiquitination; ISS:UniProtKB.::GO:0010212; P:response to ionizing radiation; ISS:UniProtKB.::GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
23Q96K76    1375   UBP47_HUMAN Ubiquitin carboxyl-terminal hydro...3920.00000003     60.5     22     40GO:0005737; C:cytoplasm; IDA:UniProtKB.::GO:0019005; C:SCF ubiquitin ligase complex; IDA:UniProtKB.
GO:0004221; F:ubiquitin thiolesterase activity; IEA:InterPro.::GO:0004843; F:ubiquitin-specific protease activity; IDA:UniProtKB.::GO:0071987; F:WD40-repeat domain binding; IPI:UniProtKB.
GO:0006284; P:base-excision repair; IMP:UniProtKB.::GO:0034644; P:cellular response to UV; ISS:UniProtKB.::GO:0035520; P:monoubiquitinated protein deubiquitination; IDA:UniProtKB.::GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB.::GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IMP:UniProtKB.::GO:0010972; P:negative regulation of G2/M transition of mitotic cell cycle; IMP:UniProtKB.::GO:0045892; P:negative regulation of transcription, DNA-dependent; IMP:UniProtKB.::GO:0030307; P:positive regulation of cell growth; IMP:UniProtKB.::GO:0042493; P:response to drug; IMP:UniProtKB.::GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
24P34547    426   UBPX_CAEEL Probable ubiquitin carboxyl-termin...3900.00000003     59.3     24     41GO:0044297; C:cell body; IDA:WormBase.::GO:0005768; C:endosome; IDA:WormBase.
GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.::GO:0035255; F:ionotropic glutamate receptor binding; IPI:WormBase.::GO:0004221; F:ubiquitin thiolesterase activity; IEA:InterPro.
GO:0040027; P:negative regulation of vulval development; IMP:WormBase.::GO:0071947; P:protein deubiquitination involved in ubiquitin-dependent protein catabolic process; IMP:WormBase.::GO:2000311; P:regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; IMP:WormBase.
25E1C1R4    1375   UBP47_CHICK Ubiquitin carboxyl-terminal hydro...3910.0000001     58.2     21     40GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO:0004221; F:ubiquitin thiolesterase activity; IEA:InterPro.::GO:0004843; F:ubiquitin-specific protease activity; ISS:UniProtKB.
GO:0006284; P:base-excision repair; ISS:UniProtKB.::GO:0035520; P:monoubiquitinated protein deubiquitination; ISS:UniProtKB.::GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
26Q9WTV6    368   UBP18_MOUSE Ubl carboxyl-terminal hydrolase 1...4010.0000004     55.8     24     37
GO:0019785; F:ISG15-specific protease activity; IMP:MGI.::GO:0004221; F:ubiquitin thiolesterase activity; IEA:InterPro.
GO:0032020; P:ISG15-protein conjugation; IMP:MGI.::GO:0035634; P:response to stilbenoid; IEP:UniProtKB.::GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
27Q9UPT9    525   UBP22_HUMAN Ubiquitin carboxyl-terminal hydro...4350.0000009     55.1     23     35GO:0000124; C:SAGA complex; IDA:UniProtKB.
GO:0030374; F:ligand-dependent nuclear receptor transcription coactivator activity; IMP:UniProtKB.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004221; F:ubiquitin thiolesterase activity; IEA:InterPro.::GO:0004843; F:ubiquitin-specific protease activity; IDA:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0009790; P:embryo development; NAS:UniProtKB.::GO:0016578; P:histone deubiquitination; IDA:UniProtKB.::GO:0043967; P:histone H4 acetylation; IDA:GOC.::GO:0016574; P:histone ubiquitination; IDA:UniProtKB.::GO:0045931; P:positive regulation of mitotic cell cycle; IMP:UniProtKB.::GO:0045893; P:positive regulation of transcription, DNA-dependent; IMP:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
28P70398    2559   USP9X_MOUSE Probable ubiquitin carboxyl-termi...4420.000001     55.1     24     36GO:0045177; C:apical part of cell; IDA:MGI.::GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO:0070410; F:co-SMAD binding; ISS:BHF-UCL.::GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.::GO:0004221; F:ubiquitin thiolesterase activity; IEA:InterPro.
GO:0030509; P:BMP signaling pathway; ISS:UniProtKB.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0016579; P:protein deubiquitination; ISS:UniProtKB.::GO:0007179; P:transforming growth factor beta receptor signaling pathway; ISS:UniProtKB.::GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
29Q9UHP3    1055   UBP25_HUMAN Ubiquitin carboxyl-terminal hydro...660.005     43.1     38     56GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0032183; F:SUMO binding; IDA:UniProtKB.::GO:0004221; F:ubiquitin thiolesterase activity; IEA:InterPro.::GO:0004843; F:ubiquitin-specific protease activity; IMP:UniProtKB.
GO:0071108; P:protein K48-linked deubiquitination; IMP:UniProtKB.::GO:0070536; P:protein K63-linked deubiquitination; IMP:UniProtKB.::GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
30P0C8Z3    514   UBP22_BOVIN Ubiquitin carboxyl-terminal hydro...4350.000001     54.3     23     35
GO:0004221; F:ubiquitin thiolesterase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
31A6NNY8    438   UBP27_HUMAN Ubiquitin carboxyl-terminal hydro...4330.000002     53.9     23     34
GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.::GO:0004221; F:ubiquitin thiolesterase activity; IEA:InterPro.
GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
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