Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YFR004W
Length:
306
Number of sequences:
5887
Description:
YFR004W RPN11 SGDID:S000001900, Chr VI from 153393-154313, Genome Release 64-1-1, Verified ORF, "Metalloprotease subunit of the 19S regulatory particle of the 26S proteasome lid; couples the deubiquitination and degradation of proteasome substrates; involved, independent of catalytic activity, in fission of mitochondria and peroxisomes"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
1P43588    306   RPN11_YEAST 26S proteasome regulatory subunit...3060     635     100     100GO:0005739; C:mitochondrion; IDA:SGD.::GO:0005634; C:nucleus; IDA:SGD.::GO:0008541; C:proteasome regulatory particle, lid subcomplex; IDA:SGD.::GO:0034515; C:proteasome storage granule; IDA:SGD.
GO:0008237; F:metallopeptidase activity; ISS:SGD.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004843; F:ubiquitin-specific protease activity; IMP:SGD.
GO:0000266; P:mitochondrial fission; IMP:SGD.::GO:0016559; P:peroxisome fission; IMP:SGD.::GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; IMP:SGD.::GO:0016579; P:protein deubiquitination; IMP:SGD.
2Q6FKS1    306   RPN11_CANGA 26S proteasome regulatory subunit...3060     556     90     95GO:0000502; C:proteasome complex; IEA:UniProtKB-KW.
3Q750E9    311   RPN11_ASHGO 26S proteasome regulatory subunit...3110     521     84     91GO:0000502; C:proteasome complex; IEA:UniProtKB-KW.
4P41878    308   RPN11_SCHPO 26S proteasome regulatory subunit...3082e-144     416     64     77GO:0034399; C:nuclear periphery; IDA:PomBase.::GO:0000502; C:proteasome complex; IDA:PomBase.
GO:0004843; F:ubiquitin-specific protease activity; IDA:PomBase.
GO:0000266; P:mitochondrial fission; ISS:PomBase.::GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; IC:PomBase.::GO:0071947; P:protein deubiquitination involved in ubiquitin-dependent protein catabolic process; IC:PomBase.::GO:0007346; P:regulation of mitotic cell cycle; IC:PomBase.::GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.::GO:0046898; P:response to cycloheximide; IEA:UniProtKB-KW.
5Q9V3H2    308   PSDE_DROME 26S proteasome non-ATPase regulato...3084e-144     415     64     77GO:0005875; C:microtubule associated complex; IDA:FlyBase.::GO:0008541; C:proteasome regulatory particle, lid subcomplex; ISS:FlyBase.
GO:0004175; F:endopeptidase activity; IDA:FlyBase.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
GO:0009987; P:cellular process; IMP:FlyBase.::GO:0006508; P:proteolysis; IDA:FlyBase.
6O35593    310   PSDE_MOUSE 26S proteasome non-ATPase regulato...2908e-144     414     68     80GO:0000502; C:proteasome complex; IEA:UniProtKB-KW.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
7O00487    310   PSDE_HUMAN 26S proteasome non-ATPase regulato...2908e-144     414     68     80GO:0005829; C:cytosol; TAS:Reactome.::GO:0005654; C:nucleoplasm; TAS:Reactome.::GO:0000502; C:proteasome complex; TAS:UniProtKB.
GO:0061133; F:endopeptidase activator activity; IMP:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0008237; F:metallopeptidase activity; TAS:UniProtKB.::GO:0070628; F:proteasome binding; IDA:UniProtKB.::GO:0004221; F:ubiquitin thiolesterase activity; TAS:UniProtKB.
GO:0031145; P:anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; TAS:Reactome.::GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome.::GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0006977; P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; TAS:Reactome.::GO:0000082; P:G1/S transition of mitotic cell cycle; TAS:Reactome.::GO:0010467; P:gene expression; TAS:Reactome.::GO:0000216; P:M/G1 transition of mitotic cell cycle; TAS:Reactome.::GO:0016071; P:mRNA metabolic process; TAS:Reactome.::GO:0051436; P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; TAS:Reactome.::GO:0051437; P:positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; TAS:Reactome.::GO:0070536; P:protein K63-linked deubiquitination; TAS:UniProtKB.::GO:0000209; P:protein polyubiquitination; TAS:Reactome.::GO:0042981; P:regulation of apoptotic process; TAS:Reactome.::GO:0006521; P:regulation of cellular amino acid metabolic process; TAS:Reactome.::GO:0061136; P:regulation of proteasomal protein catabolic process; IMP:UniProtKB.::GO:0000084; P:S phase of mitotic cell cycle; TAS:Reactome.::GO:0044281; P:small molecule metabolic process; TAS:Reactome.::GO:0016032; P:viral reproduction; TAS:Reactome.
8Q9LT08    308   PSDE_ARATH 26S proteasome non-ATPase regulato...3081e-137     399     64     76GO:0005829; C:cytosol; IDA:TAIR.::GO:0005634; C:nucleus; TAS:TAIR.::GO:0000502; C:proteasome complex; IDA:TAIR.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
GO:0030163; P:protein catabolic process; TAS:TAIR.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.::GO:0009651; P:response to salt stress; IEP:TAIR.
9O76577    312   PSDE_CAEEL 26S proteasome non-ATPase regulato...2904e-136     395     64     79GO:0000502; C:proteasome complex; IEA:UniProtKB-KW.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.
GO:0008340; P:determination of adult lifespan; IMP:WormBase.::GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.::GO:0040007; P:growth; IMP:WormBase.::GO:0040011; P:locomotion; IMP:WormBase.::GO:0002119; P:nematode larval development; IMP:WormBase.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
10Q86IJ1    306   PSDE_DICDI 26S proteasome non-ATPase regulato...3051e-126     370     58     74GO:0045335; C:phagocytic vesicle; IDA:dictyBase.::GO:0000502; C:proteasome complex; ISS:dictyBase.
GO:0004175; F:endopeptidase activity; ISS:dictyBase.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
GO:0006511; P:ubiquitin-dependent protein catabolic process; ISS:dictyBase.
11Q8SQY3    294   RPN11_ENCCU 26S proteasome regulatory subunit...2914e-113     335     59     70GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0000502; C:proteasome complex; IEA:UniProtKB-KW.
12P41883    319   YPT5_CAEEL Uncharacterized protein F37A4.5 OS...3174e-105     316     53     68
GO:0000003; P:reproduction; IMP:WormBase.
13Q9XZ58    327   CSN5_DROME COP9 signalosome complex subunit 5...1992e-39     146     43     60GO:0005737; C:cytoplasm; IDA:FlyBase.::GO:0008180; C:signalosome; IMP:UniProtKB.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.::GO:0019781; F:NEDD8 activating enzyme activity; IMP:UniProtKB.::GO:0005515; F:protein binding; IPI:UniProtKB.
GO:0007409; P:axonogenesis; IMP:FlyBase.::GO:0001751; P:compound eye photoreceptor cell differentiation; IMP:FlyBase.::GO:0008347; P:glial cell migration; IMP:FlyBase.::GO:0007095; P:mitotic cell cycle G2/M transition DNA damage checkpoint; IGI:FlyBase.::GO:0032435; P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process; IMP:FlyBase.::GO:0007314; P:oocyte anterior/posterior axis specification; IMP:FlyBase.::GO:0007310; P:oocyte dorsal/ventral axis specification; IMP:FlyBase.::GO:0045787; P:positive regulation of cell cycle; IMP:FlyBase.::GO:0000338; P:protein deneddylation; IMP:UniProtKB.::GO:0050821; P:protein stabilization; IMP:FlyBase.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
14Q54PF3    332   CSN5_DICDI COP9 signalosome complex subunit 5...1995e-37     140     39     61GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0008180; C:signalosome; IPI:dictyBase.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:dictyBase.
GO:0008283; P:cell proliferation; IMP:dictyBase.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
15Q7RXX8    336   CSN5_NEUCR COP9 signalosome complex subunit 5...2002e-36     138     37     59GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0008180; C:signalosome; IEA:UniProtKB-KW.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
16Q4P804    406   CSN5_USTMA COP9 signalosome complex subunit 5...2336e-36     138     36     58GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0008180; C:signalosome; IEA:UniProtKB-KW.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
17Q5BBF1    335   CSN5_EMENI COP9 signalosome complex subunit 5...2042e-35     135     39     56GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0008180; C:signalosome; IEA:UniProtKB-KW.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
18Q92905    334   CSN5_HUMAN COP9 signalosome complex subunit 5...1971e-33     130     41     60GO:0005852; C:eukaryotic translation initiation factor 3 complex; TAS:ProtInc.::GO:0008180; C:signalosome; IDA:UniProtKB.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0008237; F:metallopeptidase activity; IMP:UniProtKB.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0003713; F:transcription coactivator activity; TAS:ProtInc.::GO:0003743; F:translation initiation factor activity; TAS:ProtInc.
GO:0010388; P:cullin deneddylation; IDA:UniProtKB.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.::GO:0046328; P:regulation of JNK cascade; IDA:UniProtKB.::GO:0006366; P:transcription from RNA polymerase II promoter; TAS:ProtInc.
19O35864    334   CSN5_MOUSE COP9 signalosome complex subunit 5...1971e-33     130     41     60GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0008180; C:signalosome; IDA:MGI.::GO:0005667; C:transcription factor complex; TAS:MGI.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:MGI.::GO:0003713; F:transcription coactivator activity; TAS:MGI.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.::GO:0051726; P:regulation of cell cycle; IMP:MGI.
20Q9FVU9    358   CSN5A_ARATH COP9 signalosome complex subunit ...2582e-33     130     36     54GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0008180; C:signalosome; IPI:TAIR.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:TAIR.
GO:0000085; P:G2 phase of mitotic cell cycle; IMP:TAIR.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.::GO:0010100; P:negative regulation of photomorphogenesis; IGI:TAIR.::GO:0000338; P:protein deneddylation; IGI:TAIR.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.::GO:0009585; P:red, far-red light phototransduction; IEA:UniProtKB-KW.::GO:0009733; P:response to auxin stimulus; IGI:TAIR.::GO:0010387; P:signalosome assembly; IMP:TAIR.
21Q6GLM9    332   CSN5_XENLA COP9 signalosome complex subunit 5...1973e-33     129     41     60GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0008180; C:signalosome; IEA:UniProtKB-KW.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
22Q6P635    334   CSN5_XENTR COP9 signalosome complex subunit 5...1973e-33     129     41     60GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0008180; C:signalosome; IEA:UniProtKB-KW.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
23Q6PC30    334   CSN5_DANRE COP9 signalosome complex subunit 5...1973e-33     129     41     60GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0008180; C:signalosome; IEA:UniProtKB-KW.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
24Q8LAZ7    357   CSN5B_ARATH COP9 signalosome complex subunit ...1834e-33     129     44     60GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0008180; C:signalosome; IPI:TAIR.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.
GO:0010388; P:cullin deneddylation; IMP:TAIR.::GO:0000085; P:G2 phase of mitotic cell cycle; IMP:TAIR.::GO:0010100; P:negative regulation of photomorphogenesis; IGI:TAIR.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.::GO:0009585; P:red, far-red light phototransduction; IEA:UniProtKB-KW.::GO:0031347; P:regulation of defense response; IMP:TAIR.::GO:0009733; P:response to auxin stimulus; IGI:TAIR.::GO:0010387; P:signalosome assembly; IMP:TAIR.::GO:0010093; P:specification of floral organ identity; IMP:TAIR.
25P91001    368   CSN5_CAEEL COP9 signalosome complex subunit 5...2038e-33     129     37     56GO:0031672; C:A band; IDA:WormBase.::GO:0008180; C:signalosome; ISS:WormBase.
GO:0017151; F:DEAD/H-box RNA helicase binding; IPI:WormBase.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.::GO:0008022; F:protein C-terminus binding; IPI:WormBase.
GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0000910; P:cytokinesis; IMP:WormBase.::GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.::GO:0008406; P:gonad development; IMP:WormBase.::GO:0040007; P:growth; IMP:WormBase.::GO:0040035; P:hermaphrodite genitalia development; IMP:WormBase.::GO:0002119; P:nematode larval development; IMP:WormBase.::GO:0048477; P:oogenesis; IMP:WormBase.::GO:0000338; P:protein deneddylation; IGI:WormBase.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
26Q6C703    354   CSN5_YARLI COP9 signalosome complex subunit 5...2311e-32     128     35     54GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0008180; C:signalosome; IEA:UniProtKB-KW.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
27Q4WZP2    334   CSN5_ASPFU COP9 signalosome complex subunit 5...2091e-32     128     37     56GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0008180; C:signalosome; IEA:UniProtKB-KW.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
28Q6BMQ3    469   CSN5_DEBHA COP9 signalosome complex subunit 5...2074e-32     128     36     56GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0008180; C:signalosome; IEA:UniProtKB-KW.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
29Q4IJM4    340   CSN5_GIBZE COP9 signalosome complex subunit 5...1994e-32     126     37     55GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0008180; C:signalosome; IEA:UniProtKB-KW.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
30P0CQ24    371   CSN5_CRYNJ COP9 signalosome complex subunit 5...2041e-31     125     37     55GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0008180; C:signalosome; IEA:UniProtKB-KW.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
31P0CQ25    371   CSN5_CRYNB COP9 signalosome complex subunit 5...2041e-31     125     37     55GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0008180; C:signalosome; IEA:UniProtKB-KW.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
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