Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YFL029C
Length:
368
Number of sequences:
5887
Description:
YFL029C CAK1 SGDID:S000001865, Chr VI from 79161-78055, Genome Release 64-1-1, reverse complement, Verified ORF, "Cyclin-dependent kinase-activating kinase required for passage through the cell cycle, phosphorylates and activates Cdc28p; nucleotide-binding pocket differs significantly from those of most other protein kinases"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
661O54784    448   DAPK3_MOUSE Death-associated protein kinase 3...1050.0000002     56.6     30     55GO:0000775; C:chromosome, centromeric region; IEA:UniProtKB-SubCell.::GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.::GO:0016605; C:PML body; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IDA:UniProtKB.::GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.::GO:0006917; P:induction of apoptosis; IMP:UniProtKB.::GO:0007243; P:intracellular protein kinase cascade; IDA:UniProtKB.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
662O35491    499   CLK2_MOUSE Dual specificity protein kinase CL...1150.0000002     56.6     30     51GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.::GO:0004712; F:protein serine/threonine/tyrosine kinase activity; IEA:EC.::GO:0004713; F:protein tyrosine kinase activity; IDA:MGI.
GO:0045721; P:negative regulation of gluconeogenesis; IMP:UniProtKB.::GO:0018108; P:peptidyl-tyrosine phosphorylation; IDA:MGI.::GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.::GO:0043484; P:regulation of RNA splicing; ISS:UniProtKB.::GO:0010212; P:response to ionizing radiation; ISS:UniProtKB.::GO:0032526; P:response to retinoic acid; IDA:MGI.
663Q9H2K8    898   TAOK3_HUMAN Serine/threonine-protein kinase T...1020.0000002     57     36     53GO:0005739; C:mitochondrion; IDA:HPA.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004860; F:protein kinase inhibitor activity; TAS:ProtInc.::GO:0004674; F:protein serine/threonine kinase activity; IDA:HGNC.
GO:0006281; P:DNA repair; IEA:UniProtKB-KW.::GO:0031572; P:G2/M transition DNA damage checkpoint; IMP:UniProtKB.::GO:0000165; P:MAPK cascade; IMP:HGNC.::GO:0046329; P:negative regulation of JNK cascade; IDA:HGNC.::GO:0046330; P:positive regulation of JNK cascade; IMP:HGNC.::GO:0046777; P:protein autophosphorylation; IDA:HGNC.
664P0CS76    466   SSN3_CRYNJ Serine/threonine-protein kinase SS...1010.0000002     56.6     31     51GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004693; F:cyclin-dependent protein kinase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0008353; F:RNA polymerase II carboxy-terminal domain kinase activity; IEA:EC.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
665P0CS77    466   SSN3_CRYNB Serine/threonine-protein kinase SS...1010.0000002     56.6     31     51GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004693; F:cyclin-dependent protein kinase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0008353; F:RNA polymerase II carboxy-terminal domain kinase activity; IEA:EC.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
666Q9P0L2    795   MARK1_HUMAN Serine/threonine-protein kinase M...990.0000002     56.6     38     55GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0015630; C:microtubule cytoskeleton; TAS:ProtInc.::GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0005524; F:ATP binding; IDA:UniProtKB.::GO:0000287; F:magnesium ion binding; IDA:UniProtKB.::GO:0070300; F:phosphatidic acid binding; IDA:UniProtKB.::GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; IDA:UniProtKB.::GO:0001786; F:phosphatidylserine binding; IDA:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.::GO:0050321; F:tau-protein kinase activity; ISS:UniProtKB.
GO:0007243; P:intracellular protein kinase cascade; IDA:UniProtKB.::GO:0001764; P:neuron migration; ISS:UniProtKB.::GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW.
667O55098    966   STK10_MOUSE Serine/threonine-protein kinase 1...1060.0000002     57     34     53GO:0005886; C:plasma membrane; ISS:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0071593; P:lymphocyte aggregation; IMP:UniProtKB.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.::GO:2000401; P:regulation of lymphocyte migration; IMP:UniProtKB.
668Q9Z2B5    1114   E2AK3_MOUSE Eukaryotic translation initiation...1250.0000002     57     30     50GO:0005789; C:endoplasmic reticulum membrane; IDA:MGI.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004694; F:eukaryotic translation initiation factor 2alpha kinase activity; ISS:UniProtKB.::GO:0005515; F:protein binding; IPI:IntAct.
GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IMP:MGI.::GO:0030282; P:bone mineralization; IMP:MGI.::GO:0019722; P:calcium-mediated signaling; IMP:MGI.::GO:0002063; P:chondrocyte development; IMP:MGI.::GO:0031018; P:endocrine pancreas development; ISS:UniProtKB.::GO:0007029; P:endoplasmic reticulum organization; IMP:MGI.::GO:0030968; P:endoplasmic reticulum unfolded protein response; ISS:UniProtKB.::GO:0006983; P:ER overload response; ISS:UniProtKB.::GO:0045444; P:fat cell differentiation; IDA:MGI.::GO:0030073; P:insulin secretion; IMP:MGI.::GO:0048009; P:insulin-like growth factor receptor signaling pathway; IMP:MGI.::GO:0007595; P:lactation; IMP:MGI.::GO:0031642; P:negative regulation of myelination; IMP:MGI.::GO:0017148; P:negative regulation of translation; IDA:MGI.::GO:0032092; P:positive regulation of protein binding; IMP:MGI.::GO:0009967; P:positive regulation of signal transduction; IDA:MGI.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.::GO:0051260; P:protein homooligomerization; ISS:UniProtKB.::GO:0019217; P:regulation of fatty acid metabolic process; IMP:MGI.::GO:0032933; P:SREBP-mediated signaling pathway; IDA:MGI.::GO:0006412; P:translation; IDA:MGI.::GO:0006926; P:virus-infected cell apoptotic process; IMP:MGI.
669E9PTG8    967   STK10_RAT Serine/threonine-protein kinase 10 ...1090.0000002     56.6     34     52GO:0005886; C:plasma membrane; ISS:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0071593; P:lymphocyte aggregation; ISS:UniProtKB.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.::GO:2000401; P:regulation of lymphocyte migration; ISS:UniProtKB.
670Q54RJ4    979   IKSA_DICDI Probable serine/threonine-protein ...1160.0000002     56.6     35     53GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
671Q9C5C0    615   MPK18_ARATH Mitogen-activated protein kinase ...1110.0000002     56.6     32     51GO:0005737; C:cytoplasm; IDA:TAIR.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004707; F:MAP kinase activity; IEA:EC.::GO:0005515; F:protein binding; IPI:IntAct.
GO:0043622; P:cortical microtubule organization; IMP:TAIR.
672Q9NZJ5    1116   E2AK3_HUMAN Eukaryotic translation initiation...1250.0000002     56.6     30     49GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004694; F:eukaryotic translation initiation factor 2alpha kinase activity; IDA:UniProtKB.::GO:0042802; F:identical protein binding; IPI:IntAct.::GO:0019903; F:protein phosphatase binding; IPI:UniProtKB.
GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; ISS:UniProtKB.::GO:0006987; P:activation of signaling protein activity involved in unfolded protein response; TAS:Reactome.::GO:0030282; P:bone mineralization; ISS:UniProtKB.::GO:0019722; P:calcium-mediated signaling; ISS:UniProtKB.::GO:0002063; P:chondrocyte development; ISS:UniProtKB.::GO:0031018; P:endocrine pancreas development; IMP:UniProtKB.::GO:0007029; P:endoplasmic reticulum organization; ISS:UniProtKB.::GO:0006983; P:ER overload response; IDA:UniProtKB.::GO:0030073; P:insulin secretion; ISS:UniProtKB.::GO:0048009; P:insulin-like growth factor receptor signaling pathway; ISS:UniProtKB.::GO:0031642; P:negative regulation of myelination; ISS:UniProtKB.::GO:0032057; P:negative regulation of translational initiation in response to stress; TAS:UniProtKB.::GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.::GO:0051260; P:protein homooligomerization; IMP:UniProtKB.
673P49760    499   CLK2_HUMAN Dual specificity protein kinase CL...1150.0000002     56.2     30     51GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.::GO:0004712; F:protein serine/threonine/tyrosine kinase activity; IEA:EC.::GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
GO:0045721; P:negative regulation of gluconeogenesis; ISS:UniProtKB.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.::GO:0043484; P:regulation of RNA splicing; IDA:UniProtKB.::GO:0010212; P:response to ionizing radiation; IMP:UniProtKB.
674Q03963    515   E2AK2_MOUSE Interferon-induced, double-strand...1030.0000002     56.2     31     54GO:0005622; C:intracellular; IEA:InterPro.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003725; F:double-stranded RNA binding; IDA:MGI.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0030968; P:endoplasmic reticulum unfolded protein response; IDA:MGI.::GO:0033689; P:negative regulation of osteoblast proliferation; ISS:UniProtKB.::GO:0046777; P:protein autophosphorylation; IDA:MGI.::GO:0009615; P:response to virus; IEA:UniProtKB-KW.::GO:0006412; P:translation; IDA:MGI.::GO:0006926; P:virus-infected cell apoptotic process; IDA:MGI.
675Q00771    414   KCC1_EMENI Calcium/calmodulin-dependent prote...960.0000002     56.2     33     56
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0004683; F:calmodulin-dependent protein kinase activity; IEA:EC.
676Q69Z98    735   BRSK2_MOUSE Serine/threonine-protein kinase B...1000.0000002     56.6     34     51
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0000287; F:magnesium ion binding; IC:UniProtKB.::GO:0019901; F:protein kinase binding; IPI:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.::GO:0050321; F:tau-protein kinase activity; IDA:UniProtKB.
GO:0007409; P:axonogenesis; IMP:UniProtKB.::GO:0030010; P:establishment of cell polarity; IMP:UniProtKB.::GO:0018105; P:peptidyl-serine phosphorylation; IDA:MGI.
677Q9FJ54    439   CIPKK_ARATH CBL-interacting serine/threonine-...1000.0000002     56.2     35     51GO:0005829; C:cytosol; TAS:TAIR.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; TAS:TAIR.
GO:0009737; P:response to abscisic acid stimulus; IMP:TAIR.::GO:0007165; P:signal transduction; IEA:InterPro.
678Q0GGW5    440   STK11_CHICK Serine/threonine-protein kinase S...1010.0000002     56.2     29     54GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0016020; C:membrane; ISS:UniProtKB.::GO:0005739; C:mitochondrion; ISS:UniProtKB.::GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0005524; F:ATP binding; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; ISS:UniProtKB.::GO:0002039; F:p53 binding; ISS:UniProtKB.::GO:0030295; F:protein kinase activator activity; ISS:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0007050; P:cell cycle arrest; ISS:UniProtKB.::GO:0030010; P:establishment of cell polarity; ISS:UniProtKB.::GO:0042593; P:glucose homeostasis; ISS:UniProtKB.::GO:0030308; P:negative regulation of cell growth; ISS:UniProtKB.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.::GO:0006974; P:response to DNA damage stimulus; IEA:UniProtKB-KW.::GO:0010212; P:response to ionizing radiation; ISS:UniProtKB.::GO:0072332; P:signal transduction by p53 class mediator resulting in induction of apoptosis; ISS:UniProtKB.::GO:0001944; P:vasculature development; ISS:UniProtKB.
679Q96L34    752   MARK4_HUMAN MAP/microtubule affinity-regulati...990.0000002     56.6     36     55GO:0005813; C:centrosome; IDA:UniProtKB.::GO:0043005; C:neuron projection; IDA:UniProtKB.
GO:0005524; F:ATP binding; NAS:UniProtKB.::GO:0043015; F:gamma-tubulin binding; IDA:UniProtKB.::GO:0008017; F:microtubule binding; IDA:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.::GO:0050321; F:tau-protein kinase activity; IDA:UniProtKB.::GO:0043130; F:ubiquitin binding; NAS:UniProtKB.
GO:0001578; P:microtubule bundle formation; IEP:UniProtKB.::GO:0007399; P:nervous system development; IDA:UniProtKB.::GO:0043068; P:positive regulation of programmed cell death; NAS:UniProtKB.
680Q9LDI3    446   CIPKO_ARATH CBL-interacting serine/threonine-...1030.0000002     56.2     35     53GO:0009705; C:plant-type vacuole membrane; IDA:TAIR.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0009651; P:response to salt stress; IMP:TAIR.::GO:0007165; P:signal transduction; IEA:InterPro.
681P0CP70    988   ATG1_CRYNJ Serine/threonine-protein kinase AT...1190.0000002     56.6     32     47GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0006914; P:autophagy; IEA:UniProtKB-KW.::GO:0015031; P:protein transport; IEA:UniProtKB-KW.
682Q9I958    361   MK14B_CYPCA Mitogen-activated protein kinase ...1050.0000002     55.8     30     53GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004707; F:MAP kinase activity; IDA:UniProtKB.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006950; P:response to stress; IDA:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
683Q6GM53    743   IKKA_XENLA Inhibitor of nuclear factor kappa-...980.0000002     56.6     40     52GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008384; F:IkappaB kinase activity; IEA:EC.
684Q8SSH1    516   Y255_ENCCU Probable serine/threonine-protein ...1200.0000002     56.2     33     50
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
685Q3T0N5    366   MK13_BOVIN Mitogen-activated protein kinase 1...1050.0000002     55.8     30     54
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004707; F:MAP kinase activity; IEA:EC.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006950; P:response to stress; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
686Q9QYZ3    484   SMK2B_MOUSE Sperm motility kinase 2B OS=Mus m...1010.0000002     56.2     33     52
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
687P31325    406   PHKG2_RAT Phosphorylase b kinase gamma cataly...1080.0000002     55.8     33     50GO:0005964; C:phosphorylase kinase complex; IDA:RGD.::GO:0005625; C:soluble fraction; IDA:RGD.
GO:0005524; F:ATP binding; IDA:RGD.::GO:0005516; F:calmodulin binding; IDA:RGD.::GO:0019899; F:enzyme binding; IDA:RGD.::GO:0004689; F:phosphorylase kinase activity; IDA:RGD.::GO:0050321; F:tau-protein kinase activity; IEA:EC.
GO:0005978; P:glycogen biosynthetic process; IEA:InterPro.
688Q8C0X8    640   SMKX_MOUSE Sperm motility kinase X OS=Mus mus...1140.0000002     56.2     33     53
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
689P0CP71    988   ATG1_CRYNB Serine/threonine-protein kinase AT...1190.0000002     56.6     32     47GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0006914; P:autophagy; IEA:UniProtKB-KW.::GO:0015031; P:protein transport; IEA:UniProtKB-KW.
690P83104    393   M3K7L_DROME Putative mitogen-activated protei...2220.0000002     55.8     25     47
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004709; F:MAP kinase kinase kinase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
691P49759    484   CLK1_HUMAN Dual specificity protein kinase CL...1150.0000002     56.2     29     51GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; TAS:ProtInc.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.::GO:0004712; F:protein serine/threonine/tyrosine kinase activity; IEA:EC.
GO:0008283; P:cell proliferation; TAS:ProtInc.::GO:0043484; P:regulation of RNA splicing; IMP:UniProtKB.
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