Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YFL029C
Length:
368
Number of sequences:
5887
Description:
YFL029C CAK1 SGDID:S000001865, Chr VI from 79161-78055, Genome Release 64-1-1, reverse complement, Verified ORF, "Cyclin-dependent kinase-activating kinase required for passage through the cell cycle, phosphorylates and activates Cdc28p; nucleotide-binding pocket differs significantly from those of most other protein kinases"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
511Q23023    856   UNC51_CAEEL Serine/threonine-protein kinase u...1220.00000004     58.9     29     51GO:0030424; C:axon; IDA:WormBase.::GO:0043025; C:neuronal cell body; IDA:WormBase.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0043277; P:apoptotic cell clearance; IMP:WormBase.::GO:0006914; P:autophagy; IGI:WormBase.::GO:0048675; P:axon extension; IMP:WormBase.::GO:0007411; P:axon guidance; IMP:WormBase.::GO:0016477; P:cell migration; IMP:WormBase.::GO:0040024; P:dauer larval development; IGI:WormBase.::GO:0008340; P:determination of adult lifespan; IGI:WormBase.::GO:0070265; P:necrotic cell death; IMP:WormBase.::GO:0012501; P:programmed cell death; IGI:WormBase.::GO:0046777; P:protein autophosphorylation; IDA:WormBase.::GO:0030516; P:regulation of axon extension; IMP:WormBase.::GO:0040014; P:regulation of multicellular organism growth; IGI:WormBase.::GO:0032880; P:regulation of protein localization; IMP:WormBase.::GO:0035121; P:tail morphogenesis; IMP:WormBase.
512Q60EY8    466   CIPKK_ORYSJ CBL-interacting protein kinase 20...1010.00000004     58.5     34     55
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0007165; P:signal transduction; IEA:InterPro.
513P28547    348   CSK2A_THEPA Casein kinase II subunit alpha OS...1640.00000004     58.2     24     46GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
514Q5QN75    355   M2K1_ORYSJ Mitogen-activated protein kinase k...1200.00000004     58.2     34     52
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
515P49185    411   MK08_RAT Mitogen-activated protein kinase 8 O...1110.00000004     58.2     33     53GO:0033267; C:axon part; IDA:RGD.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0032839; C:dendrite cytoplasm; IDA:RGD.::GO:0005739; C:mitochondrion; IDA:RGD.::GO:0005634; C:nucleus; IDA:RGD.::GO:0043204; C:perikaryon; IDA:RGD.::GO:0031982; C:vesicle; IDA:RGD.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004705; F:JUN kinase activity; ISS:UniProtKB.::GO:0005515; F:protein binding; IPI:RGD.
GO:0006954; P:inflammatory response; IDA:RGD.::GO:0043066; P:negative regulation of apoptotic process; IDA:RGD.::GO:0031175; P:neuron projection development; IMP:RGD.::GO:0043065; P:positive regulation of apoptotic process; IEP:RGD.::GO:0030335; P:positive regulation of cell migration; IDA:RGD.::GO:0045740; P:positive regulation of DNA replication; IMP:RGD.::GO:0031116; P:positive regulation of microtubule polymerization; IMP:RGD.::GO:0006355; P:regulation of transcription, DNA-dependent; IDA:RGD.::GO:0009408; P:response to heat; IDA:RGD.::GO:0042542; P:response to hydrogen peroxide; IDA:RGD.::GO:0006970; P:response to osmotic stress; IDA:RGD.::GO:0048545; P:response to steroid hormone stimulus; IEP:RGD.
516Q2KJ16    406   PHKG2_BOVIN Phosphorylase b kinase gamma cata...1080.00000004     58.2     33     51GO:0005964; C:phosphorylase kinase complex; IEA:InterPro.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0004689; F:phosphorylase kinase activity; IEA:EC.::GO:0050321; F:tau-protein kinase activity; IEA:EC.
GO:0005978; P:glycogen biosynthetic process; IEA:InterPro.
517Q8N4C8    1332   MINK1_HUMAN Misshapen-like kinase 1 OS=Homo s...1020.00000004     58.9     35     54GO:0030424; C:axon; IEA:UniProtKB-SubCell.::GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005794; C:Golgi apparatus; IDA:UniProtKB.::GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.::GO:0014069; C:postsynaptic density; IEA:UniProtKB-SubCell.::GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
GO:0005524; F:ATP binding; ISS:UniProtKB.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.::GO:0005083; F:small GTPase regulator activity; IEA:InterPro.
GO:0031532; P:actin cytoskeleton reorganization; IMP:UniProtKB.::GO:0048813; P:dendrite morphogenesis; ISS:UniProtKB.::GO:0007254; P:JNK cascade; TAS:ProtInc.::GO:0046330; P:positive regulation of JNK cascade; IMP:UniProtKB.::GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.::GO:2000311; P:regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; ISS:UniProtKB.::GO:0030334; P:regulation of cell migration; IMP:UniProtKB.::GO:0022407; P:regulation of cell-cell adhesion; IMP:UniProtKB.::GO:0001952; P:regulation of cell-matrix adhesion; IMP:UniProtKB.::GO:0007268; P:synaptic transmission; ISS:UniProtKB.
518Q9JM52    1308   MINK1_MOUSE Misshapen-like kinase 1 OS=Mus mu...1020.00000004     58.9     35     54GO:0030424; C:axon; IEA:UniProtKB-SubCell.::GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.::GO:0014069; C:postsynaptic density; IEA:UniProtKB-SubCell.::GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
GO:0005524; F:ATP binding; IDA:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.::GO:0005083; F:small GTPase regulator activity; IEA:InterPro.
GO:0048813; P:dendrite morphogenesis; ISS:UniProtKB.::GO:0007243; P:intracellular protein kinase cascade; IDA:UniProtKB.::GO:0045060; P:negative thymic T cell selection; IMP:MGI.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.::GO:2000311; P:regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; ISS:UniProtKB.::GO:0006950; P:response to stress; IDA:UniProtKB.::GO:0007268; P:synaptic transmission; ISS:UniProtKB.
519Q6AXJ9    350   CDKL1_DANRE Cyclin-dependent kinase-like 1 OS...1020.00000004     58.2     29     51GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004693; F:cyclin-dependent protein kinase activity; IEA:EC.
520F1NBT0    969   STK10_CHICK Serine/threonine-protein kinase 1...1090.00000004     58.9     35     52GO:0005886; C:plasma membrane; ISS:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0071593; P:lymphocyte aggregation; ISS:UniProtKB.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.::GO:2000401; P:regulation of lymphocyte migration; ISS:UniProtKB.
521B7ZR30    950   STK10_XENLA Serine/threonine-protein kinase 1...1040.00000004     58.9     38     54GO:0005886; C:plasma membrane; ISS:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0042801; F:polo kinase kinase activity; IDA:UniProtKB.::GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
GO:0000086; P:G2/M transition of mitotic cell cycle; TAS:UniProtKB.::GO:0071593; P:lymphocyte aggregation; ISS:UniProtKB.::GO:0001556; P:oocyte maturation; IDA:UniProtKB.::GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.::GO:2000401; P:regulation of lymphocyte migration; ISS:UniProtKB.
522Q75CH3    972   ATG1_ASHGO Serine/threonine-protein kinase AT...2090.00000004     58.9     26     45GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0006914; P:autophagy; IEA:UniProtKB-KW.::GO:0015031; P:protein transport; IEA:UniProtKB-KW.
523O35099    1380   M3K5_MOUSE Mitogen-activated protein kinase k...1050.00000004     58.9     35     56GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; ISS:UniProtKB.::GO:0008656; F:cysteine-type endopeptidase activator activity involved in apoptotic process; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; ISS:UniProtKB.::GO:0004709; F:MAP kinase kinase kinase activity; IDA:UniProtKB.::GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.::GO:0019901; F:protein kinase binding; IPI:UniProtKB.
GO:0000187; P:activation of MAPK activity; IDA:MGI.::GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
524Q4WUN7    378   MPKC_ASPFU Mitogen-activated protein kinase m...1130.00000004     58.2     29     53
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004707; F:MAP kinase activity; IEA:EC.
525P0C5D6    334   SAPK3_ORYSJ Serine/threonine-protein kinase S...1080.00000004     57.8     35     54
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0009738; P:abscisic acid mediated signaling pathway; IEA:UniProtKB-KW.
526A2ZAB5    334   SAPK3_ORYSI Serine/threonine-protein kinase S...1080.00000004     57.8     35     54
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0009738; P:abscisic acid mediated signaling pathway; IEA:UniProtKB-KW.
527Q9S7U9    363   M2K2_ARATH Mitogen-activated protein kinase k...1060.00000004     58.2     32     57GO:0005737; C:cytoplasm; IDA:TAIR.::GO:0005886; C:plasma membrane; IDA:TAIR.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004708; F:MAP kinase kinase activity; IDA:TAIR.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0009631; P:cold acclimation; IMP:TAIR.::GO:0009814; P:defense response, incompatible interaction; IGI:TAIR.::GO:0009651; P:response to salt stress; IDA:TAIR.
528P15735    406   PHKG2_HUMAN Phosphorylase b kinase gamma cata...1080.00000004     58.2     33     51GO:0005829; C:cytosol; TAS:Reactome.::GO:0005964; C:phosphorylase kinase complex; TAS:UniProtKB.
GO:0005524; F:ATP binding; NAS:UniProtKB.::GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0004689; F:phosphorylase kinase activity; TAS:UniProtKB.::GO:0050321; F:tau-protein kinase activity; TAS:UniProtKB.
GO:0006006; P:glucose metabolic process; TAS:Reactome.::GO:0005978; P:glycogen biosynthetic process; IEA:InterPro.::GO:0005980; P:glycogen catabolic process; TAS:Reactome.::GO:0045819; P:positive regulation of glycogen catabolic process; TAS:UniProtKB.
529Q9H093    628   NUAK2_HUMAN NUAK family SNF1-like kinase 2 OS...1070.00000004     58.5     34     54
GO:0005524; F:ATP binding; IDA:UniProtKB.::GO:0000287; F:magnesium ion binding; IDA:UniProtKB.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO:0030036; P:actin cytoskeleton organization; IDA:UniProtKB.::GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0042149; P:cellular response to glucose starvation; IDA:UniProtKB.::GO:0043066; P:negative regulation of apoptotic process; IDA:UniProtKB.
530Q8VHF0    797   MARK3_RAT MAP/microtubule affinity-regulating...990.00000004     58.5     38     56GO:0005886; C:plasma membrane; ISS:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB.
531Q5R7G9    628   NUAK2_PONAB NUAK family SNF1-like kinase 2 OS...1070.00000005     58.5     34     54
GO:0005524; F:ATP binding; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; ISS:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB.
GO:0030036; P:actin cytoskeleton organization; ISS:UniProtKB.::GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0042149; P:cellular response to glucose starvation; ISS:UniProtKB.::GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
532Q9Z1B7    366   MK13_MOUSE Mitogen-activated protein kinase 1...1050.00000005     57.8     30     55
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004707; F:MAP kinase activity; ISS:UniProtKB.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
533Q9HFF4    1023   PPK1_SCHPO Serine/threonine-protein kinase pp...1510.00000005     58.5     28     46
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; TAS:PomBase.
GO:0007165; P:signal transduction; NAS:PomBase.
534Q9WTY9    366   MK13_RAT Mitogen-activated protein kinase 13 ...1050.00000005     57.8     30     55GO:0005625; C:soluble fraction; IDA:RGD.
GO:0005524; F:ATP binding; IDA:RGD.::GO:0004707; F:MAP kinase activity; ISS:UniProtKB.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
535P36005    433   KDX1_YEAST Serine/threonine-protein kinase KD...1670.00000005     58.2     25     47
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
536P49138    386   MAPK2_MOUSE MAP kinase-activated protein kina...1150.00000005     57.8     32     50GO:0005737; C:cytoplasm; IDA:UniProtKB.::GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO:0070935; P:3'-UTR-mediated mRNA stabilization; ISS:UniProtKB.::GO:0031572; P:G2/M transition DNA damage checkpoint; ISS:UniProtKB.::GO:0006954; P:inflammatory response; IMP:UniProtKB.::GO:0048839; P:inner ear development; IDA:MGI.::GO:0044351; P:macropinocytosis; IMP:UniProtKB.::GO:0032675; P:regulation of interleukin-6 production; IMP:UniProtKB.::GO:0032680; P:regulation of tumor necrosis factor production; IMP:UniProtKB.::GO:0032496; P:response to lipopolysaccharide; IMP:UniProtKB.::GO:0002224; P:toll-like receptor signaling pathway; IMP:UniProtKB.
537P06782    633   SNF1_YEAST Carbon catabolite-derepressing pro...1000.00000005     58.5     35     56GO:0031588; C:AMP-activated protein kinase complex; IDA:SGD.::GO:0000324; C:fungal-type vacuole; IPI:SGD.::GO:0005739; C:mitochondrion; IDA:SGD.::GO:0005641; C:nuclear envelope lumen; IDA:SGD.::GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
GO:0004679; F:AMP-activated protein kinase activity; IDA:SGD.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.
GO:0042710; P:biofilm formation; IMP:SGD.::GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW.::GO:0007155; P:cell adhesion; IMP:SGD.::GO:0006995; P:cellular response to nitrogen starvation; IDA:SGD.::GO:0001403; P:invasive growth in response to glucose limitation; IMP:SGD.::GO:0017148; P:negative regulation of translation; IMP:SGD.::GO:0045722; P:positive regulation of gluconeogenesis; IMP:SGD.::GO:0007124; P:pseudohyphal growth; IMP:SGD.::GO:0001302; P:replicative cell aging; IMP:SGD.::GO:0007165; P:signal transduction; TAS:SGD.
538P53778    367   MK12_HUMAN Mitogen-activated protein kinase 1...1050.00000005     57.8     32     54GO:0005829; C:cytosol; TAS:Reactome.::GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.::GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0000287; F:magnesium ion binding; IDA:UniProtKB.::GO:0004707; F:MAP kinase activity; TAS:ProtInc.::GO:0005515; F:protein binding; IPI:UniProtKB.
GO:0007050; P:cell cycle arrest; TAS:ProtInc.::GO:0006975; P:DNA damage induced protein phosphorylation; TAS:ProtInc.::GO:0007517; P:muscle organ development; TAS:ProtInc.::GO:0045445; P:myoblast differentiation; IDA:UniProtKB.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0018105; P:peptidyl-serine phosphorylation; IDA:BHF-UCL.::GO:0051149; P:positive regulation of muscle cell differentiation; TAS:Reactome.::GO:0007265; P:Ras protein signal transduction; TAS:Reactome.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
539Q9HG11    415   MPKC_EMENI Mitogen-activated protein kinase m...1070.00000005     57.8     29     54
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004707; F:MAP kinase activity; IEA:EC.
540P49139    366   MAPK2_RABIT MAP kinase-activated protein kina...1170.00000005     57.8     32     50GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB.
GO:0070935; P:3'-UTR-mediated mRNA stabilization; ISS:UniProtKB.::GO:0031572; P:G2/M transition DNA damage checkpoint; ISS:UniProtKB.::GO:0006954; P:inflammatory response; ISS:UniProtKB.::GO:0044351; P:macropinocytosis; ISS:UniProtKB.::GO:0032675; P:regulation of interleukin-6 production; ISS:UniProtKB.::GO:0032680; P:regulation of tumor necrosis factor production; ISS:UniProtKB.::GO:0032496; P:response to lipopolysaccharide; ISS:UniProtKB.::GO:0002224; P:toll-like receptor signaling pathway; ISS:UniProtKB.
541Q38HL5    366   HOG1_EURHE Mitogen-activated protein kinase h...1020.00000005     57.8     31     52GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004707; F:MAP kinase activity; IEA:EC.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
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