Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YFL005W
Length:
215
Number of sequences:
5887
Description:
YFL005W SEC4 SGDID:S000001889, Chr VI from 130334-130981, Genome Release 64-1-1, Verified ORF, "Rab family GTPase essential for vesicle-mediated exocytic secretion and autophagy; associates with the exocyst component Sec15p and may regulate polarized delivery of transport vesicles to the exocyst at the plasma membrane"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
691Q17QI8    236   RHOV_BOVIN Rho-related GTP-binding protein Rh...1892e-18     84.7     28     49GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
692O17915    215   RAN_CAEEL GTP-binding nuclear protein ran-1 O...1582e-18     84.7     28     53GO:0000777; C:condensed chromosome kinetochore; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.
GO:0006915; P:apoptotic process; IMP:WormBase.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.::GO:0040007; P:growth; IMP:WormBase.::GO:0006886; P:intracellular protein transport; IEA:InterPro.::GO:0040011; P:locomotion; IMP:WormBase.::GO:0046785; P:microtubule polymerization; IMP:WormBase.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0002119; P:nematode larval development; IMP:WormBase.::GO:0006913; P:nucleocytoplasmic transport; IEA:InterPro.::GO:0048477; P:oogenesis; IMP:WormBase.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
693P60764    192   RAC3_MOUSE Ras-related C3 botulinum toxin sub...1682e-18     84.3     29     50GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0012505; C:endomembrane system; ISS:UniProtKB.::GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; ISS:UniProtKB.::GO:0005515; F:protein binding; IPI:IntAct.
GO:0030036; P:actin cytoskeleton organization; ISS:UniProtKB.::GO:0030031; P:cell projection assembly; ISS:UniProtKB.::GO:0050885; P:neuromuscular process controlling balance; IMP:MGI.::GO:0031175; P:neuron projection development; IDA:MGI.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
694P60763    192   RAC3_HUMAN Ras-related C3 botulinum toxin sub...1682e-18     84.3     29     50GO:0005829; C:cytosol; TAS:Reactome.::GO:0012505; C:endomembrane system; IDA:UniProtKB.::GO:0031941; C:filamentous actin; IDA:MGI.::GO:0030426; C:growth cone; IDA:MGI.::GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.::GO:0043025; C:neuronal cell body; IDA:MGI.::GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; IDA:UniProtKB.::GO:0005515; F:protein binding; IPI:IntAct.
GO:0030036; P:actin cytoskeleton organization; IDA:UniProtKB.::GO:0030031; P:cell projection assembly; IDA:UniProtKB.::GO:0051056; P:regulation of small GTPase mediated signal transduction; TAS:Reactome.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.
695Q95KD9    199   DIRA2_MACFA GTP-binding protein Di-Ras2 OS=Ma...1612e-18     84.3     32     52GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; IEA:InterPro.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
696Q96HU8    199   DIRA2_HUMAN GTP-binding protein Di-Ras2 OS=Ho...1612e-18     84.3     32     52GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; IEA:InterPro.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
697P34148    195   RACB_DICDI Rho-related protein racB OS=Dictyo...1682e-18     84.3     27     52GO:0005737; C:cytoplasm; IDA:dictyBase.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:dictyBase.
GO:0030041; P:actin filament polymerization; IMP:dictyBase.::GO:0031152; P:aggregation involved in sorocarp development; IMP:dictyBase.::GO:0006935; P:chemotaxis; IMP:dictyBase.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
698Q24815    163   RACB_ENTHI Rho-related protein racB OS=Entamo...1612e-18     83.6     32     48GO:0005622; C:intracellular; IEA:InterPro.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
699P22126    213   RAS1_NEUCR Protein ras-1 OS=1257 / FGSC 987)....1532e-18     84.3     31     54GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; IEA:InterPro.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
700P22122    192   RHO_DISOM Ras-like GTP-binding protein O-RHO ...1652e-18     84     30     53GO:0005622; C:intracellular; IEA:InterPro.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
701Q8J212    208   RHO1_KLULA GTP-binding protein Rho1 OS=1267 /...1672e-18     84     30     54GO:0005622; C:intracellular; IEA:InterPro.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
702Q6RUV5    192   RAC1_RAT Ras-related C3 botulinum toxin subst...1682e-18     83.6     29     51GO:0000139; C:Golgi membrane; IDA:RGD.::GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IDA:RGD.::GO:0003924; F:GTPase activity; IDA:RGD.::GO:0019901; F:protein kinase binding; IPI:BHF-UCL.::GO:0017137; F:Rab GTPase binding; IPI:RGD.
GO:0007015; P:actin filament organization; IMP:RGD.::GO:0045453; P:bone resorption; IDA:RGD.::GO:0008283; P:cell proliferation; IMP:RGD.::GO:0002551; P:mast cell chemotaxis; IMP:RGD.::GO:0045740; P:positive regulation of DNA replication; IMP:RGD.::GO:0016601; P:Rac protein signal transduction; TAS:RGD.::GO:0030334; P:regulation of cell migration; ISS:UniProtKB.
703P63001    192   RAC1_MOUSE Ras-related C3 botulinum toxin sub...1682e-18     83.6     29     51GO:0005829; C:cytosol; TAS:Reactome.::GO:0019897; C:extrinsic to plasma membrane; IDA:MGI.::GO:0030027; C:lamellipodium; IDA:MGI.::GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.::GO:0005624; C:membrane fraction; IDA:MGI.::GO:0001891; C:phagocytic cup; IDA:UniProtKB.::GO:0032587; C:ruffle membrane; IDA:UniProtKB.
GO:0005525; F:GTP binding; IDA:MGI.::GO:0030742; F:GTP-dependent protein binding; IPI:UniProtKB.::GO:0003924; F:GTPase activity; IDA:MGI.
GO:0048532; P:anatomical structure arrangement; IMP:MGI.::GO:0002093; P:auditory receptor cell morphogenesis; IMP:MGI.::GO:0007411; P:axon guidance; IMP:MGI.::GO:0045216; P:cell-cell junction organization; IMP:MGI.::GO:0021799; P:cerebral cortex radially oriented cell migration; IMP:MGI.::GO:0090103; P:cochlea morphogenesis; IMP:MGI.::GO:0007010; P:cytoskeleton organization; IDA:MGI.::GO:0048813; P:dendrite morphogenesis; IGI:MGI.::GO:0071542; P:dopaminergic neuron differentiation; IGI:MGI.::GO:0021831; P:embryonic olfactory bulb interneuron precursor migration; IMP:MGI.::GO:0043652; P:engulfment of apoptotic cell; IDA:BHF-UCL.::GO:0003382; P:epithelial cell morphogenesis; IMP:MGI.::GO:0006972; P:hyperosmotic response; IDA:MGI.::GO:0030032; P:lamellipodium assembly; IDA:MGI.::GO:0030838; P:positive regulation of actin filament polymerization; IDA:MGI.::GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity; IMP:MGI.::GO:0030334; P:regulation of cell migration; IMP:MGI.::GO:0097178; P:ruffle assembly; IMP:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; IDA:MGI.::GO:0034446; P:substrate adhesion-dependent cell spreading; IDA:MGI.::GO:0060071; P:Wnt receptor signaling pathway, planar cell polarity pathway; IGI:MGI.
704P63000    192   RAC1_HUMAN Ras-related C3 botulinum toxin sub...1682e-18     83.6     29     51GO:0005829; C:cytosol; TAS:Reactome.::GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0005525; F:GTP binding; IDA:UniProtKB.::GO:0003924; F:GTPase activity; TAS:UniProtKB.::GO:0031996; F:thioesterase binding; IPI:UniProtKB.
GO:0030041; P:actin filament polymerization; TAS:UniProtKB.::GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0007411; P:axon guidance; TAS:Reactome.::GO:0048870; P:cell motility; IDA:UniProtKB.::GO:0007160; P:cell-matrix adhesion; NAS:BHF-UCL.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0006954; P:inflammatory response; TAS:ProtInc.::GO:0030032; P:lamellipodium assembly; IMP:UniProtKB.::GO:0051668; P:localization within membrane; IMP:BHF-UCL.::GO:0032707; P:negative regulation of interleukin-23 production; IDA:BHF-UCL.::GO:0048261; P:negative regulation of receptor-mediated endocytosis; TAS:UniProtKB.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0030168; P:platelet activation; TAS:Reactome.::GO:0010592; P:positive regulation of lamellipodium assembly; IDA:MGI.::GO:0035025; P:positive regulation of Rho protein signal transduction; TAS:UniProtKB.::GO:0030334; P:regulation of cell migration; IMP:UniProtKB.::GO:0050690; P:regulation of defense response to virus by virus; TAS:Reactome.::GO:0010310; P:regulation of hydrogen peroxide metabolic process; TAS:BHF-UCL.::GO:0060263; P:regulation of respiratory burst; IDA:BHF-UCL.::GO:0031529; P:ruffle organization; TAS:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.::GO:0031295; P:T cell costimulation; TAS:Reactome.::GO:0016032; P:viral reproduction; TAS:Reactome.
705P62999    192   RAC1_CANFA Ras-related C3 botulinum toxin sub...1682e-18     83.6     29     51GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; ISS:UniProtKB.
GO:0048870; P:cell motility; ISS:UniProtKB.::GO:0030334; P:regulation of cell migration; ISS:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
706P62998    192   RAC1_BOVIN Ras-related C3 botulinum toxin sub...1682e-18     83.6     29     51GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; ISS:UniProtKB.
GO:0030334; P:regulation of cell migration; ISS:UniProtKB.
707Q5PR73    199   DIRA2_MOUSE GTP-binding protein Di-Ras2 OS=Mu...1613e-18     83.6     32     52GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; IEA:InterPro.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
708Q54EW9    194   RABU_DICDI Ras-related protein RabU OS=Dictyo...1843e-18     83.6     30     54
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
709C4YKT4    288   RAS1_CANAW Ras-like protein 1 OS=Candida albi...1523e-18     84.3     32     53GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; IEA:InterPro.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
710P0CY32    290   RAS1_CANAX Ras-like protein 1 OS=Candida albi...1523e-18     84.3     32     53GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; IEA:InterPro.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
711O96390    193   RACF1_DICDI Rho-related protein racF1 OS=Dict...1674e-18     82.8     28     50GO:0005622; C:intracellular; IEA:InterPro.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0019901; F:protein kinase binding; IPI:dictyBase.
GO:0019953; P:sexual reproduction; IEP:dictyBase.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
712Q9GPS3    193   RACF2_DICDI Rho-related protein racF2 OS=Dict...1675e-18     82.8     28     50GO:0005622; C:intracellular; IEA:InterPro.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0019901; F:protein kinase binding; ISS:dictyBase.
GO:0031152; P:aggregation involved in sorocarp development; IMP:dictyBase.::GO:0016337; P:cell-cell adhesion; IMP:dictyBase.::GO:0019953; P:sexual reproduction; IMP:dictyBase.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
713P51539    194   RAS1_HYDVU Ras-like protein RAS1 OS=Hydra vul...1495e-18     82.8     34     52GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; IEA:InterPro.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
714Q59XU5    291   RAS1_CANAL Ras-like protein 1 OS=Candida albi...1525e-18     83.6     32     53GO:0005886; C:plasma membrane; IDA:CGD.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; IDA:CGD.
GO:0044413; P:avoidance of host defenses; IMP:CGD.::GO:0019933; P:cAMP-mediated signaling; IMP:CGD.::GO:0071333; P:cellular response to glucose stimulus; IMP:CGD.::GO:0034605; P:cellular response to heat; IMP:CGD.::GO:0034599; P:cellular response to oxidative stress; IMP:CGD.::GO:0030448; P:hyphal growth; IMP:CGD.::GO:0009405; P:pathogenesis; IMP:CGD.::GO:0043065; P:positive regulation of apoptotic process; IMP:CGD.::GO:0045595; P:regulation of cell differentiation; IMP:CGD.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
715Q9VUN3    217   RANL_DROME GTP-binding nuclear protein Ran-li...1635e-18     83.2     30     56GO:0005737; C:cytoplasm; IDA:UniProtKB.::GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0005525; F:GTP binding; IDA:UniProtKB.::GO:0003924; F:GTPase activity; IEA:InterPro.::GO:0005515; F:protein binding; IPI:UniProtKB.
GO:0006886; P:intracellular protein transport; IEA:InterPro.::GO:0006913; P:nucleocytoplasmic transport; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
716P41915    225   RAN_TETTH GTP-binding nuclear protein Ran OS=...1585e-18     83.2     30     52GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; IEA:InterPro.
GO:0006886; P:intracellular protein transport; IEA:InterPro.::GO:0006913; P:nucleocytoplasmic transport; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
717Q9HF56    191   CDC42_ASHGO Cell division control protein 42 ...1686e-18     82.4     28     50GO:0005622; C:intracellular; IEA:InterPro.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
718Q24817    198   RACD_ENTHI Rho-related protein racD OS=Entamo...1806e-18     82.4     27     52GO:0005622; C:intracellular; IEA:InterPro.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
719C4YDI6    191   CDC42_CANAW Cell division control protein 42 ...1686e-18     82.4     29     51GO:0005622; C:intracellular; IEA:InterPro.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0009405; P:pathogenesis; IEA:UniProtKB-KW.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
720P0CY33    191   CDC42_CANAL Cell division control protein 42 ...1686e-18     82.4     29     51GO:0030428; C:cell septum; NAS:CGD.::GO:0005935; C:cellular bud neck; IDA:CGD.::GO:0005934; C:cellular bud tip; IDA:CGD.::GO:0031562; C:hyphal tip polarisome; IDA:CGD.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0031521; C:spitzenkorper; IDA:CGD.
GO:0005525; F:GTP binding; IDA:CGD.
GO:0007114; P:cell budding; IMP:CGD.::GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0000920; P:cytokinetic cell separation; IMP:CGD.::GO:0030010; P:establishment of cell polarity; IMP:CGD.::GO:0030448; P:hyphal growth; IMP:CGD.::GO:0009405; P:pathogenesis; IMP:CGD.::GO:0001558; P:regulation of cell growth; IMP:CGD.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
721P38542    215   RAN_BRUMA GTP-binding nuclear protein Ran OS=...1587e-18     82.8     28     53GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; IEA:InterPro.
GO:0006886; P:intracellular protein transport; IEA:InterPro.::GO:0006913; P:nucleocytoplasmic transport; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
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