Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YFL005W
Length:
215
Number of sequences:
5887
Description:
YFL005W SEC4 SGDID:S000001889, Chr VI from 130334-130981, Genome Release 64-1-1, Verified ORF, "Rab family GTPase essential for vesicle-mediated exocytic secretion and autophagy; associates with the exocyst component Sec15p and may regulate polarized delivery of transport vesicles to the exocyst at the plasma membrane"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
511Q55CB7    216   RASY_DICDI Ras-like protein rasY OS=Dictyoste...1873e-22     94.7     32     57GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; ISS:dictyBase.
GO:0007265; P:Ras protein signal transduction; ISS:dictyBase.
512Q5RFI2    221   RAB28_PONAB Ras-related protein Rab-28 OS=Pon...2174e-22     94.7     30     51GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0019003; F:GDP binding; ISS:UniProtKB.::GO:0005525; F:GTP binding; ISS:UniProtKB.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
513Q9SJZ5    176   RAA4E_ARATH Putative Ras-related protein RABA...1734e-22     94     34     50
GO:0005525; F:GTP binding; IEA:InterPro.
GO:0015031; P:protein transport; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
514Q9SBJ6    197   RAC6_ARATH Rac-like GTP-binding protein ARAC6...1714e-22     94.4     33     52GO:0005737; C:cytoplasm; IDA:TAIR.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IDA:TAIR.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
515P08644    189   RASK_RAT GTPase KRas OS=Rattus norvegicus (Ra...1514e-22     94     32     56GO:0045121; C:membrane raft; IDA:RGD.::GO:0005739; C:mitochondrion; IDA:RGD.::GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0019003; F:GDP binding; IDA:RGD.::GO:0019002; F:GMP binding; IDA:RGD.::GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0030275; F:LRR domain binding; IDA:RGD.
GO:0019221; P:cytokine-mediated signaling pathway; IMP:RGD.::GO:0043406; P:positive regulation of MAP kinase activity; IMP:RGD.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IMP:RGD.::GO:0051000; P:positive regulation of nitric-oxide synthase activity; IMP:RGD.::GO:0051384; P:response to glucocorticoid stimulus; IEP:RGD.::GO:0051385; P:response to mineralocorticoid stimulus; IEP:RGD.::GO:0035176; P:social behavior; IEP:RGD.
516P32883    189   RASK_MOUSE GTPase KRas OS=Mus musculus (Mouse...1514e-22     94     32     56GO:0005624; C:membrane fraction; IDA:MGI.::GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; IGI:MGI.::GO:0005515; F:protein binding; IPI:IntAct.
GO:0030036; P:actin cytoskeleton organization; IGI:MGI.::GO:0008284; P:positive regulation of cell proliferation; IGI:MGI.::GO:0035022; P:positive regulation of Rac protein signal transduction; IGI:MGI.::GO:0007265; P:Ras protein signal transduction; IGI:MGI.::GO:0048169; P:regulation of long-term neuronal synaptic plasticity; IGI:MGI.::GO:0032228; P:regulation of synaptic transmission, GABAergic; IGI:MGI.::GO:0051146; P:striated muscle cell differentiation; IGI:MGI.::GO:0008542; P:visual learning; IGI:MGI.
517O04369    197   RAC1_LOTJA Rac-like GTP-binding protein RAC1 ...1784e-22     94     32     51GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
518Q56JV3    184   RHEB_BOVIN GTP-binding protein Rheb OS=Bos ta...1666e-22     93.6     38     57GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; ISS:UniProtKB.::GO:0003924; F:GTPase activity; IEA:InterPro.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0032008; P:positive regulation of TOR signaling cascade; ISS:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
519Q62639    184   RHEB_RAT GTP-binding protein Rheb OS=Rattus n...1666e-22     93.6     38     57GO:0030425; C:dendrite; IDA:RGD.::GO:0043025; C:neuronal cell body; IDA:RGD.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0019003; F:GDP binding; IDA:RGD.::GO:0005525; F:GTP binding; IDA:RGD.::GO:0003924; F:GTPase activity; IDA:RGD.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:RGD.
GO:0032008; P:positive regulation of TOR signaling cascade; ISS:UniProtKB.::GO:0048168; P:regulation of neuronal synaptic plasticity; NAS:RGD.::GO:0007264; P:small GTPase mediated signal transduction; IDA:RGD.
520O94363    185   RHB1_SCHPO GTP-binding protein rhb1 OS=Schizo...1776e-22     93.6     32     57GO:0005829; C:cytosol; IDA:PomBase.::GO:0005634; C:nucleus; IDA:PomBase.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0019003; F:GDP binding; IDA:PomBase.::GO:0005525; F:GTP binding; IDA:UniProtKB.::GO:0003924; F:GTPase activity; IDA:UniProtKB.::GO:0005515; F:protein binding; IPI:PomBase.
GO:0030996; P:cell cycle arrest in response to nitrogen starvation; IMP:PomBase.::GO:0010963; P:regulation of L-arginine import; IGI:PomBase.::GO:0007264; P:small GTPase mediated signal transduction; IC:PomBase.
521Q5EFX7    188   RASK_KRYMA GTPase KRas OS=Kryptolebias marmor...1516e-22     93.6     33     57GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; IEA:InterPro.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
522Q921J2    184   RHEB_MOUSE GTP-binding protein Rheb OS=Mus mu...1667e-22     93.2     38     57GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0005681; C:spliceosomal complex; IDA:MGI.
GO:0005525; F:GTP binding; IDA:UniProtKB.::GO:0003924; F:GTPase activity; IEA:InterPro.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0019901; F:protein kinase binding; IPI:UniProtKB.
GO:0032008; P:positive regulation of TOR signaling cascade; IDA:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
523P79800    188   RASK_MELGA GTPase KRas OS=Meleagris gallopavo...1517e-22     93.6     32     57GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; IEA:InterPro.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
524Q54RY4    233   RABV_DICDI Ras-related protein RabV OS=Dictyo...1217e-22     94.4     37     62
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
525P01116    189   RASK_HUMAN GTPase KRas OS=Homo sapiens (Human...1517e-22     93.2     32     56GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.
GO:0000186; P:activation of MAPKK activity; TAS:Reactome.::GO:0007411; P:axon guidance; TAS:Reactome.::GO:0007596; P:blood coagulation; TAS:Reactome.::GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome.::GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:Reactome.::GO:0008286; P:insulin receptor signaling pathway; TAS:Reactome.::GO:0050900; P:leukocyte migration; TAS:Reactome.::GO:0000165; P:MAPK cascade; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0010628; P:positive regulation of gene expression; IMP:BHF-UCL.::GO:0001934; P:positive regulation of protein phosphorylation; IMP:BHF-UCL.::GO:0007265; P:Ras protein signal transduction; TAS:Reactome.
526Q9SU67    208   RAC8_ARATH Rac-like GTP-binding protein ARAC8...1808e-22     93.6     32     51GO:0005622; C:intracellular; IEA:InterPro.::GO:0005886; C:plasma membrane; IDA:TAIR.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
GO:0009738; P:abscisic acid mediated signaling pathway; TAS:TAIR.::GO:0009788; P:negative regulation of abscisic acid mediated signaling pathway; TAS:TAIR.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
527Q68Y52    214   RAC2_ORYSJ Rac-like GTP-binding protein 2 OS=...1761e-21     93.6     31     52GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
528Q9SSX0    214   RAC1_ORYSJ Rac-like GTP-binding protein 1 OS=...1771e-21     93.2     31     53GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0019899; F:enzyme binding; IPI:UniProtKB.::GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0006952; P:defense response; IEA:UniProtKB-KW.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
529Q15382    184   RHEB_HUMAN GTP-binding protein Rheb OS=Homo s...1661e-21     92.4     37     57GO:0005829; C:cytosol; TAS:Reactome.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; ISS:UniProtKB.::GO:0003924; F:GTPase activity; TAS:ProtInc.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0007050; P:cell cycle arrest; TAS:Reactome.::GO:0008286; P:insulin receptor signaling pathway; TAS:Reactome.::GO:0032008; P:positive regulation of TOR signaling cascade; IMP:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
530Q35638    197   RHO1_PEA Rac-like GTP-binding protein RHO1 OS...1662e-21     92.8     33     52GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
531P05774    183   RAS_CARAU Ras-like protein OS=Carassius aurat...1512e-21     92.4     32     56GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; IEA:InterPro.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
532P33153    346   CRL1_CANAW GTP-binding RHO-like protein OS=Ca...1552e-21     94.4     36     57GO:0005622; C:intracellular; IEA:InterPro.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
533Q9FLQ3    222   RAN4_ARATH GTP-binding nuclear protein Ran-4 ...1602e-21     93.2     31     53GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; IEA:InterPro.
GO:0006886; P:intracellular protein transport; IEA:InterPro.::GO:0006913; P:nucleocytoplasmic transport; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
534Q9YH38    188   RASK_CYPCA GTPase KRas OS=Cyprinus carpio (Co...1512e-21     92.4     32     57GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; IEA:InterPro.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
535P97538    208   RASM_RAT Ras-related protein M-Ras OS=Rattus ...1842e-21     92.4     35     59GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; IEA:InterPro.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
536Q38937    196   RAC5_ARATH Rac-like GTP-binding protein ARAC5...1782e-21     92     31     51GO:0005730; C:nucleolus; IDA:TAIR.::GO:0009524; C:phragmoplast; IDA:TAIR.::GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0005525; F:GTP binding; IDA:UniProtKB.::GO:0019901; F:protein kinase binding; IPI:UniProtKB.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
537Q38912    198   RAC3_ARATH Rac-like GTP-binding protein ARAC3...1812e-21     92     29     50GO:0005737; C:cytoplasm; IDA:TAIR.::GO:0005730; C:nucleolus; IDA:TAIR.::GO:0005886; C:plasma membrane; IDA:TAIR.::GO:0030427; C:site of polarized growth; IDA:TAIR.::GO:0005819; C:spindle; IDA:TAIR.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; IDA:TAIR.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
538O08989    208   RASM_MOUSE Ras-related protein M-Ras OS=Mus m...1843e-21     92     35     59GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; IEA:InterPro.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
539Q55CC0    216   RASW_DICDI Ras-like protein rasW OS=Dictyoste...1733e-21     92.4     31     57GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; ISS:dictyBase.::GO:0003924; F:GTPase activity; ISS:dictyBase.
GO:0007265; P:Ras protein signal transduction; ISS:dictyBase.
540Q8BU31    183   RAP2C_MOUSE Ras-related protein Rap-2c OS=Mus...1483e-21     91.7     36     59GO:0005829; C:cytosol; IDA:MGI.::GO:0055038; C:recycling endosome membrane; IDA:UniProtKB.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; IEA:InterPro.
GO:0030336; P:negative regulation of cell migration; IDA:MGI.::GO:0031954; P:positive regulation of protein autophosphorylation; IDA:MGI.::GO:0032486; P:Rap protein signal transduction; IDA:UniProtKB.::GO:0061097; P:regulation of protein tyrosine kinase activity; IDA:UniProtKB.
541Q9Y3L5    183   RAP2C_HUMAN Ras-related protein Rap-2c OS=Hom...1483e-21     91.7     36     59GO:0055038; C:recycling endosome membrane; ISS:UniProtKB.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; IEA:InterPro.
GO:0030336; P:negative regulation of cell migration; ISS:UniProtKB.::GO:0031954; P:positive regulation of protein autophosphorylation; ISS:UniProtKB.::GO:0032486; P:Rap protein signal transduction; ISS:UniProtKB.::GO:0061097; P:regulation of protein tyrosine kinase activity; ISS:UniProtKB.
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