Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YFL005W
Length:
215
Number of sequences:
5887
Description:
YFL005W SEC4 SGDID:S000001889, Chr VI from 130334-130981, Genome Release 64-1-1, Verified ORF, "Rab family GTPase essential for vesicle-mediated exocytic secretion and autophagy; associates with the exocyst component Sec15p and may regulate polarized delivery of transport vesicles to the exocyst at the plasma membrane"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
481P12825    189   RASN_CAVPO GTPase NRas OS=Cavia porcellus (Gu...1604e-23     97.1     34     56GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; IEA:InterPro.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
482P92978    197   RAC11_ARATH Rac-like GTP-binding protein ARAC...1714e-23     97.1     33     52GO:0045177; C:apical part of cell; IDA:TAIR.::GO:0005730; C:nucleolus; IDA:TAIR.::GO:0009524; C:phragmoplast; IDA:TAIR.::GO:0005886; C:plasma membrane; TAS:TAIR.::GO:0005819; C:spindle; IDA:TAIR.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0032794; F:GTPase activating protein binding; IPI:TAIR.
GO:0051650; P:establishment of vesicle localization; IDA:TAIR.::GO:0009860; P:pollen tube growth; IMP:TAIR.::GO:0030834; P:regulation of actin filament depolymerization; IGI:TAIR.::GO:0030833; P:regulation of actin filament polymerization; IGI:TAIR.::GO:0017157; P:regulation of exocytosis; IDA:TAIR.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
483P32253    189   RASC_DICDI Ras-like protein rasC OS=Dictyoste...1675e-23     96.7     33     58GO:0005622; C:intracellular; IC:dictyBase.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0031982; C:vesicle; IDA:dictyBase.
GO:0005525; F:GTP binding; IDA:dictyBase.::GO:0003924; F:GTPase activity; IDA:dictyBase.
GO:0030036; P:actin cytoskeleton organization; IMP:dictyBase.::GO:0007190; P:activation of adenylate cyclase activity; IGI:dictyBase.::GO:0031152; P:aggregation involved in sorocarp development; IMP:dictyBase.::GO:0008283; P:cell proliferation; IGI:dictyBase.::GO:0006928; P:cellular component movement; IMP:dictyBase.::GO:0043327; P:chemotaxis to cAMP; IMP:dictyBase.::GO:0043326; P:chemotaxis to folate; IMP:dictyBase.::GO:0007163; P:establishment or maintenance of cell polarity; IMP:dictyBase.::GO:0007188; P:G-protein signaling, coupled to cAMP nucleotide second messenger; IMP:dictyBase.::GO:0031276; P:negative regulation of lateral pseudopodium assembly; IMP:dictyBase.::GO:0030828; P:positive regulation of cGMP biosynthetic process; IMP:dictyBase.::GO:0051491; P:positive regulation of filopodium assembly; IMP:dictyBase.::GO:0031284; P:positive regulation of guanylate cyclase activity; IMP:dictyBase.::GO:0043406; P:positive regulation of MAP kinase activity; IMP:dictyBase.::GO:0051897; P:positive regulation of protein kinase B signaling cascade; IMP:dictyBase.::GO:0043491; P:protein kinase B signaling cascade; IMP:dictyBase.::GO:0007265; P:Ras protein signal transduction; IDA:dictyBase.::GO:0001558; P:regulation of cell growth; IMP:dictyBase.
484P08556    189   RASN_MOUSE GTPase NRas OS=Mus musculus (Mouse...1515e-23     96.7     34     56GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; IEA:InterPro.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
485Q2MJK3    189   RASN_PIG GTPase NRas OS=Sus scrofa (Pig). GN=...1516e-23     96.3     34     56GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; IEA:InterPro.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
486P01111    189   RASN_HUMAN GTPase NRas OS=Homo sapiens (Human...1516e-23     96.3     34     56GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; IEA:InterPro.
GO:0000186; P:activation of MAPKK activity; TAS:Reactome.::GO:0007411; P:axon guidance; TAS:Reactome.::GO:0007596; P:blood coagulation; TAS:Reactome.::GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome.::GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:Reactome.::GO:0008286; P:insulin receptor signaling pathway; TAS:Reactome.::GO:0050900; P:leukocyte migration; TAS:Reactome.::GO:0000165; P:MAPK cascade; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0007265; P:Ras protein signal transduction; TAS:Reactome.
487Q04970    189   RASN_RAT GTPase NRas OS=Rattus norvegicus (Ra...1516e-23     96.3     34     56GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; IEA:InterPro.::GO:0005515; F:protein binding; IPI:UniProtKB.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
488Q7ZYF1    273   DJ27A_XENLA DnaJ homolog subfamily C member 2...1596e-23     97.8     30     56
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0031072; F:heat shock protein binding; IEA:InterPro.::GO:0051082; F:unfolded protein binding; IEA:InterPro.
GO:0006457; P:protein folding; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
489Q6IML7    273   DJC27_RAT DnaJ homolog subfamily C member 27 ...1626e-23     97.8     30     56
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0031072; F:heat shock protein binding; IEA:InterPro.::GO:0051082; F:unfolded protein binding; IEA:InterPro.
GO:0006457; P:protein folding; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
490Q00246    291   RHO4_YEAST GTP-binding protein RHO4 OS=Saccha...1657e-23     97.8     34     56GO:0005935; C:cellular bud neck; IDA:SGD.::GO:0005622; C:intracellular; IEA:InterPro.::GO:0005624; C:membrane fraction; IDA:SGD.::GO:0005886; C:plasma membrane; IDA:SGD.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; IDA:SGD.
GO:0030011; P:maintenance of cell polarity; IGI:SGD.::GO:0090337; P:regulation of formin-nucleated actin cable assembly; IPI:SGD.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
491Q8CFP6    273   DJC27_MOUSE DnaJ homolog subfamily C member 2...1627e-23     97.8     30     56GO:0005739; C:mitochondrion; IDA:MGI.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0031072; F:heat shock protein binding; IEA:InterPro.::GO:0051082; F:unfolded protein binding; IEA:InterPro.
GO:0006457; P:protein folding; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
492P20171    189   RASH_RAT GTPase HRas OS=Rattus norvegicus (Ra...1518e-23     95.9     32     58GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0005792; C:microsome; IDA:RGD.::GO:0005886; C:plasma membrane; IDA:UniProtKB.::GO:0005625; C:soluble fraction; IDA:RGD.
GO:0005525; F:GTP binding; ISS:UniProtKB.::GO:0003924; F:GTPase activity; IEA:InterPro.
GO:0006915; P:apoptotic process; IMP:RGD.::GO:0045740; P:positive regulation of DNA replication; IMP:RGD.::GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IMP:RGD.::GO:0007265; P:Ras protein signal transduction; IMP:RGD.::GO:0035176; P:social behavior; IEP:RGD.
493Q61411    189   RASH_MOUSE GTPase HRas OS=Mus musculus (Mouse...1518e-23     95.9     32     58GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; ISS:UniProtKB.
GO:0005525; F:GTP binding; IDA:MGI.::GO:0003924; F:GTPase activity; IEA:InterPro.
GO:0008283; P:cell proliferation; IPI:MGI.::GO:0006897; P:endocytosis; IDA:MGI.::GO:0008629; P:induction of apoptosis by intracellular signals; IMP:MGI.::GO:0043524; P:negative regulation of neuron apoptotic process; IDA:MGI.::GO:0010628; P:positive regulation of gene expression; IDA:MGI.::GO:0007265; P:Ras protein signal transduction; TAS:MGI.::GO:0048169; P:regulation of long-term neuronal synaptic plasticity; IMP:MGI.
494P01112    189   RASH_HUMAN GTPase HRas OS=Homo sapiens (Human...1518e-23     95.9     32     58GO:0005829; C:cytosol; TAS:Reactome.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0005525; F:GTP binding; IDA:UniProtKB.::GO:0003924; F:GTPase activity; IEA:InterPro.::GO:0008022; F:protein C-terminus binding; IPI:UniProtKB.
GO:0000186; P:activation of MAPKK activity; TAS:Reactome.::GO:0007411; P:axon guidance; TAS:Reactome.::GO:0007596; P:blood coagulation; TAS:Reactome.::GO:0007050; P:cell cycle arrest; IDA:BHF-UCL.::GO:0090398; P:cellular senescence; IDA:BHF-UCL.::GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome.::GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:Reactome.::GO:0008286; P:insulin receptor signaling pathway; TAS:Reactome.::GO:0050900; P:leukocyte migration; TAS:Reactome.::GO:0000165; P:MAPK cascade; TAS:Reactome.::GO:0031575; P:mitotic cell cycle G1/S transition checkpoint; IDA:BHF-UCL.::GO:0008285; P:negative regulation of cell proliferation; IDA:BHF-UCL.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0009887; P:organ morphogenesis; TAS:ProtInc.::GO:0045740; P:positive regulation of DNA replication; IDA:BHF-UCL.::GO:0050679; P:positive regulation of epithelial cell proliferation; IMP:BHF-UCL.::GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IDA:BHF-UCL.::GO:0046330; P:positive regulation of JNK cascade; IDA:BHF-UCL.::GO:0001934; P:positive regulation of protein phosphorylation; IDA:BHF-UCL.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.::GO:0007265; P:Ras protein signal transduction; TAS:Reactome.::GO:0007268; P:synaptic transmission; TAS:Reactome.
495Q91806    189   RASN_XENLA GTPase NRas OS=Xenopus laevis (Afr...1619e-23     95.9     32     57GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; IEA:InterPro.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
496P13856    272   RSR1_YEAST Ras-related protein RSR1 OS=Saccha...1621e-22     97.1     34     60GO:0005935; C:cellular bud neck; IDA:SGD.::GO:0005886; C:plasma membrane; IDA:SGD.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; IDA:SGD.::GO:0004871; F:signal transducer activity; TAS:SGD.
GO:0007120; P:axial cellular bud site selection; TAS:SGD.::GO:0007121; P:bipolar cellular bud site selection; TAS:SGD.::GO:0007264; P:small GTPase mediated signal transduction; TAS:SGD.
497P08642    189   RASH_CHICK GTPase HRas OS=Gallus gallus (Chic...1511e-22     95.5     32     57GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; IEA:InterPro.
498Q3SWY9    221   RAB28_BOVIN Ras-related protein Rab-28 OS=Bos...2171e-22     96.3     31     51GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0019003; F:GDP binding; ISS:UniProtKB.::GO:0005525; F:GTP binding; ISS:UniProtKB.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
499Q55CB8    213   RASX_DICDI Ras-like protein rasX OS=Dictyoste...1741e-22     95.9     30     57GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; ISS:dictyBase.::GO:0003924; F:GTPase activity; ISS:dictyBase.
GO:0007265; P:Ras protein signal transduction; ISS:dictyBase.
500Q9XGU0    209   RAC9_ARATH Rac-like GTP-binding protein ARAC9...1821e-22     95.9     32     51GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IDA:TAIR.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
501A5D7F5    273   DJC27_BOVIN DnaJ homolog subfamily C member 2...1621e-22     96.7     31     56
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0031072; F:heat shock protein binding; IEA:InterPro.::GO:0051082; F:unfolded protein binding; IEA:InterPro.
GO:0006457; P:protein folding; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
502Q55EG6    222   RABT1_DICDI Ras-related protein RabT1 OS=Dict...1692e-22     95.9     33     60GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
503Q22038    192   RHO1_CAEEL Ras-like GTP-binding protein rhoA ...1662e-22     95.1     30     54GO:0005938; C:cell cortex; IDA:WormBase.::GO:0032154; C:cleavage furrow; IDA:WormBase.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IDA:WormBase.::GO:0003924; F:GTPase activity; IDA:WormBase.::GO:0019901; F:protein kinase binding; IPI:WormBase.
GO:0016477; P:cell migration; IMP:WormBase.::GO:0000915; P:cytokinesis, actomyosin contractile ring assembly; IMP:WormBase.::GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.::GO:0008406; P:gonad development; IMP:WormBase.::GO:0002119; P:nematode larval development; IMP:WormBase.::GO:0018991; P:oviposition; IMP:WormBase.::GO:0030728; P:ovulation; IMP:WormBase.::GO:0014057; P:positive regulation of acetylcholine secretion; IMP:WormBase.::GO:0040017; P:positive regulation of locomotion; IMP:WormBase.::GO:0032970; P:regulation of actin filament-based process; IMP:WormBase.::GO:0030241; P:skeletal muscle myosin thick filament assembly; IMP:WormBase.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
504P51157    221   RAB28_HUMAN Ras-related protein Rab-28 OS=Hom...2172e-22     95.9     30     51GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0019003; F:GDP binding; IDA:UniProtKB.::GO:0005525; F:GTP binding; IDA:UniProtKB.::GO:0003924; F:GTPase activity; TAS:ProtInc.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
505Q5M7D1    276   DJ27B_XENLA DnaJ homolog subfamily C member 2...1622e-22     96.3     29     54
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0031072; F:heat shock protein binding; IEA:InterPro.::GO:0051082; F:unfolded protein binding; IEA:InterPro.
GO:0006457; P:protein folding; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
506Q7TNZ5    183   REBL1_RAT GTPase RhebL1 OS=Rattus norvegicus ...1633e-22     94.4     35     58GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; IEA:InterPro.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
507Q39435    197   RAC1_BETVU Rac-like GTP-binding protein RHO1 ...1783e-22     94.7     32     51GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
508O00212    210   RHOD_HUMAN Rho-related GTP-binding protein Rh...1683e-22     95.1     31     55GO:0005829; C:cytosol; TAS:Reactome.::GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; TAS:ProtInc.
GO:0051056; P:regulation of small GTPase mediated signal transduction; TAS:Reactome.::GO:0007266; P:Rho protein signal transduction; TAS:ProtInc.
509Q38902    197   RAC1_ARATH Rac-like GTP-binding protein ARAC1...1713e-22     94.7     33     51GO:0016020; C:membrane; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IDA:TAIR.::GO:0009524; C:phragmoplast; IDA:TAIR.::GO:0005819; C:spindle; IDA:TAIR.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
GO:0009738; P:abscisic acid mediated signaling pathway; TAS:TAIR.::GO:0009734; P:auxin mediated signaling pathway; IMP:TAIR.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
510O42277    188   RASK_ORYLA GTPase KRas OS=Oryzias latipes (Me...1513e-22     94.4     33     57GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; IEA:InterPro.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
511Q55CB7    216   RASY_DICDI Ras-like protein rasY OS=Dictyoste...1873e-22     94.7     32     57GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; ISS:dictyBase.
GO:0007265; P:Ras protein signal transduction; ISS:dictyBase.
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