UniProt_SwissProt BLAST: Single locus

Species:

Saccharomyces cerevisiae S288C

Locus:

YER155C

Length:

2167

Number of sequences:

5887

Description:

YER155C BEM2 SGDID:S000000957, Chr V from 482848-476345, Genome Release 64-1-1, reverse complement, Verified ORF, "Rho GTPase activating protein (RhoGAP) involved in the control of cytoskeleton organization and cellular morphogenesis; required for bud emergence"

rec.	Subject	Hit Length	Description	Align.Len	E value	Bit score	% ident.	% pos.	GO associations
1	P39960	2167	BEM2_YEAST GTPase-activating protein BEM2/IPL...	2167	0	4448	100	100	GO:0005938; C:cell cortex; IDA:SGD.::GO:0005934; C:cellular bud tip; IDA:SGD.::GO:0000131; C:incipient cellular bud site; IDA:SGD.::GO:0043332; C:mating projection tip; IDA:SGD.::GO:0005739; C:mitochondrion; IDA:SGD.::GO:0005886; C:plasma membrane; IDA:SGD.
									GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0005100; F:Rho GTPase activator activity; IDA:SGD.
									GO:0030036; P:actin cytoskeleton organization; IGI:SGD.::GO:0030010; P:establishment of cell polarity; TAS:SGD.::GO:0031505; P:fungal-type cell wall organization; TAS:SGD.::GO:0035024; P:negative regulation of Rho protein signal transduction; IMP:SGD.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
2	Q9HF75	2071	BEM2_ASHGO GTPase-activating protein BEM2 OS=...	2028	0	1641	46	63	GO:0005622; C:intracellular; IEA:InterPro.
									GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.::GO:0005543; F:phospholipid binding; IEA:InterPro.
									GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
3	Q6TLK4	869	RHG27_RAT Rho GTPase-activating protein 27 OS...	197	1e-27	126	34	54	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
									GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0030675; F:Rac GTPase activator activity; IDA:HGNC.::GO:0017124; F:SH3 domain binding; IDA:HGNC.
									GO:0043089; P:positive regulation of Cdc42 GTPase activity; IDA:HGNC.::GO:0006898; P:receptor-mediated endocytosis; IMP:HGNC.::GO:0007165; P:signal transduction; IEA:InterPro.
4	A2AB59	869	RHG27_MOUSE Rho GTPase-activating protein 27 ...	197	4e-27	124	34	54	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
									GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0030675; F:Rac GTPase activator activity; ISS:UniProtKB.::GO:0017124; F:SH3 domain binding; ISS:UniProtKB.
									GO:0043089; P:positive regulation of Cdc42 GTPase activity; ISS:UniProtKB.::GO:0006898; P:receptor-mediated endocytosis; ISS:UniProtKB.::GO:0007165; P:signal transduction; IEA:InterPro.
5	Q6ZUM4	889	RHG27_HUMAN Rho GTPase-activating protein 27 ...	197	1e-26	122	34	53	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
									GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0030675; F:Rac GTPase activator activity; ISS:HGNC.::GO:0017124; F:SH3 domain binding; ISS:HGNC.
									GO:0043089; P:positive regulation of Cdc42 GTPase activity; ISS:HGNC.::GO:0006898; P:receptor-mediated endocytosis; ISS:HGNC.::GO:0007165; P:signal transduction; IEA:InterPro.
6	Q53QZ3	475	RHG15_HUMAN Rho GTPase-activating protein 15 ...	199	1e-25	116	33	53	GO:0005829; C:cytosol; TAS:Reactome.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
									GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0030675; F:Rac GTPase activator activity; IDA:MGI.
									GO:0008360; P:regulation of cell shape; IDA:MGI.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.
7	Q9P227	1491	RHG23_HUMAN Rho GTPase-activating protein 23 ...	204	2e-25	119	34	53	GO:0005622; C:intracellular; IEA:InterPro.
									GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.
									GO:0007165; P:signal transduction; IEA:InterPro.
8	Q69ZH9	1483	RHG23_MOUSE Rho GTPase-activating protein 23 ...	206	4e-25	118	33	54	GO:0005622; C:intracellular; IEA:InterPro.
									GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.
									GO:0007165; P:signal transduction; IEA:InterPro.
9	A4IF90	471	RHG15_BOVIN Rho GTPase-activating protein 15 ...	213	5e-25	114	31	53	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
									GO:0005543; F:phospholipid binding; IEA:InterPro.
									GO:0007165; P:signal transduction; IEA:InterPro.
10	Q5ZMM3	475	RHG15_CHICK Rho GTPase-activating protein 15 ...	213	5e-24	111	31	52	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
									GO:0005543; F:phospholipid binding; IEA:InterPro.
									GO:0007165; P:signal transduction; IEA:InterPro.
11	Q8C0D4	838	RHG12_MOUSE Rho GTPase-activating protein 12 ...	213	6e-24	114	30	53	GO:0005622; C:intracellular; IEA:InterPro.
									GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.
									GO:0007165; P:signal transduction; IEA:InterPro.
12	Q8IWW6	846	RHG12_HUMAN Rho GTPase-activating protein 12 ...	213	8e-24	113	30	53	GO:0005829; C:cytosol; TAS:Reactome.
									GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.
									GO:0051056; P:regulation of small GTPase mediated signal transduction; TAS:Reactome.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.
13	Q9BE31	847	RHG12_MACFA Rho GTPase-activating protein 12 ...	213	9e-24	113	30	53	GO:0005622; C:intracellular; IEA:InterPro.
									GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.
									GO:0007165; P:signal transduction; IEA:InterPro.
14	Q811M1	481	RHG15_MOUSE Rho GTPase-activating protein 15 ...	213	2e-23	110	31	53	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
									GO:0005543; F:phospholipid binding; IEA:InterPro.
									GO:0007165; P:signal transduction; IEA:InterPro.
15	Q6AYC5	482	RHG15_RAT Rho GTPase-activating protein 15 OS...	193	3e-23	109	30	52	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
									GO:0005543; F:phospholipid binding; IEA:InterPro.
									GO:0007165; P:signal transduction; IEA:InterPro.
16	A2RUV4	1935	RHG21_XENTR Rho GTPase-activating protein 21 ...	227	5e-22	108	31	52	GO:0030054; C:cell junction; IEA:UniProtKB-SubCell.::GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
									GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.
									GO:0007165; P:signal transduction; IEA:InterPro.
17	Q71M21	1902	RH21B_XENLA Rho GTPase-activating protein 21-...	227	2e-21	107	31	50	GO:0030054; C:cell junction; IEA:UniProtKB-SubCell.::GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
									GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.
									GO:0007165; P:signal transduction; IEA:InterPro.
18	Q6PAJ1	1270	BCR_MOUSE Breakpoint cluster region protein O...	199	3e-21	105	35	52	GO:0005829; C:cytosol; IDA:MGI.::GO:0005886; C:plasma membrane; IDA:MGI.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:MGI.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0030675; F:Rac GTPase activator activity; IGI:MGI.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
									GO:0030036; P:actin cytoskeleton organization; IGI:MGI.::GO:0007420; P:brain development; IGI:MGI.::GO:0042472; P:inner ear morphogenesis; IGI:MGI.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0030336; P:negative regulation of cell migration; IGI:MGI.::GO:0050728; P:negative regulation of inflammatory response; IMP:MGI.::GO:0043314; P:negative regulation of neutrophil degranulation; IGI:MGI.::GO:0050885; P:neuromuscular process controlling balance; IGI:MGI.::GO:0050766; P:positive regulation of phagocytosis; IGI:MGI.::GO:0051726; P:regulation of cell cycle; IDA:MGI.::GO:0032496; P:response to lipopolysaccharide; IMP:MGI.
19	P34288	1605	PAC1_CAEEL GTPase-activating protein pac-1 OS...	184	4e-21	105	35	54	GO:0030054; C:cell junction; IDA:WormBase.::GO:0005737; C:cytoplasm; NAS:UniProtKB.
									GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005100; F:Rho GTPase activator activity; IDA:UniProtKB.
									GO:0008105; P:asymmetric protein localization; IMP:WormBase.::GO:0010470; P:regulation of gastrulation; IMP:WormBase.::GO:0007266; P:Rho protein signal transduction; IDA:UniProtKB.
20	Q5T5U3	1957	RHG21_HUMAN Rho GTPase-activating protein 21 ...	232	4e-21	105	30	50	GO:0030054; C:cell junction; IEA:UniProtKB-SubCell.::GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
									GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.
									GO:0051683; P:establishment of Golgi localization; IDA:BHF-UCL.::GO:0007030; P:Golgi organization; IMP:BHF-UCL.::GO:0051684; P:maintenance of Golgi location; IMP:BHF-UCL.::GO:0072384; P:organelle transport along microtubule; IMP:BHF-UCL.::GO:0007165; P:signal transduction; IEA:InterPro.
21	P11274	1271	BCR_HUMAN Breakpoint cluster region protein O...	199	6e-21	104	35	51	GO:0005829; C:cytosol; TAS:Reactome.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004674; F:protein serine/threonine kinase activity; TAS:ProtInc.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
									GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.
22	Q6DFG0	1926	RH21A_XENLA Rho GTPase-activating protein 21-...	227	2e-20	103	30	50	GO:0030054; C:cell junction; IEA:UniProtKB-SubCell.::GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
									GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.
									GO:0007165; P:signal transduction; IEA:InterPro.
23	Q6DFV3	1944	RHG21_MOUSE Rho GTPase-activating protein 21 ...	238	2e-20	103	29	50	GO:0030054; C:cell junction; IEA:UniProtKB-SubCell.::GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
									GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.
									GO:0007165; P:signal transduction; IEA:InterPro.
24	Q8AVG0	862	ABR_XENLA Active breakpoint cluster region-re...	181	3e-20	102	36	51	GO:0005622; C:intracellular; IEA:InterPro.
									GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
									GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
25	Q8C4V1	747	RHG24_MOUSE Rho GTPase-activating protein 24 ...	219	3e-20	101	32	49	GO:0042995; C:cell projection; IEA:UniProtKB-SubCell.::GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.
									GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.
									GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.::GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0007165; P:signal transduction; IEA:InterPro.
26	Q5U2Z7	748	RHG24_RAT Rho GTPase-activating protein 24 OS...	222	8e-20	100	32	48	GO:0042995; C:cell projection; IEA:UniProtKB-SubCell.::GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.
									GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.
									GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.::GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0007165; P:signal transduction; IEA:InterPro.
27	A4II46	862	ABR_XENTR Active breakpoint cluster region-re...	181	1e-19	99.8	35	51	GO:0005622; C:intracellular; IEA:InterPro.
									GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
									GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
28	Q8N264	748	RHG24_HUMAN Rho GTPase-activating protein 24 ...	218	2e-19	99	33	47	GO:0042995; C:cell projection; IEA:UniProtKB-SubCell.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.
									GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.
									GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.::GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0051056; P:regulation of small GTPase mediated signal transduction; TAS:Reactome.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.
29	Q5SSL4	859	ABR_MOUSE Active breakpoint cluster region-re...	181	3e-19	98.6	35	50	GO:0005829; C:cytosol; IDA:MGI.::GO:0005886; C:plasma membrane; IDA:MGI.
									GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0030675; F:Rac GTPase activator activity; IDA:MGI.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
									GO:0030036; P:actin cytoskeleton organization; IGI:MGI.::GO:0007420; P:brain development; IGI:MGI.::GO:0042472; P:inner ear morphogenesis; IGI:MGI.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0030336; P:negative regulation of cell migration; IGI:MGI.::GO:0050728; P:negative regulation of inflammatory response; IMP:MGI.::GO:0043314; P:negative regulation of neutrophil degranulation; IGI:MGI.::GO:0050885; P:neuromuscular process controlling balance; IGI:MGI.::GO:0050766; P:positive regulation of phagocytosis; IGI:MGI.::GO:0032496; P:response to lipopolysaccharide; IMP:MGI.
30	A6QNS3	859	ABR_BOVIN Active breakpoint cluster region-re...	181	3e-19	98.6	35	50
									GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
									GO:0035556; P:intracellular signal transduction; IEA:InterPro.
31	P46941	837	TG325_CAEEL WW domain-containing protein tag-...	195	3e-19	98.6	31	52	GO:0005622; C:intracellular; IEA:InterPro.
									GO:0005543; F:phospholipid binding; IEA:InterPro.
									GO:0007165; P:signal transduction; IEA:InterPro.

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