Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YER129W
Length:
1142
Number of sequences:
5887
Description:
YER129W SAK1 SGDID:S000000931, Chr V from 417281-420709, Genome Release 64-1-1, Verified ORF, "Upstream serine/threonine kinase for the SNF1 complex; partially redundant with Elm1p and Tos3p; members of this family have functional orthology with LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
961Q3SZW1    367   TSSK1_BOVIN Testis-specific serine/threonine-...3151e-16     87     26     44GO:0001669; C:acrosomal vesicle; IEA:UniProtKB-SubCell.::GO:0019861; C:flagellum; ISS:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB.
GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.::GO:0007286; P:spermatid development; ISS:UniProtKB.
962O54992    473   MAPK5_MOUSE MAP kinase-activated protein kina...3521e-16     88.2     24     43GO:0005737; C:cytoplasm; IDA:UniProtKB.::GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0051019; F:mitogen-activated protein kinase binding; IPI:UniProtKB.::GO:0002039; F:p53 binding; IDA:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO:0032007; P:negative regulation of TOR signaling cascade; IDA:UniProtKB.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.::GO:0007265; P:Ras protein signal transduction; IMP:UniProtKB.::GO:0006417; P:regulation of translation; ISS:UniProtKB.::GO:0090400; P:stress-induced premature senescence; IMP:UniProtKB.
963P54664    301   CC2H1_TRYCO Cell division control protein 2 h...3541e-16     86.3     26     45
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004693; F:cyclin-dependent protein kinase activity; IEA:EC.
964Q2UGZ7    934   ATG1_ASPOR Serine/threonine-protein kinase at...3541e-16     89.4     27     41GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0006914; P:autophagy; IEA:UniProtKB-KW.::GO:0015031; P:protein transport; IEA:UniProtKB-KW.
965Q8XJL8    685   PKN2_CLOPE Probable serine/threonine-protein ...3561e-16     89     25     45
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008658; F:penicillin binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
966Q95YH0    380   CDK8_DICDI Probable cyclin-dependent kinase 8...2871e-16     86.7     27     45GO:0005829; C:cytosol; IDA:dictyBase.::GO:0016591; C:DNA-directed RNA polymerase II, holoenzyme; ISS:dictyBase.::GO:0005615; C:extracellular space; IDA:dictyBase.
GO:0005524; F:ATP binding; IC:dictyBase.::GO:0004693; F:cyclin-dependent protein kinase activity; IEA:EC.::GO:0016538; F:cyclin-dependent protein kinase regulator activity; ISS:dictyBase.::GO:0008353; F:RNA polymerase II carboxy-terminal domain kinase activity; IDA:dictyBase.
GO:0031152; P:aggregation involved in sorocarp development; IMP:dictyBase.::GO:0043689; P:cell-cell adhesion involved in flocculation; IMP:UniProtKB.::GO:0000082; P:G1/S transition of mitotic cell cycle; ISS:UniProtKB.::GO:0070816; P:phosphorylation of RNA polymerase II C-terminal domain; IDA:dictyBase.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
967Q925K9    273   TSSK6_MOUSE Testis-specific serine/threonine-...3061e-16     85.9     26     46
GO:0005524; F:ATP binding; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; ISS:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB.
GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.::GO:0035092; P:sperm chromatin condensation; IMP:UniProtKB.
968Q62829    544   PAK3_RAT Serine/threonine-protein kinase PAK ...3171e-16     88.2     23     44GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0051020; F:GTPase binding; IDA:RGD.::GO:0004708; F:MAP kinase kinase activity; ISS:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
GO:0007409; P:axonogenesis; ISS:UniProtKB.::GO:0016358; P:dendrite development; ISS:UniProtKB.::GO:0030833; P:regulation of actin filament polymerization; ISS:UniProtKB.
969Q80YP0    303   CDK3_MOUSE Cyclin-dependent kinase 3 OS=Mus m...3341e-16     85.9     25     49
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004693; F:cyclin-dependent protein kinase activity; IEA:EC.
GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.
970Q12469    655   SKM1_YEAST Serine/threonine-protein kinase SK...2721e-16     88.6     25     47GO:0005634; C:nucleus; IDA:SGD.::GO:0005886; C:plasma membrane; IDA:SGD.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0000920; P:cytokinetic cell separation; IMP:SGD.::GO:0010629; P:negative regulation of gene expression; IMP:SGD.::GO:0035376; P:sterol import; IMP:SGD.
971Q6DD27    896   TAOK3_XENLA Serine/threonine-protein kinase T...3161e-16     89     29     42GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0006281; P:DNA repair; IEA:UniProtKB-KW.::GO:0031572; P:G2/M transition DNA damage checkpoint; ISS:UniProtKB.::GO:0032874; P:positive regulation of stress-activated MAPK cascade; ISS:UniProtKB.
972Q9Y6E0    443   STK24_HUMAN Serine/threonine-protein kinase 2...4011e-16     87.4     26     43GO:0005829; C:cytosol; TAS:Reactome.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.::GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO:0006921; P:cellular component disassembly involved in apoptotic process; TAS:Reactome.::GO:0008631; P:induction of apoptosis by oxidative stress; IMP:UniProtKB.::GO:0030336; P:negative regulation of cell migration; IMP:UniProtKB.::GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.::GO:0048679; P:regulation of axon regeneration; IMP:UniProtKB.::GO:0007165; P:signal transduction; TAS:ProtInc.
973Q9M101    520   CDPKN_ARATH Calcium-dependent protein kinase ...4901e-16     88.2     25     44GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0019903; F:protein phosphatase binding; IPI:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0046686; P:response to cadmium ion; IEP:TAIR.
974Q54QI2    941   Y9877_DICDI Serine/threonine-protein kinase D...3291e-16     89     26     42GO:0016020; C:membrane; IEA:InterPro.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0005215; F:transporter activity; IEA:InterPro.
975P38147    527   CHK1_YEAST Serine/threonine-protein kinase CH...3111e-16     88.2     29     49GO:0005634; C:nucleus; IPI:SGD.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004674; F:protein serine/threonine kinase activity; IDA:SGD.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0000077; P:DNA damage checkpoint; IMP:SGD.
976Q6AVM3    516   CCAMK_ORYSJ Calcium and calcium/calmodulin-de...3491e-16     87.8     28     43GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0004683; F:calmodulin-dependent protein kinase activity; IEA:EC.
977O34507    648   PRKC_BACSU Serine/threonine-protein kinase Pr...2551e-16     88.6     27     45GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008658; F:penicillin binding; IEA:InterPro.::GO:0042834; F:peptidoglycan binding; IDA:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO:0071224; P:cellular response to peptidoglycan; IMP:UniProtKB.::GO:0007165; P:signal transduction; IMP:UniProtKB.::GO:0009847; P:spore germination; IMP:UniProtKB.
978Q6FKC6    567   SSN3_CANGA Serine/threonine-protein kinase SS...2081e-16     88.2     29     47GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004693; F:cyclin-dependent protein kinase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0008353; F:RNA polymerase II carboxy-terminal domain kinase activity; IEA:EC.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
979Q86CS2    668   ATG1_DICDI Serine/threonine-protein kinase at...3221e-16     88.6     25     46GO:0034045; C:pre-autophagosomal structure membrane; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; ISS:dictyBase.
GO:0048102; P:autophagic cell death; IMP:dictyBase.::GO:0006995; P:cellular response to nitrogen starvation; IMP:dictyBase.::GO:0016236; P:macroautophagy; IMP:dictyBase.::GO:0070265; P:necrotic cell death; IDA:dictyBase.::GO:0046777; P:protein autophosphorylation; IDA:dictyBase.::GO:0015031; P:protein transport; IEA:UniProtKB-KW.::GO:0031288; P:sorocarp morphogenesis; IMP:dictyBase.::GO:0030435; P:sporulation resulting in formation of a cellular spore; IMP:dictyBase.
980F1LP90    1336   MINK1_RAT Misshapen-like kinase 1 OS=Rattus n...2861e-16     89.4     27     46GO:0030424; C:axon; IEA:UniProtKB-SubCell.::GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.::GO:0014069; C:postsynaptic density; IEA:UniProtKB-SubCell.::GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB.::GO:0005083; F:small GTPase regulator activity; IEA:InterPro.
GO:0048813; P:dendrite morphogenesis; IMP:UniProtKB.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.::GO:2000311; P:regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; IMP:UniProtKB.::GO:0007268; P:synaptic transmission; IMP:UniProtKB.
981Q8IW41    473   MAPK5_HUMAN MAP kinase-activated protein kina...3521e-16     87.8     24     43GO:0005737; C:cytoplasm; IDA:HPA.::GO:0005634; C:nucleus; IDA:HPA.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004708; F:MAP kinase kinase activity; TAS:ProtInc.::GO:0002039; F:p53 binding; IDA:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO:0032007; P:negative regulation of TOR signaling cascade; ISS:UniProtKB.::GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.::GO:0007265; P:Ras protein signal transduction; IDA:UniProtKB.::GO:0006417; P:regulation of translation; IDA:UniProtKB.::GO:0090400; P:stress-induced premature senescence; IDA:UniProtKB.
982Q75D46    753   BUR1_ASHGO Serine/threonine-protein kinase BU...3711e-16     88.6     24     43GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004693; F:cyclin-dependent protein kinase activity; IEA:EC.::GO:0008353; F:RNA polymerase II carboxy-terminal domain kinase activity; IEA:EC.
983Q63651    564   RK_RAT Rhodopsin kinase OS=Rattus norvegicus ...2511e-16     88.2     29     47GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004703; F:G-protein coupled receptor kinase activity; IEA:InterPro.::GO:0050254; F:rhodopsin kinase activity; IDA:RGD.
GO:0046777; P:protein autophosphorylation; IDA:RGD.::GO:0022400; P:regulation of rhodopsin mediated signaling pathway; ISS:UniProtKB.::GO:0042493; P:response to drug; IEP:RGD.::GO:0009586; P:rhodopsin mediated phototransduction; TAS:RGD.::GO:0038032; P:termination of G-protein coupled receptor signaling pathway; IEA:InterPro.
984Q9WUT3    733   KS6A2_MOUSE Ribosomal protein S6 kinase alpha...3282e-16     87.8     25     44GO:0005737; C:cytoplasm; IDA:MGI.::GO:0005634; C:nucleus; ISS:UniProtKB.::GO:0005819; C:spindle; IDA:MGI.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:MGI.::GO:0004711; F:ribosomal protein S6 kinase activity; IDA:MGI.
GO:0002035; P:brain renin-angiotensin system; IDA:MGI.::GO:0010659; P:cardiac muscle cell apoptotic process; IDA:MGI.::GO:0071322; P:cellular response to carbohydrate stimulus; IDA:MGI.::GO:0060047; P:heart contraction; IDA:MGI.::GO:0007507; P:heart development; IDA:MGI.::GO:0007243; P:intracellular protein kinase cascade; IEA:InterPro.::GO:0000089; P:mitotic metaphase; IDA:MGI.::GO:0045786; P:negative regulation of cell cycle; ISS:UniProtKB.::GO:0008285; P:negative regulation of cell proliferation; ISS:UniProtKB.::GO:0001556; P:oocyte maturation; IDA:MGI.::GO:0018105; P:peptidyl-serine phosphorylation; IDA:MGI.::GO:0043065; P:positive regulation of apoptotic process; ISS:UniProtKB.::GO:0010628; P:positive regulation of gene expression; IDA:MGI.::GO:0070613; P:regulation of protein processing; IDA:MGI.
985P18654    740   KS6A3_MOUSE Ribosomal protein S6 kinase alpha...3302e-16     88.2     25     42GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0019901; F:protein kinase binding; IPI:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IDA:MGI.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0007243; P:intracellular protein kinase cascade; IEA:InterPro.::GO:0032496; P:response to lipopolysaccharide; IMP:UniProtKB.::GO:0006950; P:response to stress; IEA:UniProtKB-KW.::GO:0002224; P:toll-like receptor signaling pathway; IMP:UniProtKB.
986P51812    740   KS6A3_HUMAN Ribosomal protein S6 kinase alpha...3302e-16     88.2     25     42GO:0005829; C:cytosol; TAS:Reactome.::GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0043027; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process; IDA:UniProtKB.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; TAS:ProtInc.
GO:0007411; P:axon guidance; TAS:Reactome.::GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0007417; P:central nervous system development; TAS:ProtInc.::GO:0045087; P:innate immune response; TAS:Reactome.::GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; TAS:Reactome.::GO:0043066; P:negative regulation of apoptotic process; TAS:UniProtKB.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0045597; P:positive regulation of cell differentiation; TAS:UniProtKB.::GO:0030307; P:positive regulation of cell growth; TAS:UniProtKB.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:BHF-UCL.::GO:0043620; P:regulation of DNA-dependent transcription in response to stress; TAS:UniProtKB.::GO:0043555; P:regulation of translation in response to stress; TAS:UniProtKB.::GO:0032496; P:response to lipopolysaccharide; ISS:UniProtKB.::GO:0001501; P:skeletal system development; TAS:ProtInc.::GO:0051403; P:stress-activated MAPK cascade; TAS:Reactome.::GO:0007268; P:synaptic transmission; TAS:Reactome.::GO:0008063; P:Toll signaling pathway; TAS:Reactome.::GO:0034130; P:toll-like receptor 1 signaling pathway; TAS:Reactome.::GO:0034134; P:toll-like receptor 2 signaling pathway; TAS:Reactome.::GO:0034138; P:toll-like receptor 3 signaling pathway; TAS:Reactome.::GO:0034142; P:toll-like receptor 4 signaling pathway; TAS:Reactome.::GO:0035666; P:TRIF-dependent toll-like receptor signaling pathway; TAS:Reactome.
987Q21734    784   KS6A1_CAEEL Putative ribosomal protein S6 kin...3260.000000000000001     85.9     25     45
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0007243; P:intracellular protein kinase cascade; IEA:InterPro.
988Q15349    733   KS6A2_HUMAN Ribosomal protein S6 kinase alpha...3260.000000000000004     84     25     43GO:0005829; C:cytosol; TAS:Reactome.::GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; TAS:ProtInc.
GO:0007411; P:axon guidance; TAS:Reactome.::GO:0045087; P:innate immune response; TAS:Reactome.::GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; TAS:Reactome.::GO:0045786; P:negative regulation of cell cycle; IDA:UniProtKB.::GO:0008285; P:negative regulation of cell proliferation; IDA:UniProtKB.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0043065; P:positive regulation of apoptotic process; IDA:UniProtKB.::GO:0051403; P:stress-activated MAPK cascade; TAS:Reactome.::GO:0007268; P:synaptic transmission; TAS:Reactome.::GO:0008063; P:Toll signaling pathway; TAS:Reactome.::GO:0034130; P:toll-like receptor 1 signaling pathway; TAS:Reactome.::GO:0034134; P:toll-like receptor 2 signaling pathway; TAS:Reactome.::GO:0034138; P:toll-like receptor 3 signaling pathway; TAS:Reactome.::GO:0034142; P:toll-like receptor 4 signaling pathway; TAS:Reactome.::GO:0035666; P:TRIF-dependent toll-like receptor signaling pathway; TAS:Reactome.
989P18652    752   KS6AA_CHICK Ribosomal protein S6 kinase 2 alp...2760.00000000000002     82     27     43
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0007243; P:intracellular protein kinase cascade; IEA:InterPro.
990Q6PFQ0    740   KS6A6_DANRE Ribosomal protein S6 kinase alpha...3290.00000000000003     81.3     25     42
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0007243; P:intracellular protein kinase cascade; IEA:InterPro.
991Q9UK32    745   KS6A6_HUMAN Ribosomal protein S6 kinase alpha...3300.00000000000004     80.9     25     42GO:0005829; C:cytosol; TAS:Reactome.::GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0007411; P:axon guidance; TAS:Reactome.::GO:0007417; P:central nervous system development; TAS:ProtInc.::GO:0006978; P:DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; IMP:UniProtKB.::GO:0007243; P:intracellular protein kinase cascade; IEA:InterPro.::GO:0045992; P:negative regulation of embryonic development; ISS:UniProtKB.::GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; ISS:UniProtKB.::GO:2000381; P:negative regulation of mesoderm development; ISS:UniProtKB.::GO:0007268; P:synaptic transmission; TAS:Reactome.
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