Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YER125W
Length:
809
Number of sequences:
5887
Description:
YER125W RSP5 SGDID:S000000927, Chr V from 410189-412618, Genome Release 64-1-1, Verified ORF, "E3 ubiquitin ligase of the NEDD4 family; involved in regulating many cellular processes including MVB sorting, heat shock response, transcription, endocytosis, and ribosome stability; human homolog is involved in Liddle syndrome; mutant tolerates aneuploidy"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
91Q9LYZ7    1502   UPL4_ARATH E3 ubiquitin-protein ligase UPL4 O...4301e-21     105     25     43GO:0005622; C:intracellular; IEA:InterPro.
GO:0016881; F:acid-amino acid ligase activity; IEA:InterPro.::GO:0005488; F:binding; IEA:InterPro.
GO:0006464; P:protein modification process; IEA:InterPro.
92P33202    1483   UFD4_YEAST Ubiquitin fusion degradation prote...3142e-20     101     27     43GO:0005739; C:mitochondrion; IDA:SGD.
GO:0005515; F:protein binding; IPI:IntAct.::GO:0004842; F:ubiquitin-protein ligase activity; IBA:RefGenome.
GO:0006513; P:protein monoubiquitination; TAS:SGD.::GO:0000209; P:protein polyubiquitination; TAS:SGD.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome.
93Q9VR91    4912   HERC2_DROME Probable E3 ubiquitin-protein lig...2643e-20     100     27     48GO:0005622; C:intracellular; IEA:InterPro.
GO:0020037; F:heme binding; IEA:InterPro.::GO:0004842; F:ubiquitin-protein ligase activity; IBA:RefGenome.
GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome.
94Q8SSY6    1887   SPKUL_DICDI Bifunctional serine/threonine-pro...800.095     40     31     51GO:0005622; C:intracellular; IEA:InterPro.
GO:0016881; F:acid-amino acid ligase activity; IEA:InterPro.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
95Q5T447    861   HECD3_HUMAN E3 ubiquitin-protein ligase HECTD...3452e-18     94.4     24     44GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.
GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB.
GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; IDA:UniProtKB.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome.
96Q3U487    861   HECD3_MOUSE E3 ubiquitin-protein ligase HECTD...3451e-17     91.7     24     43GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0019905; F:syntaxin binding; IPI:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB.
GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; ISS:UniProtKB.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome.
97Q6WWW4    1888   UPL3_ARATH E3 ubiquitin-protein ligase UPL3 O...4231e-16     89     23     40GO:0005622; C:intracellular; IEA:InterPro.::GO:0005886; C:plasma membrane; IDA:TAIR.
GO:0016881; F:acid-amino acid ligase activity; IEA:InterPro.::GO:0005488; F:binding; IEA:InterPro.
GO:0042023; P:DNA endoreduplication; IMP:TAIR.::GO:0006464; P:protein modification process; IEA:InterPro.::GO:0010091; P:trichome branching; IMP:TAIR.
98P46938    488   YAP1_MOUSE Yorkie homolog OS=Mus musculus (Mo...720.019     42     36     50GO:0005737; C:cytoplasm; IDA:MGI.::GO:0005634; C:nucleus; IDA:MGI.
GO:0003682; F:chromatin binding; IDA:MGI.::GO:0070064; F:proline-rich region binding; IPI:MGI.::GO:0001076; F:RNA polymerase II transcription factor binding transcription factor activity; IPI:MGI.::GO:0003713; F:transcription coactivator activity; IDA:UniProtKB.::GO:0044212; F:transcription regulatory region DNA binding; ISS:UniProtKB.
GO:0071480; P:cellular response to gamma radiation; ISS:UniProtKB.::GO:0006975; P:DNA damage induced protein phosphorylation; ISS:UniProtKB.::GO:0030216; P:keratinocyte differentiation; IMP:MGI.::GO:0043066; P:negative regulation of apoptotic process; IGI:MGI.::GO:0030857; P:negative regulation of epithelial cell differentiation; IDA:MGI.::GO:0090263; P:positive regulation of canonical Wnt receptor signaling pathway; IDA:MGI.::GO:0008284; P:positive regulation of cell proliferation; IDA:MGI.::GO:0046622; P:positive regulation of organ growth; IDA:MGI.::GO:0010837; P:regulation of keratinocyte proliferation; IMP:MGI.::GO:0072091; P:regulation of stem cell proliferation; IDA:MGI.::GO:0035019; P:somatic stem cell maintenance; IDA:MGI.::GO:0001570; P:vasculogenesis; IMP:MGI.
99Q2EJA0    469   YAP1_RAT Yorkie homolog OS=Rattus norvegicus ...720.022     42     36     50GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0044212; F:transcription regulatory region DNA binding; ISS:UniProtKB.
GO:0071480; P:cellular response to gamma radiation; ISS:UniProtKB.::GO:0006975; P:DNA damage induced protein phosphorylation; ISS:UniProtKB.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
100P46937    504   YAP1_HUMAN Yorkie homolog OS=Homo sapiens (Hu...600.009     43.1     33     48GO:0005829; C:cytosol; TAS:Reactome.::GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0003713; F:transcription coactivator activity; IDA:UniProtKB.::GO:0003714; F:transcription corepressor activity; IDA:UniProtKB.::GO:0044212; F:transcription regulatory region DNA binding; IDA:UniProtKB.
GO:0008283; P:cell proliferation; IDA:UniProtKB.::GO:0071480; P:cellular response to gamma radiation; IDA:UniProtKB.::GO:0060242; P:contact inhibition; IDA:UniProtKB.::GO:0035329; P:hippo signaling cascade; TAS:UniProtKB.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006974; P:response to DNA damage stimulus; IDA:UniProtKB.::GO:0006367; P:transcription initiation from RNA polymerase II promoter; TAS:Reactome.
101Q9ULT8    2610   HECD1_HUMAN E3 ubiquitin-protein ligase HECTD...2003e-16     87.4     29     49GO:0005622; C:intracellular; IEA:InterPro.
GO:0046872; F:metal ion binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; IBA:RefGenome.
GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome.
102Q10435    1647   YDE1_SCHPO Probable ubiquitin fusion degradat...4684e-16     87     24     42GO:0005829; C:cytosol; IDA:PomBase.::GO:0005634; C:nucleus; IDA:PomBase.::GO:0043234; C:protein complex; NAS:PomBase.
GO:0005488; F:binding; IEA:InterPro.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:PomBase.
GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ISS:RefGenome.
103Q45VV3    418   YORKI_DROME Protein yorkie OS=Drosophila mela...390.26     38.1     36     54GO:0005737; C:cytoplasm; IDA:UniProtKB.::GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0003713; F:transcription coactivator activity; IMP:UniProtKB.::GO:0008134; F:transcription factor binding; IPI:FlyBase.
GO:0035212; P:cell competition in a multicellular organism; IMP:FlyBase.::GO:0035329; P:hippo signaling cascade; IMP:UniProtKB.::GO:0002011; P:morphogenesis of an epithelial sheet; IMP:FlyBase.::GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:FlyBase.::GO:0072089; P:stem cell proliferation; IDA:FlyBase.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
104Q69ZR2    2618   HECD1_MOUSE E3 ubiquitin-protein ligase HECTD...2070.000000000000006     83.2     29     48GO:0005622; C:intracellular; IEA:InterPro.
GO:0046872; F:metal ion binding; IEA:InterPro.::GO:0004842; F:ubiquitin-protein ligase activity; IEA:InterPro.
GO:0001843; P:neural tube closure; IMP:UniProtKB.
105Q9Y4D8    3996   K0614_HUMAN Probable E3 ubiquitin-protein lig...3550.000000000003     74.3     25     39GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005622; C:intracellular; IEA:InterPro.
GO:0004842; F:ubiquitin-protein ligase activity; IBA:RefGenome.
GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome.
106C6KTB7    10287   ALTH1_PLAF7 Putative E3 ubiquitin-protein lig...2820.000000000003     74.3     26     48GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005622; C:intracellular; IEA:InterPro.
GO:0016881; F:acid-amino acid ligase activity; IEA:InterPro.
GO:0006464; P:protein modification process; IEA:InterPro.
107Q4L1J4    1255   MAGI1_RAT Membrane-associated guanylate kinas...430.21     38.9     47     56GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005923; C:tight junction; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
108Q6RHR9    1471   MAGI1_MOUSE Membrane-associated guanylate kin...820.18     39.3     34     41GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0005923; C:tight junction; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:MGI.
109Q96QZ7    1491   MAGI1_HUMAN Membrane-associated guanylate kin...820.21     38.9     34     41GO:0042995; C:cell projection; IDA:UniProtKB.::GO:0005737; C:cytoplasm; IDA:UniProtKB.::GO:0005923; C:tight junction; IEA:UniProtKB-SubCell.
GO:0051393; F:alpha-actinin binding; IPI:UniProtKB.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008022; F:protein C-terminus binding; TAS:ProtInc.
GO:0007155; P:cell adhesion; TAS:ProtInc.::GO:0007166; P:cell surface receptor signaling pathway; TAS:ProtInc.::GO:0006461; P:protein complex assembly; NAS:ProtInc.
110Q8IX03    1113   KIBRA_HUMAN Protein KIBRA OS=Homo sapiens (Hu...300.02     42.4     53     63GO:0005829; C:cytosol; TAS:Reactome.::GO:0005794; C:Golgi apparatus; IDA:HPA.::GO:0005634; C:nucleus; IDA:UniProtKB.::GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.::GO:0032587; C:ruffle membrane; IDA:UniProtKB.
GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0003713; F:transcription coactivator activity; IDA:UniProtKB.
GO:0016477; P:cell migration; IDA:UniProtKB.::GO:0035329; P:hippo signaling cascade; TAS:Reactome.::GO:0043410; P:positive regulation of MAPK cascade; IDA:UniProtKB.::GO:0035330; P:regulation of hippo signaling cascade; IMP:UniProtKB.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
111Q5SXA9    1104   KIBRA_MOUSE Protein KIBRA OS=Mus musculus (Mo...300.025     42     53     63GO:0005634; C:nucleus; ISS:UniProtKB.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.::GO:0032587; C:ruffle membrane; ISS:UniProtKB.
GO:0016477; P:cell migration; ISS:UniProtKB.::GO:0043410; P:positive regulation of MAPK cascade; ISS:UniProtKB.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
112A4IIJ3    1108   KIBRA_XENTR Protein KIBRA OS=Xenopus tropical...391.8     35.8     44     56GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
113Q91WL8    414   WWOX_MOUSE WW domain-containing oxidoreductas...340.38     37.7     47     65GO:0005739; C:mitochondrion; IDA:MGI.::GO:0005634; C:nucleus; IDA:BHF-UCL.
GO:0019899; F:enzyme binding; IPI:BHF-UCL.::GO:0000166; F:nucleotide binding; IEA:InterPro.::GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0071560; P:cellular response to transforming growth factor beta stimulus; IDA:BHF-UCL.::GO:0006917; P:induction of apoptosis; IDA:MGI.::GO:0030178; P:negative regulation of Wnt receptor signaling pathway; ISS:UniProtKB.::GO:0001649; P:osteoblast differentiation; IMP:MGI.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.::GO:0048705; P:skeletal system morphogenesis; IMP:MGI.::GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW.
114Q5R9W5    414   WWOX_PONAB WW domain-containing oxidoreductas...340.81     36.6     47     65GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0000166; F:nucleotide binding; IEA:InterPro.::GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0030178; P:negative regulation of Wnt receptor signaling pathway; ISS:UniProtKB.::GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW.
115Q9NZC7    414   WWOX_HUMAN WW domain-containing oxidoreductas...340.45     37.4     47     65GO:0005829; C:cytosol; IDA:BHF-UCL.::GO:0005794; C:Golgi apparatus; IDA:UniProtKB.::GO:0005739; C:mitochondrion; ISS:BHF-UCL.::GO:0005634; C:nucleus; IDA:BHF-UCL.
GO:0050662; F:coenzyme binding; TAS:UniProtKB.::GO:0019899; F:enzyme binding; IPI:BHF-UCL.::GO:0000166; F:nucleotide binding; IEA:InterPro.::GO:0016491; F:oxidoreductase activity; NAS:UniProtKB.::GO:0046983; F:protein dimerization activity; TAS:UniProtKB.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0071560; P:cellular response to transforming growth factor beta stimulus; IDA:BHF-UCL.::GO:0006917; P:induction of apoptosis; ISS:BHF-UCL.::GO:0030178; P:negative regulation of Wnt receptor signaling pathway; IDA:UniProtKB.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:BHF-UCL.::GO:0048705; P:skeletal system morphogenesis; ISS:BHF-UCL.::GO:0008202; P:steroid metabolic process; TAS:UniProtKB.::GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW.
116Q5F389    414   WWOX_CHICK WW domain-containing oxidoreductas...340.13     39.3     50     65GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0000166; F:nucleotide binding; IEA:InterPro.::GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW.
117A1A5G4    1107   MAGI3_XENTR Membrane-associated guanylate kin...460.078     40.4     48     57GO:0005923; C:tight junction; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
118Q6AWC2    1192   WWC2_HUMAN Protein WWC2 OS=Homo sapiens (Huma...300.011     43.1     53     67
119Q6NXJ0    1187   WWC2_MOUSE Protein WWC2 OS=Mus musculus (Mous...300.014     42.7     53     67
120Q5F488    1128   MAGI3_CHICK Membrane-associated guanylate kin...450.28     38.5     47     58GO:0005923; C:tight junction; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
121Q9EQJ9    1476   MAGI3_MOUSE Membrane-associated guanylate kin...590.49     37.7     41     54GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0005923; C:tight junction; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005109; F:frizzled binding; IPI:MGI.
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