Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YER125W
Length:
809
Number of sequences:
5887
Description:
YER125W RSP5 SGDID:S000000927, Chr V from 410189-412618, Genome Release 64-1-1, Verified ORF, "E3 ubiquitin ligase of the NEDD4 family; involved in regulating many cellular processes including MVB sorting, heat shock response, transcription, endocytosis, and ribosome stability; human homolog is involved in Liddle syndrome; mutant tolerates aneuploidy"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
271O00445    386   SYT5_HUMAN Synaptotagmin-5 OS=Homo sapiens (H...1390.82     36.6     27     46GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0055038; C:recycling endosome membrane; IEA:UniProtKB-SubCell.::GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005215; F:transporter activity; IEA:InterPro.
GO:0006112; P:energy reserve metabolic process; TAS:Reactome.::GO:0050796; P:regulation of insulin secretion; TAS:Reactome.::GO:0044281; P:small molecule metabolic process; TAS:Reactome.::GO:0007268; P:synaptic transmission; TAS:ProtInc.
272Q4WTT2    966   SET2_ASPFU Histone-lysine N-methyltransferase...810.85     37     36     43GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:EC.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
273Q9UT00    1225   YKH3_SCHPO Uncharacterized protein PYUK71.03c...540.87     37     33     54GO:0051286; C:cell tip; IDA:PomBase.::GO:0030659; C:cytoplasmic vesicle membrane; NAS:PomBase.::GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0005794; C:Golgi apparatus; IDA:PomBase.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005509; F:calcium ion binding; NAS:PomBase.::GO:0008289; F:lipid binding; ISS:PomBase.
GO:0006906; P:vesicle fusion; NAS:PomBase.
274O95704    486   APBB3_HUMAN Amyloid beta A4 precursor protein...460.92     36.6     43     59GO:0015629; C:actin cytoskeleton; IDA:HPA.::GO:0005737; C:cytoplasm; IDA:HPA.
275Q86YQ8    564   CPNE8_HUMAN Copine-8 OS=Homo sapiens (Human)....961     36.6     29     40
276Q7TNF0    405   DOC2A_MOUSE Double C2-like domain-containing ...931     36.2     27     44GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.::GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.::GO:0019717; C:synaptosome; IEA:UniProtKB-SubCell.
GO:0005544; F:calcium-dependent phospholipid binding; IEA:UniProtKB-KW.::GO:0005215; F:transporter activity; IEA:InterPro.
GO:0017158; P:regulation of calcium ion-dependent exocytosis; IMP:UniProtKB.
277Q9R0N9    491   SYT9_MOUSE Synaptotagmin-9 OS=Mus musculus (M...1431.4     35.8     26     45GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0031045; C:dense core granule; IDA:MGI.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
GO:0042802; F:identical protein binding; IPI:IntAct.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005215; F:transporter activity; IEA:InterPro.
278Q925C0    491   SYT9_RAT Synaptotagmin-9 OS=Rattus norvegicus...1431.3     36.2     26     45GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0031045; C:dense core granule; IDA:RGD.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0030667; C:secretory granule membrane; IDA:RGD.::GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005215; F:transporter activity; IEA:InterPro.
GO:0017158; P:regulation of calcium ion-dependent exocytosis; IMP:RGD.::GO:0050796; P:regulation of insulin secretion; IMP:RGD.
279Q812E4    753   SYTL5_RAT Synaptotagmin-like protein 5 OS=Rat...741.1     36.6     31     50GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0017137; F:Rab GTPase binding; IEA:InterPro.
GO:0006886; P:intracellular protein transport; IEA:InterPro.
280P70611    403   DOC2A_RAT Double C2-like domain-containing pr...931.1     36.2     27     44GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005764; C:lysosome; IDA:UniProtKB.::GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.::GO:0019717; C:synaptosome; IEA:UniProtKB-SubCell.
GO:0005544; F:calcium-dependent phospholipid binding; IEA:UniProtKB-KW.::GO:0005215; F:transporter activity; IEA:InterPro.
GO:0016079; P:synaptic vesicle exocytosis; IEP:RGD.
281Q8LFN9    336   AGD13_ARATH Probable ADP-ribosylation factor ...761.1     36.2     29     43
GO:0008060; F:ARF GTPase activator activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0009555; P:pollen development; IMP:TAIR.::GO:0032312; P:regulation of ARF GTPase activity; IEA:InterPro.
282P41885    1106   RBF1_CAEEL Rabphilin-1 OS=Caenorhabditis eleg...891.2     36.6     33     47GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0016020; C:membrane; IEA:InterPro.::GO:0008021; C:synaptic vesicle; IDA:WormBase.
GO:0017137; F:Rab GTPase binding; IEA:InterPro.::GO:0005215; F:transporter activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006887; P:exocytosis; IEA:UniProtKB-KW.::GO:0006886; P:intracellular protein transport; IEA:InterPro.::GO:0040017; P:positive regulation of locomotion; IMP:WormBase.
283Q9Y6V0    5065   PCLO_HUMAN Protein piccolo OS=Homo sapiens (H...1011.2     36.6     31     48GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005856; C:cytoskeleton; NAS:UniProtKB.::GO:0016020; C:membrane; IEA:InterPro.::GO:0008021; C:synaptic vesicle; IEA:InterPro.
GO:0005509; F:calcium ion binding; ISS:UniProtKB.::GO:0005544; F:calcium-dependent phospholipid binding; ISS:UniProtKB.::GO:0005522; F:profilin binding; ISS:UniProtKB.::GO:0005215; F:transporter activity; IEA:InterPro.
GO:0007010; P:cytoskeleton organization; ISS:UniProtKB.::GO:0016079; P:synaptic vesicle exocytosis; NAS:UniProtKB.
284P49147    748   PA24A_CHICK Cytosolic phospholipase A2 OS=Gal...571.3     36.2     35     54GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell.
GO:0004622; F:lysophospholipase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004623; F:phospholipase A2 activity; IEA:EC.
GO:0009395; P:phospholipid catabolic process; IEA:InterPro.
285P11533    3660   DMD_CHICK Dystrophin OS=Gallus gallus (Chicke...1911.4     36.2     23     38GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0042383; C:sarcolemma; IEA:UniProtKB-SubCell.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
286P40748    588   SYT3_RAT Synaptotagmin-3 OS=Rattus norvegicus...1432.7     35     26     45GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
GO:0005509; F:calcium ion binding; TAS:RGD.::GO:0005544; F:calcium-dependent phospholipid binding; IDA:RGD.::GO:0030276; F:clathrin binding; IDA:BHF-UCL.::GO:0019905; F:syntaxin binding; IDA:RGD.::GO:0005215; F:transporter activity; IEA:InterPro.
GO:0017156; P:calcium ion-dependent exocytosis; TAS:RGD.::GO:0016079; P:synaptic vesicle exocytosis; TAS:RGD.
287Q9R0N5    386   SYT5_MOUSE Synaptotagmin-5 OS=Mus musculus (M...1391.5     35.8     27     47GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0031045; C:dense core granule; IDA:MGI.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0043005; C:neuron projection; IDA:MGI.::GO:0043025; C:neuronal cell body; IDA:MGI.::GO:0048471; C:perinuclear region of cytoplasm; IDA:MGI.::GO:0005886; C:plasma membrane; TAS:Reactome.::GO:0055038; C:recycling endosome membrane; IEA:UniProtKB-SubCell.::GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0046982; F:protein heterodimerization activity; IPI:UniProtKB.::GO:0005215; F:transporter activity; IEA:InterPro.
288Q5R8A5    749   PA24A_PONAB Cytosolic phospholipase A2 OS=Pon...571.5     36.2     37     53GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell.
GO:0005509; F:calcium ion binding; ISS:UniProtKB.::GO:0005544; F:calcium-dependent phospholipid binding; ISS:UniProtKB.::GO:0004622; F:lysophospholipase activity; IEA:EC.::GO:0004623; F:phospholipase A2 activity; IEA:EC.
GO:0009395; P:phospholipid catabolic process; IEA:InterPro.
289P47712    749   PA24A_HUMAN Cytosolic phospholipase A2 OS=Hom...571.5     36.2     37     53GO:0005829; C:cytosol; NAS:UniProtKB.::GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
GO:0005509; F:calcium ion binding; IDA:UniProtKB.::GO:0005544; F:calcium-dependent phospholipid binding; IDA:UniProtKB.::GO:0004622; F:lysophospholipase activity; IEA:EC.
GO:0009395; P:phospholipid catabolic process; IEA:InterPro.::GO:0006663; P:platelet activating factor biosynthetic process; NAS:UniProtKB.::GO:0030168; P:platelet activation; TAS:Reactome.
290Q14183    400   DOC2A_HUMAN Double C2-like domain-containing ...951.5     35.8     26     43GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.::GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.::GO:0019717; C:synaptosome; IEA:UniProtKB-SubCell.
GO:0005544; F:calcium-dependent phospholipid binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0005215; F:transporter activity; IEA:InterPro.
GO:0007399; P:nervous system development; TAS:ProtInc.::GO:0017158; P:regulation of calcium ion-dependent exocytosis; IMP:UniProtKB.
291O35681    587   SYT3_MOUSE Synaptotagmin-3 OS=Mus musculus (M...1432.3     35.4     27     45GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0046982; F:protein heterodimerization activity; IPI:UniProtKB.::GO:0042803; F:protein homodimerization activity; IDA:BHF-UCL.::GO:0005215; F:transporter activity; IEA:InterPro.
292Q9BQG1    590   SYT3_HUMAN Synaptotagmin-3 OS=Homo sapiens (H...1433     35     27     45GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005768; C:endosome; IDA:LIFEdb.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005215; F:transporter activity; IEA:InterPro.
293P50393    752   PA24A_RAT Cytosolic phospholipase A2 OS=Rattu...571.7     35.8     37     53GO:0005829; C:cytosol; IDA:RGD.::GO:0005624; C:membrane fraction; IDA:RGD.::GO:0005634; C:nucleus; IDA:RGD.::GO:0048471; C:perinuclear region of cytoplasm; IDA:RGD.::GO:0042588; C:zymogen granule; IDA:RGD.
GO:0005509; F:calcium ion binding; ISS:UniProtKB.::GO:0047498; F:calcium-dependent phospholipase A2 activity; IDA:RGD.::GO:0005544; F:calcium-dependent phospholipid binding; ISS:UniProtKB.::GO:0004622; F:lysophospholipase activity; IEA:EC.
GO:0007568; P:aging; IEP:RGD.::GO:0019369; P:arachidonic acid metabolic process; IMP:RGD.::GO:0046697; P:decidualization; IMP:RGD.::GO:0001554; P:luteolysis; IEP:RGD.::GO:0001542; P:ovulation from ovarian follicle; IMP:RGD.::GO:0009395; P:phospholipid catabolic process; IEA:InterPro.::GO:0043065; P:positive regulation of apoptotic process; IMP:RGD.::GO:0030501; P:positive regulation of bone mineralization; IEP:RGD.::GO:0008284; P:positive regulation of cell proliferation; IMP:RGD.::GO:0031622; P:positive regulation of fever generation; IEP:RGD.::GO:0031394; P:positive regulation of prostaglandin biosynthetic process; IMP:RGD.::GO:0031340; P:positive regulation of vesicle fusion; IMP:RGD.::GO:0051592; P:response to calcium ion; IMP:RGD.::GO:0051384; P:response to glucocorticoid stimulus; IEP:RGD.::GO:0009408; P:response to heat; IEP:RGD.::GO:0042542; P:response to hydrogen peroxide; IEP:RGD.::GO:0032496; P:response to lipopolysaccharide; IEP:RGD.::GO:0051597; P:response to methylmercury; IEP:RGD.::GO:0010243; P:response to organic nitrogen; IEP:RGD.::GO:0033280; P:response to vitamin D; IEP:RGD.::GO:0043129; P:surfactant homeostasis; IMP:RGD.
294P47713    748   PA24A_MOUSE Cytosolic phospholipase A2 OS=Mus...571.7     35.8     37     53GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0005783; C:endoplasmic reticulum; IDA:MGI.::GO:0005794; C:Golgi apparatus; IDA:MGI.
GO:0005509; F:calcium ion binding; ISS:UniProtKB.::GO:0005544; F:calcium-dependent phospholipid binding; ISS:UniProtKB.::GO:0004622; F:lysophospholipase activity; IEA:EC.
GO:0050482; P:arachidonic acid secretion; IDA:UniProtKB.::GO:0071236; P:cellular response to antibiotic; IDA:MGI.::GO:0046456; P:icosanoid biosynthetic process; IMP:MGI.::GO:0009395; P:phospholipid catabolic process; IEA:InterPro.
295P48018    422   SYT1_BOVIN Synaptotagmin-1 OS=Bos taurus (Bov...1401.8     35.8     27     44GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0042584; C:chromaffin granule membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0005215; F:transporter activity; IEA:InterPro.
296Q96C24    671   SYTL4_HUMAN Synaptotagmin-like protein 4 OS=H...591.8     35.8     34     56GO:0005813; C:centrosome; IDA:HPA.::GO:0005768; C:endosome; IDA:UniProtKB.::GO:0019898; C:extrinsic to membrane; ISS:UniProtKB.::GO:0005634; C:nucleus; IDA:HPA.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0008021; C:synaptic vesicle; IEA:InterPro.::GO:0030658; C:transport vesicle membrane; IEA:UniProtKB-SubCell.
GO:0042043; F:neurexin family protein binding; ISS:UniProtKB.::GO:0005543; F:phospholipid binding; ISS:UniProtKB.::GO:0017137; F:Rab GTPase binding; IEA:InterPro.::GO:0005215; F:transporter activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006886; P:intracellular protein transport; IEA:InterPro.::GO:0071985; P:multivesicular body sorting pathway; IMP:UniProtKB.::GO:0045921; P:positive regulation of exocytosis; IMP:UniProtKB.::GO:0050714; P:positive regulation of protein secretion; IMP:UniProtKB.
297Q8VHQ7    672   SYTL4_RAT Synaptotagmin-like protein 4 OS=Rat...591.8     35.8     34     56GO:0016324; C:apical plasma membrane; IDA:RGD.::GO:0019898; C:extrinsic to membrane; ISS:UniProtKB.::GO:0030667; C:secretory granule membrane; IDA:RGD.::GO:0030658; C:transport vesicle membrane; IEA:UniProtKB-SubCell.
GO:0042043; F:neurexin family protein binding; ISS:UniProtKB.::GO:0005543; F:phospholipid binding; ISS:UniProtKB.::GO:0017137; F:Rab GTPase binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006887; P:exocytosis; ISS:UniProtKB.::GO:0006886; P:intracellular protein transport; IEA:InterPro.
298P47191    424   SYT1_CHICK Synaptotagmin-1 OS=Gallus gallus (...1401.8     35.4     27     44GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0042584; C:chromaffin granule membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
GO:0005215; F:transporter activity; IEA:InterPro.
299Q60HC0    419   SYT1_MACFA Synaptotagmin-1 OS=Macaca fascicul...1401.9     35.4     27     44GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0042584; C:chromaffin granule membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005215; F:transporter activity; IEA:InterPro.
300P21579    422   SYT1_HUMAN Synaptotagmin-1 OS=Homo sapiens (H...1401.9     35.4     27     44GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0042584; C:chromaffin granule membrane; IEA:UniProtKB-SubCell.::GO:0060201; C:clathrin sculpted acetylcholine transport vesicle membrane; TAS:Reactome.::GO:0061202; C:clathrin sculpted gamma-aminobutyric acid transport vesicle membrane; TAS:Reactome.::GO:0060203; C:clathrin sculpted glutamate transport vesicle membrane; TAS:Reactome.::GO:0070083; C:clathrin sculpted monoamine transport vesicle membrane; TAS:Reactome.::GO:0030666; C:endocytic vesicle membrane; TAS:Reactome.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; TAS:Reactome.::GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
GO:0005545; F:1-phosphatidylinositol binding; TAS:UniProtKB.::GO:0050750; F:low-density lipoprotein particle receptor binding; IDA:MGI.::GO:0017075; F:syntaxin-1 binding; TAS:UniProtKB.::GO:0005215; F:transporter activity; IEA:InterPro.
GO:0005513; P:detection of calcium ion; TAS:UniProtKB.::GO:0014047; P:glutamate secretion; TAS:Reactome.::GO:0051260; P:protein homooligomerization; TAS:UniProtKB.
301Q7LZQ8    671   KPCB_XENLA Protein kinase C beta type OS=Xeno...971.9     35.8     26     53GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0050681; F:androgen receptor binding; ISS:UniProtKB.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003682; F:chromatin binding; ISS:UniProtKB.::GO:0042393; F:histone binding; ISS:UniProtKB.::GO:0035403; F:histone kinase activity (H3-T6 specific); ISS:UniProtKB.::GO:0030374; F:ligand-dependent nuclear receptor transcription coactivator activity; ISS:UniProtKB.::GO:0004697; F:protein kinase C activity; IEA:EC.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0042113; P:B cell activation; ISS:UniProtKB.::GO:0050853; P:B cell receptor signaling pathway; ISS:UniProtKB.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; ISS:UniProtKB.::GO:0006357; P:regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
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