Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YER125W
Length:
809
Number of sequences:
5887
Description:
YER125W RSP5 SGDID:S000000927, Chr V from 410189-412618, Genome Release 64-1-1, Verified ORF, "E3 ubiquitin ligase of the NEDD4 family; involved in regulating many cellular processes including MVB sorting, heat shock response, transcription, endocytosis, and ribosome stability; human homolog is involved in Liddle syndrome; mutant tolerates aneuploidy"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
151P46936    448   YAP1_CHICK Yorkie homolog OS=Gallus gallus (C...1380.011     42.7     30     43GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0044212; F:transcription regulatory region DNA binding; ISS:UniProtKB.
GO:0071480; P:cellular response to gamma radiation; ISS:UniProtKB.::GO:0006975; P:DNA damage induced protein phosphorylation; ISS:UniProtKB.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
152B6RSP1    1197   PKHA7_DANRE Pleckstrin homology domain-contai...411.7     36.2     39     54GO:0005813; C:centrosome; ISS:UniProtKB.::GO:0005915; C:zonula adherens; ISS:UniProtKB.
GO:0070097; F:delta-catenin binding; ISS:UniProtKB.::GO:0005543; F:phospholipid binding; IEA:InterPro.
GO:0090136; P:epithelial cell-cell adhesion; ISS:UniProtKB.::GO:0045218; P:zonula adherens maintenance; ISS:UniProtKB.
153Q62770    2204   UN13C_RAT Protein unc-13 homolog C OS=Rattus ...1380.00006     50.8     27     46GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IDA:RGD.::GO:0042734; C:presynaptic membrane; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0006887; P:exocytosis; IEA:UniProtKB-KW.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0046928; P:regulation of neurotransmitter secretion; TAS:RGD.
154Q8NB66    2214   UN13C_HUMAN Protein unc-13 homolog C OS=Homo ...1380.00006     50.8     27     46GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.::GO:0042734; C:presynaptic membrane; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0006887; P:exocytosis; IEA:UniProtKB-KW.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.
155B4HEJ6    1295   KIBRA_DROSE Protein kibra OS=Drosophila seche...340.75     37.4     38     65GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.::GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0035330; P:regulation of hippo signaling cascade; ISS:UniProtKB.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
156B4PSQ2    1288   KIBRA_DROYA Protein kibra OS=Drosophila yakub...340.81     37     38     65GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.::GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0035330; P:regulation of hippo signaling cascade; ISS:UniProtKB.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
157Q9Z1N9    1602   UN13B_MOUSE Protein unc-13 homolog B OS=Mus m...1430.00007     50.4     25     45GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.::GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0001566; F:non-kinase phorbol ester receptor activity; TAS:MGI.
GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0048172; P:regulation of short-term neuronal synaptic plasticity; IMP:MGI.::GO:0035249; P:synaptic transmission, glutamatergic; IMP:MGI.::GO:0016081; P:synaptic vesicle docking involved in exocytosis; IGI:MGI.::GO:0016082; P:synaptic vesicle priming; IMP:MGI.
158B3P3M8    1283   KIBRA_DROER Protein kibra OS=Drosophila erect...340.83     37     38     65GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.::GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0035330; P:regulation of hippo signaling cascade; ISS:UniProtKB.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
159Q9VFG8    1288   KIBRA_DROME Protein kibra OS=Drosophila melan...340.87     37     38     65GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.::GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005515; F:protein binding; IPI:UniProtKB.
GO:0001745; P:compound eye morphogenesis; IGI:FlyBase.::GO:0035330; P:regulation of hippo signaling cascade; IMP:UniProtKB.::GO:0006355; P:regulation of transcription, DNA-dependent; IDA:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
160Q8K0T7    2210   UN13C_MOUSE Protein unc-13 homolog C OS=Mus m...1380.00009     50.1     27     46GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.::GO:0042734; C:presynaptic membrane; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0001566; F:non-kinase phorbol ester receptor activity; TAS:MGI.
GO:0006887; P:exocytosis; IEA:UniProtKB-KW.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0007268; P:synaptic transmission; IMP:MGI.
161Q62769    1622   UN13B_RAT Protein unc-13 homolog B OS=Rattus ...1380.0001     49.7     25     45GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0006887; P:exocytosis; IEA:UniProtKB-KW.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.
162Q9ZVT9    1020   C2GR1_ARATH C2 and GRAM domain-containing pro...690.016     42.7     35     58GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
163Q8L7A4    385   AGD11_ARATH Probable ADP-ribosylation factor ...870.0003     47.8     33     47
GO:0008060; F:ARF GTPase activator activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0032312; P:regulation of ARF GTPase activity; IEA:InterPro.
164O14795    1591   UN13B_HUMAN Protein unc-13 homolog B OS=Homo ...1430.0003     48.5     24     45GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005794; C:Golgi apparatus; TAS:ProtInc.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004872; F:receptor activity; TAS:ProtInc.::GO:0004871; F:signal transducer activity; TAS:ProtInc.
GO:0007588; P:excretion; TAS:ProtInc.::GO:0006917; P:induction of apoptosis; TAS:ProtInc.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.
165Q9EPK5    395   WWTR1_MOUSE WW domain-containing transcriptio...302.4     35     43     63GO:0005737; C:cytoplasm; IDA:MGI.::GO:0005667; C:transcription factor complex; IDA:MGI.
GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.::GO:0003713; F:transcription coactivator activity; IDA:UniProtKB.::GO:0003714; F:transcription corepressor activity; IGI:MGI.
GO:0060271; P:cilium morphogenesis; IMP:MGI.::GO:0032835; P:glomerulus development; IMP:MGI.::GO:0045599; P:negative regulation of fat cell differentiation; IGI:MGI.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IGI:MGI.::GO:0001649; P:osteoblast differentiation; IMP:MGI.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
166P27715    2155   UNC13_CAEEL Phorbol ester/diacylglycerol-bind...1380.0006     47.4     24     43GO:0048786; C:presynaptic active zone; IDA:WormBase.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0007411; P:axon guidance; IMP:WormBase.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0040010; P:positive regulation of growth rate; IMP:WormBase.::GO:0046662; P:regulation of oviposition; IMP:WormBase.::GO:0043051; P:regulation of pharyngeal pumping; IMP:WormBase.
167Q6ZWJ1    553   STXB4_HUMAN Syntaxin-binding protein 4 OS=Hom...303.8     34.7     47     60GO:0005737; C:cytoplasm; IDA:HPA.::GO:0045111; C:intermediate filament cytoskeleton; IDA:HPA.::GO:0005634; C:nucleus; IDA:HPA.
GO:0005509; F:calcium ion binding; IEA:InterPro.
168Q13526    163   PIN1_HUMAN Peptidyl-prolyl cis-trans isomeras...326     33.1     41     59GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0030496; C:midbody; IDA:MGI.::GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
GO:0032794; F:GTPase activating protein binding; IPI:BHF-UCL.::GO:0031434; F:mitogen-activated protein kinase kinase binding; IPI:BHF-UCL.::GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IDA:BHF-UCL.::GO:0050815; F:phosphoserine binding; IDA:BHF-UCL.::GO:0050816; F:phosphothreonine binding; IDA:BHF-UCL.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0019221; P:cytokine-mediated signaling pathway; TAS:Reactome.::GO:0045087; P:innate immune response; TAS:Reactome.::GO:2000146; P:negative regulation of cell motility; IDA:BHF-UCL.::GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; IDA:BHF-UCL.::GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; IDA:BHF-UCL.::GO:0032480; P:negative regulation of type I interferon production; TAS:Reactome.::GO:0001934; P:positive regulation of protein phosphorylation; IGI:MGI.::GO:0032321; P:positive regulation of Rho GTPase activity; IMP:BHF-UCL.::GO:0051443; P:positive regulation of ubiquitin-protein ligase activity; IDA:BHF-UCL.::GO:0006457; P:protein folding; IEA:UniProtKB-KW.::GO:0032465; P:regulation of cytokinesis; IMP:MGI.::GO:0007088; P:regulation of mitosis; TAS:ProtInc.::GO:0060393; P:regulation of pathway-restricted SMAD protein phosphorylation; IDA:BHF-UCL.
169Q0JHU5    159   ERG1_ORYSJ Elicitor-responsive protein 1 OS=O...990.002     42.7     31     46GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005544; F:calcium-dependent phospholipid binding; IEA:UniProtKB-KW.
170A2WWV5    159   ERG1_ORYSI Elicitor-responsive protein 1 OS=O...990.002     42.7     31     46GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005544; F:calcium-dependent phospholipid binding; IEA:UniProtKB-KW.
171P21521    474   SY65_DROME Synaptotagmin 1 OS=Drosophila mela...1430.003     44.7     29     49GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0030285; C:integral to synaptic vesicle membrane; NAS:FlyBase.::GO:0031594; C:neuromuscular junction; IDA:FlyBase.
GO:0005544; F:calcium-dependent phospholipid binding; TAS:FlyBase.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0005215; F:transporter activity; IEA:InterPro.
GO:0048791; P:calcium ion-dependent exocytosis of neurotransmitter; IMP:FlyBase.::GO:0008345; P:larval locomotory behavior; IMP:FlyBase.::GO:0007317; P:regulation of pole plasm oskar mRNA localization; IMP:FlyBase.::GO:0050803; P:regulation of synapse structure and activity; IMP:FlyBase.::GO:0048488; P:synaptic vesicle endocytosis; IDA:FlyBase.
172Q5BIN5    163   PIN1_BOVIN Peptidyl-prolyl cis-trans isomeras...326.4     32.7     41     59GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IEA:UniProtKB-KW.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0006457; P:protein folding; IEA:UniProtKB-KW.::GO:0042127; P:regulation of cell proliferation; ISS:AgBase.
173Q5RJH2    878   MCTP2_MOUSE Multiple C2 and transmembrane dom...850.003     44.7     34     48GO:0016021; C:integral to membrane; ISS:HGNC.::GO:0005624; C:membrane fraction; ISS:HGNC.
GO:0005509; F:calcium ion binding; ISS:HGNC.
174Q6DN12    878   MCTP2_HUMAN Multiple C2 and transmembrane dom...850.004     44.7     34     48GO:0016021; C:integral to membrane; IDA:HGNC.::GO:0005624; C:membrane fraction; IDA:HGNC.
GO:0005509; F:calcium ion binding; IDA:HGNC.
GO:0019722; P:calcium-mediated signaling; NAS:HGNC.
175Q9WV89    557   STXB4_MOUSE Syntaxin-binding protein 4 OS=Mus...304.4     34.3     47     60GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:MGI.
GO:0015758; P:glucose transport; IDA:MGI.::GO:0008286; P:insulin receptor signaling pathway; IDA:MGI.::GO:0006605; P:protein targeting; IDA:MGI.
176Q9Z0R4    1714   ITSN1_MOUSE Intersectin-1 OS=Mus musculus (Mo...720.006     43.9     36     54GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0030139; C:endocytic vesicle; IDA:MGI.::GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.::GO:0030027; C:lamellipodium; IDA:MGI.::GO:0016020; C:membrane; IEA:UniProtKB-KW.::GO:0045202; C:synapse; IEA:UniProtKB-KW.::GO:0019717; C:synaptosome; IEA:UniProtKB-SubCell.
GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0019209; F:kinase activator activity; IDA:MGI.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0043524; P:negative regulation of neuron apoptotic process; IMP:MGI.::GO:0051897; P:positive regulation of protein kinase B signaling cascade; IDA:MGI.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IDA:MGI.
177Q9QUR7    165   PIN1_MOUSE Peptidyl-prolyl cis-trans isomeras...326.7     32.7     41     59GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IEA:UniProtKB-KW.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0006457; P:protein folding; IEA:UniProtKB-KW.::GO:0042127; P:regulation of cell proliferation; IMP:MGI.::GO:0032465; P:regulation of cytokinesis; IMP:MGI.
178P41823    428   SY65_APLCA Synaptotagmin-1 OS=Aplysia califor...1410.007     43.5     30     48GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0030285; C:integral to synaptic vesicle membrane; IDA:UniProtKB.
GO:0005509; F:calcium ion binding; IDA:UniProtKB.::GO:0000149; F:SNARE binding; IDA:UniProtKB.::GO:0005215; F:transporter activity; IEA:InterPro.
GO:0045955; P:negative regulation of calcium ion-dependent exocytosis; IDA:UniProtKB.::GO:0016079; P:synaptic vesicle exocytosis; IDA:UniProtKB.
179Q15811    1721   ITSN1_HUMAN Intersectin-1 OS=Homo sapiens (Hu...720.007     43.9     36     54GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005905; C:coated pit; IDA:UniProtKB.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IDA:UniProtKB.::GO:0045202; C:synapse; IEA:UniProtKB-KW.::GO:0019717; C:synaptosome; IEA:UniProtKB-SubCell.
GO:0005509; F:calcium ion binding; NAS:UniProtKB.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0070064; F:proline-rich region binding; IPI:UniProtKB.::GO:0032947; F:protein complex scaffold; IDA:UniProtKB.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.::GO:0048488; P:synaptic vesicle endocytosis; TAS:ProtInc.
180Q9HAU0    1116   PKHA5_HUMAN Pleckstrin homology domain-contai...349     33.5     44     50
GO:0005545; F:1-phosphatidylinositol binding; NAS:UniProtKB.::GO:0005515; F:protein binding; IPI:IntAct.
181Q6PFQ7    802   RASL2_MOUSE Ras GTPase-activating protein 4 O...900.011     43.1     32     51GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005099; F:Ras GTPase activator activity; IBA:RefGenome.
GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0046580; P:negative regulation of Ras protein signal transduction; IBA:RefGenome.
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