rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
91 | Q9JHL4 | 436 | DBNL_RAT Drebrin-like protein OS=Rattus norve... | 57 | 0.0004 | 45.8 | 44 | 63 | GO:0005938; C:cell cortex; ISS:UniProtKB.::GO:0030027; C:lamellipodium; ISS:UniProtKB.::GO:0014069; C:postsynaptic density; IDA:RGD. | | | | | | | | | | | | | | | | | | | | GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0016601; P:Rac protein signal transduction; ISS:UniProtKB. | 92 | P00527 | 528 | YES_AVISY Tyrosine-protein kinase transformin... | 59 | 0.0004 | 45.8 | 47 | 63 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC. | | | | | | | | | | | 93 | A8XI74 | 277 | CED2_CAEBR Cell death abnormality protein 2 O... | 43 | 0.0005 | 45.1 | 47 | 67 | | | | | | | | | | | GO:0032403; F:protein complex binding; ISS:UniProtKB. | | | | | | | | | | GO:0031532; P:actin cytoskeleton reorganization; ISS:UniProtKB.::GO:0006915; P:apoptotic process; ISS:UniProtKB.::GO:0016477; P:cell migration; ISS:UniProtKB.::GO:0043652; P:engulfment of apoptotic cell; ISS:UniProtKB.::GO:0007165; P:signal transduction; ISS:UniProtKB. | 94 | P07948 | 512 | LYN_HUMAN Tyrosine-protein kinase Lyn OS=Homo... | 51 | 0.0005 | 45.4 | 45 | 63 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005794; C:Golgi apparatus; IDA:UniProtKB.::GO:0045121; C:membrane raft; IDA:UniProtKB.::GO:0005634; C:nucleus; IDA:UniProtKB.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0044325; F:ion channel binding; IPI:BHF-UCL.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; TAS:Reactome.::GO:0004716; F:receptor signaling protein tyrosine kinase activity; TAS:ProtInc. | | | | | | | | | | GO:0001782; P:B cell homeostasis; ISS:UniProtKB.::GO:0071300; P:cellular response to retinoic acid; IMP:BHF-UCL.::GO:0097028; P:dendritic cell differentiation; ISS:UniProtKB.::GO:0030218; P:erythrocyte differentiation; ISS:UniProtKB.::GO:0002774; P:Fc receptor mediated inhibitory signaling pathway; ISS:UniProtKB.::GO:0002431; P:Fc receptor mediated stimulatory signaling pathway; ISS:UniProtKB.::GO:0045087; P:innate immune response; IEA:UniProtKB-KW.::GO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW.::GO:0060397; P:JAK-STAT cascade involved in growth hormone signaling pathway; TAS:Reactome.::GO:0050900; P:leukocyte migration; TAS:Reactome.::GO:0031663; P:lipopolysaccharide-mediated signaling pathway; ISS:UniProtKB.::GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; ISS:UniProtKB.::GO:0050777; P:negative regulation of immune response; TAS:UniProtKB.::GO:0043407; P:negative regulation of MAP kinase activity; ISS:UniProtKB.::GO:0070667; P:negative regulation of mast cell proliferation; ISS:UniProtKB.::GO:0001933; P:negative regulation of protein phosphorylation; ISS:UniProtKB.::GO:0034136; P:negative regulation of toll-like receptor 2 signaling pathway; ISS:UniProtKB.::GO:0034144; P:negative regulation of toll-like receptor 4 signaling pathway; ISS:UniProtKB.::GO:0018108; P:peptidyl-tyrosine phosphorylation; IDA:UniProtKB.::GO:0030168; P:platelet activation; TAS:Reactome.::GO:0002576; P:platelet degranulation; ISS:UniProtKB.::GO:2000670; P:positive regulation of dendritic cell apoptotic process; ISS:UniProtKB.::GO:0070668; P:positive regulation of mast cell proliferation; IMP:UniProtKB.::GO:0010976; P:positive regulation of neuron projection development; IMP:BHF-UCL.::GO:0070304; P:positive regulation of stress-activated protein kinase signaling cascade; IDA:UniProtKB.::GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; ISS:UniProtKB.::GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.::GO:0050855; P:regulation of B cell receptor signaling pathway; ISS:UniProtKB.::GO:0033628; P:regulation of cell adhesion mediated by integrin; IMP:UniProtKB.::GO:0045646; P:regulation of erythrocyte differentiation; ISS:UniProtKB.::GO:0043304; P:regulation of mast cell degranulation; ISS:UniProtKB.::GO:0090025; P:regulation of monocyte chemotaxis; IMP:UniProtKB.::GO:0090330; P:regulation of platelet aggregation; ISS:UniProtKB.::GO:0006974; P:response to DNA damage stimulus; IDA:UniProtKB.::GO:0031295; P:T cell costimulation; TAS:Reactome.::GO:0002513; P:tolerance induction to self antigen; ISS:UniProtKB. | 95 | O42287 | 1270 | ITSN1_XENLA Intersectin-1 OS=Xenopus laevis (... | 63 | 0.65 | 35.8 | 35 | 52 | GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-KW.::GO:0045202; C:synapse; IEA:UniProtKB-KW.::GO:0019717; C:synaptosome; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro. | | | | | | | | | | GO:0006897; P:endocytosis; IEA:UniProtKB-KW. | 96 | Q9UJU6 | 430 | DBNL_HUMAN Drebrin-like protein OS=Homo sapie... | 57 | 0.0005 | 45.4 | 44 | 63 | GO:0005938; C:cell cortex; ISS:UniProtKB.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0030027; C:lamellipodium; ISS:UniProtKB. | | | | | | | | | | GO:0003779; F:actin binding; ISS:UniProtKB.::GO:0008047; F:enzyme activator activity; TAS:ProtInc. | | | | | | | | | | GO:0007257; P:activation of JUN kinase activity; TAS:ProtInc.::GO:0006921; P:cellular component disassembly involved in apoptotic process; TAS:Reactome.::GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0016601; P:Rac protein signal transduction; ISS:UniProtKB. | 97 | Q91WL0 | 600 | ES8L3_MOUSE Epidermal growth factor receptor ... | 65 | 0.0007 | 45.1 | 40 | 55 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | | | | | | | | | | | | 98 | Q7ZXQ9 | 447 | DBNLA_XENLA Drebrin-like protein A OS=Xenopus... | 80 | 0.0007 | 45.1 | 33 | 55 | GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0003779; F:actin binding; IEA:UniProtKB-KW. | | | | | | | | | | | 99 | E9Q634 | 1107 | MYO1E_MOUSE Unconventional myosin-Ie OS=Mus m... | 54 | 0.0007 | 45.4 | 43 | 57 | GO:0005912; C:adherens junction; IDA:UniProtKB.::GO:0005911; C:cell-cell junction; IDA:UniProtKB.::GO:0030136; C:clathrin-coated vesicle; IEA:UniProtKB-SubCell.::GO:0016459; C:myosin complex; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051015; F:actin filament binding; ISS:UniProtKB.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0042623; F:ATPase activity, coupled; ISS:UniProtKB.::GO:0005516; F:calmodulin binding; ISS:UniProtKB.::GO:0003774; F:motor activity; IEA:InterPro.::GO:0035091; F:phosphatidylinositol binding; ISS:UniProtKB. | | | | | | | | | | GO:0006897; P:endocytosis; ISS:UniProtKB.::GO:0032836; P:glomerular basement membrane development; IMP:UniProtKB.::GO:0003094; P:glomerular filtration; IMP:UniProtKB.::GO:0072015; P:glomerular visceral epithelial cell development; IMP:UniProtKB.::GO:0001701; P:in utero embryonic development; IMP:MGI.::GO:0048008; P:platelet-derived growth factor receptor signaling pathway; IMP:MGI.::GO:0035166; P:post-embryonic hemopoiesis; IMP:MGI.::GO:0001570; P:vasculogenesis; IMP:MGI. | 100 | Q12929 | 822 | EPS8_HUMAN Epidermal growth factor receptor k... | 59 | 0.0008 | 45.1 | 34 | 66 | | | | | | | | | | | GO:0005070; F:SH3/SH2 adaptor activity; TAS:ProtInc. | | | | | | | | | | GO:0008283; P:cell proliferation; TAS:ProtInc.::GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:ProtInc. | 101 | Q5R4H4 | 822 | EPS8_PONAB Epidermal growth factor receptor k... | 59 | 0.0009 | 45.1 | 34 | 66 | | | | | | | | | | | | | | | | | | | | | | 102 | P27447 | 544 | YES_XIPHE Tyrosine-protein kinase Yes OS=Xiph... | 56 | 0.001 | 44.7 | 46 | 63 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC. | | | | | | | | | | | 103 | P10936 | 537 | YES_XENLA Tyrosine-protein kinase Yes OS=Xeno... | 56 | 0.001 | 44.3 | 46 | 64 | GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC. | | | | | | | | | | | 104 | Q9NHC3 | 279 | CED2_CAEEL Cell death abnormality protein 2 O... | 40 | 0.001 | 43.9 | 48 | 70 | GO:0005886; C:plasma membrane; NAS:WormBase. | | | | | | | | | | GO:0032403; F:protein complex binding; IPI:UniProtKB. | | | | | | | | | | GO:0031532; P:actin cytoskeleton reorganization; IMP:UniProtKB.::GO:0006915; P:apoptotic process; IMP:UniProtKB.::GO:0016477; P:cell migration; IMP:UniProtKB.::GO:0043652; P:engulfment of apoptotic cell; IMP:UniProtKB.::GO:0007165; P:signal transduction; IMP:UniProtKB. | 105 | Q9Z0R4 | 1714 | ITSN1_MOUSE Intersectin-1 OS=Mus musculus (Mo... | 54 | 0.013 | 41.2 | 31 | 65 | GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0030139; C:endocytic vesicle; IDA:MGI.::GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.::GO:0030027; C:lamellipodium; IDA:MGI.::GO:0016020; C:membrane; IEA:UniProtKB-KW.::GO:0045202; C:synapse; IEA:UniProtKB-KW.::GO:0019717; C:synaptosome; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0019209; F:kinase activator activity; IDA:MGI.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0043524; P:negative regulation of neuron apoptotic process; IMP:MGI.::GO:0051897; P:positive regulation of protein kinase B signaling cascade; IDA:MGI.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IDA:MGI. | 106 | A6H7G2 | 423 | DBNL_BOVIN Drebrin-like protein OS=Bos taurus... | 57 | 0.001 | 43.9 | 42 | 63 | GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell. | | | | | | | | | | | | | | | | | | | | GO:0006897; P:endocytosis; IEA:UniProtKB-KW. | 107 | Q08509 | 821 | EPS8_MOUSE Epidermal growth factor receptor k... | 60 | 0.002 | 44.3 | 32 | 62 | GO:0017146; C:N-methyl-D-aspartate selective glutamate receptor complex; IDA:MGI.::GO:0014069; C:postsynaptic density; IDA:MGI.::GO:0019717; C:synaptosome; IDA:MGI. | | | | | | | | | | GO:0005515; F:protein binding; IPI:UniProtKB. | | | | | | | | | | GO:0031532; P:actin cytoskeleton reorganization; IMP:MGI.::GO:0051017; P:actin filament bundle assembly; IGI:MGI.::GO:0008344; P:adult locomotory behavior; IMP:MGI.::GO:0048149; P:behavioral response to ethanol; IMP:MGI. | 108 | P13115 | 532 | SRC1_XENLA Tyrosine-protein kinase Src-1 OS=X... | 52 | 0.002 | 43.9 | 48 | 71 | GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC. | | | | | | | | | | | 109 | Q9WVE9 | 1217 | ITSN1_RAT Intersectin-1 OS=Rattus norvegicus ... | 55 | 0.035 | 40 | 36 | 62 | GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.::GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-KW.::GO:0045202; C:synapse; IEA:UniProtKB-KW.::GO:0019717; C:synaptosome; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro. | | | | | | | | | | GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0006887; P:exocytosis; TAS:RGD. | 110 | Q557J6 | 481 | DBNL_DICDI Drebrin-like protein OS=Dictyostel... | 65 | 0.002 | 43.9 | 37 | 60 | GO:0031252; C:cell leading edge; IDA:dictyBase.::GO:0030864; C:cortical actin cytoskeleton; IDA:dictyBase.::GO:0005615; C:extracellular space; IDA:dictyBase.::GO:0097203; C:phagocytic cup lip; IDA:dictyBase.::GO:0045335; C:phagocytic vesicle; IDA:dictyBase.::GO:0031143; C:pseudopodium; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0003779; F:actin binding; ISS:dictyBase.::GO:0032037; F:myosin I heavy chain binding; IPI:dictyBase.::GO:0005522; F:profilin binding; IPI:dictyBase.::GO:0019901; F:protein kinase binding; IPI:dictyBase. | | | | | | | | | | GO:0006928; P:cellular component movement; IMP:dictyBase.::GO:0050765; P:negative regulation of phagocytosis; IMP:dictyBase.::GO:0031269; P:pseudopodium assembly; IMP:dictyBase. | 111 | P46109 | 303 | CRKL_HUMAN Crk-like protein OS=Homo sapiens (... | 75 | 0.002 | 43.1 | 33 | 51 | GO:0005829; C:cytosol; TAS:Reactome. | | | | | | | | | | GO:0005070; F:SH3/SH2 adaptor activity; TAS:ProtInc.::GO:0004871; F:signal transducer activity; TAS:ProtInc. | | | | | | | | | | GO:0007254; P:JNK cascade; TAS:ProtInc.::GO:0007265; P:Ras protein signal transduction; TAS:ProtInc. | 112 | O75886 | 525 | STAM2_HUMAN Signal transducing adapter molecu... | 105 | 0.002 | 43.9 | 29 | 50 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IDA:HPA. | | | | | | | | | | GO:0005515; F:protein binding; IPI:IntAct. | | | | | | | | | | GO:0016044; P:cellular membrane organization; TAS:Reactome.::GO:0016197; P:endosome transport; TAS:Reactome.::GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome.::GO:0006886; P:intracellular protein transport; IEA:InterPro.::GO:0042059; P:negative regulation of epidermal growth factor receptor signaling pathway; TAS:Reactome. | 113 | Q6TGW5 | 214 | OSTF1_DANRE Osteoclast-stimulating factor 1 O... | 67 | 0.002 | 42.7 | 42 | 57 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | | | | | | | | | | | | 114 | P13116 | 532 | SRC2_XENLA Tyrosine-protein kinase Src-2 OS=X... | 52 | 0.002 | 43.5 | 48 | 69 | GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC. | | | | | | | | | | | 115 | P27446 | 537 | FYN_XIPHE Tyrosine-protein kinase Fyn OS=Xiph... | 88 | 0.002 | 43.5 | 39 | 51 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC. | | | | | | | | | | GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW. | 116 | Q04736 | 541 | YES_MOUSE Tyrosine-protein kinase Yes OS=Mus ... | 52 | 0.002 | 43.5 | 46 | 69 | GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC. | | | | | | | | | | GO:0015758; P:glucose transport; IDA:MGI. | 117 | P08630 | 786 | BTKL_DROME Tyrosine-protein kinase Btk29A OS=... | 61 | 0.002 | 43.5 | 38 | 57 | GO:0005737; C:cytoplasm; IDA:FlyBase.::GO:0045172; C:germline ring canal; IDA:UniProtKB.::GO:0005886; C:plasma membrane; IDA:FlyBase. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.::GO:0005543; F:phospholipid binding; IEA:InterPro. | | | | | | | | | | GO:0030036; P:actin cytoskeleton organization; IMP:FlyBase.::GO:0007349; P:cellularization; IMP:FlyBase.::GO:0007619; P:courtship behavior; NAS:FlyBase.::GO:0008340; P:determination of adult lifespan; IMP:UniProtKB.::GO:0042023; P:DNA endoreduplication; IMP:FlyBase.::GO:0007391; P:dorsal closure; TAS:FlyBase.::GO:0007301; P:female germline ring canal formation; IDA:UniProtKB.::GO:0008258; P:head involution; IMP:FlyBase.::GO:0007485; P:imaginal disc-derived male genitalia development; IMP:UniProtKB.::GO:0007254; P:JNK cascade; TAS:FlyBase.::GO:0030717; P:karyosome formation; IMP:FlyBase.::GO:0007424; P:open tracheal system development; IMP:FlyBase.::GO:0030723; P:ovarian fusome organization; IMP:FlyBase.::GO:0030833; P:regulation of actin filament polymerization; IMP:FlyBase.::GO:0007435; P:salivary gland morphogenesis; IMP:FlyBase.::GO:0046960; P:sensitization; IMP:FlyBase. | 118 | Q6XJU9 | 214 | OSTF1_MONAL Osteoclast-stimulating factor 1 O... | 67 | 0.002 | 42.4 | 42 | 57 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | | | | | | | | | | | | 119 | O00160 | 1098 | MYO1F_HUMAN Unconventional myosin-If OS=Homo ... | 58 | 0.002 | 43.5 | 41 | 60 | GO:0016461; C:unconventional myosin complex; NAS:UniProtKB. | | | | | | | | | | GO:0003779; F:actin binding; NAS:UniProtKB.::GO:0005524; F:ATP binding; NAS:UniProtKB.::GO:0005516; F:calmodulin binding; NAS:UniProtKB.::GO:0003774; F:motor activity; IEA:InterPro. | | | | | | | | | | | 120 | Q9VU84 | 531 | DBNL_DROME Drebrin-like protein OS=Drosophila... | 75 | 0.003 | 43.1 | 31 | 57 | GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0005856; C:cytoskeleton; IDA:UniProtKB. | | | | | | | | | | GO:0003779; F:actin binding; IC:UniProtKB. | | | | | | | | | | | 121 | P70248 | 1099 | MYO1F_MOUSE Unconventional myosin-If OS=Mus m... | 58 | 0.003 | 43.5 | 41 | 60 | GO:0016459; C:myosin complex; IEA:UniProtKB-KW. | | | | | | | | | | GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0003774; F:motor activity; IEA:InterPro. | | | | | | | | | | |