Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YER118C
Length:
367
Number of sequences:
5887
Description:
YER118C SHO1 SGDID:S000000920, Chr V from 399055-397952, Genome Release 64-1-1, reverse complement, Verified ORF, "Transmembrane osmosensor involved in activation of the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol response pathway; phosphorylated by Hog1p; interacts with Pbs2p, Msb2p, Hkr1p, and Ste11p"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
181P62994    217   GRB2_RAT Growth factor receptor-bound protein...530.72     35     34     57GO:0005829; C:cytosol; TAS:Reactome.::GO:0005768; C:endosome; ISS:UniProtKB.::GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; ISS:UniProtKB.::GO:0043234; C:protein complex; IDA:RGD.
GO:0005154; F:epidermal growth factor receptor binding; ISS:UniProtKB.::GO:0043560; F:insulin receptor substrate binding; IPI:RGD.::GO:0001784; F:phosphotyrosine binding; IPI:RGD.::GO:0019904; F:protein domain specific binding; IPI:RGD.
GO:0007568; P:aging; IPI:RGD.::GO:0051291; P:protein heterooligomerization; IDA:RGD.::GO:0007265; P:Ras protein signal transduction; TAS:RGD.
182Q5R4J7    217   GRB2_PONAB Growth factor receptor-bound prote...530.72     35     34     57GO:0005768; C:endosome; ISS:UniProtKB.::GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; ISS:UniProtKB.
183P62993    217   GRB2_HUMAN Growth factor receptor-bound prote...530.72     35     34     57GO:0005829; C:cytosol; TAS:HGNC.::GO:0005768; C:endosome; IDA:UniProtKB.::GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0070436; C:Grb2-EGFR complex; IDA:BHF-UCL.::GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0046875; F:ephrin receptor binding; IPI:UniProtKB.::GO:0005154; F:epidermal growth factor receptor binding; IPI:UniProtKB.::GO:0043560; F:insulin receptor substrate binding; IPI:UniProtKB.::GO:0005168; F:neurotrophin TRKA receptor binding; IPI:UniProtKB.::GO:0019901; F:protein kinase binding; IPI:BHF-UCL.::GO:0005070; F:SH3/SH2 adaptor activity; TAS:UniProtKB.
GO:0007411; P:axon guidance; TAS:Reactome.::GO:0007267; P:cell-cell signaling; TAS:UniProtKB.::GO:0071479; P:cellular response to ionizing radiation; IMP:BHF-UCL.::GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:UniProtKB.::GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:Reactome.::GO:0008286; P:insulin receptor signaling pathway; IPI:UniProtKB.::GO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW.::GO:0050900; P:leukocyte migration; TAS:Reactome.::GO:0042059; P:negative regulation of epidermal growth factor receptor signaling pathway; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0030168; P:platelet activation; TAS:Reactome.::GO:2000379; P:positive regulation of reactive oxygen species metabolic process; IMP:BHF-UCL.::GO:0007265; P:Ras protein signal transduction; TAS:UniProtKB.::GO:0031623; P:receptor internalization; IMP:BHF-UCL.::GO:0042770; P:signal transduction in response to DNA damage; IMP:BHF-UCL.::GO:0031295; P:T cell costimulation; TAS:Reactome.
184P00526    526   SRC_RSVP Tyrosine-protein kinase transforming...520.037     39.7     46     65
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.
185P25020    526   SRC_RSVH1 Tyrosine-protein kinase transformin...520.037     39.7     46     65
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.
186Q4P5J4    593   HSE1_USTMA Class E vacuolar protein-sorting m...970.038     39.7     27     48GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
GO:0006886; P:intracellular protein transport; IEA:InterPro.
187Q63768    304   CRK_RAT Adapter molecule crk OS=Rattus norveg...540.038     39.3     31     67GO:0005829; C:cytosol; TAS:Reactome.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0007257; P:activation of JUN kinase activity; TAS:RGD.::GO:0048013; P:ephrin receptor signaling pathway; ISS:UniProtKB.::GO:0032956; P:regulation of actin cytoskeleton organization; ISS:UniProtKB.::GO:0051270; P:regulation of cellular component movement; TAS:RGD.::GO:0035020; P:regulation of Rac protein signal transduction; IMP:RGD.::GO:0032319; P:regulation of Rho GTPase activity; ISS:UniProtKB.
188Q9QZM5    476   ABI1_RAT Abl interactor 1 OS=Rattus norvegicu...600.039     39.7     38     52GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0030175; C:filopodium; IEA:UniProtKB-SubCell.::GO:0030426; C:growth cone; IEA:UniProtKB-SubCell.::GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0045202; C:synapse; IEA:UniProtKB-KW.::GO:0019717; C:synaptosome; IEA:UniProtKB-SubCell.
189P46108    304   CRK_HUMAN Adapter molecule crk OS=Homo sapien...540.039     39.3     31     67GO:0005829; C:cytosol; TAS:Reactome.::GO:0005768; C:endosome; TAS:Reactome.::GO:0005634; C:nucleus; TAS:ProtInc.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0046875; F:ephrin receptor binding; IPI:UniProtKB.::GO:0042169; F:SH2 domain binding; IPI:UniProtKB.
GO:0000186; P:activation of MAPKK activity; TAS:Reactome.::GO:0048013; P:ephrin receptor signaling pathway; IDA:UniProtKB.::GO:0008286; P:insulin receptor signaling pathway; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0030168; P:platelet activation; TAS:Reactome.::GO:0032956; P:regulation of actin cytoskeleton organization; IDA:UniProtKB.::GO:0032319; P:regulation of Rho GTPase activity; IDA:UniProtKB.::GO:0006357; P:regulation of transcription from RNA polymerase II promoter; TAS:ProtInc.
190Q91ZR2    614   SNX18_MOUSE Sorting nexin-18 OS=Mus musculus ...590.04     39.7     37     63GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.::GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.::GO:0031234; C:extrinsic to internal side of plasma membrane; ISS:UniProtKB.
GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
GO:0007154; P:cell communication; IEA:InterPro.::GO:0006897; P:endocytosis; ISS:UniProtKB.::GO:0043547; P:positive regulation of GTPase activity; ISS:UniProtKB.::GO:0015031; P:protein transport; IEA:UniProtKB-KW.
191Q64010    304   CRK_MOUSE Adapter molecule crk OS=Mus musculu...540.04     39.3     31     67GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0046875; F:ephrin receptor binding; IPI:UniProtKB.::GO:0045309; F:protein phosphorylated amino acid binding; IDA:MGI.::GO:0005070; F:SH3/SH2 adaptor activity; IPI:BHF-UCL.
GO:0048013; P:ephrin receptor signaling pathway; ISS:UniProtKB.::GO:0032956; P:regulation of actin cytoskeleton organization; ISS:UniProtKB.::GO:0032319; P:regulation of Rho GTPase activity; ISS:UniProtKB.
192P63185    526   SRC_RSVSE Tyrosine-protein kinase transformin...520.041     39.7     46     65
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.
193Q9Y5X1    595   SNX9_HUMAN Sorting nexin-9 OS=Homo sapiens (H...580.042     39.7     29     64GO:0030136; C:clathrin-coated vesicle; IEA:UniProtKB-SubCell.::GO:0030659; C:cytoplasmic vesicle membrane; IDA:UniProtKB.::GO:0031234; C:extrinsic to internal side of plasma membrane; IDA:UniProtKB.::GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0001726; C:ruffle; IEA:UniProtKB-SubCell.::GO:0005802; C:trans-Golgi network; IDA:UniProtKB.
GO:0005545; F:1-phosphatidylinositol binding; IDA:UniProtKB.::GO:0042803; F:protein homodimerization activity; IPI:UniProtKB.::GO:0031625; F:ubiquitin protein ligase binding; IPI:UniProtKB.
GO:0007154; P:cell communication; IEA:InterPro.::GO:0006886; P:intracellular protein transport; IMP:UniProtKB.::GO:0060988; P:lipid tube assembly; IDA:UniProtKB.::GO:0043547; P:positive regulation of GTPase activity; IDA:UniProtKB.::GO:0032461; P:positive regulation of protein oligomerization; IDA:UniProtKB.::GO:0006898; P:receptor-mediated endocytosis; IMP:UniProtKB.
194Q8CBW3    481   ABI1_MOUSE Abl interactor 1 OS=Mus musculus (...600.043     39.3     38     52GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0030175; C:filopodium; IEA:UniProtKB-SubCell.::GO:0030426; C:growth cone; IEA:UniProtKB-SubCell.::GO:0030027; C:lamellipodium; IDA:MGI.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0045202; C:synapse; IEA:UniProtKB-KW.::GO:0019717; C:synaptosome; IEA:UniProtKB-SubCell.
GO:0005515; F:protein binding; IPI:IntAct.::GO:0030296; F:protein tyrosine kinase activator activity; IDA:MGI.
GO:0001756; P:somitogenesis; IMP:MGI.
195Q9UNF0    486   PACN2_HUMAN Protein kinase C and casein kinas...580.045     39.3     38     62GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell.
GO:0005215; F:transporter activity; TAS:ProtInc.
GO:0030036; P:actin cytoskeleton organization; TAS:ProtInc.::GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
196Q07883    217   GRB2_CHICK Growth factor receptor-bound prote...470.68     35     36     57GO:0005768; C:endosome; ISS:UniProtKB.::GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; ISS:UniProtKB.
197Q5R411    444   PACN1_PONAB Protein kinase C and casein kinas...1390.048     39.3     25     47
GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
198Q9Z0R6    1659   ITSN2_MOUSE Intersectin-2 OS=Mus musculus (Mo...551.3     35     38     58GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
199P19706    1147   MYSB_ACACA Myosin heavy chain IB OS=Acanthamo...580.053     39.3     41     60GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003774; F:motor activity; IEA:InterPro.
200O60861    476   GAS7_HUMAN Growth arrest-specific protein 7 O...620.054     38.9     32     53GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003700; F:sequence-specific DNA binding transcription factor activity; TAS:ProtInc.
GO:0007050; P:cell cycle arrest; TAS:ProtInc.
201O93436    468   STAM2_CHICK Signal transducing adapter molecu...1050.055     38.9     28     49GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
GO:0006886; P:intracellular protein transport; IEA:InterPro.
202Q6GUF4    550   FBP1L_XENTR Formin-binding protein 1-like OS=...590.057     38.9     31     61GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.::GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
203Q6GPJ9    229   GRB2B_XENLA Growth factor receptor-bound prot...530.54     35.4     36     57GO:0005768; C:endosome; ISS:UniProtKB.::GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0005154; F:epidermal growth factor receptor binding; ISS:UniProtKB.::GO:0043560; F:insulin receptor substrate binding; ISS:UniProtKB.
GO:0007143; P:female meiosis; IDA:UniProtKB.::GO:0008286; P:insulin receptor signaling pathway; ISS:UniProtKB.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
204P87379    229   GRB2A_XENLA Growth factor receptor-bound prot...534.3     32.7     34     55GO:0005768; C:endosome; ISS:UniProtKB.::GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0005154; F:epidermal growth factor receptor binding; ISS:UniProtKB.::GO:0043560; F:insulin receptor substrate binding; ISS:UniProtKB.
GO:0007143; P:female meiosis; IDA:UniProtKB.::GO:0008286; P:insulin receptor signaling pathway; ISS:UniProtKB.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
205P42687    497   SPK1_DUGTI Tyrosine-protein kinase SPK-1 OS=D...610.063     38.9     38     56
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.
206P42690    506   SRK4_SPOLA Tyrosine-protein kinase isoform SR...580.067     38.9     43     62GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.
207O55043    646   ARHG7_RAT Rho guanine nucleotide exchange fac...720.067     38.9     32     57GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.::GO:0005925; C:focal adhesion; IDA:RGD.::GO:0030426; C:growth cone; IDA:RGD.::GO:0001726; C:ruffle; IEA:UniProtKB-SubCell.
GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
GO:0043615; P:astrocyte cell migration; IMP:RGD.::GO:0043065; P:positive regulation of apoptotic process; ISS:UniProtKB.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IDA:RGD.
208O88811    523   STAM2_MOUSE Signal transducing adapter molecu...540.069     38.9     35     63GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
GO:0006886; P:intracellular protein transport; IEA:InterPro.
209Q8TE67    593   ES8L3_HUMAN Epidermal growth factor receptor ...540.069     38.9     35     56GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
210Q9Z0W5    441   PACN1_RAT Protein kinase C and casein kinase ...1430.07     38.5     24     47
GO:0007010; P:cytoskeleton organization; IDA:RGD.::GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
211Q8IZP0    508   ABI1_HUMAN Abl interactor 1 OS=Homo sapiens (...600.072     38.9     38     50GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; TAS:ProtInc.::GO:0005783; C:endoplasmic reticulum; TAS:ProtInc.::GO:0030175; C:filopodium; IDA:UniProtKB.::GO:0030426; C:growth cone; IEA:UniProtKB-SubCell.::GO:0030027; C:lamellipodium; IDA:UniProtKB.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0005625; C:soluble fraction; TAS:ProtInc.::GO:0045202; C:synapse; IEA:UniProtKB-KW.::GO:0019717; C:synaptosome; IEA:UniProtKB-SubCell.
GO:0008092; F:cytoskeletal protein binding; TAS:ProtInc.
GO:0008154; P:actin polymerization or depolymerization; NAS:UniProtKB.::GO:0006928; P:cellular component movement; IDA:UniProtKB.::GO:0008285; P:negative regulation of cell proliferation; TAS:ProtInc.::GO:0018108; P:peptidyl-tyrosine phosphorylation; IDA:MGI.::GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; TAS:ProtInc.
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