rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
61 | Q5VV41 | 709 | ARHGG_HUMAN Rho guanine nucleotide exchange f... | 64 | 0.018 | 42.7 | 30 | 48 | GO:0005829; C:cytosol; TAS:Reactome. | | | | | | | | | | GO:0030165; F:PDZ domain binding; IPI:BHF-UCL.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0030971; F:receptor tyrosine kinase binding; IPI:UniProtKB.::GO:0017048; F:Rho GTPase binding; IPI:UniProtKB.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IDA:UniProtKB. | | | | | | | | | | GO:0032864; P:activation of Cdc42 GTPase activity; IDA:BHF-UCL.::GO:0032863; P:activation of Rac GTPase activity; IMP:UniProtKB.::GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0060326; P:cell chemotaxis; IMP:UniProtKB.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0090004; P:positive regulation of establishment of protein localization in plasma membrane; IMP:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome. | 62 | Q9BX66 | 1292 | SRBS1_HUMAN Sorbin and SH3 domain-containing ... | 60 | 0.019 | 42.7 | 30 | 58 | GO:0005813; C:centrosome; IDA:HPA.::GO:0005829; C:cytosol; ISS:BHF-UCL.::GO:0005925; C:focal adhesion; IDA:HPA.::GO:0045121; C:membrane raft; ISS:UniProtKB.::GO:0005634; C:nucleus; IDA:UniProtKB.::GO:0001725; C:stress fiber; ISS:UniProtKB.::GO:0005915; C:zonula adherens; TAS:ProtInc. | | | | | | | | | | GO:0003779; F:actin binding; TAS:ProtInc.::GO:0005158; F:insulin receptor binding; IDA:UniProtKB.::GO:0005070; F:SH3/SH2 adaptor activity; ISS:BHF-UCL. | | | | | | | | | | GO:0048041; P:focal adhesion assembly; ISS:UniProtKB.::GO:0015758; P:glucose transport; ISS:UniProtKB.::GO:0008286; P:insulin receptor signaling pathway; ISS:UniProtKB.::GO:0006936; P:muscle contraction; TAS:Reactome.::GO:0090004; P:positive regulation of establishment of protein localization in plasma membrane; ISS:BHF-UCL.::GO:0046326; P:positive regulation of glucose import; ISS:BHF-UCL.::GO:0045725; P:positive regulation of glycogen biosynthetic process; ISS:BHF-UCL.::GO:0046889; P:positive regulation of lipid biosynthetic process; ISS:BHF-UCL.::GO:0043149; P:stress fiber assembly; ISS:UniProtKB. | 63 | Q7Z5H3 | 698 | RHG22_HUMAN Rho GTPase-activating protein 22 ... | 114 | 0.019 | 42.7 | 23 | 44 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro. | | | | | | | | | | GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.::GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0051056; P:regulation of small GTPase mediated signal transduction; TAS:Reactome.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 64 | Q9HB21 | 404 | PKHA1_HUMAN Pleckstrin homology domain-contai... | 111 | 0.02 | 42.4 | 26 | 41 | GO:0005737; C:cytoplasm; IDA:UniProtKB.::GO:0005634; C:nucleus; IDA:HPA.::GO:0032587; C:ruffle membrane; IDA:UniProtKB. | | | | | | | | | | GO:0030165; F:PDZ domain binding; IPI:UniProtKB.::GO:0043325; F:phosphatidylinositol-3,4-bisphosphate binding; IDA:UniProtKB. | | | | | | | | | | GO:0050853; P:B cell receptor signaling pathway; IDA:UniProtKB.::GO:0070301; P:cellular response to hydrogen peroxide; IDA:UniProtKB.::GO:0045184; P:establishment of protein localization; IDA:UniProtKB.::GO:0051898; P:negative regulation of protein kinase B signaling cascade; IMP:UniProtKB.::GO:0014065; P:phosphatidylinositol 3-kinase cascade; IDA:UniProtKB.::GO:0031529; P:ruffle organization; IDA:UniProtKB. | 65 | P79114 | 2052 | MYO10_BOVIN Unconventionnal myosin-X OS=Bos t... | 91 | 0.024 | 42.7 | 27 | 48 | GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; TAS:UniProtKB.::GO:0031527; C:filopodium membrane; IEA:UniProtKB-SubCell.::GO:0032433; C:filopodium tip; IDA:UniProtKB.::GO:0030027; C:lamellipodium; IDA:MGI.::GO:0016459; C:myosin complex; IEA:UniProtKB-KW.::GO:0001726; C:ruffle; IDA:MGI. | | | | | | | | | | GO:0051015; F:actin filament binding; IDA:UniProtKB.::GO:0030898; F:actin-dependent ATPase activity; IDA:UniProtKB.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IDA:UniProtKB.::GO:0060002; F:plus-end directed microfilament motor activity; IDA:UniProtKB. | | | | | | | | | | GO:0030705; P:cytoskeleton-dependent intracellular transport; IDA:UniProtKB.::GO:0008360; P:regulation of cell shape; IMP:UniProtKB.::GO:0051489; P:regulation of filopodium assembly; IDA:UniProtKB. | 66 | Q9HD67 | 2058 | MYO10_HUMAN Unconventionnal myosin-X OS=Homo ... | 96 | 0.025 | 42.4 | 27 | 50 | GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0031527; C:filopodium membrane; IEA:UniProtKB-SubCell.::GO:0032433; C:filopodium tip; ISS:UniProtKB.::GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.::GO:0016459; C:myosin complex; IEA:UniProtKB-KW.::GO:0001726; C:ruffle; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0051015; F:actin filament binding; ISS:UniProtKB.::GO:0030898; F:actin-dependent ATPase activity; ISS:UniProtKB.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; ISS:UniProtKB.::GO:0060002; F:plus-end directed microfilament motor activity; ISS:UniProtKB. | | | | | | | | | | GO:0007411; P:axon guidance; TAS:Reactome.::GO:0030705; P:cytoskeleton-dependent intracellular transport; ISS:UniProtKB.::GO:0008360; P:regulation of cell shape; IMP:UniProtKB.::GO:0051489; P:regulation of filopodium assembly; IMP:UniProtKB. | 67 | F8VQB6 | 2062 | MYO10_MOUSE Unconventionnal myosin-X OS=Mus m... | 96 | 0.026 | 42.4 | 27 | 50 | GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0031527; C:filopodium membrane; IEA:UniProtKB-SubCell.::GO:0032433; C:filopodium tip; ISS:UniProtKB.::GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.::GO:0016459; C:myosin complex; IEA:UniProtKB-KW.::GO:0043005; C:neuron projection; IDA:MGI.::GO:0043025; C:neuronal cell body; IDA:MGI.::GO:0001726; C:ruffle; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0051015; F:actin filament binding; ISS:UniProtKB.::GO:0030898; F:actin-dependent ATPase activity; ISS:UniProtKB.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; ISS:UniProtKB.::GO:0060002; F:plus-end directed microfilament motor activity; ISS:UniProtKB. | | | | | | | | | | GO:0048870; P:cell motility; IC:MGI.::GO:0030705; P:cytoskeleton-dependent intracellular transport; ISS:UniProtKB.::GO:0022409; P:positive regulation of cell-cell adhesion; IGI:MGI.::GO:0008360; P:regulation of cell shape; ISS:UniProtKB.::GO:0051489; P:regulation of filopodium assembly; ISS:UniProtKB. | 68 | Q9Y2H5 | 1048 | PKHA6_HUMAN Pleckstrin homology domain-contai... | 111 | 0.03 | 42 | 23 | 41 | | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro. | | | | | | | | | | | 69 | O94478 | 420 | MU137_SCHPO Meiotically up-regulated gene 137... | 126 | 0.034 | 41.6 | 29 | 48 | GO:0032153; C:cell division site; IDA:PomBase.::GO:0005829; C:cytosol; IDA:PomBase.::GO:0005634; C:nucleus; IDA:PomBase. | | | | | | | | | | | | | | | | | | | | GO:0007126; P:meiosis; IEP:PomBase. | 70 | Q7TQG1 | 1173 | PKHA6_MOUSE Pleckstrin homology domain-contai... | 111 | 0.034 | 42 | 23 | 41 | | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro. | | | | | | | | | | | 71 | Q9W0K0 | 490 | JIP1_DROME JNK-interacting protein 1 OS=Droso... | 84 | 0.037 | 41.6 | 27 | 51 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0042802; F:identical protein binding; IPI:IntAct.::GO:0019894; F:kinesin binding; IPI:UniProtKB.::GO:0005078; F:MAP-kinase scaffold activity; IPI:UniProtKB.::GO:0019901; F:protein kinase binding; IPI:UniProtKB. | | | | | | | | | | GO:0048490; P:anterograde synaptic vesicle transport; IMP:FlyBase.::GO:0019896; P:axon transport of mitochondrion; IMP:FlyBase.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.::GO:0046328; P:regulation of JNK cascade; ISS:UniProtKB.::GO:0048491; P:retrograde synaptic vesicle transport; IMP:FlyBase. | 72 | Q8BUL6 | 383 | PKHA1_MOUSE Pleckstrin homology domain-contai... | 111 | 0.04 | 41.2 | 26 | 41 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | | | | | | | | | | | GO:0008209; P:androgen metabolic process; IMP:MGI.::GO:0008210; P:estrogen metabolic process; IGI:MGI.::GO:0060325; P:face morphogenesis; IMP:MGI.::GO:0033327; P:Leydig cell differentiation; IMP:MGI.::GO:0001553; P:luteinization; IGI:MGI.::GO:0035264; P:multicellular organism growth; IMP:MGI.::GO:0060021; P:palate development; IMP:MGI.::GO:0048008; P:platelet-derived growth factor receptor signaling pathway; IMP:MGI.::GO:0009791; P:post-embryonic development; IMP:MGI.::GO:0048705; P:skeletal system morphogenesis; IMP:MGI.::GO:0007283; P:spermatogenesis; IMP:MGI. | 73 | D3ZJP6 | 2060 | MYO10_RAT Unconventionnal myosin-X OS=Rattus ... | 89 | 0.041 | 42 | 27 | 49 | GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0031527; C:filopodium membrane; IEA:UniProtKB-SubCell.::GO:0032433; C:filopodium tip; ISS:UniProtKB.::GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.::GO:0016459; C:myosin complex; IEA:UniProtKB-KW.::GO:0001726; C:ruffle; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0051015; F:actin filament binding; ISS:UniProtKB.::GO:0030898; F:actin-dependent ATPase activity; ISS:UniProtKB.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; ISS:UniProtKB.::GO:0060002; F:plus-end directed microfilament motor activity; ISS:UniProtKB. | | | | | | | | | | GO:0030705; P:cytoskeleton-dependent intracellular transport; ISS:UniProtKB.::GO:0008360; P:regulation of cell shape; ISS:UniProtKB.::GO:0051489; P:regulation of filopodium assembly; ISS:UniProtKB. | 74 | O94875 | 1100 | SRBS2_HUMAN Sorbin and SH3 domain-containing ... | 64 | 0.041 | 41.6 | 34 | 56 | GO:0015629; C:actin cytoskeleton; TAS:ProtInc.::GO:0005622; C:intracellular; IEA:InterPro.::GO:0005634; C:nucleus; NAS:UniProtKB.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.::GO:0030018; C:Z disc; NAS:UniProtKB. | | | | | | | | | | GO:0008093; F:cytoskeletal adaptor activity; TAS:ProtInc.::GO:0005200; F:structural constituent of cytoskeleton; TAS:ProtInc.::GO:0008307; F:structural constituent of muscle; TAS:ProtInc.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | | 75 | Q13387 | 824 | JIP2_HUMAN C-Jun-amino-terminal kinase-intera... | 56 | 0.048 | 41.2 | 27 | 55 | GO:0005737; C:cytoplasm; IDA:UniProtKB.::GO:0014069; C:postsynaptic density; ISS:BHF-UCL. | | | | | | | | | | GO:0001540; F:beta-amyloid binding; NAS:UniProtKB.::GO:0019894; F:kinesin binding; ISS:UniProtKB.::GO:0005078; F:MAP-kinase scaffold activity; NAS:UniProtKB.::GO:0030295; F:protein kinase activator activity; IDA:MGI.::GO:0019901; F:protein kinase binding; IPI:UniProtKB. | | | | | | | | | | GO:0001662; P:behavioral fear response; ISS:BHF-UCL.::GO:0048813; P:dendrite morphogenesis; ISS:BHF-UCL.::GO:0000165; P:MAPK cascade; IDA:MGI.::GO:0046958; P:nonassociative learning; ISS:BHF-UCL.::GO:0045768; P:positive regulation of anti-apoptosis; NAS:UniProtKB.::GO:2000311; P:regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; ISS:BHF-UCL.::GO:0060079; P:regulation of excitatory postsynaptic membrane potential; ISS:BHF-UCL.::GO:0046328; P:regulation of JNK cascade; IDA:UniProtKB.::GO:2000310; P:regulation of N-methyl-D-aspartate selective glutamate receptor activity; ISS:BHF-UCL.::GO:0051966; P:regulation of synaptic transmission, glutamatergic; ISS:BHF-UCL.::GO:0007172; P:signal complex assembly; TAS:ProtInc.::GO:0035176; P:social behavior; ISS:BHF-UCL. | 76 | O35413 | 1196 | SRBS2_RAT Sorbin and SH3 domain-containing pr... | 76 | 3.8 | 35.4 | 28 | 50 | GO:0043025; C:neuronal cell body; IDA:RGD.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.::GO:0014069; C:postsynaptic density; IDA:RGD. | | | | | | | | | | GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | | 77 | Q3UTJ2 | 1180 | SRBS2_MOUSE Sorbin and SH3 domain-containing ... | 64 | 0.053 | 41.2 | 33 | 56 | GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.::GO:0030018; C:Z disc; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | | 78 | Q9ERE9 | 830 | JIP2_MOUSE C-Jun-amino-terminal kinase-intera... | 56 | 0.054 | 41.2 | 27 | 55 | GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0043025; C:neuronal cell body; IDA:MGI.::GO:0014069; C:postsynaptic density; IDA:BHF-UCL. | | | | | | | | | | GO:0019894; F:kinesin binding; IPI:UniProtKB.::GO:0019901; F:protein kinase binding; ISS:UniProtKB. | | | | | | | | | | GO:0001662; P:behavioral fear response; IMP:BHF-UCL.::GO:0048813; P:dendrite morphogenesis; IMP:BHF-UCL.::GO:0007254; P:JNK cascade; IDA:MGI.::GO:0007617; P:mating behavior; IMP:BHF-UCL.::GO:0046958; P:nonassociative learning; IMP:BHF-UCL.::GO:2000311; P:regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; IMP:BHF-UCL.::GO:0060079; P:regulation of excitatory postsynaptic membrane potential; IMP:BHF-UCL.::GO:0046328; P:regulation of JNK cascade; ISS:UniProtKB.::GO:2000310; P:regulation of N-methyl-D-aspartate selective glutamate receptor activity; IMP:BHF-UCL.::GO:0051966; P:regulation of synaptic transmission, glutamatergic; IMP:BHF-UCL.::GO:0035176; P:social behavior; IMP:BHF-UCL. | 79 | Q9Y5K6 | 639 | CD2AP_HUMAN CD2-associated protein OS=Homo sa... | 119 | 0.058 | 41.2 | 28 | 49 | GO:0005737; C:cytoplasm; IDA:HPA.::GO:0031941; C:filamentous actin; IDA:UniProtKB.::GO:0005730; C:nucleolus; IDA:HPA.::GO:0005886; C:plasma membrane; IDA:HPA.::GO:0001726; C:ruffle; IDA:UniProtKB. | | | | | | | | | | GO:0017124; F:SH3 domain binding; IPI:UniProtKB.::GO:0005200; F:structural constituent of cytoskeleton; TAS:ProtInc. | | | | | | | | | | GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0006461; P:protein complex assembly; TAS:ProtInc.::GO:0007165; P:signal transduction; NAS:ProtInc.::GO:0006930; P:substrate-dependent cell migration, cell extension; TAS:ProtInc. | 80 | Q969H4 | 720 | CNKR1_HUMAN Connector enhancer of kinase supp... | 169 | 0.064 | 40.8 | 25 | 38 | GO:0005938; C:cell cortex; IDA:MGI.::GO:0005911; C:cell-cell junction; TAS:ProtInc.::GO:0005886; C:plasma membrane; TAS:ProtInc. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0030674; F:protein binding, bridging; IDA:MGI. | | | | | | | | | | GO:0007266; P:Rho protein signal transduction; IPI:MGI.::GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; TAS:ProtInc. | 81 | P09769 | 529 | FGR_HUMAN Tyrosine-protein kinase Fgr OS=Homo... | 75 | 0.083 | 40.4 | 28 | 49 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.::GO:0005758; C:mitochondrial intermembrane space; IEA:UniProtKB-SubCell.::GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0034988; F:Fc-gamma receptor I complex binding; IDA:UniProtKB.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IDA:UniProtKB.::GO:0001784; F:phosphotyrosine binding; ISS:UniProtKB.::GO:0019901; F:protein kinase binding; ISS:UniProtKB. | | | | | | | | | | GO:0007596; P:blood coagulation; TAS:Reactome.::GO:0050830; P:defense response to Gram-positive bacterium; ISS:UniProtKB.::GO:0002768; P:immune response-regulating cell surface receptor signaling pathway; TAS:UniProtKB.::GO:0045087; P:innate immune response; IEA:UniProtKB-KW.::GO:0007229; P:integrin-mediated signaling pathway; IMP:UniProtKB.::GO:0018108; P:peptidyl-tyrosine phosphorylation; IDA:UniProtKB.::GO:0030335; P:positive regulation of cell migration; ISS:UniProtKB.::GO:0050715; P:positive regulation of cytokine secretion; ISS:UniProtKB.::GO:0043306; P:positive regulation of mast cell degranulation; ISS:UniProtKB.::GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity; IMP:UniProtKB.::GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase cascade; IMP:UniProtKB.::GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.::GO:0008360; P:regulation of cell shape; ISS:UniProtKB.::GO:0045088; P:regulation of innate immune response; ISS:UniProtKB.::GO:0050764; P:regulation of phagocytosis; ISS:UniProtKB.::GO:0045859; P:regulation of protein kinase activity; ISS:UniProtKB.::GO:0009615; P:response to virus; TAS:ProtInc. | 82 | Q8N5V2 | 710 | NGEF_HUMAN Ephexin-1 OS=Homo sapiens (Human).... | 106 | 0.088 | 40.4 | 24 | 47 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0030426; C:growth cone; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IDA:HPA. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0048013; P:ephrin receptor signaling pathway; ISS:UniProtKB.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0061002; P:negative regulation of dendritic spine morphogenesis; ISS:UniProtKB.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0043087; P:regulation of GTPase activity; ISS:UniProtKB.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome. | 83 | Q5RDX5 | 709 | NGEF_PONAB Ephexin-1 OS=Pongo abelii (Sumatra... | 106 | 0.1 | 40.4 | 24 | 47 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0030426; C:growth cone; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0048013; P:ephrin receptor signaling pathway; ISS:UniProtKB.::GO:0061002; P:negative regulation of dendritic spine morphogenesis; ISS:UniProtKB.::GO:0043087; P:regulation of GTPase activity; ISS:UniProtKB.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 84 | Q8BL80 | 702 | RHG22_MOUSE Rho GTPase-activating protein 22 ... | 114 | 0.12 | 40 | 22 | 45 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro. | | | | | | | | | | GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.::GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0007165; P:signal transduction; IEA:InterPro.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 85 | Q9UN19 | 280 | DAPP1_HUMAN Dual adapter for phosphotyrosine ... | 110 | 0.12 | 39.3 | 27 | 39 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005886; C:plasma membrane; IDA:UniProtKB. | | | | | | | | | | GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IDA:UniProtKB.::GO:0043325; F:phosphatidylinositol-3,4-bisphosphate binding; IDA:UniProtKB.::GO:0004725; F:protein tyrosine phosphatase activity; NAS:UniProtKB. | | | | | | | | | | GO:0007165; P:signal transduction; TAS:ProtInc. | 86 | O77506 | 263 | LASP1_RABIT LIM and SH3 domain protein 1 OS=O... | 67 | 0.15 | 38.9 | 31 | 49 | GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006811; P:ion transport; IEA:UniProtKB-KW. | 87 | Q61792 | 263 | LASP1_MOUSE LIM and SH3 domain protein 1 OS=M... | 64 | 0.19 | 38.5 | 31 | 50 | GO:0030864; C:cortical actin cytoskeleton; ISS:UniProtKB.::GO:0005925; C:focal adhesion; IDA:MGI. | | | | | | | | | | GO:0051015; F:actin filament binding; IDA:MGI.::GO:0015075; F:ion transmembrane transporter activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | | 88 | Q9V9J3 | 517 | SRC42_DROME Tyrosine-protein kinase Src42A OS... | 82 | 0.19 | 39.3 | 26 | 52 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC. | | | | | | | | | | GO:0051017; P:actin filament bundle assembly; IMP:FlyBase.::GO:0043277; P:apoptotic cell clearance; IMP:FlyBase.::GO:0048749; P:compound eye development; IMP:FlyBase.::GO:0007395; P:dorsal closure, spreading of leading edge cells; IMP:FlyBase.::GO:0046529; P:imaginal disc fusion, thorax closure; IMP:FlyBase.::GO:0007476; P:imaginal disc-derived wing morphogenesis; IMP:FlyBase.::GO:0007254; P:JNK cascade; TAS:FlyBase.::GO:0042059; P:negative regulation of epidermal growth factor receptor signaling pathway; IGI:FlyBase.::GO:0007424; P:open tracheal system development; IMP:FlyBase.::GO:0018108; P:peptidyl-tyrosine phosphorylation; IMP:FlyBase.::GO:0007435; P:salivary gland morphogenesis; IMP:FlyBase.::GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IGI:FlyBase.::GO:0006099; P:tricarboxylic acid cycle; IDA:FlyBase. | 89 | Q5R5W0 | 261 | LASP1_PONAB LIM and SH3 domain protein 1 OS=P... | 64 | 0.2 | 38.5 | 31 | 50 | GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006811; P:ion transport; IEA:UniProtKB-KW. | 90 | Q99MZ8 | 263 | LASP1_RAT LIM and SH3 domain protein 1 OS=Rat... | 64 | 0.21 | 38.5 | 31 | 50 | GO:0030864; C:cortical actin cytoskeleton; IDA:UniProtKB. | | | | | | | | | | GO:0015075; F:ion transmembrane transporter activity; IDA:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | | 91 | Q5I0D6 | 502 | NOSTN_RAT Nostrin OS=Rattus norvegicus (Rat).... | 63 | 0.22 | 38.9 | 27 | 59 | GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | | | | | | | | | | | GO:0006897; P:endocytosis; IEA:UniProtKB-KW. |