UniProt_SwissProt BLAST: Single locus

Species:

Saccharomyces cerevisiae S288C

Locus:

YER114C

Length:

1040

Number of sequences:

5887

Description:

YER114C BOI2 SGDID:S000000916, Chr V from 393712-390590, Genome Release 64-1-1, reverse complement, Verified ORF, "Protein implicated in polar growth, functionally redundant with Boi1p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain"

rec.	Subject	Hit Length	Description	Align.Len	E value	Bit score	% ident.	% pos.	GO associations
31	P63034	400	CYH2_MOUSE Cytohesin-2 OS=Mus musculus (Mouse...	44	0.0005	47.4	45	55	GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0005886; C:plasma membrane; ISS:UniProtKB.
									GO:0005086; F:ARF guanyl-nucleotide exchange factor activity; IBA:RefGenome.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.
									GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.::GO:0030155; P:regulation of cell adhesion; IBA:RefGenome.
32	P34512	393	GRP1_CAEEL GTP exchange factor for ARFs 1 OS=...	129	0.0007	47	28	45	GO:0005737; C:cytoplasm; IBA:RefGenome.
									GO:0005086; F:ARF guanyl-nucleotide exchange factor activity; IBA:RefGenome.::GO:0005543; F:phospholipid binding; IEA:InterPro.
									GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
33	Q5DU31	406	ICEF1_MOUSE Interactor protein for cytohesin ...	128	0.0009	46.6	27	43	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
									GO:0005543; F:phospholipid binding; IEA:InterPro.
34	Q8BZT2	735	SH3R2_MOUSE Putative E3 ubiquitin-protein lig...	52	0.0009	47	35	63
									GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008157; F:protein phosphatase 1 binding; ISS:UniProtKB.::GO:0004864; F:protein phosphatase inhibitor activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
									GO:0010923; P:negative regulation of phosphatase activity; ISS:UniProtKB.
35	Q86I31	885	GACFF_DICDI Rho GTPase-activating protein gac...	110	0.001	47	25	42	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.
									GO:0007165; P:signal transduction; IEA:InterPro.
36	Q80VL0	406	ICEF1_RAT Interactor protein for cytohesin ex...	131	0.001	46.2	27	41	GO:0005829; C:cytosol; IDA:RGD.::GO:0005886; C:plasma membrane; IDA:RGD.
									GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0019904; F:protein domain specific binding; IPI:RGD.
									GO:0033126; P:positive regulation of GTP catabolic process; IDA:RGD.
37	A5D8S5	867	SH3R1_DANRE E3 ubiquitin-protein ligase SH3RF...	58	0.85	37.4	33	50	GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
									GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
38	Q8C120	878	SH3R3_MOUSE SH3 domain-containing RING finger...	56	1	37	30	54
									GO:0008270; F:zinc ion binding; IEA:InterPro.
39	Q8TEJ3	882	SH3R3_HUMAN SH3 domain-containing RING finger...	56	0.73	37.7	32	52
									GO:0008270; F:zinc ion binding; IEA:InterPro.
40	Q498M5	735	SH3R2_RAT Putative E3 ubiquitin-protein ligas...	52	0.002	45.8	35	63
									GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008157; F:protein phosphatase 1 binding; ISS:UniProtKB.::GO:0004864; F:protein phosphatase inhibitor activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
									GO:0010923; P:negative regulation of phosphatase activity; ISS:UniProtKB.
41	Q76MY7	399	CYH2_CHLAE Cytohesin-2 OS=Chlorocebus aethiop...	44	0.002	45.1	48	57	GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0005886; C:plasma membrane; ISS:UniProtKB.
									GO:0005086; F:ARF guanyl-nucleotide exchange factor activity; IEA:InterPro.::GO:0005543; F:phospholipid binding; IEA:InterPro.
									GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
42	O08967	399	CYH3_MOUSE Cytohesin-3 OS=Mus musculus (Mouse...	44	0.003	44.7	48	57	GO:0005737; C:cytoplasm; IDA:MGI.::GO:0005886; C:plasma membrane; IDA:MGI.::GO:0001726; C:ruffle; IPI:MGI.
									GO:0005086; F:ARF guanyl-nucleotide exchange factor activity; IBA:RefGenome.::GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IDA:MGI.::GO:0005515; F:protein binding; IPI:MGI.
									GO:0090162; P:establishment of epithelial cell polarity; IMP:MGI.::GO:0045785; P:positive regulation of cell adhesion; IDA:MGI.::GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
43	Q3U5C8	713	ARHGG_MOUSE Rho guanine nucleotide exchange f...	64	0.004	45.1	31	45	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; ISS:UniProtKB.
									GO:0032863; P:activation of Rac GTPase activity; ISS:UniProtKB.::GO:0060326; P:cell chemotaxis; ISS:UniProtKB.::GO:0090004; P:positive regulation of establishment of protein localization in plasma membrane; ISS:UniProtKB.
44	Q9UIA0	394	CYH4_HUMAN Cytohesin-4 OS=Homo sapiens (Human...	44	0.005	44.3	48	57	GO:0005737; C:cytoplasm; IBA:RefGenome.::GO:0005886; C:plasma membrane; IDA:UniProtKB.
									GO:0005086; F:ARF guanyl-nucleotide exchange factor activity; IBA:RefGenome.::GO:0005543; F:phospholipid binding; IEA:InterPro.
									GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.::GO:0030155; P:regulation of cell adhesion; IBA:RefGenome.
45	Q8IZC4	609	RTKN2_HUMAN Rhotekin-2 OS=Homo sapiens (Human...	134	0.005	44.3	22	46	GO:0005622; C:intracellular; IEA:InterPro.
									GO:0005543; F:phospholipid binding; IEA:InterPro.
									GO:0007165; P:signal transduction; IEA:InterPro.
46	Q80YW0	393	CYH4_MOUSE Cytohesin-4 OS=Mus musculus (Mouse...	44	0.005	44.3	48	57	GO:0005737; C:cytoplasm; IBA:RefGenome.::GO:0005886; C:plasma membrane; ISS:UniProtKB.
									GO:0005086; F:ARF guanyl-nucleotide exchange factor activity; IBA:RefGenome.::GO:0005543; F:phospholipid binding; IEA:InterPro.
									GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.::GO:0030155; P:regulation of cell adhesion; IBA:RefGenome.
47	Q8TEC5	729	SH3R2_HUMAN Putative E3 ubiquitin-protein lig...	52	0.006	44.3	33	62
									GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008157; F:protein phosphatase 1 binding; IDA:UniProtKB.::GO:0004864; F:protein phosphatase inhibitor activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
									GO:0010923; P:negative regulation of phosphatase activity; IDA:UniProtKB.
48	Q54KA7	986	SECG_DICDI Ankyrin repeat, PH and SEC7 domain...	115	0.007	44.3	27	44	GO:0005829; C:cytosol; IDA:dictyBase.::GO:0005764; C:lysosome; IDA:dictyBase.
									GO:0005086; F:ARF guanyl-nucleotide exchange factor activity; IEA:InterPro.::GO:0005543; F:phospholipid binding; IEA:InterPro.
									GO:0031589; P:cell-substrate adhesion; IMP:dictyBase.::GO:0006935; P:chemotaxis; IMP:dictyBase.::GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
49	Q9H4E7	631	DEFI6_HUMAN Differentially expressed in FDCP ...	187	0.008	43.9	23	41	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IDA:HPA.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
									GO:0005543; F:phospholipid binding; IEA:InterPro.
50	Q5BKC9	701	NGEF_RAT Ephexin-1 OS=Rattus norvegicus (Rat)...	106	0.008	43.9	25	48	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0030426; C:growth cone; IEA:UniProtKB-SubCell.
									GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
									GO:0048013; P:ephrin receptor signaling pathway; ISS:UniProtKB.::GO:0061002; P:negative regulation of dendritic spine morphogenesis; ISS:UniProtKB.::GO:0043087; P:regulation of GTPase activity; ISS:UniProtKB.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
51	Q9R237	708	JIP1_RAT C-Jun-amino-terminal kinase-interact...	73	0.008	43.9	32	51	GO:0044295; C:axonal growth cone; IDA:MGI.::GO:0005829; C:cytosol; IDA:RGD.::GO:0044294; C:dendritic growth cone; IDA:MGI.::GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0048471; C:perinuclear region of cytoplasm; IDA:RGD.
									GO:0008432; F:JUN kinase binding; IPI:RGD.::GO:0019894; F:kinesin binding; ISS:UniProtKB.::GO:0005078; F:MAP-kinase scaffold activity; IMP:RGD.::GO:0031434; F:mitogen-activated protein kinase kinase binding; IPI:RGD.::GO:0031435; F:mitogen-activated protein kinase kinase kinase binding; IPI:RGD.
									GO:0006916; P:anti-apoptosis; IDA:RGD.::GO:0046329; P:negative regulation of JNK cascade; IMP:RGD.::GO:0043508; P:negative regulation of JUN kinase activity; IMP:RGD.
52	Q8CHT1	710	NGEF_MOUSE Ephexin-1 OS=Mus musculus (Mouse)....	106	0.009	43.9	25	48	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0030426; C:growth cone; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
									GO:0046875; F:ephrin receptor binding; IPI:UniProtKB.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
									GO:0048013; P:ephrin receptor signaling pathway; IDA:UniProtKB.::GO:0061002; P:negative regulation of dendritic spine morphogenesis; IDA:UniProtKB.::GO:0043087; P:regulation of GTPase activity; IDA:UniProtKB.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
53	Q9WVI9	707	JIP1_MOUSE C-Jun-amino-terminal kinase-intera...	73	0.009	43.9	32	51	GO:0044297; C:cell body; IDA:MGI.::GO:0005829; C:cytosol; IDA:MGI.::GO:0044302; C:dentate gyrus mossy fiber; IDA:MGI.::GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0005624; C:membrane fraction; IDA:MGI.::GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.::GO:0045202; C:synapse; IDA:MGI.
									GO:0019894; F:kinesin binding; IPI:UniProtKB.::GO:0005078; F:MAP-kinase scaffold activity; NAS:UniProtKB.::GO:0005515; F:protein binding; IPI:IntAct.
									GO:0006916; P:anti-apoptosis; IDA:MGI.::GO:0007258; P:JUN phosphorylation; IDA:MGI.::GO:0006355; P:regulation of transcription, DNA-dependent; IDA:MGI.::GO:0016192; P:vesicle-mediated transport; IDA:MGI.
54	Q9UQF2	711	JIP1_HUMAN C-Jun-amino-terminal kinase-intera...	67	0.01	43.5	36	51	GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
									GO:0019894; F:kinesin binding; IPI:UniProtKB.::GO:0005078; F:MAP-kinase scaffold activity; IPI:UniProtKB.::GO:0004860; F:protein kinase inhibitor activity; TAS:ProtInc.
									GO:0016192; P:vesicle-mediated transport; ISS:UniProtKB.
55	Q8C2K1	630	DEFI6_MOUSE Differentially expressed in FDCP ...	188	0.012	43.1	24	41	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
									GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.
56	Q9R1Z8	733	VINEX_MOUSE Vinexin OS=Mus musculus (Mouse). ...	58	0.014	43.1	31	60	GO:0005737; C:cytoplasm; IDA:MGI.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005925; C:focal adhesion; IDA:MGI.::GO:0005634; C:nucleus; IDA:MGI.
									GO:0008134; F:transcription factor binding; IPI:MGI.
									GO:0031589; P:cell-substrate adhesion; IDA:MGI.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:MGI.::GO:0043410; P:positive regulation of MAPK cascade; IDA:MGI.
57	O60504	671	VINEX_HUMAN Vinexin OS=Homo sapiens (Human). ...	58	0.015	43.1	31	60	GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
									GO:0005515; F:protein binding; IPI:IntAct.::GO:0005200; F:structural constituent of cytoskeleton; TAS:ProtInc.::GO:0017166; F:vinculin binding; IPI:UniProtKB.
									GO:0006936; P:muscle contraction; TAS:Reactome.::GO:0051496; P:positive regulation of stress fiber assembly; IDA:UniProtKB.
58	P78314	561	3BP2_HUMAN SH3 domain-binding protein 2 OS=Ho...	114	0.017	42.7	28	47
									GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.::GO:0005070; F:SH3/SH2 adaptor activity; TAS:ProtInc.
									GO:0007165; P:signal transduction; TAS:ProtInc.
59	Q2KI41	410	CYH2_BOVIN Cytohesin-2 OS=Bos taurus (Bovine)...	56	0.017	42.4	38	48	GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0005886; C:plasma membrane; ISS:UniProtKB.
									GO:0005086; F:ARF guanyl-nucleotide exchange factor activity; ISS:RefGenome.::GO:0005543; F:phospholipid binding; IEA:InterPro.
									GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.::GO:0030155; P:regulation of cell adhesion; ISS:RefGenome.
60	Q62417	1290	SRBS1_MOUSE Sorbin and SH3 domain-containing ...	60	0.018	42.7	30	58	GO:0005913; C:cell-cell adherens junction; IDA:UniProtKB.::GO:0005829; C:cytosol; IDA:BHF-UCL.::GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.::GO:0045121; C:membrane raft; IDA:UniProtKB.::GO:0005634; C:nucleus; ISS:UniProtKB.::GO:0001725; C:stress fiber; IDA:UniProtKB.
									GO:0005158; F:insulin receptor binding; IDA:UniProtKB.::GO:0019901; F:protein kinase binding; IDA:MGI.::GO:0005070; F:SH3/SH2 adaptor activity; IPI:BHF-UCL.
									GO:0048041; P:focal adhesion assembly; IDA:UniProtKB.::GO:0015758; P:glucose transport; IDA:UniProtKB.::GO:0008286; P:insulin receptor signaling pathway; IDA:UniProtKB.::GO:0090004; P:positive regulation of establishment of protein localization in plasma membrane; IMP:BHF-UCL.::GO:0046326; P:positive regulation of glucose import; IMP:BHF-UCL.::GO:0045725; P:positive regulation of glycogen biosynthetic process; IMP:BHF-UCL.::GO:0046889; P:positive regulation of lipid biosynthetic process; IMP:BHF-UCL.::GO:0043149; P:stress fiber assembly; IDA:UniProtKB.
61	Q5VV41	709	ARHGG_HUMAN Rho guanine nucleotide exchange f...	64	0.018	42.7	30	48	GO:0005829; C:cytosol; TAS:Reactome.
									GO:0030165; F:PDZ domain binding; IPI:BHF-UCL.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0030971; F:receptor tyrosine kinase binding; IPI:UniProtKB.::GO:0017048; F:Rho GTPase binding; IPI:UniProtKB.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IDA:UniProtKB.
									GO:0032864; P:activation of Cdc42 GTPase activity; IDA:BHF-UCL.::GO:0032863; P:activation of Rac GTPase activity; IMP:UniProtKB.::GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0060326; P:cell chemotaxis; IMP:UniProtKB.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0090004; P:positive regulation of establishment of protein localization in plasma membrane; IMP:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.

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