Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
Home About FGC Use Cases Species List

UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YER019W
Length:
477
Number of sequences:
5887
Description:
YER019W ISC1 SGDID:S000000821, Chr V from 192797-194230, Genome Release 64-1-1, Verified ORF, "Mitochondrial membrane localized inositol phosphosphingolipid phospholipase C, hydrolyzes complex sphingolipids to produce ceramide; activated by phosphatidylserine, cardiolipin, and phosphatidylglycerol; mediates Na+ and Li+ halotolerance"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
1P40015    477   ISC1_YEAST Inositol phosphosphingolipids phos...4770     997     100     100GO:0005783; C:endoplasmic reticulum; IDA:SGD.::GO:0031307; C:integral to mitochondrial outer membrane; IDA:SGD.
GO:0052712; F:inositol phosphosphingolipid phospholipase activity; IDA:SGD.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0046513; P:ceramide biosynthetic process; IMP:SGD.::GO:0009651; P:response to salt stress; IMP:SGD.::GO:0030149; P:sphingolipid catabolic process; IDA:SGD.
2O74369    424   CSS1_SCHPO Inositol phosphosphingolipids phos...4547e-75     248     34     51GO:0005783; C:endoplasmic reticulum; IDA:PomBase.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005739; C:mitochondrion; ISS:PomBase.::GO:0005886; C:plasma membrane; IDA:PomBase.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004629; F:phospholipase C activity; ISS:PomBase.::GO:0004767; F:sphingomyelin phosphodiesterase activity; IEA:EC.
GO:0046513; P:ceramide biosynthetic process; ISS:PomBase.::GO:0051278; P:fungal-type cell wall polysaccharide biosynthetic process; IMP:PomBase.::GO:0030149; P:sphingolipid catabolic process; ISS:PomBase.
3O45870    434   NSMA_CAEEL Putative neutral sphingomyelinase ...4518e-37     145     27     43GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004767; F:sphingomyelin phosphodiesterase activity; IEA:EC.
4O60906    423   NSMA_HUMAN Sphingomyelin phosphodiesterase 2 ...3198e-32     129     28     44GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004767; F:sphingomyelin phosphodiesterase activity; TAS:ProtInc.
GO:0006687; P:glycosphingolipid metabolic process; TAS:Reactome.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0044281; P:small molecule metabolic process; TAS:Reactome.::GO:0006684; P:sphingomyelin metabolic process; TAS:ProtInc.
5O70572    419   NSMA_MOUSE Sphingomyelin phosphodiesterase 2 ...3251e-31     129     28     43GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004767; F:sphingomyelin phosphodiesterase activity; IMP:MGI.
6Q9ET64    422   NSMA_RAT Sphingomyelin phosphodiesterase 2 OS...2277e-30     124     30     49GO:0005901; C:caveola; IDA:RGD.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005624; C:membrane fraction; IDA:RGD.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004767; F:sphingomyelin phosphodiesterase activity; IDA:RGD.
GO:0046513; P:ceramide biosynthetic process; IDA:RGD.::GO:0007243; P:intracellular protein kinase cascade; IMP:RGD.::GO:0009612; P:response to mechanical stimulus; IMP:RGD.
7Q9VZS6    442   NSMA_DROME Putative neutral sphingomyelinase ...3035e-29     122     27     45GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004767; F:sphingomyelin phosphodiesterase activity; IEA:EC.
8P17627    556   PHL_LEPIR Sphingomyelinase C OS=Leptospira in...1690.015     41.6     25     40GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO:0004767; F:sphingomyelin phosphodiesterase activity; IEA:EC.
9P59116    623   PHL2_LEPIN Sphingomyelinase C 2 OS=(strain 56...1560.13     38.5     25     37GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO:0004767; F:sphingomyelin phosphodiesterase activity; IEA:EC.
10Q9NUJ7    323   PLCX1_HUMAN PI-PLC X domain-containing protei...883.9     33.5     30     51
GO:0004629; F:phospholipase C activity; IEA:InterPro.
GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0006629; P:lipid metabolic process; IEA:InterPro.
11Q02452    473   NIFD_FRAAL Nitrogenase molybdenum-iron protei...446.1     33.1     39     50GO:0016612; C:molybdenum-iron nitrogenase complex; IEA:InterPro.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0018697; F:carbonyl sulfide nitrogenase activity; IEA:EC.::GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0016163; F:nitrogenase activity; IEA:EC.
GO:0009399; P:nitrogen fixation; IEA:UniProtKB-KW.
12Q96AE7    1141   TTC17_HUMAN Tetratricopeptide repeat protein ...586.9     33.1     34     53
GO:0005488; F:binding; IEA:InterPro.
records
Previous ‹‹ ›› Next Total records: 12 1 - 12
Elimate unknown annotation:
Filter for keyword on hit description:
Select upper E value:
Select lower bit score:
Select lower %idenity value:
Select lower %positive value:
Taxonomic division:
Lower limit on hit length:
Lower limit on alignment length::