Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YER018C
Length:
221
Number of sequences:
5887
Description:
YER018C SPC25 SGDID:S000000820, Chr V from 192624-191959, Genome Release 64-1-1, reverse complement, Verified ORF, "Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
1P40014    221   SPC25_YEAST Kinetochore protein SPC25 OS=Sacc...2216e-158     443     100     100GO:0000778; C:condensed nuclear chromosome kinetochore; IDA:SGD.::GO:0031262; C:Ndc80 complex; IDA:SGD.
GO:0005515; F:protein binding; IPI:IntAct.::GO:0005200; F:structural constituent of cytoskeleton; IPI:SGD.
GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007059; P:chromosome segregation; IMP:SGD.::GO:0007020; P:microtubule nucleation; IPI:SGD.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.
2Q6CUV0    227   SPC25_KLULA Probable kinetochore protein SPC2...2230.0000000004     60.8     26     49GO:0000777; C:condensed chromosome kinetochore; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.
3Q751Z6    231   SPC25_ASHGO Probable kinetochore protein SPC2...2380.00002     47.8     28     44GO:0000777; C:condensed chromosome kinetochore; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.
4Q90988    1189   SMC2_CHICK Structural maintenance of chromoso...1210.06     37.7     24     51GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.::GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.::GO:0006310; P:DNA recombination; IEA:InterPro.::GO:0006281; P:DNA repair; IEA:InterPro.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0007062; P:sister chromatid cohesion; IEA:InterPro.
5E1X022    1226   SMC_BACMS Chromosome partition protein Smc OS...1110.16     36.6     22     48GO:0005694; C:chromosome; IEA:InterPro.::GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO:0030261; P:chromosome condensation; IEA:InterPro.::GO:0006310; P:DNA recombination; IEA:InterPro.::GO:0006281; P:DNA repair; IEA:InterPro.::GO:0007062; P:sister chromatid cohesion; IEA:InterPro.
6Q05070    496   Y4393_NOSS1 Uncharacterized protein alr4393 O...1130.2     36.2     34     50GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
7P02545    664   LMNA_HUMAN Prelamin-A/C OS=Homo sapiens (Huma...1250.23     35.8     27     54GO:0005737; C:cytoplasm; IDA:HPA.::GO:0005638; C:lamin filament; TAS:UniProtKB.::GO:0005635; C:nuclear envelope; IDA:UniProtKB.::GO:0005654; C:nucleoplasm; TAS:Reactome.::GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0005198; F:structural molecule activity; IEA:InterPro.
GO:0006987; P:activation of signaling protein activity involved in unfolded protein response; TAS:Reactome.::GO:0006921; P:cellular component disassembly involved in apoptotic process; TAS:Reactome.::GO:0071456; P:cellular response to hypoxia; IEP:UniProtKB.::GO:0030951; P:establishment or maintenance of microtubule cytoskeleton polarity; ISS:BHF-UCL.::GO:0007517; P:muscle organ development; IMP:UniProtKB.::GO:0090343; P:positive regulation of cell aging; IDA:UniProtKB.::GO:0042981; P:regulation of apoptotic process; ISS:BHF-UCL.::GO:0030334; P:regulation of cell migration; ISS:BHF-UCL.
8Q5UR33    1351   YR555_MIMIV Uncharacterized protein R555 OS=A...1870.62     34.7     20     44
9P40340    1379   TBP7_YEAST Tat-binding homolog 7 OS=Saccharom...680.64     34.7     31     54GO:0042406; C:extrinsic to endoplasmic reticulum membrane; IDA:SGD.::GO:0005634; C:nucleus; IDA:SGD.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003682; F:chromatin binding; IDA:SGD.::GO:0042393; F:histone binding; IDA:SGD.::GO:0017111; F:nucleoside-triphosphatase activity; IEA:InterPro.
GO:0031936; P:negative regulation of chromatin silencing; IMP:SGD.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:SGD.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:SGD.
10A6VU29    854   IF2_MARMS Translation initiation factor IF-2 ...930.64     34.7     25     48GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; IEA:InterPro.::GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
11Q7N8N8    165   SKP_PHOLL Chaperone protein skp OS=Photorhabd...770.99     33.1     32     52GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
GO:0051082; F:unfolded protein binding; IEA:InterPro.
12Q55GF9    1320   ICPA_DICDI Inner centromere protein A OS=Dict...911.2     33.9     29     48GO:0005813; C:centrosome; IDA:dictyBase.::GO:0000775; C:chromosome, centromeric region; IEA:UniProtKB-SubCell.::GO:0032154; C:cleavage furrow; IDA:dictyBase.::GO:0005634; C:nucleus; IMP:GOC.::GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
GO:0005515; F:protein binding; IPI:IntAct.
GO:0007059; P:chromosome segregation; IMP:dictyBase.::GO:0000910; P:cytokinesis; IMP:dictyBase.::GO:0007067; P:mitosis; IMP:dictyBase.::GO:0030472; P:mitotic spindle organization in nucleus; IMP:dictyBase.::GO:0008104; P:protein localization; IMP:dictyBase.
13Q3A523    210   KGUA_PELCD Guanylate kinase OS=Pelobacter car...341.3     33.1     38     76GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004385; F:guanylate kinase activity; IEA:EC.
GO:0006163; P:purine nucleotide metabolic process; IEA:InterPro.
14O55715    165   084L_IIV6 Uncharacterized protein 084L OS=Inv...611.7     32.3     31     56GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
15P40758    410   GLNK_BACSU Sensor histidine kinase glnK OS=Ba...791.8     33.1     22     52GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0000155; F:two-component sensor activity; IEA:InterPro.
GO:0018106; P:peptidyl-histidine phosphorylation; IEA:InterPro.
16Q03R31    519   RNY1_LACBA Ribonuclease Y 1 OS=Lactobacillus ...1412.4     32.7     27     47GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0008663; F:2',3'-cyclic-nucleotide 2'-phosphodiesterase activity; IEA:InterPro.::GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:InterPro.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
17Q6S003    1873   KIF8_DICDI Kinesin-related protein 8 OS=Dicty...982.6     32.7     24     47GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0005874; C:microtubule; IEA:UniProtKB-KW.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003777; F:microtubule motor activity; IEA:InterPro.
GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007018; P:microtubule-based movement; IEA:InterPro.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0006810; P:transport; IEA:UniProtKB-KW.
18Q9S340    165   SKP_PHOLU Chaperone protein skp OS=Photorhabd...772.6     32     32     51GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
GO:0051082; F:unfolded protein binding; IEA:InterPro.
19Q5BDI8    257   SPC25_EMENI Probable kinetochore protein spc2...1672.9     32.3     24     38GO:0000777; C:condensed chromosome kinetochore; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.
20Q3ZD69    664   LMNA_PIG Prelamin-A/C OS=Sus scrofa (Pig). GN...993     32.3     28     55GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.::GO:0005635; C:nuclear envelope; ISS:UniProtKB.
GO:0005198; F:structural molecule activity; IEA:InterPro.
GO:0090343; P:positive regulation of cell aging; ISS:UniProtKB.::GO:0034504; P:protein localization to nucleus; ISS:UniProtKB.
21Q9UPQ0    1083   LIMC1_HUMAN LIM and calponin homology domains...1093.1     32.7     25     42
GO:0003779; F:actin binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0031032; P:actomyosin structure organization; IEA:InterPro.
22Q0VF96    1302   CGNL1_HUMAN Cingulin-like protein 1 OS=Homo s...773.9     32.3     31     57GO:0016459; C:myosin complex; IEA:InterPro.::GO:0005923; C:tight junction; IEA:UniProtKB-SubCell.
GO:0003774; F:motor activity; IEA:InterPro.
23Q9H2G2    1235   SLK_HUMAN STE20-like serine/threonine-protein...1028     31.2     25     46GO:0005737; C:cytoplasm; IDA:HPA.::GO:0005886; C:plasma membrane; IDA:HPA.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:InterPro.::GO:0004518; F:nuclease activity; IEA:InterPro.::GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0006289; P:nucleotide-excision repair; IEA:InterPro.::GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.
24P32908    1225   SMC1_YEAST Structural maintenance of chromoso...1004     32.3     24     47GO:0034990; C:nuclear mitotic cohesin complex; IDA:SGD.
GO:0003680; F:AT DNA binding; IDA:SGD.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0000217; F:DNA secondary structure binding; IDA:SGD.::GO:0003690; F:double-stranded DNA binding; IDA:SGD.::GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0030261; P:chromosome condensation; IEA:InterPro.::GO:0006310; P:DNA recombination; IEA:InterPro.::GO:0006302; P:double-strand break repair; IMP:SGD.::GO:0007064; P:mitotic sister chromatid cohesion; IGI:SGD.
25Q9C438    1313   ATG11_PICPA Autophagy-related protein 11 OS=P...1244.2     32.3     21     43GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
GO:0006914; P:autophagy; IEA:UniProtKB-KW.::GO:0015031; P:protein transport; IEA:UniProtKB-KW.
26Q6ZP65    573   BICR1_HUMAN Bicaudal D-related protein 1 OS=H...665     32     33     55GO:0005813; C:centrosome; ISS:UniProtKB.
GO:0034452; F:dynactin binding; ISS:UniProtKB.::GO:0017137; F:Rab GTPase binding; ISS:UniProtKB.
GO:0055107; P:Golgi to secretory granule transport; ISS:UniProtKB.::GO:0031175; P:neuron projection development; ISS:UniProtKB.
27P0CP38    666   NDE1_CRYNJ Nuclear distribution protein nudE ...925.4     31.6     28     53GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0005874; C:microtubule; IEA:UniProtKB-KW.
GO:0006810; P:transport; IEA:UniProtKB-KW.
28P0CP39    666   NDE1_CRYNB Nuclear distribution protein nudE ...925.6     31.6     28     53GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0005874; C:microtubule; IEA:UniProtKB-KW.
GO:0006810; P:transport; IEA:UniProtKB-KW.
29P48678    665   LMNA_MOUSE Prelamin-A/C OS=Mus musculus (Mous...685.8     31.6     29     56GO:0005638; C:lamin filament; IDA:MGI.::GO:0005635; C:nuclear envelope; IDA:UniProtKB.::GO:0005634; C:nucleus; IDA:BHF-UCL.::GO:0048471; C:perinuclear region of cytoplasm; ISS:BHF-UCL.
GO:0005515; F:protein binding; IPI:MGI.::GO:0005198; F:structural molecule activity; IEA:InterPro.
GO:0071456; P:cellular response to hypoxia; ISS:BHF-UCL.::GO:0030010; P:establishment of cell polarity; NAS:BHF-UCL.::GO:0030951; P:establishment or maintenance of microtubule cytoskeleton polarity; IMP:BHF-UCL.::GO:0007517; P:muscle organ development; ISS:BHF-UCL.::GO:0006998; P:nuclear envelope organization; IGI:MGI.::GO:0090343; P:positive regulation of cell aging; ISS:UniProtKB.::GO:0042981; P:regulation of apoptotic process; IDA:BHF-UCL.::GO:0030334; P:regulation of cell migration; IMP:BHF-UCL.::GO:0035105; P:sterol regulatory element binding protein import into nucleus; IMP:MGI.::GO:0055015; P:ventricular cardiac muscle cell development; IMP:MGI.
30Q8J1G7    945   CIN8_ASHGO Kinesin-like protein CIN8 OS=Y-105...975.8     31.6     26     48GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0005874; C:microtubule; IEA:UniProtKB-KW.::GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003777; F:microtubule motor activity; IEA:InterPro.
GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007018; P:microtubule-based movement; IEA:InterPro.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.
31P48679    665   LMNA_RAT Prelamin-A/C OS=Rattus norvegicus (R...685.8     31.6     29     56GO:0005626; C:insoluble fraction; IDA:RGD.::GO:0005635; C:nuclear envelope; ISS:UniProtKB.::GO:0016363; C:nuclear matrix; IDA:RGD.
GO:0005198; F:structural molecule activity; TAS:RGD.
GO:0006998; P:nuclear envelope organization; TAS:RGD.::GO:0090343; P:positive regulation of cell aging; ISS:UniProtKB.::GO:0007283; P:spermatogenesis; IEP:RGD.
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