Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YEL060C
Length:
635
Number of sequences:
5887
Description:
YEL060C PRB1 SGDID:S000000786, Chr V from 41953-40046, Genome Release 64-1-1, reverse complement, Verified ORF, "Vacuolar proteinase B (yscB), a serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation; activity inhibited by Pbi2p"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
121Q5VJ73    396   SUB5_TRIVC Subtilisin-like protease 5 OS=Tric...4167e-62     216     37     56GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO:0042802; F:identical protein binding; IEA:InterPro.::GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
GO:0043086; P:negative regulation of catalytic activity; IEA:InterPro.::GO:0009405; P:pathogenesis; IEA:UniProtKB-KW.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
122Q64K32    396   SUB5_ARTBE Subtilisin-like protease 5 OS=Arth...4169e-62     216     37     56GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO:0042802; F:identical protein binding; IEA:InterPro.::GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
GO:0043086; P:negative regulation of catalytic activity; IEA:InterPro.::GO:0009405; P:pathogenesis; IEA:UniProtKB-KW.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
123E4V5C5    400   SUB11_ARTGP Subtilisin-like protease 11 OS=gy...4117e-61     214     36     51GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO:0042802; F:identical protein binding; IEA:InterPro.::GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
GO:0043086; P:negative regulation of catalytic activity; IEA:InterPro.::GO:0009405; P:pathogenesis; IEA:UniProtKB-KW.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
124C5NZ70    407   SUB2C_COCP7 Subtilisin-like protease CPC735_0...4213e-60     212     35     52GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO:0042802; F:identical protein binding; IEA:InterPro.::GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
GO:0043086; P:negative regulation of catalytic activity; IEA:InterPro.::GO:0009405; P:pathogenesis; IEA:UniProtKB-KW.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
125E4UY04    397   SUB12_ARTGP Subtilisin-like protease 12 OS=gy...4107e-57     202     34     52GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO:0042802; F:identical protein binding; IEA:InterPro.::GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
GO:0043086; P:negative regulation of catalytic activity; IEA:InterPro.::GO:0009405; P:pathogenesis; IEA:UniProtKB-KW.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
126C5FX37    401   SUB10_ARTOC Subtilisin-like protease 10 OS=ca...4151e-56     202     35     52GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO:0042802; F:identical protein binding; IEA:InterPro.::GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
GO:0043086; P:negative regulation of catalytic activity; IEA:InterPro.::GO:0009405; P:pathogenesis; IEA:UniProtKB-KW.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
127C5NZT2    377   SUB4B_COCP7 Subtilisin-like protease CPC735_0...3622e-55     198     38     50GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO:0042802; F:identical protein binding; IEA:InterPro.::GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
GO:0043086; P:negative regulation of catalytic activity; IEA:InterPro.::GO:0009405; P:pathogenesis; IEA:UniProtKB-KW.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
128D4DIS6    522   SUB10_TRIVH Subtilisin-like protease 10 OS=Tr...3739e-54     197     35     52GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO:0042802; F:identical protein binding; IEA:InterPro.::GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
GO:0043086; P:negative regulation of catalytic activity; IEA:InterPro.::GO:0009405; P:pathogenesis; IEA:UniProtKB-KW.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
129P25381    491   RRT12_YEAST Subtilase-type proteinase RRT12 O...3931e-53     196     36     51GO:0005619; C:ascospore wall; IDA:SGD.::GO:0005635; C:nuclear envelope; IDA:SGD.
GO:0042802; F:identical protein binding; IEA:InterPro.::GO:0004252; F:serine-type endopeptidase activity; IBA:RefGenome.
GO:0030476; P:ascospore wall assembly; IMP:SGD.::GO:0043086; P:negative regulation of catalytic activity; IEA:InterPro.::GO:0006508; P:proteolysis; IBA:RefGenome.
130D4AQG0    522   SUB10_ARTBC Subtilisin-like protease 10 OS=(T...3652e-53     196     37     52GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO:0042802; F:identical protein binding; IEA:InterPro.::GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
GO:0043086; P:negative regulation of catalytic activity; IEA:InterPro.::GO:0009405; P:pathogenesis; IEA:UniProtKB-KW.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
131D4D1U5    397   SUB12_TRIVH Subtilisin-like protease 12 OS=Tr...4111e-52     191     35     51GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO:0042802; F:identical protein binding; IEA:InterPro.::GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
GO:0043086; P:negative regulation of catalytic activity; IEA:InterPro.::GO:0009405; P:pathogenesis; IEA:UniProtKB-KW.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
132P09230    454   AEP_YARLI Alkaline extracellular protease OS=...4274e-51     188     33     50GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO:0042802; F:identical protein binding; IEA:InterPro.::GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
GO:0043086; P:negative regulation of catalytic activity; IEA:InterPro.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
133D4AQA9    416   SUB12_ARTBC Subtilisin-like protease 12 OS=(T...4443e-48     179     32     49GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO:0042802; F:identical protein binding; IEA:InterPro.::GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
GO:0043086; P:negative regulation of catalytic activity; IEA:InterPro.::GO:0009405; P:pathogenesis; IEA:UniProtKB-KW.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
134Q80W65    694   PCSK9_MOUSE Proprotein convertase subtilisin/...3773e-38     154     31     48GO:0005788; C:endoplasmic reticulum lumen; TAS:Reactome.::GO:0005615; C:extracellular space; IDA:HGNC.
GO:0042802; F:identical protein binding; IEA:InterPro.::GO:0050750; F:low-density lipoprotein particle receptor binding; IDA:HGNC.::GO:0004252; F:serine-type endopeptidase activity; ISS:HGNC.
GO:0032869; P:cellular response to insulin stimulus; IDA:HGNC.::GO:0009267; P:cellular response to starvation; IDA:HGNC.::GO:0042632; P:cholesterol homeostasis; ISS:HGNC.::GO:0008203; P:cholesterol metabolic process; IDA:MGI.::GO:0001822; P:kidney development; IEP:HGNC.::GO:0042157; P:lipoprotein metabolic process; IDA:MGI.::GO:0001889; P:liver development; IEP:HGNC.::GO:0032802; P:low-density lipoprotein particle receptor catabolic process; ISS:HGNC.::GO:0043086; P:negative regulation of catalytic activity; IEA:InterPro.::GO:0030182; P:neuron differentiation; IDA:HGNC.::GO:0006644; P:phospholipid metabolic process; IDA:MGI.::GO:0043525; P:positive regulation of neuron apoptotic process; ISS:HGNC.::GO:0016540; P:protein autoprocessing; ISS:HGNC.::GO:0006508; P:proteolysis; IBA:RefGenome.::GO:0032803; P:regulation of low-density lipoprotein particle receptor catabolic process; IMP:MGI.::GO:0006641; P:triglyceride metabolic process; IDA:MGI.
135A8T658    690   PCSK9_PONPY Proprotein convertase subtilisin/...3843e-37     150     31     49GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO:0042802; F:identical protein binding; IEA:InterPro.::GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.::GO:0043086; P:negative regulation of catalytic activity; IEA:InterPro.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
136P59996    691   PCSK9_RAT Proprotein convertase subtilisin/ke...3541e-36     149     31     48GO:0005615; C:extracellular space; ISS:HGNC.::GO:0005791; C:rough endoplasmic reticulum; IDA:RGD.
GO:0042802; F:identical protein binding; IEA:InterPro.::GO:0050750; F:low-density lipoprotein particle receptor binding; ISS:HGNC.::GO:0004252; F:serine-type endopeptidase activity; ISS:HGNC.
GO:0032869; P:cellular response to insulin stimulus; IDA:HGNC.::GO:0009267; P:cellular response to starvation; IDA:HGNC.::GO:0042632; P:cholesterol homeostasis; IEP:RGD.::GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.::GO:0006917; P:induction of apoptosis; IMP:RGD.::GO:0001822; P:kidney development; IEP:HGNC.::GO:0001889; P:liver development; IEP:HGNC.::GO:0032802; P:low-density lipoprotein particle receptor catabolic process; ISS:HGNC.::GO:0043086; P:negative regulation of catalytic activity; IEA:InterPro.::GO:0030182; P:neuron differentiation; ISS:HGNC.::GO:0043525; P:positive regulation of neuron apoptotic process; IDA:HGNC.::GO:0016540; P:protein autoprocessing; IDA:RGD.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
137A8T6A1    690   PCSK9_ATEGE Proprotein convertase subtilisin/...3933e-36     147     30     48GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO:0042802; F:identical protein binding; IEA:InterPro.::GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.::GO:0043086; P:negative regulation of catalytic activity; IEA:InterPro.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
138A8T6A6    690   PCSK9_LAGLA Proprotein convertase subtilisin/...3934e-36     147     30     48GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO:0042802; F:identical protein binding; IEA:InterPro.::GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.::GO:0043086; P:negative regulation of catalytic activity; IEA:InterPro.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
139A8T695    691   PCSK9_SAIBB Proprotein convertase subtilisin/...3939e-36     146     30     47GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO:0042802; F:identical protein binding; IEA:InterPro.::GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.::GO:0043086; P:negative regulation of catalytic activity; IEA:InterPro.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
140A8T655    692   PCSK9_PANPA Proprotein convertase subtilisin/...3571e-35     146     31     49GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO:0042802; F:identical protein binding; IEA:InterPro.::GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.::GO:0043086; P:negative regulation of catalytic activity; IEA:InterPro.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
141A8T650    690   PCSK9_GORGO Proprotein convertase subtilisin/...3571e-35     146     31     49GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO:0042802; F:identical protein binding; IEA:InterPro.::GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.::GO:0043086; P:negative regulation of catalytic activity; IEA:InterPro.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
142A8T644    692   PCSK9_PANTR Proprotein convertase subtilisin/...3571e-35     146     31     49GO:0005615; C:extracellular space; ISS:RefGenome.
GO:0042802; F:identical protein binding; IEA:InterPro.::GO:0004252; F:serine-type endopeptidase activity; ISS:RefGenome.
GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.::GO:0043086; P:negative regulation of catalytic activity; IEA:InterPro.::GO:0006508; P:proteolysis; ISS:RefGenome.
143A8T688    690   PCSK9_CALJA Proprotein convertase subtilisin/...3931e-35     145     30     47
GO:0042802; F:identical protein binding; IEA:InterPro.
GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.::GO:0043086; P:negative regulation of catalytic activity; IEA:InterPro.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
144Q8NBP7    692   PCSK9_HUMAN Proprotein convertase subtilisin/...3572e-35     145     31     49GO:0005615; C:extracellular space; IDA:HGNC.::GO:0031232; C:extrinsic to external side of plasma membrane; IC:BHF-UCL.::GO:0005770; C:late endosome; IDA:BHF-UCL.::GO:0005764; C:lysosome; IDA:BHF-UCL.::GO:0048471; C:perinuclear region of cytoplasm; IDA:BHF-UCL.
GO:0034190; F:apolipoprotein receptor binding; IDA:BHF-UCL.::GO:0042802; F:identical protein binding; IEA:InterPro.::GO:0050750; F:low-density lipoprotein particle receptor binding; IPI:BHF-UCL.::GO:0004252; F:serine-type endopeptidase activity; IDA:HGNC.::GO:0070326; F:very-low-density lipoprotein particle receptor binding; IDA:BHF-UCL.
GO:0032869; P:cellular response to insulin stimulus; ISS:HGNC.::GO:0009267; P:cellular response to starvation; ISS:HGNC.::GO:0042632; P:cholesterol homeostasis; IMP:HGNC.::GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.::GO:0001822; P:kidney development; ISS:HGNC.::GO:0001889; P:liver development; ISS:HGNC.::GO:0032802; P:low-density lipoprotein particle receptor catabolic process; IDA:HGNC.::GO:0007041; P:lysosomal transport; IDA:BHF-UCL.::GO:0043086; P:negative regulation of catalytic activity; IEA:InterPro.::GO:0010989; P:negative regulation of low-density lipoprotein particle clearance; IDA:BHF-UCL.::GO:0001920; P:negative regulation of receptor recycling; IDA:BHF-UCL.::GO:0030182; P:neuron differentiation; ISS:HGNC.::GO:0043525; P:positive regulation of neuron apoptotic process; IMP:HGNC.::GO:0002092; P:positive regulation of receptor internalization; IDA:BHF-UCL.::GO:0016540; P:protein autoprocessing; IDA:HGNC.::GO:0006508; P:proteolysis; IBA:RefGenome.::GO:0010469; P:regulation of receptor activity; IDA:BHF-UCL.
145A8T677    684   PCSK9_CALMO Proprotein convertase subtilisin/...3935e-35     144     30     48GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO:0042802; F:identical protein binding; IEA:InterPro.::GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.::GO:0043086; P:negative regulation of catalytic activity; IEA:InterPro.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
146A8T682    686   PCSK9_SAGLB Proprotein convertase subtilisin/...3916e-35     144     30     47GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO:0042802; F:identical protein binding; IEA:InterPro.::GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.::GO:0043086; P:negative regulation of catalytic activity; IEA:InterPro.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
147A8T662    692   PCSK9_MACNE Proprotein convertase subtilisin/...3582e-34     142     31     49GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO:0042802; F:identical protein binding; IEA:InterPro.::GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.::GO:0043086; P:negative regulation of catalytic activity; IEA:InterPro.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
148A8T666    692   PCSK9_MACMU Proprotein convertase subtilisin/...3582e-34     142     31     49GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO:0042802; F:identical protein binding; IEA:InterPro.::GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.::GO:0043086; P:negative regulation of catalytic activity; IEA:InterPro.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
149A8T672    692   PCSK9_COLGU Proprotein convertase subtilisin/...3582e-34     142     31     49GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO:0042802; F:identical protein binding; IEA:InterPro.::GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.::GO:0043086; P:negative regulation of catalytic activity; IEA:InterPro.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
150P27693    380   ELYA_BACAO Alkaline protease OS=Bacillus alca...2808e-34     137     38     54GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO:0042802; F:identical protein binding; IEA:InterPro.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
GO:0043086; P:negative regulation of catalytic activity; IEA:InterPro.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
151Q99405    380   PRTM_BACSK M-protease OS=Bacillus clausii (st...2813e-33     135     37     54GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO:0042802; F:identical protein binding; IEA:InterPro.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
GO:0043086; P:negative regulation of catalytic activity; IEA:InterPro.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
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