UniProt_SwissProt BLAST: Single locus

Species:

Saccharomyces cerevisiae S288C

Locus:

YEL021W

Length:

267

Number of sequences:

5887

Description:

YEL021W URA3 SGDID:S000000747, Chr V from 116167-116970, Genome Release 64-1-1, Verified ORF, "Orotidine-5'-phosphate (OMP) decarboxylase, catalyzes the sixth enzymatic step in the de novo biosynthesis of pyrimidines, converting OMP into uridine monophosphate (UMP); converts 5-FOA into 5-fluorouracil, a toxic compound"

rec.	Subject	Hit Length	Description	Align.Len	E value	Bit score	% ident.	% pos.	GO associations
31	Q7Z8L4	276	PYRF_PENCA Orotidine 5'-phosphate decarboxyla...	275	1e-87	268	50	67
									GO:0004590; F:orotidine-5'-phosphate decarboxylase activity; IEA:EC.
									GO:0006207; P:'de novo' pyrimidine base biosynthetic process; IEA:InterPro.::GO:0044205; P:'de novo' UMP biosynthetic process; IEA:InterPro.
32	Q8J269	276	PYRF_PENNA Orotidine 5'-phosphate decarboxyla...	275	2e-87	268	51	67
									GO:0004590; F:orotidine-5'-phosphate decarboxylase activity; IEA:EC.
									GO:0006207; P:'de novo' pyrimidine base biosynthetic process; IEA:InterPro.::GO:0044205; P:'de novo' UMP biosynthetic process; IEA:InterPro.
33	P21593	267	PYRF_PHYBL Orotidine 5'-phosphate decarboxyla...	260	3e-87	267	54	71
									GO:0004590; F:orotidine-5'-phosphate decarboxylase activity; IEA:EC.
									GO:0006207; P:'de novo' pyrimidine base biosynthetic process; IEA:InterPro.::GO:0044205; P:'de novo' UMP biosynthetic process; IEA:InterPro.
34	Q1E9A1	274	PYRF_COCIM Orotidine 5'-phosphate decarboxyla...	272	9e-87	266	50	68
									GO:0004590; F:orotidine-5'-phosphate decarboxylase activity; IEA:EC.
									GO:0006207; P:'de novo' pyrimidine base biosynthetic process; IEA:InterPro.::GO:0044205; P:'de novo' UMP biosynthetic process; IEA:InterPro.
35	P32431	265	PYRF_MUCCL Orotidine 5'-phosphate decarboxyla...	260	1e-86	265	52	70
									GO:0004590; F:orotidine-5'-phosphate decarboxylase activity; IEA:EC.
									GO:0006207; P:'de novo' pyrimidine base biosynthetic process; IEA:InterPro.::GO:0044205; P:'de novo' UMP biosynthetic process; IEA:InterPro.
36	Q71HN5	265	PYRF_RHIOR Orotidine 5'-phosphate decarboxyla...	263	2e-86	265	52	70
									GO:0004590; F:orotidine-5'-phosphate decarboxylase activity; IEA:EC.
									GO:0006207; P:'de novo' pyrimidine base biosynthetic process; IEA:InterPro.::GO:0044205; P:'de novo' UMP biosynthetic process; IEA:InterPro.
37	P43230	265	PYRF_RHINI Orotidine 5'-phosphate decarboxyla...	263	2e-86	265	52	70
									GO:0004590; F:orotidine-5'-phosphate decarboxylase activity; IEA:EC.
									GO:0006207; P:'de novo' pyrimidine base biosynthetic process; IEA:InterPro.::GO:0044205; P:'de novo' UMP biosynthetic process; IEA:InterPro.
38	Q4VWW3	274	PYRF_COCPS Orotidine 5'-phosphate decarboxyla...	272	3e-86	265	50	68
									GO:0004590; F:orotidine-5'-phosphate decarboxylase activity; IEA:EC.
									GO:0006207; P:'de novo' pyrimidine base biosynthetic process; IEA:InterPro.::GO:0044205; P:'de novo' UMP biosynthetic process; IEA:InterPro.
39	O13410	278	PYRF_ASPFU Orotidine 5'-phosphate decarboxyla...	275	3e-86	265	50	67
									GO:0004590; F:orotidine-5'-phosphate decarboxylase activity; IEA:EC.
									GO:0006207; P:'de novo' pyrimidine base biosynthetic process; IEA:InterPro.::GO:0044205; P:'de novo' UMP biosynthetic process; IEA:InterPro.
40	P14965	264	PYRF_SCHPO Orotidine 5'-phosphate decarboxyla...	263	6e-85	261	51	70	GO:0005829; C:cytosol; IDA:PomBase.::GO:0005634; C:nucleus; IDA:PomBase.
									GO:0004590; F:orotidine-5'-phosphate decarboxylase activity; IGI:PomBase.
									GO:0006207; P:'de novo' pyrimidine base biosynthetic process; IGI:PomBase.::GO:0044205; P:'de novo' UMP biosynthetic process; IEA:InterPro.
41	P09463	278	PYRF_PENCH Orotidine 5'-phosphate decarboxyla...	277	1e-84	261	50	65
									GO:0004590; F:orotidine-5'-phosphate decarboxylase activity; IEA:EC.
									GO:0006207; P:'de novo' pyrimidine base biosynthetic process; IEA:InterPro.::GO:0044205; P:'de novo' UMP biosynthetic process; IEA:InterPro.
42	P07817	277	PYRF_ASPNG Orotidine 5'-phosphate decarboxyla...	273	1e-83	258	49	67
									GO:0004590; F:orotidine-5'-phosphate decarboxylase activity; IEA:EC.
									GO:0006207; P:'de novo' pyrimidine base biosynthetic process; IEA:InterPro.::GO:0044205; P:'de novo' UMP biosynthetic process; IEA:InterPro.
43	O13416	277	PYRF_ASPOR Orotidine 5'-phosphate decarboxyla...	275	2e-83	258	50	66
									GO:0004590; F:orotidine-5'-phosphate decarboxylase activity; IEA:EC.
									GO:0006207; P:'de novo' pyrimidine base biosynthetic process; IEA:InterPro.::GO:0044205; P:'de novo' UMP biosynthetic process; IEA:InterPro.
44	Q5J2D0	277	PYRF_ASPAW Orotidine 5'-phosphate decarboxyla...	273	4e-83	257	49	67
									GO:0004590; F:orotidine-5'-phosphate decarboxylase activity; IEA:EC.
									GO:0006207; P:'de novo' pyrimidine base biosynthetic process; IEA:InterPro.::GO:0044205; P:'de novo' UMP biosynthetic process; IEA:InterPro.
45	Q96WP7	277	PYRF_ASPKA Orotidine 5'-phosphate decarboxyla...	273	7e-82	254	49	66
									GO:0004590; F:orotidine-5'-phosphate decarboxylase activity; IEA:EC.
									GO:0006207; P:'de novo' pyrimidine base biosynthetic process; IEA:InterPro.::GO:0044205; P:'de novo' UMP biosynthetic process; IEA:InterPro.
46	P10652	274	PYRF_EMENI Orotidine 5'-phosphate decarboxyla...	275	2e-81	252	49	65
									GO:0004590; F:orotidine-5'-phosphate decarboxylase activity; IEA:EC.
									GO:0006207; P:'de novo' pyrimidine base biosynthetic process; IEA:InterPro.::GO:0044205; P:'de novo' UMP biosynthetic process; IEA:InterPro.
47	Q9Y720	263	PYRF_RHIPU Orotidine 5'-phosphate decarboxyla...	259	7e-81	251	53	69
									GO:0004590; F:orotidine-5'-phosphate decarboxylase activity; IEA:EC.
									GO:0006207; P:'de novo' pyrimidine base biosynthetic process; IEA:InterPro.::GO:0044205; P:'de novo' UMP biosynthetic process; IEA:InterPro.
48	Q5R514	480	UMPS_PONAB Uridine 5'-monophosphate synthase ...	250	3e-79	253	52	69
									GO:0004588; F:orotate phosphoribosyltransferase activity; IEA:EC.::GO:0004590; F:orotidine-5'-phosphate decarboxylase activity; IEA:EC.
									GO:0006207; P:'de novo' pyrimidine base biosynthetic process; IEA:InterPro.::GO:0044205; P:'de novo' UMP biosynthetic process; IEA:InterPro.
49	Q42586	476	UMPS_ARATH Uridine 5'-monophosphate synthase ...	264	7e-79	252	51	66	GO:0005829; C:cytosol; IDA:TAIR.
									GO:0004588; F:orotate phosphoribosyltransferase activity; IGI:TAIR.::GO:0004590; F:orotidine-5'-phosphate decarboxylase activity; IGI:TAIR.
									GO:0006207; P:'de novo' pyrimidine base biosynthetic process; IEA:InterPro.::GO:0044205; P:'de novo' UMP biosynthetic process; IEA:InterPro.::GO:0016036; P:cellular response to phosphate starvation; IEP:TAIR.::GO:0046686; P:response to cadmium ion; IEP:TAIR.
50	P13439	481	UMPS_MOUSE Uridine 5'-monophosphate synthase ...	267	2e-78	251	50	66
									GO:0004588; F:orotate phosphoribosyltransferase activity; IEA:EC.::GO:0004590; F:orotidine-5'-phosphate decarboxylase activity; IEA:EC.
									GO:0006207; P:'de novo' pyrimidine base biosynthetic process; IEA:InterPro.::GO:0044205; P:'de novo' UMP biosynthetic process; IEA:InterPro.
51	P11172	480	UMPS_HUMAN Uridine 5'-monophosphate synthase ...	250	5e-78	250	52	69	GO:0005829; C:cytosol; TAS:Reactome.::GO:0005634; C:nucleus; IDA:UniProtKB.
									GO:0004588; F:orotate phosphoribosyltransferase activity; IDA:UniProtKB.::GO:0004590; F:orotidine-5'-phosphate decarboxylase activity; IDA:UniProtKB.
									GO:0006207; P:'de novo' pyrimidine base biosynthetic process; IEA:InterPro.::GO:0044205; P:'de novo' UMP biosynthetic process; IEA:InterPro.::GO:0046134; P:pyrimidine nucleoside biosynthetic process; TAS:Reactome.
52	Q9HFV8	278	PYRF_PASFU Orotidine 5'-phosphate decarboxyla...	272	1e-77	243	46	63
									GO:0004590; F:orotidine-5'-phosphate decarboxylase activity; IEA:EC.
									GO:0006207; P:'de novo' pyrimidine base biosynthetic process; IEA:InterPro.::GO:0044205; P:'de novo' UMP biosynthetic process; IEA:InterPro.
53	P31754	480	UMPS_BOVIN Uridine 5'-monophosphate synthase ...	263	3e-77	248	50	67
									GO:0004588; F:orotate phosphoribosyltransferase activity; IEA:EC.::GO:0004590; F:orotidine-5'-phosphate decarboxylase activity; IEA:EC.
									GO:0006207; P:'de novo' pyrimidine base biosynthetic process; IEA:InterPro.::GO:0044205; P:'de novo' UMP biosynthetic process; IEA:InterPro.
54	Q9HF68	280	PYRF_SOLCC Orotidine 5'-phosphate decarboxyla...	271	8e-76	238	47	62
									GO:0004590; F:orotidine-5'-phosphate decarboxylase activity; IEA:EC.
									GO:0006207; P:'de novo' pyrimidine base biosynthetic process; IEA:InterPro.::GO:0044205; P:'de novo' UMP biosynthetic process; IEA:InterPro.
55	Q9C131	285	PYRF_PARBR Orotidine 5'-phosphate decarboxyla...	280	6e-75	236	46	62
									GO:0004590; F:orotidine-5'-phosphate decarboxylase activity; IEA:EC.
									GO:0006207; P:'de novo' pyrimidine base biosynthetic process; IEA:InterPro.::GO:0044205; P:'de novo' UMP biosynthetic process; IEA:InterPro.
56	Q9P8X9	270	PYRF_AURPU Orotidine 5'-phosphate decarboxyla...	257	5e-74	233	48	67
									GO:0004590; F:orotidine-5'-phosphate decarboxylase activity; IEA:EC.
									GO:0006207; P:'de novo' pyrimidine base biosynthetic process; IEA:InterPro.::GO:0044205; P:'de novo' UMP biosynthetic process; IEA:InterPro.
57	Q42942	461	UMPS_TOBAC Uridine 5'-monophosphate synthase ...	262	2e-73	238	52	65
									GO:0004588; F:orotate phosphoribosyltransferase activity; IEA:EC.::GO:0004590; F:orotidine-5'-phosphate decarboxylase activity; IEA:EC.
									GO:0006207; P:'de novo' pyrimidine base biosynthetic process; IEA:InterPro.::GO:0044205; P:'de novo' UMP biosynthetic process; IEA:InterPro.
58	P09556	478	UMPS_DICDI Uridine 5'-monophosphate synthase ...	255	3e-73	238	45	67	GO:0045335; C:phagocytic vesicle; IDA:dictyBase.
									GO:0004588; F:orotate phosphoribosyltransferase activity; IGI:dictyBase.::GO:0004590; F:orotidine-5'-phosphate decarboxylase activity; IMP:dictyBase.
									GO:0006207; P:'de novo' pyrimidine base biosynthetic process; IEA:InterPro.::GO:0044205; P:'de novo' UMP biosynthetic process; IEA:InterPro.
59	Q25566	494	UMPS_NAEGR Uridine 5'-monophosphate synthase ...	265	4e-68	225	46	65
									GO:0004588; F:orotate phosphoribosyltransferase activity; IEA:EC.::GO:0004590; F:orotidine-5'-phosphate decarboxylase activity; IEA:EC.
									GO:0006207; P:'de novo' pyrimidine base biosynthetic process; IEA:InterPro.::GO:0044205; P:'de novo' UMP biosynthetic process; IEA:InterPro.
60	Q01637	493	UMPS_DROME Uridine 5'-monophosphate synthase ...	268	1e-61	207	44	61	GO:0005875; C:microtubule associated complex; IDA:FlyBase.
									GO:0004588; F:orotate phosphoribosyltransferase activity; IMP:FlyBase.::GO:0004590; F:orotidine-5'-phosphate decarboxylase activity; IMP:FlyBase.
									GO:0006207; P:'de novo' pyrimidine base biosynthetic process; IC:FlyBase.::GO:0044205; P:'de novo' UMP biosynthetic process; IEA:InterPro.
61	P78748	396	PYRF_SORMK Orotidine 5'-phosphate decarboxyla...	226	5e-22	97.4	31	47
									GO:0004590; F:orotidine-5'-phosphate decarboxylase activity; IEA:EC.
									GO:0006207; P:'de novo' pyrimidine base biosynthetic process; IEA:InterPro.::GO:0006221; P:pyrimidine nucleotide biosynthetic process; IEA:UniProtKB-KW.

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