Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YEL012W
Length:
218
Number of sequences:
5887
Description:
YEL012W UBC8 SGDID:S000000738, Chr V from 131772-131776,131900-132551, Genome Release 64-1-1, Verified ORF, "Ubiquitin-conjugating enzyme that negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1,6-bisphosphatase (FBPase); cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
91Q5R7J6    152   UBE2N_PONAB Ubiquitin-conjugating enzyme E2 N...1283e-21     90.9     38     55GO:0035370; C:UBC13-UEV1A complex; ISS:UniProtKB.::GO:0000151; C:ubiquitin ligase complex; ISS:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.
GO:0070534; P:protein K63-linked ubiquitination; ISS:UniProtKB.
92P61089    152   UBE2N_MOUSE Ubiquitin-conjugating enzyme E2 N...1283e-21     90.9     38     55GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0005634; C:nucleus; ISS:UniProtKB.::GO:0031372; C:UBC13-MMS2 complex; ISS:HGNC.::GO:0035370; C:UBC13-UEV1A complex; ISS:UniProtKB.::GO:0000151; C:ubiquitin ligase complex; ISS:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0043130; F:ubiquitin binding; ISS:HGNC.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.
GO:0000729; P:DNA double-strand break processing; ISS:HGNC.::GO:0000724; P:double-strand break repair via homologous recombination; ISS:HGNC.::GO:0016574; P:histone ubiquitination; ISS:HGNC.::GO:0045739; P:positive regulation of DNA repair; ISS:HGNC.::GO:0031058; P:positive regulation of histone modification; ISS:HGNC.::GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; ISS:HGNC.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISS:HGNC.::GO:0051443; P:positive regulation of ubiquitin-protein ligase activity; ISS:HGNC.::GO:0006301; P:postreplication repair; ISS:HGNC.::GO:0070534; P:protein K63-linked ubiquitination; ISS:UniProtKB.::GO:0033182; P:regulation of histone ubiquitination; ISS:HGNC.::GO:0050852; P:T cell receptor signaling pathway; ISS:HGNC.::GO:0006511; P:ubiquitin-dependent protein catabolic process; IDA:MGI.
93P61088    152   UBE2N_HUMAN Ubiquitin-conjugating enzyme E2 N...1283e-21     90.9     38     55GO:0005829; C:cytosol; TAS:Reactome.::GO:0005634; C:nucleus; IDA:UniProtKB.::GO:0031372; C:UBC13-MMS2 complex; IDA:HGNC.::GO:0035370; C:UBC13-UEV1A complex; IDA:UniProtKB.::GO:0000151; C:ubiquitin ligase complex; IDA:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0043130; F:ubiquitin binding; IDA:HGNC.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB.
GO:0019221; P:cytokine-mediated signaling pathway; TAS:Reactome.::GO:0000729; P:DNA double-strand break processing; IMP:HGNC.::GO:0000724; P:double-strand break repair via homologous recombination; IMP:HGNC.::GO:0016574; P:histone ubiquitination; IMP:HGNC.::GO:0045087; P:innate immune response; TAS:Reactome.::GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; TAS:Reactome.::GO:0070423; P:nucleotide-binding oligomerization domain containing signaling pathway; TAS:Reactome.::GO:0045739; P:positive regulation of DNA repair; IMP:HGNC.::GO:0031058; P:positive regulation of histone modification; IMP:HGNC.::GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IMP:HGNC.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IMP:UniProtKB.::GO:0051443; P:positive regulation of ubiquitin-protein ligase activity; IMP:HGNC.::GO:0006301; P:postreplication repair; IMP:HGNC.::GO:0070534; P:protein K63-linked ubiquitination; IDA:UniProtKB.::GO:0033182; P:regulation of histone ubiquitination; IMP:HGNC.::GO:0050852; P:T cell receptor signaling pathway; IMP:UniProtKB.::GO:0008063; P:Toll signaling pathway; TAS:Reactome.::GO:0034130; P:toll-like receptor 1 signaling pathway; TAS:Reactome.::GO:0034134; P:toll-like receptor 2 signaling pathway; TAS:Reactome.::GO:0034142; P:toll-like receptor 4 signaling pathway; TAS:Reactome.
94Q0P5K3    152   UBE2N_BOVIN Ubiquitin-conjugating enzyme E2 N...1283e-21     90.9     38     55GO:0035370; C:UBC13-UEV1A complex; ISS:UniProtKB.::GO:0000151; C:ubiquitin ligase complex; ISS:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.
GO:0070534; P:protein K63-linked ubiquitination; ISS:UniProtKB.
95Q9EQX9    152   UBE2N_RAT Ubiquitin-conjugating enzyme E2 N O...1283e-21     90.9     38     55GO:0035370; C:UBC13-UEV1A complex; ISS:UniProtKB.::GO:0000151; C:ubiquitin ligase complex; ISS:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.
GO:0006281; P:DNA repair; IEA:UniProtKB-KW.::GO:0070534; P:protein K63-linked ubiquitination; ISS:UniProtKB.::GO:0006511; P:ubiquitin-dependent protein catabolic process; TAS:RGD.
96P21734    215   UBC1_YEAST Ubiquitin-conjugating enzyme E2 1 ...1193e-21     92     37     61GO:0000502; C:proteasome complex; IPI:SGD.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:SGD.
GO:0006897; P:endocytosis; TAS:SGD.::GO:0030433; P:ER-associated protein catabolic process; IMP:SGD.::GO:0006513; P:protein monoubiquitination; TAS:SGD.::GO:0000209; P:protein polyubiquitination; TAS:SGD.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IMP:SGD.::GO:0006950; P:response to stress; IEA:UniProtKB-KW.::GO:0009847; P:spore germination; TAS:SGD.::GO:0016050; P:vesicle organization; IMP:SGD.
97Q95044    177   UBE2C_SPISO Ubiquitin-conjugating enzyme E2 C...1443e-21     91.3     38     58
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004842; F:ubiquitin-protein ligase activity; IEA:EC.
GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.
98Q86K32    154   UBE2N_DICDI Probable ubiquitin-conjugating en...1502e-20     89     35     51
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004842; F:ubiquitin-protein ligase activity; IEA:EC.
GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
99P56616    179   UBE2C_XENLA Ubiquitin-conjugating enzyme E2 C...1482e-20     89     36     57GO:0005680; C:anaphase-promoting complex; ISS:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004842; F:ubiquitin-protein ligase activity; IEA:EC.
GO:0031145; P:anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; ISS:UniProtKB.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0010458; P:exit from mitosis; ISS:UniProtKB.::GO:0010994; P:free ubiquitin chain polymerization; ISS:UniProtKB.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0070979; P:protein K11-linked ubiquitination; ISS:UniProtKB.
100Q32LD2    195   UBE2T_BOVIN Ubiquitin-conjugating enzyme E2 T...1298e-20     87.8     33     60GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003682; F:chromatin binding; ISS:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.
GO:0006281; P:DNA repair; ISS:UniProtKB.::GO:0051865; P:protein autoubiquitination; ISS:UniProtKB.::GO:0070979; P:protein K11-linked ubiquitination; ISS:UniProtKB.::GO:0044314; P:protein K27-linked ubiquitination; ISS:UniProtKB.::GO:0035519; P:protein K29-linked ubiquitination; ISS:UniProtKB.::GO:0070936; P:protein K48-linked ubiquitination; ISS:UniProtKB.::GO:0085020; P:protein K6-linked ubiquitination; ISS:UniProtKB.::GO:0070534; P:protein K63-linked ubiquitination; ISS:UniProtKB.::GO:0006513; P:protein monoubiquitination; ISS:UniProtKB.
101P52492    156   UBC11_YEAST Ubiquitin-conjugating enzyme E2-1...1389e-20     87     35     61GO:0005737; C:cytoplasm; IC:SGD.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004842; F:ubiquitin-protein ligase activity; IEA:EC.
GO:0006513; P:protein monoubiquitination; TAS:SGD.::GO:0000209; P:protein polyubiquitination; TAS:SGD.
102O00762    179   UBE2C_HUMAN Ubiquitin-conjugating enzyme E2 C...1482e-19     86.7     33     57GO:0005680; C:anaphase-promoting complex; IDA:UniProtKB.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB.
GO:0051488; P:activation of anaphase-promoting complex activity; TAS:UniProtKB.::GO:0031145; P:anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; IDA:UniProtKB.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0008054; P:cyclin catabolic process; IDA:UniProtKB.::GO:0010458; P:exit from mitosis; IMP:UniProtKB.::GO:0010994; P:free ubiquitin chain polymerization; IDA:UniProtKB.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0007094; P:mitotic cell cycle spindle assembly checkpoint; TAS:Reactome.::GO:0051436; P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; TAS:Reactome.::GO:0048015; P:phosphatidylinositol-mediated signaling; NAS:UniProtKB.::GO:0031536; P:positive regulation of exit from mitosis; IMP:UniProtKB.::GO:0051437; P:positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; TAS:Reactome.::GO:0070979; P:protein K11-linked ubiquitination; IDA:UniProtKB.::GO:0070936; P:protein K48-linked ubiquitination; IDA:UniProtKB.::GO:0007051; P:spindle organization; NAS:UniProtKB.
103Q9LJZ5    181   UBC19_ARATH Ubiquitin-conjugating enzyme E2 1...1252e-19     86.7     38     60GO:0005737; C:cytoplasm; IDA:TAIR.::GO:0005634; C:nucleus; IDA:TAIR.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:TAIR.
GO:0008283; P:cell proliferation; IEP:TAIR.::GO:0006511; P:ubiquitin-dependent protein catabolic process; IDA:TAIR.
104Q4R9D1    179   UBE2C_MACFA Ubiquitin-conjugating enzyme E2 C...1482e-19     86.3     33     57GO:0005680; C:anaphase-promoting complex; ISS:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.
GO:0031145; P:anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; ISS:UniProtKB.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0010458; P:exit from mitosis; ISS:UniProtKB.::GO:0010994; P:free ubiquitin chain polymerization; ISS:UniProtKB.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0070979; P:protein K11-linked ubiquitination; ISS:UniProtKB.::GO:0070936; P:protein K48-linked ubiquitination; ISS:UniProtKB.
105P61087    200   UBE2K_MOUSE Ubiquitin-conjugating enzyme E2 K...1036e-19     85.5     34     61GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0031625; F:ubiquitin protein ligase binding; ISS:UniProtKB.
GO:0070936; P:protein K48-linked ubiquitination; ISS:UniProtKB.
106P61086    200   UBE2K_HUMAN Ubiquitin-conjugating enzyme E2 K...1036e-19     85.5     34     61GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0031625; F:ubiquitin protein ligase binding; IPI:UniProtKB.::GO:0034450; F:ubiquitin-ubiquitin ligase activity; IDA:UniProtKB.
GO:0070936; P:protein K48-linked ubiquitination; IDA:UniProtKB.::GO:0006511; P:ubiquitin-dependent protein catabolic process; TAS:ProtInc.
107P61085    200   UBE2K_BOVIN Ubiquitin-conjugating enzyme E2 K...1036e-19     85.5     34     61GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0031625; F:ubiquitin protein ligase binding; ISS:UniProtKB.
GO:0070936; P:protein K48-linked ubiquitination; ISS:UniProtKB.
108Q54XS6    153   UBE2C_DICDI Probable ubiquitin-conjugating en...1496e-19     84.7     34     58
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004842; F:ubiquitin-protein ligase activity; IEA:EC.
109Q32PA5    179   UBE2C_BOVIN Ubiquitin-conjugating enzyme E2 C...1486e-19     85.1     32     57GO:0005680; C:anaphase-promoting complex; ISS:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.
GO:0031145; P:anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; ISS:UniProtKB.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0010458; P:exit from mitosis; ISS:UniProtKB.::GO:0010994; P:free ubiquitin chain polymerization; ISS:UniProtKB.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0070979; P:protein K11-linked ubiquitination; ISS:UniProtKB.::GO:0070936; P:protein K48-linked ubiquitination; ISS:UniProtKB.
110Q9NPD8    197   UBE2T_HUMAN Ubiquitin-conjugating enzyme E2 T...1309e-19     85.1     33     58GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003682; F:chromatin binding; IDA:UniProtKB.::GO:0031625; F:ubiquitin protein ligase binding; IPI:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB.
GO:0006281; P:DNA repair; IMP:UniProtKB.::GO:0051865; P:protein autoubiquitination; IDA:UniProtKB.::GO:0070979; P:protein K11-linked ubiquitination; IDA:UniProtKB.::GO:0044314; P:protein K27-linked ubiquitination; IDA:UniProtKB.::GO:0035519; P:protein K29-linked ubiquitination; IDA:UniProtKB.::GO:0070936; P:protein K48-linked ubiquitination; IDA:UniProtKB.::GO:0085020; P:protein K6-linked ubiquitination; IDA:UniProtKB.::GO:0070534; P:protein K63-linked ubiquitination; IDA:UniProtKB.::GO:0006513; P:protein monoubiquitination; IDA:UniProtKB.
111Q9FI61    192   UBC27_ARATH Ubiquitin-conjugating enzyme E2 2...1541e-18     84.7     31     51GO:0005829; C:cytosol; IDA:TAIR.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:TAIR.
GO:0006511; P:ubiquitin-dependent protein catabolic process; IDA:TAIR.
112P52486    199   UBCD4_DROME Ubiquitin-conjugating enzyme E2-2...1051e-18     84.3     34     60
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004842; F:ubiquitin-protein ligase activity; IEA:EC.
113Q9CQ37    204   UBE2T_MOUSE Ubiquitin-conjugating enzyme E2 T...1642e-18     84     29     54GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003682; F:chromatin binding; ISS:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.
GO:0006281; P:DNA repair; ISS:UniProtKB.::GO:0051865; P:protein autoubiquitination; ISS:UniProtKB.::GO:0070979; P:protein K11-linked ubiquitination; ISS:UniProtKB.::GO:0044314; P:protein K27-linked ubiquitination; ISS:UniProtKB.::GO:0035519; P:protein K29-linked ubiquitination; ISS:UniProtKB.::GO:0070936; P:protein K48-linked ubiquitination; ISS:UniProtKB.::GO:0085020; P:protein K6-linked ubiquitination; ISS:UniProtKB.::GO:0070534; P:protein K63-linked ubiquitination; ISS:UniProtKB.::GO:0006513; P:protein monoubiquitination; ISS:UniProtKB.
114P52483    207   UB2E3_MOUSE Ubiquitin-conjugating enzyme E2 E...1513e-18     83.6     30     54GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.
GO:0070979; P:protein K11-linked ubiquitination; ISS:UniProtKB.::GO:0070936; P:protein K48-linked ubiquitination; ISS:UniProtKB.::GO:0070534; P:protein K63-linked ubiquitination; ISS:UniProtKB.::GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
115Q969T4    207   UB2E3_HUMAN Ubiquitin-conjugating enzyme E2 E...1513e-18     83.6     30     54GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005730; C:nucleolus; IDA:HPA.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB.
GO:0070979; P:protein K11-linked ubiquitination; IDA:UniProtKB.::GO:0070936; P:protein K48-linked ubiquitination; IDA:UniProtKB.::GO:0070534; P:protein K63-linked ubiquitination; IDA:UniProtKB.::GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
116Q2T9X7    207   UB2E3_BOVIN Ubiquitin-conjugating enzyme E2 E...1513e-18     83.6     30     54GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.
GO:0070979; P:protein K11-linked ubiquitination; ISS:UniProtKB.::GO:0070936; P:protein K48-linked ubiquitination; ISS:UniProtKB.::GO:0070534; P:protein K63-linked ubiquitination; ISS:UniProtKB.::GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
117Q941B6    409   UBC37_ARATH Probable ubiquitin-conjugating en...1144e-18     85.5     37     59
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004842; F:ubiquitin-protein ligase activity; IEA:EC.
118Q91W82    201   UB2E2_MOUSE Ubiquitin-conjugating enzyme E2 E...1514e-18     83.2     30     54
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004842; F:ubiquitin-protein ligase activity; IEA:EC.
119Q96LR5    201   UB2E2_HUMAN Ubiquitin-conjugating enzyme E2 E...1515e-18     83.2     30     54GO:0005730; C:nucleolus; IDA:HPA.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0042296; F:ISG15 ligase activity; IDA:HGNC.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB.
GO:0032020; P:ISG15-protein conjugation; IDA:HGNC.::GO:0070979; P:protein K11-linked ubiquitination; IDA:UniProtKB.::GO:0070936; P:protein K48-linked ubiquitination; IDA:UniProtKB.::GO:0070534; P:protein K63-linked ubiquitination; IDA:UniProtKB.
120Q9P6I1    160   UBC16_SCHPO Ubiquitin-conjugating enzyme E2 1...1536e-18     82     33     51GO:0005829; C:cytosol; IDA:PomBase.::GO:0005634; C:nucleus; IDA:PomBase.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:PomBase.
GO:0007031; P:peroxisome organization; ISS:PomBase.
121Q75AF2    184   UBC12_ASHGO NEDD8-conjugating enzyme UBC12 OS...1049e-18     82     42     60
GO:0016881; F:acid-amino acid ligase activity; IEA:InterPro.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
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