Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YDR490C
Length:
766
Number of sequences:
5887
Description:
YDR490C PKH1 SGDID:S000002898, Chr IV from 1434268-1431968, Genome Release 64-1-1, reverse complement, Verified ORF, "Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh2p"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
901P18653    724   KS6A1_MOUSE Ribosomal protein S6 kinase alpha...2737e-23     107     31     47GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0005819; C:spindle; IDA:MGI.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB.
GO:0007243; P:intracellular protein kinase cascade; IEA:InterPro.::GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.::GO:2000491; P:positive regulation of hepatic stellate cell activation; ISS:UniProtKB.
902Q8BTW9    593   PAK4_MOUSE Serine/threonine-protein kinase PA...2737e-23     107     29     50GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
903Q15831    433   STK11_HUMAN Serine/threonine-protein kinase S...2837e-23     105     29     48GO:0005737; C:cytoplasm; IDA:UniProtKB.::GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0016020; C:membrane; ISS:UniProtKB.::GO:0005739; C:mitochondrion; IDA:UniProtKB.::GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0005524; F:ATP binding; IDA:UniProtKB.::GO:0000287; F:magnesium ion binding; IDA:UniProtKB.::GO:0002039; F:p53 binding; IDA:UniProtKB.::GO:0030295; F:protein kinase activator activity; IDA:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO:0043276; P:anoikis; IMP:BHF-UCL.::GO:0006914; P:autophagy; IEA:UniProtKB-KW.::GO:0007050; P:cell cycle arrest; IDA:UniProtKB.::GO:0006112; P:energy reserve metabolic process; TAS:Reactome.::GO:0030010; P:establishment of cell polarity; ISS:UniProtKB.::GO:0042593; P:glucose homeostasis; ISS:UniProtKB.::GO:0008286; P:insulin receptor signaling pathway; TAS:Reactome.::GO:0030308; P:negative regulation of cell growth; ISS:UniProtKB.::GO:0030511; P:positive regulation of transforming growth factor beta receptor signaling pathway; IMP:BHF-UCL.::GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.::GO:0042304; P:regulation of fatty acid biosynthetic process; TAS:Reactome.::GO:0046320; P:regulation of fatty acid oxidation; TAS:Reactome.::GO:0006974; P:response to DNA damage stimulus; IEA:UniProtKB-KW.::GO:0010212; P:response to ionizing radiation; ISS:UniProtKB.::GO:0072332; P:signal transduction by p53 class mediator resulting in induction of apoptosis; IDA:UniProtKB.::GO:0044281; P:small molecule metabolic process; TAS:Reactome.::GO:0001944; P:vasculature development; ISS:UniProtKB.
904O96013    591   PAK4_HUMAN Serine/threonine-protein kinase PA...2737e-23     107     29     50GO:0005794; C:Golgi apparatus; TAS:ProtInc.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0006915; P:apoptotic process; TAS:UniProtKB.::GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0016049; P:cell growth; TAS:UniProtKB.::GO:0016477; P:cell migration; TAS:UniProtKB.::GO:0008283; P:cell proliferation; TAS:UniProtKB.::GO:0007010; P:cytoskeleton organization; TAS:UniProtKB.::GO:0007165; P:signal transduction; TAS:UniProtKB.
905Q9URY1    672   PPK16_SCHPO Serine/threonine-protein kinase p...2917e-23     107     27     45GO:0032153; C:cell division site; IDA:PomBase.::GO:0051286; C:cell tip; IDA:PomBase.::GO:0005829; C:cytosol; IDA:PomBase.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; TAS:PomBase.
GO:0051519; P:activation of bipolar cell growth; IMP:PomBase.::GO:0007126; P:meiosis; IEA:UniProtKB-KW.::GO:0007165; P:signal transduction; NAS:PomBase.
906O70405    1051   ULK1_MOUSE Serine/threonine-protein kinase UL...2367e-23     108     29     50GO:0030659; C:cytoplasmic vesicle membrane; IDA:MGI.::GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0005624; C:membrane fraction; IDA:MGI.::GO:0043005; C:neuron projection; IDA:MGI.::GO:0043025; C:neuronal cell body; IDA:MGI.::GO:0034045; C:pre-autophagosomal structure membrane; IDA:UniProtKB.::GO:0070969; C:ULK1-ATG13-FIP200 complex; IPI:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0019901; F:protein kinase binding; IPI:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO:0000045; P:autophagic vacuole assembly; IMP:UniProtKB.::GO:0048675; P:axon extension; IMP:MGI.::GO:0021707; P:cerebellar granule cell differentiation; IMP:MGI.::GO:0048671; P:negative regulation of collateral sprouting; IMP:MGI.::GO:0010508; P:positive regulation of autophagy; IMP:UniProtKB.::GO:0046777; P:protein autophosphorylation; IDA:MGI.::GO:0008104; P:protein localization; ISS:UniProtKB.::GO:0021933; P:radial glia guided migration of cerebellar granule cell; IMP:MGI.::GO:0007265; P:Ras protein signal transduction; IDA:MGI.::GO:0031623; P:receptor internalization; IMP:MGI.::GO:0051386; P:regulation of nerve growth factor receptor signaling pathway; IMP:MGI.
907Q94CU5    943   NEK5_ORYSJ Serine/threonine-protein kinase Ne...2677e-23     108     30     48
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
908Q8RX66    568   NEK3_ARATH Serine/threonine-protein kinase Ne...2677e-23     107     32     48
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
909B1WAS2    697   HUNK_XENTR Hormonally up-regulated neu tumor-...2827e-23     107     29     48
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
910Q90ZY4    385   SBK1_DANRE Serine/threonine-protein kinase SB...2838e-23     105     30     47GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
911Q7XKA8    370   SAPK5_ORYSJ Serine/threonine-protein kinase S...2028e-23     104     32     53
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0009738; P:abscisic acid mediated signaling pathway; IEA:UniProtKB-KW.
912Q8C0V7    499   SMKW_MOUSE Sperm motility kinase W OS=Mus mus...2788e-23     106     27     46
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004672; F:protein kinase activity; IEA:InterPro.
913O14047    312   PPK11_SCHPO Serine/threonine-protein kinase p...2679e-23     103     29     47GO:0032153; C:cell division site; IDA:PomBase.::GO:0005829; C:cytosol; IDA:PomBase.::GO:0005634; C:nucleus; IDA:PomBase.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; TAS:PomBase.
GO:0051519; P:activation of bipolar cell growth; IMP:PomBase.
914Q8IYT8    1036   ULK2_HUMAN Serine/threonine-protein kinase UL...2309e-23     108     27     52GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.::GO:0034045; C:pre-autophagosomal structure membrane; IDA:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO:0006914; P:autophagy; IEA:UniProtKB-KW.::GO:0007409; P:axonogenesis; IEA:InterPro.::GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.::GO:0010506; P:regulation of autophagy; IDA:UniProtKB.::GO:0042594; P:response to starvation; ISS:UniProtKB.::GO:0007165; P:signal transduction; IEA:InterPro.
915Q54XJ4    1495   Y8901_DICDI Probable serine/threonine-protein...2009e-23     108     28     50
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
916Q95QC4    802   DCLK_CAEEL Serine/threonine-protein kinase zy...2731e-22     107     29     51GO:0005813; C:centrosome; IDA:WormBase.::GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004683; F:calmodulin-dependent protein kinase activity; ISS:WormBase.::GO:0008017; F:microtubule binding; IDA:WormBase.
GO:0010171; P:body morphogenesis; IMP:WormBase.::GO:0040001; P:establishment of mitotic spindle localization; IMP:WormBase.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0040011; P:locomotion; IMP:WormBase.::GO:0007020; P:microtubule nucleation; IMP:WormBase.::GO:0046785; P:microtubule polymerization; IMP:WormBase.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.::GO:0007026; P:negative regulation of microtubule depolymerization; IDA:WormBase.
917Q9H1R3    596   MYLK2_HUMAN Myosin light chain kinase 2, skel...2731e-22     106     27     46GO:0005634; C:nucleus; IDA:UniProtKB.::GO:0030017; C:sarcomere; IC:BHF-UCL.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005516; F:calmodulin binding; ISS:BHF-UCL.::GO:0004683; F:calmodulin-dependent protein kinase activity; ISS:BHF-UCL.::GO:0004687; F:myosin light chain kinase activity; IDA:BHF-UCL.
GO:0060048; P:cardiac muscle contraction; IC:BHF-UCL.::GO:0055008; P:cardiac muscle tissue morphogenesis; IMP:BHF-UCL.::GO:0018107; P:peptidyl-threonine phosphorylation; IDA:UniProtKB.::GO:0010628; P:positive regulation of gene expression; IDA:UniProtKB.::GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.::GO:0032971; P:regulation of muscle filament sliding; IDA:BHF-UCL.::GO:0035914; P:skeletal muscle cell differentiation; IDA:UniProtKB.
918Q62925    1493   M3K1_RAT Mitogen-activated protein kinase kin...2741e-22     108     26     45GO:0005737; C:cytoplasm; IDA:RGD.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.::GO:0005624; C:membrane fraction; IDA:RGD.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008432; F:JUN kinase binding; IPI:RGD.::GO:0004706; F:JUN kinase kinase kinase activity; IDA:RGD.::GO:0004710; F:MAPK/ERK kinase kinase activity; IDA:RGD.::GO:0051019; F:mitogen-activated protein kinase binding; IPI:RGD.::GO:0031434; F:mitogen-activated protein kinase kinase binding; IPI:RGD.::GO:0046625; F:sphingolipid binding; IPI:RGD.::GO:0004842; F:ubiquitin-protein ligase activity; IMP:RGD.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0032232; P:negative regulation of actin filament bundle assembly; IDA:RGD.::GO:0018105; P:peptidyl-serine phosphorylation; IDA:RGD.::GO:0043065; P:positive regulation of apoptotic process; IMP:RGD.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:RGD.::GO:0050434; P:positive regulation of viral transcription; IDA:RGD.::GO:0046777; P:protein autophosphorylation; IDA:RGD.::GO:0051259; P:protein oligomerization; IDA:RGD.::GO:0000209; P:protein polyubiquitination; IMP:RGD.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IGI:RGD.::GO:0006970; P:response to osmotic stress; IMP:RGD.
919Q8WTQ7    553   GRK7_HUMAN G protein-coupled receptor kinase ...2811e-22     106     30     48GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004703; F:G-protein coupled receptor kinase activity; IEA:EC.::GO:0050254; F:rhodopsin kinase activity; IDA:UniProtKB.
GO:0046777; P:protein autophosphorylation; IMP:UniProtKB.::GO:0007165; P:signal transduction; IEA:InterPro.::GO:0038032; P:termination of G-protein coupled receptor signaling pathway; IEA:InterPro.::GO:0007601; P:visual perception; IEA:UniProtKB-KW.
920Q9C958    361   SRK2B_ARATH Serine/threonine-protein kinase S...1981e-22     104     34     51
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0009651; P:response to salt stress; IDA:TAIR.
921O59697    423   PPK25_SCHPO Serine/threonine-protein kinase p...2691e-22     104     27     48GO:0005829; C:cytosol; IDA:PomBase.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; TAS:PomBase.
GO:0007165; P:signal transduction; NAS:PomBase.
922P31374    1356   PSK1_YEAST Serine/threonine-protein kinase PS...2841e-22     107     29     48GO:0005737; C:cytoplasm; IDA:SGD.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IMP:SGD.::GO:0004871; F:signal transducer activity; IEA:InterPro.
GO:0045719; P:negative regulation of glycogen biosynthetic process; IMP:SGD.::GO:0060917; P:regulation of (1->6)-beta-D-glucan biosynthetic process; IGI:SGD.::GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
923Q9P286    719   PAK7_HUMAN Serine/threonine-protein kinase PA...2732e-22     106     27     51GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0006915; P:apoptotic process; TAS:UniProtKB.::GO:0016049; P:cell growth; TAS:UniProtKB.::GO:0016477; P:cell migration; TAS:UniProtKB.::GO:0008283; P:cell proliferation; TAS:UniProtKB.::GO:0007010; P:cytoskeleton organization; TAS:UniProtKB.::GO:0007165; P:signal transduction; TAS:UniProtKB.
924O62305    720   KCC2D_CAEEL Calcium/calmodulin-dependent prot...2682e-22     106     28     47GO:0005954; C:calcium- and calmodulin-dependent protein kinase complex; TAS:UniProtKB.::GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0043005; C:neuron projection; IDA:WormBase.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0009931; F:calcium-dependent protein serine/threonine kinase activity; IDA:WormBase.::GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0004683; F:calmodulin-dependent protein kinase activity; IDA:WormBase.::GO:0044325; F:ion channel binding; IPI:WormBase.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0040011; P:locomotion; IMP:WormBase.::GO:0007067; P:mitosis; IMP:WormBase.::GO:0018107; P:peptidyl-threonine phosphorylation; IDA:WormBase.::GO:0006950; P:response to stress; IEA:UniProtKB-KW.
925Q0WPH8    956   NEK5_ARATH Serine/threonine-protein kinase Ne...2732e-22     107     29     49GO:0055028; C:cortical microtubule; IDA:TAIR.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0009913; P:epidermal cell differentiation; IMP:TAIR.::GO:0007017; P:microtubule-based process; IMP:TAIR.
926Q8C015    719   PAK7_MOUSE Serine/threonine-protein kinase PA...2732e-22     106     27     51GO:0005739; C:mitochondrion; IDA:MGI.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IDA:MGI.
GO:0006916; P:anti-apoptosis; IDA:MGI.::GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
927Q9PU85    323   PIM3_COTJA Serine/threonine-protein kinase pi...2782e-22     103     28     47GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
928D4A280    718   PAK7_RAT Serine/threonine-protein kinase PAK ...2732e-22     106     27     51GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
929Q0UY20    972   ATG1_PHANO Serine/threonine-protein kinase at...3222e-22     106     24     44GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0006914; P:autophagy; IEA:UniProtKB-KW.::GO:0015031; P:protein transport; IEA:UniProtKB-KW.
930Q5UQ78    450   YR517_MIMIV Putative serine/threonine-protein...2932e-22     104     29     45
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
931Q3UIZ8    795   MYLK3_MOUSE Putative myosin light chain kinas...2712e-22     106     27     46GO:0005737; C:cytoplasm; IDA:BHF-UCL.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004683; F:calmodulin-dependent protein kinase activity; IDA:BHF-UCL.::GO:0004687; F:myosin light chain kinase activity; IDA:BHF-UCL.
GO:0045214; P:sarcomere organization; IDA:BHF-UCL.
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