Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YDR490C
Length:
766
Number of sequences:
5887
Description:
YDR490C PKH1 SGDID:S000002898, Chr IV from 1434268-1431968, Genome Release 64-1-1, reverse complement, Verified ORF, "Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh2p"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
661Q8WU08    396   ST32A_HUMAN Serine/threonine-protein kinase 3...2833e-26     115     26     51
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
662P21146    689   ARBK1_BOVIN Beta-adrenergic receptor kinase 1...3263e-26     118     27     49GO:0005829; C:cytosol; IDA:BHF-UCL.::GO:0016020; C:membrane; IDA:BHF-UCL.
GO:0031694; F:alpha-2A adrenergic receptor binding; IPI:BHF-UCL.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0047696; F:beta-adrenergic receptor kinase activity; IEA:EC.::GO:0031755; F:Edg-2 lysophosphatidic acid receptor binding; ISS:UniProtKB.::GO:0004703; F:G-protein coupled receptor kinase activity; IDA:BHF-UCL.::GO:0005543; F:phospholipid binding; IEA:InterPro.
GO:0060048; P:cardiac muscle contraction; IMP:BHF-UCL.::GO:0007213; P:G-protein coupled acetylcholine receptor signaling pathway; IDA:BHF-UCL.::GO:0002031; P:G-protein coupled receptor internalization; IDA:UniProtKB.::GO:0007507; P:heart development; ISS:AgBase.::GO:0006886; P:intracellular protein transport; IMP:BHF-UCL.::GO:0045988; P:negative regulation of striated muscle contraction; IMP:BHF-UCL.::GO:0003108; P:negative regulation of the force of heart contraction by chemical signal; IMP:BHF-UCL.::GO:0018105; P:peptidyl-serine phosphorylation; IDA:BHF-UCL.::GO:0038032; P:termination of G-protein coupled receptor signaling pathway; IEA:InterPro.
663Q75GK4    447   CIPK7_ORYSJ CBL-interacting protein kinase 7 ...2763e-26     116     30     49
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0007165; P:signal transduction; IEA:InterPro.
664Q63433    946   PKN1_RAT Serine/threonine-protein kinase N1 O...2993e-26     119     29     49GO:0032154; C:cleavage furrow; ISS:UniProtKB.::GO:0005768; C:endosome; ISS:UniProtKB.::GO:0030496; C:midbody; ISS:UniProtKB.::GO:0005634; C:nucleus; ISS:UniProtKB.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0050681; F:androgen receptor binding; ISS:UniProtKB.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003682; F:chromatin binding; ISS:UniProtKB.::GO:0017049; F:GTP-Rho binding; ISS:UniProtKB.::GO:0042393; F:histone binding; ISS:UniProtKB.::GO:0042826; F:histone deacetylase binding; ISS:UniProtKB.::GO:0035402; F:histone kinase activity (H3-T11 specific); ISS:UniProtKB.::GO:0030374; F:ligand-dependent nuclear receptor transcription coactivator activity; ISS:UniProtKB.::GO:0004697; F:protein kinase C activity; IEA:EC.::GO:0048365; F:Rac GTPase binding; ISS:UniProtKB.
GO:0010631; P:epithelial cell migration; ISS:UniProtKB.::GO:2000145; P:regulation of cell motility; ISS:UniProtKB.::GO:0006357; P:regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.::GO:0007165; P:signal transduction; IEA:InterPro.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
665Q9Z265    546   CHK2_MOUSE Serine/threonine-protein kinase Ch...2893e-26     117     31     47GO:0016605; C:PML body; ISS:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB.
GO:0006915; P:apoptotic process; IMP:MGI.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0006975; P:DNA damage induced protein phosphorylation; ISS:UniProtKB.::GO:0008630; P:DNA damage response, signal transduction resulting in induction of apoptosis; ISS:UniProtKB.::GO:0006302; P:double-strand break repair; ISS:UniProtKB.::GO:0000086; P:G2/M transition of mitotic cell cycle; ISS:UniProtKB.::GO:0045893; P:positive regulation of transcription, DNA-dependent; ISS:UniProtKB.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.::GO:0042176; P:regulation of protein catabolic process; ISS:UniProtKB.::GO:0010332; P:response to gamma radiation; IDA:MGI.::GO:0072428; P:signal transduction involved in intra-S DNA damage checkpoint; ISS:UniProtKB.::GO:0090307; P:spindle assembly involved in mitosis; ISS:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
666Q8T2I8    1167   SEPA_DICDI Serine/threonine-protein kinase se...2784e-26     119     28     49GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0051301; P:cell division; IEA:UniProtKB-KW.
667Q9D2E1    268   TSSK3_MOUSE Testis-specific serine/threonine-...2674e-26     113     28     51GO:0005622; C:intracellular; IC:UniProtKB.
GO:0005524; F:ATP binding; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; ISS:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB.
GO:0035556; P:intracellular signal transduction; NAS:UniProtKB.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.::GO:0048240; P:sperm capacitation; NAS:UniProtKB.
668O70291    574   GRK4_MOUSE G protein-coupled receptor kinase ...2784e-26     117     30     51GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004703; F:G-protein coupled receptor kinase activity; IEA:EC.
GO:0007165; P:signal transduction; IEA:InterPro.::GO:0038032; P:termination of G-protein coupled receptor signaling pathway; IEA:InterPro.
669Q62070    370   PIM2_MOUSE Serine/threonine-protein kinase pi...2714e-26     115     28     47
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO:0006916; P:anti-apoptosis; IDA:MGI.::GO:0008637; P:apoptotic mitochondrial changes; IDA:MGI.::GO:0000082; P:G1/S transition of mitotic cell cycle; ISS:UniProtKB.::GO:0008285; P:negative regulation of cell proliferation; ISS:UniProtKB.::GO:0010508; P:positive regulation of autophagy; IMP:UniProtKB.::GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IDA:UniProtKB.::GO:0045893; P:positive regulation of transcription, DNA-dependent; IMP:UniProtKB.::GO:0050821; P:protein stabilization; IDA:UniProtKB.
670Q5RAJ5    1315   STK36_PONAB Serine/threonine-protein kinase 3...2705e-26     118     28     50GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0008134; F:transcription factor binding; ISS:UniProtKB.
GO:0042384; P:cilium assembly; ISS:UniProtKB.::GO:0007228; P:positive regulation of hh target transcription factor activity; ISS:UniProtKB.::GO:0045880; P:positive regulation of smoothened signaling pathway; ISS:UniProtKB.::GO:0009791; P:post-embryonic development; ISS:UniProtKB.
671Q99MK8    689   ARBK1_MOUSE Beta-adrenergic receptor kinase 1...3265e-26     117     26     49
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0047696; F:beta-adrenergic receptor kinase activity; IEA:EC.::GO:0004703; F:G-protein coupled receptor kinase activity; IDA:MGI.::GO:0005543; F:phospholipid binding; IEA:InterPro.
GO:0002029; P:desensitization of G-protein coupled receptor protein signaling pathway; IMP:MGI.::GO:0007507; P:heart development; IMP:MGI.::GO:0018105; P:peptidyl-serine phosphorylation; IDA:MGI.::GO:0018107; P:peptidyl-threonine phosphorylation; IDA:MGI.::GO:0038032; P:termination of G-protein coupled receptor signaling pathway; IEA:InterPro.
672Q8AYC9    476   CHK1_CHICK Serine/threonine-protein kinase Ch...2745e-26     115     28     48GO:0005813; C:centrosome; ISS:UniProtKB.::GO:0000785; C:chromatin; ISS:UniProtKB.::GO:0000794; C:condensed nuclear chromosome; ISS:UniProtKB.::GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0035402; F:histone kinase activity (H3-T11 specific); ISS:UniProtKB.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0048096; P:chromatin-mediated maintenance of transcription; ISS:UniProtKB.::GO:0006975; P:DNA damage induced protein phosphorylation; ISS:UniProtKB.::GO:0000724; P:double-strand break repair via homologous recombination; TAS:Reactome.::GO:0031572; P:G2/M transition DNA damage checkpoint; ISS:UniProtKB.::GO:0045839; P:negative regulation of mitosis; ISS:UniProtKB.::GO:0010569; P:regulation of double-strand break repair via homologous recombination; ISS:UniProtKB.::GO:2000615; P:regulation of histone H3-K9 acetylation; ISS:UniProtKB.::GO:0046602; P:regulation of mitotic centrosome separation; ISS:UniProtKB.::GO:0010767; P:regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage; ISS:UniProtKB.
673Q75H77    362   SAPKA_ORYSJ Serine/threonine-protein kinase S...3295e-26     114     27     48
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0009738; P:abscisic acid mediated signaling pathway; IEA:UniProtKB-KW.
674A0AUV4    508   SMKY_MOUSE Sperm motility kinase Y OS=Mus mus...2685e-26     116     29     47
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
675Q75V57    361   SAPK9_ORYSJ Serine/threonine-protein kinase S...2775e-26     114     29     49
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0009738; P:abscisic acid mediated signaling pathway; IEA:UniProtKB-KW.
676Q8G6P9    690   PKNB_BIFLO Probable serine/threonine-protein ...2746e-26     117     27     49
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008658; F:penicillin binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
677Q86UX6    486   ST32C_HUMAN Serine/threonine-protein kinase 3...2706e-26     115     28     48
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
678Q6PHR2    472   ULK3_HUMAN Serine/threonine-protein kinase UL...2776e-26     115     30     50GO:0000407; C:pre-autophagosomal structure; TAS:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO:0006914; P:autophagy; TAS:UniProtKB.::GO:0090398; P:cellular senescence; TAS:UniProtKB.::GO:0045879; P:negative regulation of smoothened signaling pathway; IDA:UniProtKB.::GO:0045880; P:positive regulation of smoothened signaling pathway; IDA:UniProtKB.::GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.
679P32866    714   GPRK2_DROME G protein-coupled receptor kinase...3326e-26     117     28     48GO:0005737; C:cytoplasm; IDA:FlyBase.::GO:0005886; C:plasma membrane; IDA:FlyBase.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004703; F:G-protein coupled receptor kinase activity; IMP:FlyBase.
GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0050830; P:defense response to Gram-positive bacterium; IMP:FlyBase.::GO:0007474; P:imaginal disc-derived wing vein specification; IMP:FlyBase.::GO:0048477; P:oogenesis; IEA:UniProtKB-KW.::GO:0002805; P:regulation of antimicrobial peptide biosynthetic process; IMP:FlyBase.::GO:0008589; P:regulation of smoothened signaling pathway; IDA:FlyBase.::GO:0008592; P:regulation of Toll signaling pathway; IGI:FlyBase.::GO:0007224; P:smoothened signaling pathway; IMP:FlyBase.::GO:0038032; P:termination of G-protein coupled receptor signaling pathway; IEA:InterPro.
680O96017    543   CHK2_HUMAN Serine/threonine-protein kinase Ch...2876e-26     116     32     48GO:0016605; C:PML body; IDA:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.::GO:0019901; F:protein kinase binding; IPI:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0044257; P:cellular protein catabolic process; IMP:UniProtKB.::GO:0006975; P:DNA damage induced protein phosphorylation; IMP:UniProtKB.::GO:0008630; P:DNA damage response, signal transduction resulting in induction of apoptosis; IDA:UniProtKB.::GO:0006302; P:double-strand break repair; IMP:UniProtKB.::GO:0000086; P:G2/M transition of mitotic cell cycle; IMP:UniProtKB.::GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:UniProtKB.::GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.::GO:0042176; P:regulation of protein catabolic process; IMP:UniProtKB.::GO:0090399; P:replicative senescence; NAS:BHF-UCL.::GO:0072428; P:signal transduction involved in intra-S DNA damage checkpoint; IMP:UniProtKB.::GO:0090307; P:spindle assembly involved in mitosis; IMP:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
681Q9NY57    414   ST32B_HUMAN Serine/threonine-protein kinase 3...2876e-26     114     28     51
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
682Q54W86    928   MYLKF_DICDI Probable myosin light chain kinas...3007e-26     117     29     48
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004687; F:myosin light chain kinase activity; IEA:EC.
683Q8BWW9    983   PKN2_MOUSE Serine/threonine-protein kinase N2...2807e-26     117     28     50GO:0043296; C:apical junction complex; IDA:UniProtKB.::GO:0032154; C:cleavage furrow; ISS:UniProtKB.::GO:0005737; C:cytoplasm; IDA:MGI.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0030027; C:lamellipodium; ISS:UniProtKB.::GO:0030496; C:midbody; ISS:UniProtKB.::GO:0005634; C:nucleus; IDA:MGI.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0042826; F:histone deacetylase binding; ISS:UniProtKB.::GO:0004697; F:protein kinase C activity; IEA:EC.
GO:0043297; P:apical junction assembly; IDA:UniProtKB.::GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.::GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0010631; P:epithelial cell migration; ISS:UniProtKB.::GO:0071777; P:positive regulation of cell cycle cytokinesis; ISS:UniProtKB.::GO:0045931; P:positive regulation of mitotic cell cycle; ISS:UniProtKB.::GO:2000145; P:regulation of cell motility; ISS:UniProtKB.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0007165; P:signal transduction; IEA:InterPro.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
684Q64682    689   ARBK1_MESAU Beta-adrenergic receptor kinase 1...3267e-26     117     27     49
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0047696; F:beta-adrenergic receptor kinase activity; IEA:EC.::GO:0004703; F:G-protein coupled receptor kinase activity; IEA:InterPro.::GO:0005543; F:phospholipid binding; IEA:InterPro.
GO:0007165; P:signal transduction; IEA:InterPro.::GO:0038032; P:termination of G-protein coupled receptor signaling pathway; IEA:InterPro.
685O77708    533   KCC2D_RABIT Calcium/calmodulin-dependent prot...2737e-26     115     30     49GO:0005954; C:calcium- and calmodulin-dependent protein kinase complex; TAS:UniProtKB.::GO:0033017; C:sarcoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0004683; F:calmodulin-dependent protein kinase activity; IEA:EC.
GO:0010613; P:positive regulation of cardiac muscle hypertrophy; ISS:UniProtKB.::GO:0060341; P:regulation of cellular localization; ISS:UniProtKB.
686P15791    533   KCC2D_RAT Calcium/calmodulin-dependent protei...2739e-26     115     30     49GO:0005954; C:calcium- and calmodulin-dependent protein kinase complex; TAS:UniProtKB.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0033017; C:sarcoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0004683; F:calmodulin-dependent protein kinase activity; IEA:EC.
GO:0010613; P:positive regulation of cardiac muscle hypertrophy; ISS:UniProtKB.::GO:0060341; P:regulation of cellular localization; ISS:UniProtKB.
687Q9YHZ5    310   PIM2_DANRE Serine/threonine-protein kinase pi...2941e-25     113     28     46
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0030097; P:hemopoiesis; NAS:ZFIN.
688Q6P5Z2    889   PKN3_HUMAN Serine/threonine-protein kinase N3...2831e-25     117     28     49GO:0005794; C:Golgi apparatus; TAS:ProtInc.::GO:0005634; C:nucleus; TAS:ProtInc.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004697; F:protein kinase C activity; IEA:EC.
GO:0010631; P:epithelial cell migration; IDA:UniProtKB.::GO:0007165; P:signal transduction; TAS:ProtInc.
689Q80YE7    1442   DAPK1_MOUSE Death-associated protein kinase 1...2741e-25     117     28     49GO:0005829; C:cytosol; TAS:Reactome.
GO:0005524; F:ATP binding; IDA:UniProtKB.::GO:0005516; F:calmodulin binding; IDA:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0006916; P:anti-apoptosis; IMP:UniProtKB.::GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:ProtInc.::GO:0007243; P:intracellular protein kinase cascade; IDA:UniProtKB.::GO:2000310; P:regulation of N-methyl-D-aspartate selective glutamate receptor activity; IMP:UniProtKB.
690P0C5D6    334   SAPK3_ORYSJ Serine/threonine-protein kinase S...2721e-25     113     30     49
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0009738; P:abscisic acid mediated signaling pathway; IEA:UniProtKB-KW.
691A2ZAB5    334   SAPK3_ORYSI Serine/threonine-protein kinase S...2721e-25     113     30     49
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0009738; P:abscisic acid mediated signaling pathway; IEA:UniProtKB-KW.
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