UniProt_SwissProt BLAST: Single locus

Species:

Saccharomyces cerevisiae S288C

Locus:

YDR490C

Length:

766

Number of sequences:

5887

Description:

YDR490C PKH1 SGDID:S000002898, Chr IV from 1434268-1431968, Genome Release 64-1-1, reverse complement, Verified ORF, "Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh2p"

rec.	Subject	Hit Length	Description	Align.Len	E value	Bit score	% ident.	% pos.	GO associations
571	Q95ZQ4	626	AAPK2_CAEEL 5'-AMP-activated protein kinase c...	276	3e-28	124	29	49	GO:0030424; C:axon; IDA:WormBase.::GO:0005737; C:cytoplasm; IDA:WormBase.::GO:0043025; C:neuronal cell body; IDA:WormBase.
									GO:0004679; F:AMP-activated protein kinase activity; IDA:WormBase.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.
									GO:0008340; P:determination of adult lifespan; IMP:WormBase.::GO:0051729; P:germline cell cycle switching, mitotic to meiotic cell cycle; IMP:WormBase.::GO:0018105; P:peptidyl-serine phosphorylation; IDA:WormBase.::GO:0061066; P:positive regulation of dauer larval development; IGI:WormBase.::GO:0006950; P:response to stress; IEA:UniProtKB-KW.
572	B4MXR8	787	PLK4_DROWI Serine/threonine-protein kinase PL...	274	3e-28	125	28	50	GO:0005814; C:centriole; IEA:UniProtKB-SubCell.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004713; F:protein tyrosine kinase activity; IEA:InterPro.
573	Q9LYQ8	456	CIPK2_ARATH CBL-interacting serine/threonine-...	270	3e-28	122	32	53
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
									GO:0007165; P:signal transduction; IEA:InterPro.
574	Q5R7G9	628	NUAK2_PONAB NUAK family SNF1-like kinase 2 OS...	270	3e-28	124	29	49
									GO:0005524; F:ATP binding; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; ISS:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB.
									GO:0030036; P:actin cytoskeleton organization; ISS:UniProtKB.::GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0042149; P:cellular response to glucose starvation; ISS:UniProtKB.::GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
575	Q66HE5	630	NUAK2_RAT NUAK family SNF1-like kinase 2 OS=R...	270	3e-28	124	29	49
									GO:0005524; F:ATP binding; IDA:UniProtKB.::GO:0000287; F:magnesium ion binding; IDA:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
									GO:0030036; P:actin cytoskeleton organization; ISS:UniProtKB.::GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0042149; P:cellular response to glucose starvation; IDA:UniProtKB.::GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
576	Q9BYT3	514	STK33_HUMAN Serine/threonine-protein kinase 3...	274	3e-28	122	28	50	GO:0005794; C:Golgi apparatus; IDA:HPA.::GO:0005634; C:nucleus; IDA:HPA.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB.
									GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.
577	Q9H093	628	NUAK2_HUMAN NUAK family SNF1-like kinase 2 OS...	270	3e-28	124	29	49
									GO:0005524; F:ATP binding; IDA:UniProtKB.::GO:0000287; F:magnesium ion binding; IDA:UniProtKB.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
									GO:0030036; P:actin cytoskeleton organization; IDA:UniProtKB.::GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0042149; P:cellular response to glucose starvation; IDA:UniProtKB.::GO:0043066; P:negative regulation of apoptotic process; IDA:UniProtKB.
578	Q1PE17	534	CDPKI_ARATH Calcium-dependent protein kinase ...	278	3e-28	123	31	48	GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
579	P11801	424	KPSH1_HUMAN Serine/threonine-protein kinase H...	266	4e-28	122	30	50	GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.::GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
									GO:0005524; F:ATP binding; NAS:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; NAS:UniProtKB.
580	P06782	633	SNF1_YEAST Carbon catabolite-derepressing pro...	292	4e-28	124	28	53	GO:0031588; C:AMP-activated protein kinase complex; IDA:SGD.::GO:0000324; C:fungal-type vacuole; IPI:SGD.::GO:0005739; C:mitochondrion; IDA:SGD.::GO:0005641; C:nuclear envelope lumen; IDA:SGD.::GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
									GO:0004679; F:AMP-activated protein kinase activity; IDA:SGD.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.
									GO:0042710; P:biofilm formation; IMP:SGD.::GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW.::GO:0007155; P:cell adhesion; IMP:SGD.::GO:0006995; P:cellular response to nitrogen starvation; IDA:SGD.::GO:0001403; P:invasive growth in response to glucose limitation; IMP:SGD.::GO:0017148; P:negative regulation of translation; IMP:SGD.::GO:0045722; P:positive regulation of gluconeogenesis; IMP:SGD.::GO:0007124; P:pseudohyphal growth; IMP:SGD.::GO:0001302; P:replicative cell aging; IMP:SGD.::GO:0007165; P:signal transduction; TAS:SGD.
581	Q5Z6X0	514	CIPKP_ORYSJ CBL-interacting protein kinase 25...	278	4e-28	122	26	50
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
									GO:0007165; P:signal transduction; IEA:InterPro.
582	Q0VD22	486	STK33_BOVIN Serine/threonine-protein kinase 3...	274	4e-28	122	28	50	GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
583	B4GXC2	755	DCLK_DROPE Serine/threonine-protein kinase GL...	278	4e-28	124	29	50
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB.
									GO:0035556; P:intracellular signal transduction; IEA:InterPro.
584	P23647	805	FUSED_DROME Serine/threonine-protein kinase f...	261	4e-28	124	31	51	GO:0035301; C:Hedgehog signaling complex; IPI:FlyBase.::GO:0016020; C:membrane; IDA:FlyBase.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004674; F:protein serine/threonine kinase activity; IDA:FlyBase.
									GO:0007293; P:germarium-derived egg chamber formation; IMP:FlyBase.::GO:0007228; P:positive regulation of hh target transcription factor activity; IMP:FlyBase.::GO:0042993; P:positive regulation of transcription factor import into nucleus; IMP:FlyBase.::GO:0031647; P:regulation of protein stability; IDA:FlyBase.::GO:0030162; P:regulation of proteolysis; NAS:FlyBase.::GO:0007367; P:segment polarity determination; IMP:FlyBase.
585	P93759	530	CDPKE_ARATH Calcium-dependent protein kinase ...	285	5e-28	122	30	48	GO:0005737; C:cytoplasm; IDA:TAIR.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
586	O42844	504	KCC2_SCHPO Calcium/calmodulin-dependent prote...	305	6e-28	122	29	47	GO:0030428; C:cell septum; IDA:PomBase.::GO:0005737; C:cytoplasm; IDA:PomBase.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005509; F:calcium ion binding; TAS:PomBase.::GO:0005516; F:calmodulin binding; TAS:PomBase.::GO:0004683; F:calmodulin-dependent protein kinase activity; IMP:PomBase.
									GO:0051519; P:activation of bipolar cell growth; IMP:PomBase.::GO:0034599; P:cellular response to oxidative stress; IMP:PomBase.::GO:0033314; P:mitotic cell cycle DNA replication checkpoint; IMP:PomBase.::GO:0031098; P:stress-activated protein kinase signaling cascade; IGI:PomBase.
587	B5DK35	755	DCLK_DROPS Serine/threonine-protein kinase GA...	278	6e-28	124	29	50
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB.
									GO:0035556; P:intracellular signal transduction; IEA:InterPro.
588	Q9QYZ3	484	SMK2B_MOUSE Sperm motility kinase 2B OS=Mus m...	296	6e-28	121	28	47
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
589	Q9FZ36	651	M3K2_ARATH Mitogen-activated protein kinase k...	277	7e-28	123	28	49	GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0005874; C:microtubule; IEA:UniProtKB-KW.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004709; F:MAP kinase kinase kinase activity; IEA:EC.
									GO:0043622; P:cortical microtubule organization; IMP:UniProtKB.::GO:0000910; P:cytokinesis; IGI:TAIR.
590	O94547	580	SRK1_SCHPO Serine/threonine-protein kinase sr...	336	7e-28	122	26	45	GO:0005737; C:cytoplasm; IDA:PomBase.::GO:0005634; C:nucleus; IDA:PomBase.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004683; F:calmodulin-dependent protein kinase activity; ISS:PomBase.::GO:0005515; F:protein binding; IPI:IntAct.
									GO:0007126; P:meiosis; IEA:UniProtKB-KW.::GO:0010972; P:negative regulation of G2/M transition of mitotic cell cycle; TAS:PomBase.::GO:0040020; P:regulation of meiosis; IMP:PomBase.::GO:0007088; P:regulation of mitosis; IPI:PomBase.::GO:0031098; P:stress-activated protein kinase signaling cascade; IGI:PomBase.
591	Q3UYH7	688	ARBK2_MOUSE Beta-adrenergic receptor kinase 2...	331	8e-28	123	27	47
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0047696; F:beta-adrenergic receptor kinase activity; IEA:EC.::GO:0004703; F:G-protein coupled receptor kinase activity; IDA:MGI.::GO:0005543; F:phospholipid binding; IEA:InterPro.
									GO:0007165; P:signal transduction; IEA:InterPro.::GO:0038032; P:termination of G-protein coupled receptor signaling pathway; IEA:InterPro.
592	Q8BZN4	639	NUAK2_MOUSE NUAK family SNF1-like kinase 2 OS...	277	8e-28	123	29	48
									GO:0005524; F:ATP binding; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; ISS:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB.
									GO:0030036; P:actin cytoskeleton organization; ISS:UniProtKB.::GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0042149; P:cellular response to glucose starvation; ISS:UniProtKB.::GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
593	B4J3F1	762	PLK4_DROGR Serine/threonine-protein kinase PL...	274	8e-28	123	27	49	GO:0005814; C:centriole; IEA:UniProtKB-SubCell.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004713; F:protein tyrosine kinase activity; IEA:InterPro.
594	Q9LT35	416	NEK6_ARATH Serine/threonine-protein kinase Ne...	314	8e-28	120	28	48
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
595	O08678	793	MARK1_RAT Serine/threonine-protein kinase MAR...	237	9e-28	123	31	51	GO:0005737; C:cytoplasm; IDA:UniProtKB.::GO:0015630; C:microtubule cytoskeleton; NAS:RGD.::GO:0005886; C:plasma membrane; ISS:UniProtKB.
									GO:0005524; F:ATP binding; IDA:UniProtKB.::GO:0000287; F:magnesium ion binding; IDA:UniProtKB.::GO:0070300; F:phosphatidic acid binding; ISS:UniProtKB.::GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; ISS:UniProtKB.::GO:0001786; F:phosphatidylserine binding; ISS:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.::GO:0050321; F:tau-protein kinase activity; IDA:UniProtKB.
									GO:0007243; P:intracellular protein kinase cascade; IDA:UniProtKB.::GO:0000226; P:microtubule cytoskeleton organization; IDA:RGD.::GO:0001764; P:neuron migration; IDA:UniProtKB.::GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW.
596	D3ZML2	735	BRSK2_RAT Serine/threonine-protein kinase BRS...	271	9e-28	123	27	49	GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0005634; C:nucleus; ISS:UniProtKB.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB.::GO:0050321; F:tau-protein kinase activity; ISS:UniProtKB.
									GO:0007409; P:axonogenesis; ISS:UniProtKB.::GO:0030010; P:establishment of cell polarity; ISS:UniProtKB.::GO:0031572; P:G2/M transition DNA damage checkpoint; ISS:UniProtKB.::GO:0009411; P:response to UV; ISS:UniProtKB.
597	Q18846	772	KS6A2_CAEEL Putative ribosomal protein S6 kin...	278	1e-27	123	29	51
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
									GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.::GO:0040007; P:growth; IMP:WormBase.::GO:0007243; P:intracellular protein kinase cascade; IEA:InterPro.::GO:0002119; P:nematode larval development; IMP:WormBase.
598	Q8IY84	436	NIM1_HUMAN Serine/threonine-protein kinase NI...	311	1e-27	120	27	48
									GO:0005524; F:ATP binding; IDA:UniProtKB.::GO:0000287; F:magnesium ion binding; IDA:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
599	O88866	714	HUNK_MOUSE Hormonally up-regulated neu tumor-...	270	1e-27	123	32	50
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
600	Q91YA2	424	KPSH1_MOUSE Serine/threonine-protein kinase H...	266	1e-27	120	30	49	GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.::GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
601	Q4FZD7	595	PLK5_MOUSE Inactive serine/threonine-protein ...	270	1e-27	122	28	46	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005730; C:nucleolus; IDA:UniProtKB.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0016772; F:transferase activity, transferring phosphorus-containing groups; IEA:InterPro.
									GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0002357; P:defense response to tumor cell; IDA:UniProtKB.::GO:0008285; P:negative regulation of cell proliferation; IDA:UniProtKB.::GO:0010976; P:positive regulation of neuron projection development; IDA:UniProtKB.::GO:0006468; P:protein phosphorylation; IEA:InterPro.::GO:2000045; P:regulation of G1/S transition of mitotic cell cycle; IMP:UniProtKB.::GO:0006974; P:response to DNA damage stimulus; IDA:UniProtKB.::GO:0006927; P:transformed cell apoptotic process; IMP:UniProtKB.

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