Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YDR456W
Length:
633
Number of sequences:
5887
Description:
YDR456W NHX1 SGDID:S000002864, Chr IV from 1367485-1369386, Genome Release 64-1-1, Verified ORF, "Na+/H+ and K+/H+ exchanger, required for intracellular sequestration of Na+ and K+; located in the vacuole and late endosome compartments; required for osmotolerance to acute hypertonic shock and for vacuolar fusion"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
1Q04121    633   NHX1_YEAST Endosomal/prevacuolar sodium/hydro...6330     1287     100     100GO:0005769; C:early endosome; IDA:SGD.::GO:0000329; C:fungal-type vacuole membrane; IDA:SGD.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.::GO:0005802; C:trans-Golgi network; IDA:SGD.
GO:0015386; F:potassium:hydrogen antiporter activity; IMP:SGD.::GO:0015385; F:sodium:hydrogen antiporter activity; IMP:SGD.
GO:0007035; P:vacuolar acidification; IMP:SGD.
2O13726    567   YDO6_SCHPO Uncharacterized Na(+)/H(+) antipor...5730     556     53     72GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; ISS:PomBase.
GO:0015386; F:potassium:hydrogen antiporter activity; ISS:PomBase.::GO:0015385; F:sodium:hydrogen antiporter activity; ISS:PomBase.
GO:0006885; P:regulation of pH; ISS:PomBase.
3Q92581    669   SL9A6_HUMAN Sodium/hydrogen exchanger 6 OS=Ho...4446e-82     278     38     57GO:0031901; C:early endosome membrane; IDA:UniProtKB.::GO:0005789; C:endoplasmic reticulum membrane; IDA:UniProtKB.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005792; C:microsome; IDA:UniProtKB.::GO:0005886; C:plasma membrane; IDA:UniProtKB.::GO:0055038; C:recycling endosome membrane; IDA:UniProtKB.
GO:0015385; F:sodium:hydrogen antiporter activity; TAS:ProtInc.
GO:0006885; P:regulation of pH; IEA:InterPro.
4Q8BZ00    644   SL9A9_MOUSE Sodium/hydrogen exchanger 9 OS=Mu...5041e-81     276     35     53GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
GO:0015385; F:sodium:hydrogen antiporter activity; IEA:InterPro.
GO:0006885; P:regulation of pH; IEA:InterPro.
5Q8IVB4    645   SL9A9_HUMAN Sodium/hydrogen exchanger 9 OS=Ho...4971e-80     273     34     54GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0031902; C:late endosome membrane; TAS:Reactome.::GO:0055037; C:recycling endosome; IDA:UniProtKB.
GO:0015385; F:sodium:hydrogen antiporter activity; IEA:InterPro.
GO:0006885; P:regulation of pH; IEA:InterPro.
6Q8BLV3    726   SL9A7_MOUSE Sodium/hydrogen exchanger 7 OS=Mu...4845e-80     274     34     54GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; ISS:UniProtKB.::GO:0055038; C:recycling endosome membrane; ISS:UniProtKB.::GO:0005802; C:trans-Golgi network; ISS:UniProtKB.
GO:0015386; F:potassium:hydrogen antiporter activity; ISS:UniProtKB.::GO:0015385; F:sodium:hydrogen antiporter activity; ISS:UniProtKB.
GO:0006885; P:regulation of pH; ISS:UniProtKB.
7Q96T83    725   SL9A7_HUMAN Sodium/hydrogen exchanger 7 OS=Ho...4841e-76     264     34     53GO:0000139; C:Golgi membrane; TAS:Reactome.::GO:0016021; C:integral to membrane; IDA:UniProtKB.::GO:0055038; C:recycling endosome membrane; IDA:UniProtKB.::GO:0005802; C:trans-Golgi network; IDA:UniProtKB.
GO:0015386; F:potassium:hydrogen antiporter activity; IDA:UniProtKB.::GO:0042803; F:protein homodimerization activity; TAS:UniProtKB.::GO:0015385; F:sodium:hydrogen antiporter activity; IDA:UniProtKB.
GO:0006885; P:regulation of pH; IDA:UniProtKB.
8Q552S0    674   NHE1_DICDI Sodium/hydrogen exchanger 1 OS=Dic...4626e-64     229     32     56GO:0005737; C:cytoplasm; IDA:dictyBase.::GO:0016021; C:integral to membrane; ISS:dictyBase.::GO:0031256; C:leading edge membrane; IDA:dictyBase.
GO:0015385; F:sodium:hydrogen antiporter activity; ISS:dictyBase.
GO:0097230; P:cell motility in response to potassium ion; IMP:dictyBase.::GO:0036051; P:protein localization to trailing edge; IMP:dictyBase.::GO:0051453; P:regulation of intracellular pH; IMP:dictyBase.
9Q8R4D1    576   SL9A8_MOUSE Sodium/hydrogen exchanger 8 OS=Mu...4619e-61     218     32     54GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0015386; F:potassium:hydrogen antiporter activity; IDA:MGI.::GO:0015385; F:sodium:hydrogen antiporter activity; IDA:MGI.
GO:0051453; P:regulation of intracellular pH; IDA:MGI.
10Q4L208    575   SL9A8_RAT Sodium/hydrogen exchanger 8 OS=Ratt...4611e-60     217     32     54GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
11Q8RWU6    535   NHX6_ARATH Sodium/hydrogen exchanger 6 OS=Ara...5133e-60     216     30     49GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.::GO:0032580; C:Golgi cisterna membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0015385; F:sodium:hydrogen antiporter activity; IEA:InterPro.
GO:0006885; P:regulation of pH; IEA:InterPro.
12Q5ZJ75    574   SL9A8_CHICK Sodium/hydrogen exchanger 8 OS=Ga...4616e-60     216     31     54GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0015385; F:sodium:hydrogen antiporter activity; IEA:InterPro.
GO:0006885; P:regulation of pH; IEA:InterPro.
13Q9Y2E8    581   SL9A8_HUMAN Sodium/hydrogen exchanger 8 OS=Ho...4617e-60     215     32     54GO:0000139; C:Golgi membrane; TAS:Reactome.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
14Q8S397    529   NHX4_ARATH Sodium/hydrogen exchanger 4 OS=Ara...4174e-54     198     32     55GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IDA:TAIR.::GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
GO:0015385; F:sodium:hydrogen antiporter activity; IDA:TAIR.
GO:0055075; P:potassium ion homeostasis; IMP:TAIR.::GO:0006885; P:regulation of pH; IEA:InterPro.
15Q8S396    521   NHX5_ARATH Sodium/hydrogen exchanger 5 OS=Ara...4571e-51     191     33     52GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.::GO:0032580; C:Golgi cisterna membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0015385; F:sodium:hydrogen antiporter activity; IEA:InterPro.
GO:0010351; P:lithium ion transport; IGI:TAIR.::GO:0006885; P:regulation of pH; IEA:InterPro.
16Q84WG1    503   NHX3_ARATH Sodium/hydrogen exchanger 3 OS=Ara...4486e-50     186     30     52GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005774; C:vacuolar membrane; IDA:TAIR.
GO:0015385; F:sodium:hydrogen antiporter activity; IEA:InterPro.
GO:0006885; P:regulation of pH; IEA:InterPro.::GO:0009651; P:response to salt stress; IMP:TAIR.
17Q56XP4    546   NHX2_ARATH Sodium/hydrogen exchanger 2 OS=Ara...4712e-47     179     30     50GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
GO:0015385; F:sodium:hydrogen antiporter activity; IEA:InterPro.
GO:0006885; P:regulation of pH; IEA:InterPro.
18Q68KI4    538   NHX1_ARATH Sodium/hydrogen exchanger 1 OS=Ara...4701e-46     177     30     52GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0000325; C:plant-type vacuole; TAS:TAIR.::GO:0005886; C:plasma membrane; IDA:TAIR.::GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0015385; F:sodium:hydrogen antiporter activity; IDA:TAIR.
GO:0048366; P:leaf development; IMP:TAIR.::GO:0010351; P:lithium ion transport; IGI:TAIR.::GO:0006885; P:regulation of pH; IEA:InterPro.::GO:0009651; P:response to salt stress; IMP:TAIR.
19P48763    813   SL9A2_RAT Sodium/hydrogen exchanger 2 OS=Ratt...4432e-45     176     30     51GO:0016324; C:apical plasma membrane; TAS:RGD.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0015385; F:sodium:hydrogen antiporter activity; IDA:RGD.
20P50482    809   SL9A2_RABIT Sodium/hydrogen exchanger 2 OS=Or...4432e-44     173     29     50GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
21Q4R8V4    542   SL9A8_MACFA Sodium/hydrogen exchanger 8 OS=Ma...4616e-44     169     29     48GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0015385; F:sodium:hydrogen antiporter activity; IEA:InterPro.
GO:0006885; P:regulation of pH; IEA:InterPro.
22Q9UBY0    812   SL9A2_HUMAN Sodium/hydrogen exchanger 2 OS=Ho...4431e-43     171     30     50GO:0016021; C:integral to membrane; TAS:ProtInc.::GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0015385; F:sodium:hydrogen antiporter activity; TAS:ProtInc.
23Q01345    759   NHEB_ONCMY Na(+)/H(+) exchanger beta OS=Oncor...4292e-42     166     28     50GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0015385; F:sodium:hydrogen antiporter activity; IEA:InterPro.
GO:0006885; P:regulation of pH; IEA:InterPro.
24P26433    831   SL9A3_RAT Sodium/hydrogen exchanger 3 OS=Ratt...3851e-40     162     31     51GO:0031526; C:brush border membrane; IDA:RGD.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005515; F:protein binding; IPI:IntAct.::GO:0015385; F:sodium:hydrogen antiporter activity; IDA:RGD.
GO:0007623; P:circadian rhythm; IEP:RGD.::GO:0006898; P:receptor-mediated endocytosis; IMP:RGD.::GO:0006885; P:regulation of pH; IDA:RGD.::GO:0002028; P:regulation of sodium ion transport; IMP:RGD.::GO:0051384; P:response to glucocorticoid stimulus; IEP:RGD.
25P48764    834   SL9A3_HUMAN Sodium/hydrogen exchanger 3 OS=Ho...3852e-40     161     30     51GO:0009986; C:cell surface; ISS:UniProtKB.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0015385; F:sodium:hydrogen antiporter activity; ISS:UniProtKB.
26P26432    832   SL9A3_RABIT Sodium/hydrogen exchanger 3 OS=Or...3794e-40     160     30     52GO:0005903; C:brush border; IDA:UniProtKB.::GO:0009986; C:cell surface; IDA:UniProtKB.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0015385; F:sodium:hydrogen antiporter activity; IDA:UniProtKB.
GO:0006885; P:regulation of pH; IEA:InterPro.
27P26431    820   SL9A1_RAT Sodium/hydrogen exchanger 1 OS=Ratt...4531e-38     156     30     51GO:0016323; C:basolateral plasma membrane; IDA:RGD.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0045121; C:membrane raft; IDA:RGD.
GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0015385; F:sodium:hydrogen antiporter activity; IMP:RGD.::GO:0008134; F:transcription factor binding; IDA:RGD.
GO:0030154; P:cell differentiation; IEP:RGD.::GO:0016049; P:cell growth; IEP:RGD.::GO:0007243; P:intracellular protein kinase cascade; IMP:RGD.::GO:0045768; P:positive regulation of anti-apoptosis; IMP:RGD.::GO:0006885; P:regulation of pH; TAS:RGD.::GO:0042493; P:response to drug; IEP:RGD.::GO:0014070; P:response to organic cyclic compound; IDA:RGD.
28Q61165    820   SL9A1_MOUSE Sodium/hydrogen exchanger 1 OS=Mu...4531e-38     156     30     51GO:0016323; C:basolateral plasma membrane; TAS:MGI.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005624; C:membrane fraction; IDA:MGI.
GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0015385; F:sodium:hydrogen antiporter activity; IDA:MGI.
GO:0006885; P:regulation of pH; IDA:MGI.::GO:0001101; P:response to acid; IMP:MGI.::GO:0010447; P:response to acidity; IMP:MGI.
29Q28362    839   SL9A3_DIDMA Sodium/hydrogen exchanger 3 OS=Di...3852e-38     155     31     50GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0015385; F:sodium:hydrogen antiporter activity; IEA:InterPro.
GO:0006885; P:regulation of pH; IEA:InterPro.
30P26434    717   SL9A4_RAT Sodium/hydrogen exchanger 4 OS=Ratt...4513e-38     154     29     50GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.::GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0015385; F:sodium:hydrogen antiporter activity; IEA:InterPro.
GO:0006885; P:regulation of pH; IEA:InterPro.
31P19634    815   SL9A1_HUMAN Sodium/hydrogen exchanger 1 OS=Ho...4228e-38     153     29     53GO:0016021; C:integral to membrane; TAS:UniProtKB.
GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
GO:0006885; P:regulation of pH; TAS:UniProtKB.
records
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