Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YDR453C
Length:
196
Number of sequences:
5887
Description:
YDR453C TSA2 SGDID:S000002861, Chr IV from 1365662-1365072, Genome Release 64-1-1, reverse complement, Verified ORF, "Stress inducible cytoplasmic thioredoxin peroxidase; cooperates with Tsa1p in the removal of reactive oxygen, nitrogen and sulfur species using thioredoxin as hydrogen donor; deletion enhances the mutator phenotype of tsa1 mutants"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
1Q04120    196   TSA2_YEAST Peroxiredoxin TSA2 OS=Saccharomyce...1963e-142     401     100     100GO:0005737; C:cytoplasm; IDA:SGD.
GO:0008379; F:thioredoxin peroxidase activity; IDA:SGD.
GO:0045454; P:cell redox homeostasis; IDA:SGD.::GO:0034599; P:cellular response to oxidative stress; IMP:SGD.
2P34760    196   TSA1_YEAST Peroxiredoxin TSA1 OS=Saccharomyce...1957e-127     362     86     96GO:0005829; C:cytosol; IDA:SGD.::GO:0005844; C:polysome; IDA:SGD.
GO:0043022; F:ribosome binding; IDA:SGD.::GO:0008379; F:thioredoxin peroxidase activity; IDA:SGD.::GO:0051082; F:unfolded protein binding; IMP:SGD.
GO:0045454; P:cell redox homeostasis; IDA:SGD.::GO:0034599; P:cellular response to oxidative stress; IDA:SGD.::GO:0042262; P:DNA protection; IMP:SGD.::GO:0006457; P:protein folding; IMP:SGD.::GO:0006417; P:regulation of translation; IMP:SGD.::GO:0001302; P:replicative cell aging; IMP:SGD.::GO:0033194; P:response to hydroperoxide; IMP:SGD.
3Q9Y7F0    196   TSA1_CANAL Peroxiredoxin TSA1 OS=Candida albi...1956e-97     286     68     84GO:0009986; C:cell surface; IDA:CGD.::GO:0005737; C:cytoplasm; IDA:CGD.::GO:0030446; C:hyphal cell wall; IDA:CGD.::GO:0005634; C:nucleus; IDA:CGD.
GO:0030985; F:high molecular weight kininogen binding; IDA:CGD.::GO:0008379; F:thioredoxin peroxidase activity; IGI:CGD.
GO:0031505; P:fungal-type cell wall organization; IMP:CGD.::GO:0042744; P:hydrogen peroxide catabolic process; IGI:CGD.::GO:0030448; P:hyphal growth; IMP:CGD.::GO:0051701; P:interaction with host; IPI:CGD.
4Q9NL98    195   PRDX_ASCSU Peroxiredoxin OS=Ascaris suum (Pig...1901e-84     255     64     77GO:0005737; C:cytoplasm; NAS:UniProtKB.
GO:0008379; F:thioredoxin peroxidase activity; IDA:UniProtKB.
GO:0006979; P:response to oxidative stress; IDA:UniProtKB.
5Q9BGI3    199   PRDX2_BOVIN Peroxiredoxin-2 OS=Bos taurus (Bo...1933e-84     254     63     76
6Q61171    198   PRDX2_MOUSE Peroxiredoxin-2 OS=Mus musculus (...1938e-84     253     62     76GO:0005739; C:mitochondrion; IDA:MGI.
GO:0005515; F:protein binding; IPI:MGI.::GO:0008430; F:selenium binding; TAS:MGI.::GO:0008379; F:thioredoxin peroxidase activity; TAS:MGI.
GO:0000187; P:activation of MAPK activity; IMP:MGI.::GO:0006916; P:anti-apoptosis; IDA:MGI.::GO:0048872; P:homeostasis of number of cells; IMP:MGI.::GO:0042744; P:hydrogen peroxide catabolic process; IMP:MGI.::GO:0031665; P:negative regulation of lipopolysaccharide-mediated signaling pathway; IMP:MGI.::GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; IMP:MGI.::GO:2000378; P:negative regulation of reactive oxygen species metabolic process; IMP:MGI.::GO:0045581; P:negative regulation of T cell differentiation; IMP:MGI.::GO:0030194; P:positive regulation of blood coagulation; IMP:BHF-UCL.::GO:0010310; P:regulation of hydrogen peroxide metabolic process; IMP:MGI.::GO:0019430; P:removal of superoxide radicals; IMP:BHF-UCL.::GO:0002536; P:respiratory burst involved in inflammatory response; IMP:MGI.::GO:0032496; P:response to lipopolysaccharide; IMP:MGI.::GO:0042098; P:T cell proliferation; IMP:MGI.::GO:0048538; P:thymus development; IMP:MGI.
7P35704    198   PRDX2_RAT Peroxiredoxin-2 OS=Rattus norvegicu...1934e-83     251     62     76GO:0005829; C:cytosol; IDA:RGD.
GO:0004601; F:peroxidase activity; IEA:UniProtKB-KW.::GO:0051920; F:peroxiredoxin activity; IEA:EC.
GO:0043524; P:negative regulation of neuron apoptotic process; IMP:RGD.::GO:0006979; P:response to oxidative stress; IMP:RGD.
8Q2PFZ3    198   PRDX2_MACFA Peroxiredoxin-2 OS=Macaca fascicu...1938e-83     250     62     75GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004601; F:peroxidase activity; IEA:UniProtKB-KW.::GO:0051920; F:peroxiredoxin activity; IEA:EC.
9P32119    198   PRDX2_HUMAN Peroxiredoxin-2 OS=Homo sapiens (...1938e-83     250     62     75
GO:0008379; F:thioredoxin peroxidase activity; IDA:UniProtKB.
GO:0006916; P:anti-apoptosis; TAS:UniProtKB.::GO:0042744; P:hydrogen peroxide catabolic process; TAS:BHF-UCL.::GO:0019430; P:removal of superoxide radicals; IDA:BHF-UCL.
10Q8K3U7    198   PRDX2_CRIGR Peroxiredoxin-2 OS=Cricetulus gri...1932e-82     249     62     75GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004601; F:peroxidase activity; IEA:UniProtKB-KW.::GO:0051920; F:peroxiredoxin activity; IEA:EC.
11O74887    192   TSA1_SCHPO Peroxiredoxin tpx1 OS=Schizosaccha...1916e-80     243     61     77GO:0005829; C:cytosol; IDA:PomBase.::GO:0005634; C:nucleus; IDA:PomBase.
GO:0005515; F:protein binding; IPI:PomBase.::GO:0008379; F:thioredoxin peroxidase activity; TAS:PomBase.
GO:0045454; P:cell redox homeostasis; IMP:PomBase.::GO:0061077; P:chaperone-mediated protein folding; NAS:PomBase.::GO:0042744; P:hydrogen peroxide catabolic process; IC:PomBase.::GO:2000765; P:regulation of cytoplasmic translation; ISS:PomBase.::GO:0019430; P:removal of superoxide radicals; IC:PomBase.
12Q8T6C4    193   TDX_ECHGR Thioredoxin peroxidase OS=Echinococ...1932e-79     242     58     75GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004601; F:peroxidase activity; IEA:UniProtKB-KW.::GO:0051920; F:peroxiredoxin activity; IEA:EC.
13Q5E947    199   PRDX1_BOVIN Peroxiredoxin-1 OS=Bos taurus (Bo...1904e-78     238     60     76GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
GO:0042345; P:regulation of NF-kappaB import into nucleus; ISS:AgBase.
14Q06830    199   PRDX1_HUMAN Peroxiredoxin-1 OS=Homo sapiens (...1903e-77     236     59     76GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.::GO:0005739; C:mitochondrion; IDA:HPA.::GO:0005634; C:nucleus; IDA:MGI.
GO:0005515; F:protein binding; IPI:IntAct.::GO:0008379; F:thioredoxin peroxidase activity; IDA:BHF-UCL.
GO:0008283; P:cell proliferation; TAS:ProtInc.::GO:0042744; P:hydrogen peroxide catabolic process; IDA:BHF-UCL.::GO:0001501; P:skeletal system development; TAS:ProtInc.
15Q63716    199   PRDX1_RAT Peroxiredoxin-1 OS=Rattus norvegicu...1903e-77     236     60     75GO:0005829; C:cytosol; IDA:RGD.::GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.::GO:0005759; C:mitochondrial matrix; IDA:RGD.::GO:0005719; C:nuclear euchromatin; IDA:RGD.::GO:0005730; C:nucleolus; IDA:RGD.::GO:0005782; C:peroxisomal matrix; IDA:RGD.
GO:0020037; F:heme binding; IPI:RGD.::GO:0004601; F:peroxidase activity; IEA:UniProtKB-KW.::GO:0051920; F:peroxiredoxin activity; IDA:RGD.::GO:0042803; F:protein homodimerization activity; IDA:RGD.
GO:0006979; P:response to oxidative stress; IDA:RGD.
16Q5REY3    256   PRDX3_PONAB Thioredoxin-dependent peroxide re...1914e-77     238     58     75GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
GO:0004601; F:peroxidase activity; IEA:UniProtKB-KW.::GO:0051920; F:peroxiredoxin activity; IEA:EC.
17Q6B4U9    199   PRDX1_MYOLU Peroxiredoxin-1 OS=Myotis lucifug...1905e-77     236     59     76GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
18Q9Z0V6    257   PRDX3_RAT Thioredoxin-dependent peroxide redu...1926e-77     238     58     74GO:0005739; C:mitochondrion; IDA:RGD.
GO:0004601; F:peroxidase activity; IEA:UniProtKB-KW.::GO:0051920; F:peroxiredoxin activity; IEA:EC.
GO:0043524; P:negative regulation of neuron apoptotic process; IMP:RGD.
19P30048    256   PRDX3_HUMAN Thioredoxin-dependent peroxide re...1926e-77     238     57     74GO:0005769; C:early endosome; IDA:UniProtKB.::GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0008785; F:alkyl hydroperoxide reductase activity; NAS:UniProtKB.::GO:0043027; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process; IMP:UniProtKB.::GO:0004601; F:peroxidase activity; IEA:UniProtKB-KW.::GO:0051920; F:peroxiredoxin activity; IEA:EC.::GO:0008022; F:protein C-terminus binding; IPI:UniProtKB.::GO:0019901; F:protein kinase binding; IPI:UniProtKB.
GO:0042744; P:hydrogen peroxide catabolic process; IMP:UniProtKB.::GO:0007005; P:mitochondrion organization; IMP:UniProtKB.::GO:0030099; P:myeloid cell differentiation; ISS:UniProtKB.::GO:0033673; P:negative regulation of kinase activity; IDA:UniProtKB.::GO:0008284; P:positive regulation of cell proliferation; IDA:UniProtKB.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IDA:UniProtKB.::GO:0051881; P:regulation of mitochondrial membrane potential; IMP:UniProtKB.::GO:0032496; P:response to lipopolysaccharide; ISS:UniProtKB.
20Q17172    199   TDX2_BRUMA Thioredoxin peroxidase 2 OS=Brugia...1906e-77     235     61     75GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004601; F:peroxidase activity; IEA:UniProtKB-KW.::GO:0051920; F:peroxiredoxin activity; IEA:EC.
21P20108    257   PRDX3_MOUSE Thioredoxin-dependent peroxide re...1921e-76     236     57     74GO:0005739; C:mitochondrion; IDA:MGI.
GO:0042802; F:identical protein binding; IPI:MGI.::GO:0004601; F:peroxidase activity; IEA:UniProtKB-KW.::GO:0051920; F:peroxiredoxin activity; IEA:EC.
GO:0001893; P:maternal placenta development; IMP:MGI.::GO:0030099; P:myeloid cell differentiation; IMP:MGI.::GO:0032496; P:response to lipopolysaccharide; IMP:MGI.
22P35700    199   PRDX1_MOUSE Peroxiredoxin-1 OS=Mus musculus (...1902e-76     234     59     75GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.::GO:0005739; C:mitochondrion; IDA:MGI.
GO:0042802; F:identical protein binding; IPI:IntAct.::GO:0004601; F:peroxidase activity; IEA:UniProtKB-KW.::GO:0051920; F:peroxiredoxin activity; IEA:EC.
GO:0008283; P:cell proliferation; IMP:MGI.::GO:0034101; P:erythrocyte homeostasis; IMP:MGI.::GO:0042267; P:natural killer cell mediated cytotoxicity; IMP:MGI.::GO:0042345; P:regulation of NF-kappaB import into nucleus; IMP:MGI.::GO:0032872; P:regulation of stress-activated MAPK cascade; IMP:MGI.::GO:0019430; P:removal of superoxide radicals; IMP:MGI.
23P35705    257   PRDX3_BOVIN Thioredoxin-dependent peroxide re...1922e-76     236     57     73GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
GO:0004601; F:peroxidase activity; IEA:UniProtKB-KW.::GO:0051920; F:peroxiredoxin activity; IEA:EC.
24Q9JKY1    199   PRDX1_CRIGR Peroxiredoxin-1 OS=Cricetulus gri...1904e-76     233     59     75GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
GO:0004601; F:peroxidase activity; IEA:UniProtKB-KW.::GO:0051920; F:peroxiredoxin activity; IEA:EC.
25Q6DV14    199   PRDX1_GECJA Peroxiredoxin-1 OS=Gecko japonicu...1903e-75     231     58     74GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004601; F:peroxidase activity; IEA:UniProtKB-KW.::GO:0051920; F:peroxiredoxin activity; IEA:EC.
26P0CB50    199   PRDX1_CHICK Peroxiredoxin-1 OS=Gallus gallus ...1908e-75     230     58     74
GO:0005515; F:protein binding; IPI:IntAct.
27Q9V3P0    194   PRDX1_DROME Peroxiredoxin 1 OS=Drosophila mel...1941e-74     229     56     73GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0005875; C:microtubule associated complex; IDA:FlyBase.
GO:0005515; F:protein binding; IPI:IntAct.::GO:0008379; F:thioredoxin peroxidase activity; IDA:UniProtKB.
GO:0045454; P:cell redox homeostasis; IDA:UniProtKB.::GO:0042744; P:hydrogen peroxide catabolic process; IDA:FlyBase.::GO:0006974; P:response to DNA damage stimulus; IMP:FlyBase.
28Q90384    200   TDX_CYNPY Peroxiredoxin OS=Cynops pyrrhogaste...1902e-74     229     58     74GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004601; F:peroxidase activity; IEA:UniProtKB-KW.::GO:0051920; F:peroxiredoxin activity; IEA:EC.
29O08807    274   PRDX4_MOUSE Peroxiredoxin-4 OS=Mus musculus (...1933e-72     226     53     73GO:0005739; C:mitochondrion; IDA:MGI.
GO:0004601; F:peroxidase activity; IEA:UniProtKB-KW.::GO:0051920; F:peroxiredoxin activity; IEA:EC.
30Q9Z0V5    273   PRDX4_RAT Peroxiredoxin-4 OS=Rattus norvegicu...1934e-72     226     53     73GO:0005615; C:extracellular space; IDA:RGD.
GO:0004601; F:peroxidase activity; IEA:UniProtKB-KW.::GO:0051920; F:peroxiredoxin activity; IEA:EC.
31Q13162    271   PRDX4_HUMAN Peroxiredoxin-4 OS=Homo sapiens (...1934e-72     226     53     72
GO:0005515; F:protein binding; IPI:IntAct.::GO:0008379; F:thioredoxin peroxidase activity; TAS:ProtInc.
GO:0007252; P:I-kappaB phosphorylation; TAS:ProtInc.
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