Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YDR440W
Length:
582
Number of sequences:
5887
Description:
YDR440W DOT1 SGDID:S000002848, Chr IV from 1342493-1344241, Genome Release 64-1-1, Verified ORF, "Nucleosomal histone H3-Lys79 methylase; methylation is required for telomeric silencing, meiotic checkpoint control, and DNA damage response"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
1Q04089    582   DOT1_YEAST Histone-lysine N-methyltransferase...5820     1203     100     100GO:0005634; C:nucleus; IDA:SGD.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0031151; F:histone methyltransferase activity (H3-K79 specific); IDA:SGD.::GO:0031493; F:nucleosomal histone binding; IDA:SGD.
GO:0006348; P:chromatin silencing at telomere; IMP:SGD.::GO:0000077; P:DNA damage checkpoint; IMP:SGD.::GO:0070911; P:global genome nucleotide-excision repair; IMP:SGD.::GO:0000725; P:recombinational repair; IMP:SGD.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
2Q6FNM5    652   DOT1_CANGA Histone-lysine N-methyltransferase...6222e-149     452     41     58GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:EC.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
3Q756E1    575   DOT1_ASHGO Histone-lysine N-methyltransferase...5278e-131     401     43     59GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:EC.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
4Q6CWV1    572   DOT1_KLULA Histone-lysine N-methyltransferase...5555e-124     384     41     59GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:EC.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
5Q6C4Y5    492   DOT1_YARLI Histone-lysine N-methyltransferase...3195e-66     229     37     61GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:EC.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
6Q4WVH4    502   DOT1_ASPFU Histone-lysine N-methyltransferase...3102e-50     186     33     54GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:EC.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
7Q2U696    335   DOT1_ASPOR Histone-lysine N-methyltransferase...2975e-50     181     33     56GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:EC.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
8Q1DKD8    499   DOT1_COCIM Histone-lysine N-methyltransferase...2542e-49     183     37     60GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:EC.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
9Q6BTC8    1172   DOT1_DEBHA Histone-lysine N-methyltransferase...2787e-49     187     41     59GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:EC.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
10Q5BH89    501   DOT1_EMENI Histone-lysine N-methyltransferase...3102e-47     177     32     53GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:EC.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
11Q7SB74    531   DOT1_NEUCR Histone-lysine N-methyltransferase...2662e-44     169     38     56GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:EC.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
12Q5A309    1343   DOT1_CANAL Histone-lysine N-methyltransferase...2775e-44     173     38     56GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:EC.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
13Q4IJP1    493   DOT1_GIBZE Histone-lysine N-methyltransferase...2541e-42     164     37     59GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:EC.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
14Q2H9L1    510   DOT1_CHAGB Histone-lysine N-methyltransferase...2604e-40     157     34     55GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:EC.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
15Q4P2W8    798   DOT1_USTMA Histone-lysine N-methyltransferase...2362e-33     139     32     52GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:EC.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
16P0CN14    644   DOT1_CRYNJ Histone-lysine N-methyltransferase...3165e-29     125     30     51GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:EC.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
17P0CN15    644   DOT1_CRYNB Histone-lysine N-methyltransferase...3176e-29     125     30     50GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:EC.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
18Q8TEK3    1739   DOT1L_HUMAN Histone-lysine N-methyltransferas...2972e-25     115     28     47GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0018024; F:histone-lysine N-methyltransferase activity; IDA:UniProtKB.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0008134; F:transcription factor binding; IPI:UniProtKB.
GO:0046425; P:regulation of JAK-STAT cascade; IDA:UniProtKB.::GO:2000677; P:regulation of transcription regulatory region DNA binding; IMP:UniProtKB.
19Q8INR6    1848   DOT1L_DROME Histone-lysine N-methyltransferas...2923e-17     89.7     26     45GO:0035097; C:histone methyltransferase complex; IC:UniProtKB.
GO:0031151; F:histone methyltransferase activity (H3-K79 specific); IMP:UniProtKB.
GO:0006348; P:chromatin silencing at telomere; IMP:UniProtKB.::GO:0048096; P:chromatin-mediated maintenance of transcription; IMP:UniProtKB.
20Q55AX2    1845   DOT1L_DICDI Histone-lysine N-methyltransferas...2150.000000000001     75.1     26     46GO:0005634; C:nucleus; IDA:dictyBase.
GO:0031151; F:histone methyltransferase activity (H3-K79 specific); IDA:dictyBase.
GO:0006281; P:DNA repair; IEA:UniProtKB-KW.::GO:0031156; P:regulation of sorocarp development; IMP:dictyBase.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
21Q2J1P2    448   HGD_RHOP2 Homogentisate 1,2-dioxygenase OS=Rh...2080.084     39.3     24     38
GO:0004411; F:homogentisate 1,2-dioxygenase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0006559; P:L-phenylalanine catabolic process; IEA:UniProtKB-KW.::GO:0006572; P:tyrosine catabolic process; IEA:UniProtKB-KW.
22Q13CD3    448   HGD_RHOPS Homogentisate 1,2-dioxygenase OS=Rh...1860.13     38.9     25     41
GO:0004411; F:homogentisate 1,2-dioxygenase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0006559; P:L-phenylalanine catabolic process; IEA:UniProtKB-KW.::GO:0006572; P:tyrosine catabolic process; IEA:UniProtKB-KW.
23A4XQT3    911   SECA_PSEMY Protein translocase subunit SecA O...1180.37     37.4     27     47GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0017038; P:protein import; IEA:InterPro.::GO:0006605; P:protein targeting; IEA:InterPro.
24Q861Y6    213   NICN1_CANFA Nicolin-1 OS=Canis familiaris (Do...790.94     35.4     29     52GO:0005874; C:microtubule; IEA:UniProtKB-KW.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
25Q8HY31    367   DCUP_SHEEP Uroporphyrinogen decarboxylase OS=...623.2     34.3     29     52GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004853; F:uroporphyrinogen decarboxylase activity; IEA:EC.
GO:0006783; P:heme biosynthetic process; IEA:UniProtKB-KW.
26P13010    732   XRCC5_HUMAN X-ray repair cross-complementing ...873.6     34.3     24     45GO:0005958; C:DNA-dependent protein kinase-DNA ligase 4 complex; IEA:InterPro.::GO:0043564; C:Ku70:Ku80 complex; IDA:UniProtKB.::GO:0000783; C:nuclear telomere cap complex; TAS:BHF-UCL.::GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004003; F:ATP-dependent DNA helicase activity; TAS:ProtInc.::GO:0003690; F:double-stranded DNA binding; TAS:ProtInc.::GO:0008022; F:protein C-terminus binding; IPI:UniProtKB.::GO:0042162; F:telomeric DNA binding; IDA:BHF-UCL.::GO:0044212; F:transcription regulatory region DNA binding; IDA:BHF-UCL.
GO:0006303; P:double-strand break repair via nonhomologous end joining; IMP:UniProtKB.::GO:0019059; P:initiation of viral infection; TAS:Reactome.::GO:0045892; P:negative regulation of transcription, DNA-dependent; IMP:UniProtKB.::GO:0019047; P:provirus integration; TAS:Reactome.::GO:0000723; P:telomere maintenance; TAS:BHF-UCL.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
27Q9BSH3    213   NICN1_HUMAN Nicolin-1 OS=Homo sapiens (Human)...794.5     33.1     29     51GO:0005874; C:microtubule; IEA:UniProtKB-KW.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
28Q9SPU7    1123   TERT_ARATH Telomerase reverse transcriptase O...456.7     33.5     40     51GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0003723; F:RNA binding; IEA:InterPro.::GO:0003721; F:telomeric template RNA reverse transcriptase activity; IEA:InterPro.
GO:0050000; P:chromosome localization; IMP:TAIR.::GO:0007000; P:nucleolus organization; IMP:TAIR.::GO:0007004; P:telomere maintenance via telomerase; IMP:TAIR.
29P38995    1004   ATU2_YEAST Copper-transporting ATPase OS=Sacc...936.7     33.5     31     53GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0012510; C:trans-Golgi network transport vesicle membrane; IDA:SGD.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0019829; F:cation-transporting ATPase activity; IDA:SGD.::GO:0005507; F:copper ion binding; IDA:SGD.::GO:0004008; F:copper-exporting ATPase activity; IEA:EC.
GO:0006754; P:ATP biosynthetic process; IEA:InterPro.::GO:0006879; P:cellular iron ion homeostasis; IMP:SGD.
30Q64535    1451   ATP7B_RAT Copper-transporting ATPase 2 OS=Rat...707.4     33.5     29     51GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005923; C:tight junction; IDA:RGD.::GO:0005802; C:trans-Golgi network; IDA:RGD.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005507; F:copper ion binding; IDA:RGD.::GO:0004008; F:copper-exporting ATPase activity; TAS:RGD.::GO:0008270; F:zinc ion binding; IDA:RGD.
GO:0006754; P:ATP biosynthetic process; IEA:InterPro.::GO:0007623; P:circadian rhythm; IEP:RGD.::GO:0051591; P:response to cAMP; IEP:RGD.::GO:0010043; P:response to zinc ion; IEP:RGD.
31Q9S7J8    1001   HMA7_ARATH Copper-transporting ATPase RAN1 OS...647.4     33.5     28     53GO:0005794; C:Golgi apparatus; IDA:TAIR.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005507; F:copper ion binding; IEA:InterPro.::GO:0004008; F:copper-exporting ATPase activity; IEA:EC.
GO:0006754; P:ATP biosynthetic process; IEA:InterPro.::GO:0009873; P:ethylene mediated signaling pathway; TAS:TAIR.::GO:0010119; P:regulation of stomatal movement; IMP:TAIR.
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