Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YDR409W
Length:
904
Number of sequences:
5887
Description:
YDR409W SIZ1 SGDID:S000002817, Chr IV from 1289406-1292120, Genome Release 64-1-1, Verified ORF, "SUMO/Smt3 ligase that promotes the attachment of sumo (Smt3p; small ubiquitin-related modifier) to proteins; binds Ubc9p and may bind septins; specifically required for sumoylation of septins in vivo; localized to the septin ring"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
1Q04195    904   SIZ1_YEAST E3 SUMO-protein ligase SIZ1 OS=Sac...9040     1842     100     100GO:0005935; C:cellular bud neck; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0000790; C:nuclear chromatin; IDA:SGD.::GO:0005940; C:septin ring; IDA:SGD.
GO:0003676; F:nucleic acid binding; IEA:InterPro.::GO:0019789; F:SUMO ligase activity; IMP:SGD.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0007059; P:chromosome segregation; IMP:SGD.::GO:0016925; P:protein sumoylation; IMP:SGD.
2Q12216    726   SIZ2_YEAST E3 SUMO-protein ligase SIZ2 OS=Sac...4842e-116     378     42     61GO:0005737; C:cytoplasm; IDA:SGD.::GO:0000790; C:nuclear chromatin; IDA:SGD.
GO:0003676; F:nucleic acid binding; IEA:InterPro.::GO:0019789; F:SUMO ligase activity; IDA:SGD.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0030261; P:chromosome condensation; TAS:SGD.::GO:0007059; P:chromosome segregation; IMP:SGD.::GO:0016925; P:protein sumoylation; IDA:SGD.
3O94451    727   PLI1_SCHPO E3 SUMO-protein ligase pli1 OS=Sch...4462e-42     169     30     45GO:0005634; C:nucleus; IDA:PomBase.
GO:0003676; F:nucleic acid binding; IEA:InterPro.::GO:0019789; F:SUMO ligase activity; IDA:PomBase.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0030999; P:linear element assembly; IMP:PomBase.::GO:0016925; P:protein sumoylation; IMP:PomBase.::GO:0007131; P:reciprocal meiotic recombination; IMP:PomBase.::GO:0051983; P:regulation of chromosome segregation; IMP:PomBase.::GO:0000019; P:regulation of mitotic recombination; IMP:PomBase.::GO:0032204; P:regulation of telomere maintenance; IMP:PomBase.
4Q9JM05    507   PIAS4_MOUSE E3 SUMO-protein ligase PIAS4 OS=M...1911e-21     103     30     51GO:0016363; C:nuclear matrix; IDA:MGI.::GO:0016605; C:PML body; IEA:UniProtKB-SubCell.
GO:0003677; F:DNA binding; IDA:MGI.::GO:0019789; F:SUMO ligase activity; IDA:MGI.::GO:0003714; F:transcription corepressor activity; IDA:MGI.::GO:0031625; F:ubiquitin protein ligase binding; IPI:BHF-UCL.::GO:0008270; F:zinc ion binding; NAS:UniProtKB.
GO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW.::GO:0007275; P:multicellular organismal development; NAS:UniProtKB.::GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; IDA:BHF-UCL.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.::GO:0043065; P:positive regulation of apoptotic process; IDA:BHF-UCL.::GO:0033235; P:positive regulation of protein sumoylation; ISS:UniProtKB.::GO:0016925; P:protein sumoylation; IDA:BHF-UCL.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW.
5Q8N2W9    510   PIAS4_HUMAN E3 SUMO-protein ligase PIAS4 OS=H...1912e-21     102     30     51GO:0005737; C:cytoplasm; IDA:BHF-UCL.::GO:0016605; C:PML body; IEA:UniProtKB-SubCell.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0019789; F:SUMO ligase activity; IDA:BHF-UCL.::GO:0031625; F:ubiquitin protein ligase binding; IPI:BHF-UCL.::GO:0008270; F:zinc ion binding; NAS:UniProtKB.
GO:0033235; P:positive regulation of protein sumoylation; IDA:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW.
6Q6AZ28    572   PIAS2_RAT E3 SUMO-protein ligase PIAS2 OS=Rat...1404e-18     92.8     32     52GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.::GO:0016605; C:PML body; IEA:UniProtKB-SubCell.
GO:0050681; F:androgen receptor binding; IPI:MGI.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0035259; F:glucocorticoid receptor binding; IPI:RGD.::GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0019904; F:protein domain specific binding; IPI:RGD.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0030521; P:androgen receptor signaling pathway; IMP:RGD.::GO:0050775; P:positive regulation of dendrite morphogenesis; IMP:RGD.::GO:0045893; P:positive regulation of transcription, DNA-dependent; IMP:RGD.::GO:0060765; P:regulation of androgen receptor signaling pathway; IDA:MGI.::GO:0033574; P:response to testosterone stimulus; IEP:RGD.::GO:0007283; P:spermatogenesis; IEP:RGD.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
7Q8C5D8    621   PIAS2_MOUSE E3 SUMO-protein ligase PIAS2 OS=M...1405e-18     92.4     32     52GO:0016604; C:nuclear body; IDA:MGI.::GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.::GO:0016605; C:PML body; IEA:UniProtKB-SubCell.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:MGI.::GO:0019789; F:SUMO ligase activity; IDA:MGI.::GO:0031625; F:ubiquitin protein ligase binding; IPI:BHF-UCL.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI.::GO:0016925; P:protein sumoylation; IDA:MGI.::GO:0045667; P:regulation of osteoblast differentiation; IMP:MGI.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
8O75928    621   PIAS2_HUMAN E3 SUMO-protein ligase PIAS2 OS=H...1406e-18     92.4     32     52GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.::GO:0016605; C:PML body; IEA:UniProtKB-SubCell.
GO:0050681; F:androgen receptor binding; NAS:UniProtKB.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0019789; F:SUMO ligase activity; IDA:BHF-UCL.::GO:0003713; F:transcription coactivator activity; NAS:UniProtKB.::GO:0008270; F:zinc ion binding; TAS:ProtInc.
GO:0030521; P:androgen receptor signaling pathway; NAS:UniProtKB.::GO:0060766; P:negative regulation of androgen receptor signaling pathway; IDA:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
9O75925    651   PIAS1_HUMAN E3 SUMO-protein ligase PIAS1 OS=H...1904e-17     89.7     28     50GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
GO:0050681; F:androgen receptor binding; NAS:UniProtKB.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0019899; F:enzyme binding; IPI:UniProtKB.::GO:0019789; F:SUMO ligase activity; IDA:BHF-UCL.::GO:0003713; F:transcription coactivator activity; NAS:UniProtKB.::GO:0003714; F:transcription corepressor activity; TAS:ProtInc.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0030521; P:androgen receptor signaling pathway; NAS:UniProtKB.::GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome.::GO:0007259; P:JAK-STAT cascade; TAS:ProtInc.::GO:0033235; P:positive regulation of protein sumoylation; IDA:UniProtKB.::GO:0045893; P:positive regulation of transcription, DNA-dependent; NAS:UniProtKB.::GO:0060334; P:regulation of interferon-gamma-mediated signaling pathway; TAS:Reactome.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
10O70260    628   PIAS3_RAT E3 SUMO-protein ligase PIAS3 OS=Rat...1502e-16     87.4     30     49GO:0030425; C:dendrite; IDA:RGD.::GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.::GO:0045202; C:synapse; IDA:RGD.
GO:0003676; F:nucleic acid binding; IEA:InterPro.::GO:0015459; F:potassium channel regulator activity; IDA:RGD.::GO:0008022; F:protein C-terminus binding; IDA:RGD.::GO:0047485; F:protein N-terminus binding; IDA:RGD.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0010628; P:positive regulation of gene expression; IDA:RGD.::GO:0045838; P:positive regulation of membrane potential; IDA:RGD.::GO:0016925; P:protein sumoylation; ISS:UniProtKB.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0009725; P:response to hormone stimulus; IEP:RGD.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
11Q9Y6X2    628   PIAS3_HUMAN E3 SUMO-protein ligase PIAS3 OS=H...1503e-16     87     30     49GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0019899; F:enzyme binding; IPI:UniProtKB.::GO:0003676; F:nucleic acid binding; IEA:InterPro.::GO:0008022; F:protein C-terminus binding; IPI:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0033235; P:positive regulation of protein sumoylation; IDA:UniProtKB.::GO:0016925; P:protein sumoylation; ISS:UniProtKB.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
12O54714    628   PIAS3_MOUSE E3 SUMO-protein ligase PIAS3 OS=M...1503e-16     87     30     49GO:0005737; C:cytoplasm; IDA:UniProtKB.::GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0003676; F:nucleic acid binding; IEA:InterPro.::GO:0019789; F:SUMO ligase activity; IDA:MGI.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0033235; P:positive regulation of protein sumoylation; ISS:UniProtKB.::GO:0016925; P:protein sumoylation; ISS:UniProtKB.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
13Q94361    793   GEI17_CAEEL E3 SUMO-protein ligase gei-17 OS=...1784e-16     86.7     28     52
GO:0001085; F:RNA polymerase II transcription factor binding; IPI:WormBase.::GO:0019789; F:SUMO ligase activity; IDA:WormBase.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0010171; P:body morphogenesis; IMP:WormBase.::GO:0006281; P:DNA repair; IEA:UniProtKB-KW.::GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.::GO:0040035; P:hermaphrodite genitalia development; IMP:WormBase.::GO:0040010; P:positive regulation of growth rate; IMP:WormBase.::GO:0040018; P:positive regulation of multicellular organism growth; IMP:WormBase.::GO:0016925; P:protein sumoylation; IDA:WormBase.
14O88907    651   PIAS1_MOUSE E3 SUMO-protein ligase PIAS1 OS=M...1426e-16     85.9     30     53GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0031625; F:ubiquitin protein ligase binding; IPI:BHF-UCL.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:BHF-UCL.::GO:0033235; P:positive regulation of protein sumoylation; ISS:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
15Q9ULJ6    1067   ZMIZ1_HUMAN Zinc finger MIZ domain-containing...1120.00000000000008     79.7     33     54GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
16Q6P1E1    1072   ZMIZ1_MOUSE Zinc finger MIZ domain-containing...1120.00000000000009     79.3     33     54GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
17Q8NF64    920   ZMIZ2_HUMAN Zinc finger MIZ domain-containing...1120.0000000000008     76.3     30     54GO:0005739; C:mitochondrion; IDA:HPA.::GO:0043596; C:nuclear replication fork; IDA:UniProtKB.
GO:0030374; F:ligand-dependent nuclear receptor transcription coactivator activity; IDA:UniProtKB.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
18Q8CIE2    920   ZMIZ2_MOUSE Zinc finger MIZ domain-containing...1120.000000000001     75.5     30     54GO:0043596; C:nuclear replication fork; ISS:UniProtKB.
GO:0030374; F:ligand-dependent nuclear receptor transcription coactivator activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.
19Q6L4L4    875   SIZ1_ORYSJ E3 SUMO-protein ligase SIZ1 OS=Ory...4520.00000000003     70.9     21     40GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0003676; F:nucleic acid binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
20Q6ASW7    813   SIZ2_ORYSJ E3 SUMO-protein ligase SIZ2 OS=Ory...2500.0000000005     67     22     48GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0003676; F:nucleic acid binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
21Q680Q4    884   SIZ1_ARATH E3 SUMO-protein ligase SIZ1 OS=Ara...870.000000002     65.5     29     60GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
GO:0003676; F:nucleic acid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0019789; F:SUMO ligase activity; IDA:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0051301; P:cell division; IMP:TAIR.::GO:0016049; P:cell growth; IMP:TAIR.::GO:0016036; P:cellular response to phosphate starvation; IMP:TAIR.::GO:0006952; P:defense response; IEA:UniProtKB-KW.::GO:0010247; P:detection of phosphate ion; IDA:TAIR.::GO:0048589; P:developmental growth; IMP:UniProtKB.::GO:0009908; P:flower development; IEA:UniProtKB-KW.::GO:0010286; P:heat acclimation; IMP:UniProtKB.::GO:0009910; P:negative regulation of flower development; IMP:TAIR.::GO:0010113; P:negative regulation of systemic acquired resistance; IMP:UniProtKB.::GO:0016925; P:protein sumoylation; IDA:UniProtKB.::GO:0009787; P:regulation of abscisic acid mediated signaling pathway; IMP:TAIR.::GO:0040008; P:regulation of growth; IMP:TAIR.::GO:0090352; P:regulation of nitrate assimilation; IMP:TAIR.::GO:2000070; P:regulation of response to water deprivation; IMP:TAIR.::GO:0010337; P:regulation of salicylic acid metabolic process; IMP:TAIR.::GO:0050826; P:response to freezing; IMP:TAIR.::GO:0009414; P:response to water deprivation; IMP:UniProtKB.
22Q18DN4    9159   HMU_HALWD Halomucin OS=Haloquadratum walsbyi ...1062.6     35.8     29     54GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:InterPro.
GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0030246; F:carbohydrate binding; IEA:InterPro.::GO:0004180; F:carboxypeptidase activity; IEA:InterPro.
GO:0007156; P:homophilic cell adhesion; IEA:InterPro.
23P0C6U3    4471   R1A_CVHN1 Replicase polyprotein 1a OS=Human c...1831.4     36.6     19     42GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.::GO:0044220; C:host cell perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0048471; C:perinuclear region of cytoplasm; IEA:InterPro.::GO:0019034; C:viral replication complex; IEA:InterPro.
GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.::GO:0008242; F:omega peptidase activity; IEA:InterPro.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.::GO:0003968; F:RNA-directed RNA polymerase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0030683; P:evasion by virus of host immune response; IEA:UniProtKB-KW.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.::GO:0019079; P:viral genome replication; IEA:InterPro.::GO:0019082; P:viral protein processing; IEA:InterPro.
24P0C6X2    7182   R1AB_CVHN1 Replicase polyprotein 1ab OS=Human...1831.4     36.6     19     42GO:0044172; C:host cell endoplasmic reticulum-Golgi intermediate compartment; IEA:UniProtKB-SubCell.::GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.::GO:0044220; C:host cell perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0048471; C:perinuclear region of cytoplasm; IEA:InterPro.::GO:0019034; C:viral replication complex; IEA:InterPro.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.::GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0016896; F:exoribonuclease activity, producing 5'-phosphomonoesters; IEA:InterPro.::GO:0004386; F:helicase activity; IEA:UniProtKB-KW.::GO:0008168; F:methyltransferase activity; IEA:InterPro.::GO:0008242; F:omega peptidase activity; IEA:InterPro.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.::GO:0003968; F:RNA-directed RNA polymerase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0030683; P:evasion by virus of host immune response; IEA:UniProtKB-KW.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:InterPro.::GO:0019079; P:viral genome replication; IEA:InterPro.::GO:0019082; P:viral protein processing; IEA:InterPro.
25P0C6U5    4421   R1A_CVHN5 Replicase polyprotein 1a OS=Human c...1401.4     36.6     19     42GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.::GO:0044220; C:host cell perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0048471; C:perinuclear region of cytoplasm; IEA:InterPro.::GO:0019034; C:viral replication complex; IEA:InterPro.
GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.::GO:0008242; F:omega peptidase activity; IEA:InterPro.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.::GO:0003968; F:RNA-directed RNA polymerase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0030683; P:evasion by virus of host immune response; IEA:UniProtKB-KW.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.::GO:0019079; P:viral genome replication; IEA:InterPro.::GO:0019082; P:viral protein processing; IEA:InterPro.
26P0C6X4    7132   R1AB_CVHN5 Replicase polyprotein 1ab OS=Human...1401.4     36.6     19     42GO:0044172; C:host cell endoplasmic reticulum-Golgi intermediate compartment; IEA:UniProtKB-SubCell.::GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.::GO:0044220; C:host cell perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0048471; C:perinuclear region of cytoplasm; IEA:InterPro.::GO:0019034; C:viral replication complex; IEA:InterPro.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.::GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0016896; F:exoribonuclease activity, producing 5'-phosphomonoesters; IEA:InterPro.::GO:0004386; F:helicase activity; IEA:UniProtKB-KW.::GO:0008168; F:methyltransferase activity; IEA:InterPro.::GO:0008242; F:omega peptidase activity; IEA:InterPro.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.::GO:0003968; F:RNA-directed RNA polymerase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0030683; P:evasion by virus of host immune response; IEA:UniProtKB-KW.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:InterPro.::GO:0019079; P:viral genome replication; IEA:InterPro.::GO:0019082; P:viral protein processing; IEA:InterPro.
27P0C6U4    4441   R1A_CVHN2 Replicase polyprotein 1a OS=Human c...1391.5     36.6     19     45GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.::GO:0044220; C:host cell perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0048471; C:perinuclear region of cytoplasm; IEA:InterPro.::GO:0019034; C:viral replication complex; IEA:InterPro.
GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.::GO:0008242; F:omega peptidase activity; IEA:InterPro.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.::GO:0003968; F:RNA-directed RNA polymerase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0030683; P:evasion by virus of host immune response; IEA:UniProtKB-KW.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.::GO:0019079; P:viral genome replication; IEA:InterPro.::GO:0019082; P:viral protein processing; IEA:InterPro.
28P0C6X3    7152   R1AB_CVHN2 Replicase polyprotein 1ab OS=Human...1391.5     36.6     19     45GO:0044172; C:host cell endoplasmic reticulum-Golgi intermediate compartment; IEA:UniProtKB-SubCell.::GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.::GO:0044220; C:host cell perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0048471; C:perinuclear region of cytoplasm; IEA:InterPro.::GO:0019034; C:viral replication complex; IEA:InterPro.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.::GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0016896; F:exoribonuclease activity, producing 5'-phosphomonoesters; IEA:InterPro.::GO:0004386; F:helicase activity; IEA:UniProtKB-KW.::GO:0008168; F:methyltransferase activity; IEA:InterPro.::GO:0008242; F:omega peptidase activity; IEA:InterPro.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.::GO:0003968; F:RNA-directed RNA polymerase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0030683; P:evasion by virus of host immune response; IEA:UniProtKB-KW.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:InterPro.::GO:0019079; P:viral genome replication; IEA:InterPro.::GO:0019082; P:viral protein processing; IEA:InterPro.
29Q6J6J0    1863   BRCA1_PONPY Breast cancer type 1 susceptibili...690.13     40     33     55GO:0031436; C:BRCA1-BARD1 complex; ISS:UniProtKB.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; ISS:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.::GO:0006281; P:DNA repair; IEA:UniProtKB-KW.::GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.::GO:0045717; P:negative regulation of fatty acid biosynthetic process; ISS:UniProtKB.::GO:0051865; P:protein autoubiquitination; ISS:UniProtKB.::GO:0085020; P:protein K6-linked ubiquitination; ISS:UniProtKB.
30P38398    1863   BRCA1_HUMAN Breast cancer type 1 susceptibili...690.14     39.7     33     55GO:0070531; C:BRCA1-A complex; IDA:UniProtKB.::GO:0031436; C:BRCA1-BARD1 complex; IDA:UniProtKB.::GO:0008274; C:gamma-tubulin ring complex; NAS:UniProtKB.::GO:0005654; C:nucleoplasm; TAS:Reactome.::GO:0005886; C:plasma membrane; IDA:BHF-UCL.::GO:0030529; C:ribonucleoprotein complex; IDA:MGI.::GO:0001726; C:ruffle; IDA:BHF-UCL.
GO:0050681; F:androgen receptor binding; NAS:UniProtKB.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0003723; F:RNA binding; IDA:MGI.::GO:0003713; F:transcription coactivator activity; NAS:UniProtKB.::GO:0044212; F:transcription regulatory region DNA binding; IDA:BHF-UCL.::GO:0015631; F:tubulin binding; NAS:UniProtKB.::GO:0031625; F:ubiquitin protein ligase binding; IPI:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB.::GO:0008270; F:zinc ion binding; TAS:ProtInc.
GO:0030521; P:androgen receptor signaling pathway; NAS:UniProtKB.::GO:0006915; P:apoptotic process; TAS:UniProtKB.::GO:0071681; P:cellular response to indole-3-methanol; IDA:UniProtKB.::GO:0007059; P:chromosome segregation; IMP:UniProtKB.::GO:0006978; P:DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; TAS:UniProtKB.::GO:0008630; P:DNA damage response, signal transduction resulting in induction of apoptosis; IDA:MGI.::GO:0000724; P:double-strand break repair via homologous recombination; IDA:HGNC.::GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.::GO:0031572; P:G2/M transition DNA damage checkpoint; IMP:UniProtKB.::GO:0046600; P:negative regulation of centriole replication; NAS:UniProtKB.::GO:0045717; P:negative regulation of fatty acid biosynthetic process; IMP:UniProtKB.::GO:0051573; P:negative regulation of histone H3-K9 methylation; IDA:BHF-UCL.::GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:UniProtKB.::GO:0071158; P:positive regulation of cell cycle arrest; IDA:BHF-UCL.::GO:0045739; P:positive regulation of DNA repair; IMP:UniProtKB.::GO:0051571; P:positive regulation of histone H3-K4 methylation; IDA:BHF-UCL.::GO:2000617; P:positive regulation of histone H3-K9 acetylation; IDA:BHF-UCL.::GO:2000620; P:positive regulation of histone H4-K16 acetylation; IDA:BHF-UCL.::GO:0070512; P:positive regulation of histone H4-K20 methylation; IDA:BHF-UCL.::GO:0031398; P:positive regulation of protein ubiquitination; IDA:UniProtKB.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.::GO:0006301; P:postreplication repair; IDA:HGNC.::GO:0051865; P:protein autoubiquitination; IDA:UniProtKB.::GO:0085020; P:protein K6-linked ubiquitination; IDA:UniProtKB.::GO:2000145; P:regulation of cell motility; IDA:BHF-UCL.::GO:0042127; P:regulation of cell proliferation; TAS:UniProtKB.::GO:0006359; P:regulation of transcription from RNA polymerase III promoter; TAS:UniProtKB.::GO:0010212; P:response to ionizing radiation; IMP:UniProtKB.::GO:0034446; P:substrate adhesion-dependent cell spreading; IDA:BHF-UCL.
31Q6J6I9    1863   BRCA1_MACMU Breast cancer type 1 susceptibili...690.14     39.7     33     55GO:0031436; C:BRCA1-BARD1 complex; ISS:UniProtKB.
GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.::GO:0045717; P:negative regulation of fatty acid biosynthetic process; ISS:UniProtKB.::GO:0051865; P:protein autoubiquitination; ISS:UniProtKB.::GO:0085020; P:protein K6-linked ubiquitination; ISS:UniProtKB.
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