Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YDR388W
Length:
482
Number of sequences:
5887
Description:
YDR388W RVS167 SGDID:S000002796, Chr IV from 1250186-1251634, Genome Release 64-1-1, Verified ORF, "Actin-associated protein with roles in endocytosis and exocytosis; interacts with Rvs161p to regulate actin cytoskeleton, endocytosis, and viability following starvation or osmotic stress; recruited to bud tips by Gyl1p and Gyp5p during polarized growth; homolog of mammalian amphiphysin"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
1P39743    482   RV167_YEAST Reduced viability upon starvation...4820     987     100     100GO:0030479; C:actin cortical patch; IDA:SGD.::GO:0043332; C:mating projection tip; IDA:SGD.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.
GO:0051666; P:actin cortical patch localization; IMP:SGD.::GO:0006897; P:endocytosis; IMP:SGD.::GO:0060988; P:lipid tube assembly; IDA:SGD.
2O74352    466   HOB1_SCHPO Protein hob1 OS=Schizosaccharomyce...2762e-99     313     51     75GO:0051285; C:cell cortex of cell tip; TAS:PomBase.::GO:0031097; C:medial cortex; TAS:PomBase.
GO:0051020; F:GTPase binding; NAS:PomBase.
GO:0030702; P:chromatin silencing at centromere; IMP:PomBase.::GO:0006348; P:chromatin silencing at telomere; IMP:PomBase.::GO:0007163; P:establishment or maintenance of cell polarity; IGI:PomBase.::GO:0007346; P:regulation of mitotic cell cycle; IMP:PomBase.::GO:0006974; P:response to DNA damage stimulus; IGI:PomBase.::GO:0000723; P:telomere maintenance; IMP:PomBase.
3Q9UUM7    264   HOB3_SCHPO Protein hob3 OS=Schizosaccharomyce...2489e-16     80.9     28     46GO:0030479; C:actin cortical patch; ISS:PomBase.::GO:0051285; C:cell cortex of cell tip; IDA:PomBase.::GO:0031097; C:medial cortex; IDA:PomBase.
GO:0008092; F:cytoskeletal protein binding; ISS:PomBase.::GO:0005096; F:GTPase activator activity; IGI:PomBase.
GO:0000917; P:barrier septum assembly; IEA:UniProtKB-KW.::GO:0000915; P:cytokinesis, actomyosin contractile ring assembly; IMP:PomBase.::GO:0010687; P:site selection involved in cell cycle cytokinesis; IMP:PomBase.::GO:0007264; P:small GTPase mediated signal transduction; IGI:PomBase.
4P43603    459   LSB3_YEAST LAS seventeen-binding protein 3 OS...910.000000000007     70.9     40     57GO:0005935; C:cellular bud neck; IDA:SGD.::GO:0005739; C:mitochondrion; IDA:SGD.
GO:0005515; F:protein binding; IPI:IntAct.
GO:0051666; P:actin cortical patch localization; IMP:SGD.
5A7A261    459   LSB3_YEAS7 LAS seventeen-binding protein 3 OS...910.000000000007     70.9     40     57GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
6P32793    468   YSC84_YEAST Protein YSC84 OS=Saccharomyces ce...550.00000000002     69.3     47     73GO:0030479; C:actin cortical patch; IDA:SGD.
GO:0051015; F:actin filament binding; IDA:SGD.
GO:0051666; P:actin cortical patch localization; IMP:SGD.::GO:0051017; P:actin filament bundle assembly; IDA:SGD.::GO:0006897; P:endocytosis; IGI:SGD.
7P25343    265   RV161_YEAST Reduced viability upon starvation...2420.0000000001     65.9     26     46GO:0030479; C:actin cortical patch; IDA:SGD.::GO:0043332; C:mating projection tip; IDA:SGD.::GO:0045121; C:membrane raft; IDA:SGD.
GO:0008092; F:cytoskeletal protein binding; IPI:SGD.::GO:0019904; F:protein domain specific binding; IEA:InterPro.
GO:0051666; P:actin cortical patch localization; IMP:SGD.::GO:0031532; P:actin cytoskeleton reorganization; IMP:SGD.::GO:0000747; P:conjugation with cellular fusion; IMP:SGD.::GO:0006897; P:endocytosis; IMP:SGD.::GO:0060988; P:lipid tube assembly; IDA:SGD.::GO:0006970; P:response to osmotic stress; IMP:SGD.::GO:0042594; P:response to starvation; IMP:SGD.
8O43125    296   CSH3_SCHPO Protein csh3 OS=Schizosaccharomyce...570.0000000002     65.1     49     67GO:0005737; C:cytoplasm; IDA:PomBase.
GO:0030036; P:actin cytoskeleton organization; ISS:PomBase.
9Q5RAQ2    342   SH3Y1_PONAB SH3 domain-containing YSC84-like ...550.0000000003     65.5     47     65
10Q96HL8    342   SH3Y1_HUMAN SH3 domain-containing YSC84-like ...550.0000000003     65.5     47     65
11B0BNA1    340   SH3Y1_RAT SH3 domain-containing YSC84-like pr...550.0000000004     64.7     47     65
12O08641    340   SH3Y1_MOUSE SH3 domain-containing YSC84-like ...550.0000000005     64.7     47     65
GO:0005515; F:protein binding; IPI:IntAct.
13Q3SZ01    341   SH3Y1_BOVIN SH3 domain-containing YSC84-like ...550.0000000007     64.3     45     65
14Q9URW6    430   YIE2_SCHPO SH3 domain-containing protein PJ69...530.0000000009     64.3     45     72GO:0030479; C:actin cortical patch; ISS:PomBase.
GO:0007015; P:actin filament organization; ISS:PomBase.::GO:0006897; P:endocytosis; ISS:PomBase.
15Q9Z0R4    1714   ITSN1_MOUSE Intersectin-1 OS=Mus musculus (Mo...930.001     45.8     33     49GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0030139; C:endocytic vesicle; IDA:MGI.::GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.::GO:0030027; C:lamellipodium; IDA:MGI.::GO:0016020; C:membrane; IEA:UniProtKB-KW.::GO:0045202; C:synapse; IEA:UniProtKB-KW.::GO:0019717; C:synaptosome; IEA:UniProtKB-SubCell.
GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0019209; F:kinase activator activity; IDA:MGI.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0043524; P:negative regulation of neuron apoptotic process; IMP:MGI.::GO:0051897; P:positive regulation of protein kinase B signaling cascade; IDA:MGI.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IDA:MGI.
16O00160    1098   MYO1F_HUMAN Unconventional myosin-If OS=Homo ...2040.000000006     62.4     29     39GO:0016461; C:unconventional myosin complex; NAS:UniProtKB.
GO:0003779; F:actin binding; NAS:UniProtKB.::GO:0005524; F:ATP binding; NAS:UniProtKB.::GO:0005516; F:calmodulin binding; NAS:UniProtKB.::GO:0003774; F:motor activity; IEA:InterPro.
17Q9WVE9    1217   ITSN1_RAT Intersectin-1 OS=Rattus norvegicus ...930.001     45.1     33     49GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.::GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-KW.::GO:0045202; C:synapse; IEA:UniProtKB-KW.::GO:0019717; C:synaptosome; IEA:UniProtKB-SubCell.
GO:0005509; F:calcium ion binding; IEA:InterPro.
GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0006887; P:exocytosis; TAS:RGD.
18Q63356    1107   MYO1E_RAT Unconventional myosin-Ie OS=Rattus ...700.00000001     61.2     46     56GO:0005912; C:adherens junction; ISS:UniProtKB.::GO:0005911; C:cell-cell junction; ISS:UniProtKB.::GO:0030136; C:clathrin-coated vesicle; IEA:UniProtKB-SubCell.::GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
GO:0051015; F:actin filament binding; ISS:UniProtKB.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0042623; F:ATPase activity, coupled; ISS:UniProtKB.::GO:0005516; F:calmodulin binding; ISS:UniProtKB.::GO:0003774; F:motor activity; IEA:InterPro.::GO:0035091; F:phosphatidylinositol binding; ISS:UniProtKB.::GO:0032403; F:protein complex binding; IDA:RGD.
GO:0006897; P:endocytosis; ISS:UniProtKB.::GO:0032836; P:glomerular basement membrane development; ISS:UniProtKB.::GO:0003094; P:glomerular filtration; ISS:UniProtKB.::GO:0072015; P:glomerular visceral epithelial cell development; ISS:UniProtKB.
19A1CEK6    599   HSE1_ASPCL Class E vacuolar protein-sorting m...830.00000002     60.5     39     54GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
GO:0006886; P:intracellular protein transport; IEA:InterPro.
20Q12965    1108   MYO1E_HUMAN Unconventional myosin-Ie OS=Homo ...700.00000002     60.8     44     56GO:0005912; C:adherens junction; ISS:UniProtKB.::GO:0005911; C:cell-cell junction; ISS:UniProtKB.::GO:0030136; C:clathrin-coated vesicle; IEA:UniProtKB-SubCell.::GO:0016459; C:myosin complex; TAS:UniProtKB.
GO:0051015; F:actin filament binding; IDA:UniProtKB.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0042623; F:ATPase activity, coupled; IDA:UniProtKB.::GO:0005516; F:calmodulin binding; IDA:UniProtKB.::GO:0000146; F:microfilament motor activity; TAS:UniProtKB.::GO:0035091; F:phosphatidylinositol binding; IDA:UniProtKB.
GO:0030048; P:actin filament-based movement; TAS:UniProtKB.::GO:0006897; P:endocytosis; IMP:UniProtKB.::GO:0032836; P:glomerular basement membrane development; ISS:UniProtKB.::GO:0003094; P:glomerular filtration; ISS:UniProtKB.::GO:0072015; P:glomerular visceral epithelial cell development; ISS:UniProtKB.
21E9Q634    1107   MYO1E_MOUSE Unconventional myosin-Ie OS=Mus m...700.00000002     60.8     44     56GO:0005912; C:adherens junction; IDA:UniProtKB.::GO:0005911; C:cell-cell junction; IDA:UniProtKB.::GO:0030136; C:clathrin-coated vesicle; IEA:UniProtKB-SubCell.::GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
GO:0051015; F:actin filament binding; ISS:UniProtKB.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0042623; F:ATPase activity, coupled; ISS:UniProtKB.::GO:0005516; F:calmodulin binding; ISS:UniProtKB.::GO:0003774; F:motor activity; IEA:InterPro.::GO:0035091; F:phosphatidylinositol binding; ISS:UniProtKB.
GO:0006897; P:endocytosis; ISS:UniProtKB.::GO:0032836; P:glomerular basement membrane development; IMP:UniProtKB.::GO:0003094; P:glomerular filtration; IMP:UniProtKB.::GO:0072015; P:glomerular visceral epithelial cell development; IMP:UniProtKB.::GO:0001701; P:in utero embryonic development; IMP:MGI.::GO:0048008; P:platelet-derived growth factor receptor signaling pathway; IMP:MGI.::GO:0035166; P:post-embryonic hemopoiesis; IMP:MGI.::GO:0001570; P:vasculogenesis; IMP:MGI.
22Q15811    1721   ITSN1_HUMAN Intersectin-1 OS=Homo sapiens (Hu...2290.00000009     58.5     26     40GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005905; C:coated pit; IDA:UniProtKB.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IDA:UniProtKB.::GO:0045202; C:synapse; IEA:UniProtKB-KW.::GO:0019717; C:synaptosome; IEA:UniProtKB-SubCell.
GO:0005509; F:calcium ion binding; NAS:UniProtKB.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0070064; F:proline-rich region binding; IPI:UniProtKB.::GO:0032947; F:protein complex scaffold; IDA:UniProtKB.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.::GO:0048488; P:synaptic vesicle endocytosis; TAS:ProtInc.
23Q6DFH5    335   SH3Y1_XENLA SH3 domain-containing YSC84-like ...540.00000003     58.9     44     63
24P70248    1099   MYO1F_MOUSE Unconventional myosin-If OS=Mus m...930.00000005     59.3     39     47GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0003774; F:motor activity; IEA:InterPro.
25P10569    1168   MYSC_ACACA Myosin IC heavy chain OS=Acanthamo...570.0000001     58.5     46     67GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003774; F:motor activity; IEA:InterPro.
26Q1E878    612   HSE1_COCIM Class E vacuolar protein-sorting m...720.0000001     58.2     39     54GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
GO:0006886; P:intracellular protein transport; IEA:InterPro.
27O01498    457   STAM1_CAEEL Signal transducing adapter molecu...720.0000001     57.4     43     61GO:0044441; C:cilium part; IDA:UniProtKB.::GO:0005769; C:early endosome; IDA:WormBase.::GO:0033565; C:ESCRT-0 complex; IPI:WormBase.
GO:0008022; F:protein C-terminus binding; IPI:WormBase.::GO:0043130; F:ubiquitin binding; IDA:WormBase.
GO:0008333; P:endosome to lysosome transport; IMP:WormBase.::GO:0048013; P:ephrin receptor signaling pathway; IGI:UniProtKB.::GO:0006886; P:intracellular protein transport; IEA:InterPro.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.::GO:0043409; P:negative regulation of MAPK cascade; IMP:UniProtKB.
28O08838    683   AMPH_RAT Amphiphysin OS=Rattus norvegicus (Ra...2210.0000002     57.4     25     43GO:0043679; C:axon terminus; IDA:RGD.::GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
GO:0008022; F:protein C-terminus binding; IPI:RGD.::GO:0046982; F:protein heterodimerization activity; IPI:RGD.
GO:0045807; P:positive regulation of endocytosis; IMP:RGD.::GO:0043547; P:positive regulation of GTPase activity; IDA:RGD.
29O94868    740   FCSD2_HUMAN FCH and double SH3 domains protei...1160.0000002     57.4     34     47
GO:0005515; F:protein binding; IPI:IntAct.
30Q7TQF7    686   AMPH_MOUSE Amphiphysin OS=Mus musculus (Mouse...2210.0000002     57.4     25     43GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
GO:0007612; P:learning; IMP:MGI.::GO:0048488; P:synaptic vesicle endocytosis; IMP:MGI.
31Q7TSG5    549   SH321_MOUSE SH3 domain-containing protein 21 ...540.0000002     57     37     65
records
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