Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YDR388W
Length:
482
Number of sequences:
5887
Description:
YDR388W RVS167 SGDID:S000002796, Chr IV from 1250186-1251634, Genome Release 64-1-1, Verified ORF, "Actin-associated protein with roles in endocytosis and exocytosis; interacts with Rvs161p to regulate actin cytoskeleton, endocytosis, and viability following starvation or osmotic stress; recruited to bud tips by Gyl1p and Gyp5p during polarized growth; homolog of mammalian amphiphysin"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
241Q68F99    337   STAC3_XENTR SH3 and cysteine-rich domain-cont...710.002     43.9     32     46
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0035556; P:intracellular signal transduction; IEA:InterPro.
242Q9ULH1    1129   ASAP1_HUMAN Arf-GAP with SH3 domain, ANK repe...850.002     44.7     36     46GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0008060; F:ARF GTPase activator activity; IEA:InterPro.::GO:0008093; F:cytoskeletal adaptor activity; IEA:InterPro.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0017124; F:SH3 domain binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0060271; P:cilium morphogenesis; IMP:UniProtKB.::GO:0046847; P:filopodium assembly; IEA:InterPro.::GO:0032312; P:regulation of ARF GTPase activity; IEA:InterPro.::GO:0007165; P:signal transduction; IEA:InterPro.
243Q9P2A4    366   ABI3_HUMAN ABI gene family member 3 OS=Homo s...560.002     43.9     41     54GO:0005737; C:cytoplasm; NAS:UniProtKB.::GO:0030027; C:lamellipodium; IDA:MGI.
GO:0005515; F:protein binding; IPI:IntAct.
GO:0006928; P:cellular component movement; NAS:UniProtKB.::GO:0030334; P:regulation of cell migration; IDA:MGI.
244P50545    524   HCK_RAT Tyrosine-protein kinase HCK OS=Rattus...870.002     44.3     34     46GO:0005901; C:caveola; IEA:UniProtKB-SubCell.::GO:0042995; C:cell projection; IEA:UniProtKB-KW.::GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0031234; C:extrinsic to internal side of plasma membrane; ISS:UniProtKB.::GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.::GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0005764; C:lysosome; ISS:UniProtKB.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0030133; C:transport vesicle; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.
GO:0006887; P:exocytosis; IEA:UniProtKB-KW.::GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.::GO:0045087; P:innate immune response; IEA:UniProtKB-KW.::GO:0018108; P:peptidyl-tyrosine phosphorylation; ISS:UniProtKB.::GO:0006909; P:phagocytosis; IEA:UniProtKB-KW.::GO:2000251; P:positive regulation of actin cytoskeleton reorganization; ISS:UniProtKB.::GO:0008284; P:positive regulation of cell proliferation; ISS:UniProtKB.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.::GO:0008360; P:regulation of cell shape; ISS:UniProtKB.::GO:0050764; P:regulation of phagocytosis; ISS:UniProtKB.::GO:0071801; P:regulation of podosome assembly; ISS:UniProtKB.
245P06241    537   FYN_HUMAN Tyrosine-protein kinase Fyn OS=Homo...580.002     44.3     40     52GO:0005829; C:cytosol; TAS:Reactome.::GO:0005768; C:endosome; IDA:HGNC.::GO:0005886; C:plasma membrane; IDA:HGNC.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046875; F:ephrin receptor binding; IPI:UniProtKB.::GO:0001948; F:glycoprotein binding; IPI:BHF-UCL.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; NAS:UniProtKB.
GO:0007411; P:axon guidance; TAS:Reactome.::GO:0006816; P:calcium ion transport; NAS:UniProtKB.::GO:0007631; P:feeding behavior; TAS:ProtInc.::GO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW.::GO:0007243; P:intracellular protein kinase cascade; TAS:ProtInc.::GO:0007612; P:learning; TAS:ProtInc.::GO:0050900; P:leukocyte migration; TAS:Reactome.::GO:0030168; P:platelet activation; TAS:Reactome.::GO:0050690; P:regulation of defense response to virus by virus; TAS:Reactome.::GO:0031295; P:T cell costimulation; TAS:Reactome.::GO:0050852; P:T cell receptor signaling pathway; IDA:UniProtKB.::GO:0016032; P:viral reproduction; TAS:Reactome.
246A1Y2K1    537   FYN_PIG Tyrosine-protein kinase Fyn OS=Sus sc...580.002     44.3     40     52GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.
247Q62844    537   FYN_RAT Tyrosine-protein kinase Fyn OS=Rattus...580.002     44.3     40     52GO:0005829; C:cytosol; TAS:Reactome.::GO:0005792; C:microsome; IDA:RGD.::GO:0005739; C:mitochondrion; IDA:RGD.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0014069; C:postsynaptic density; IDA:RGD.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0042609; F:CD4 receptor binding; IPI:RGD.::GO:0042610; F:CD8 receptor binding; IPI:RGD.::GO:0001948; F:glycoprotein binding; IPI:RGD.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.::GO:0051428; F:peptide hormone receptor binding; IPI:RGD.::GO:0043548; F:phosphatidylinositol 3-kinase binding; IDA:RGD.::GO:0042608; F:T cell receptor binding; IDA:RGD.
GO:0071363; P:cellular response to growth factor stimulus; IEP:RGD.::GO:0071375; P:cellular response to peptide hormone stimulus; IEP:RGD.::GO:0035235; P:ionotropic glutamate receptor signaling pathway; TAS:RGD.::GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; IMP:UniProtKB.::GO:0018108; P:peptidyl-tyrosine phosphorylation; IDA:RGD.::GO:0046777; P:protein autophosphorylation; IDA:RGD.::GO:0042493; P:response to drug; IEP:RGD.
248P39688    537   FYN_MOUSE Tyrosine-protein kinase Fyn OS=Mus ...580.002     44.3     40     52GO:0005829; C:cytosol; TAS:Reactome.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0044325; F:ion channel binding; IPI:BHF-UCL.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.::GO:0015631; F:tubulin binding; IDA:MGI.
GO:0050798; P:activated T cell proliferation; IMP:MGI.::GO:0048813; P:dendrite morphogenesis; IMP:MGI.::GO:0050966; P:detection of mechanical stimulus involved in sensory perception of pain; IMP:MGI.::GO:0030900; P:forebrain development; IMP:MGI.::GO:0042552; P:myelination; TAS:MGI.::GO:0010629; P:negative regulation of gene expression; IMP:BHF-UCL.::GO:0042177; P:negative regulation of protein catabolic process; IMP:MGI.::GO:0001764; P:neuron migration; IMP:MGI.::GO:0018108; P:peptidyl-tyrosine phosphorylation; IDA:MGI.::GO:0046777; P:protein autophosphorylation; IDA:MGI.::GO:0008360; P:regulation of cell shape; IDA:MGI.::GO:0045471; P:response to ethanol; IGI:MGI.
249O14302    886   CYK3_SCHPO cytokinesis protein 3 OS=Schizosac...560.002     44.3     38     54GO:0005826; C:actomyosin contractile ring; NAS:PomBase.::GO:0051286; C:cell tip; IDA:PomBase.
GO:0033205; P:cell cycle cytokinesis; NAS:PomBase.
250O55033    380   NCK2_MOUSE Cytoplasmic protein NCK2 OS=Mus mu...680.049     39.7     31     50GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.::GO:0012506; C:vesicle membrane; IDA:MGI.
GO:0007015; P:actin filament organization; IMP:MGI.::GO:0016477; P:cell migration; IMP:MGI.::GO:0030032; P:lamellipodium assembly; IMP:MGI.::GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
251Q64355    560   EFS_MOUSE Embryonal Fyn-associated substrate ...650.002     44.3     35     55
GO:0017124; F:SH3 domain binding; IDA:MGI.
GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
252Q8C120    878   SH3R3_MOUSE SH3 domain-containing RING finger...802     34.7     34     45
GO:0008270; F:zinc ion binding; IEA:InterPro.
253A0JNB0    537   FYN_BOVIN Tyrosine-protein kinase Fyn OS=Bos ...580.002     44.3     40     52GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.
254O88811    523   STAM2_MOUSE Signal transducing adapter molecu...520.002     44.3     38     60GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
GO:0006886; P:intracellular protein transport; IEA:InterPro.
255Q96KQ4    1090   ASPP1_HUMAN Apoptosis-stimulating of p53 prot...530.002     44.3     38     58GO:0005737; C:cytoplasm; TAS:UniProtKB.::GO:0005634; C:nucleus; IDA:UniProtKB.::GO:0005886; C:plasma membrane; IDA:HPA.
GO:0005515; F:protein binding; IPI:UniProtKB.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0006917; P:induction of apoptosis; IDA:UniProtKB.::GO:0045786; P:negative regulation of cell cycle; TAS:UniProtKB.
256Q1AAU6    1144   ASAP1_RAT Arf-GAP with SH3 domain, ANK repeat...600.002     44.3     42     53GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0008060; F:ARF GTPase activator activity; IEA:InterPro.::GO:0008093; F:cytoskeletal adaptor activity; IEA:InterPro.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0017124; F:SH3 domain binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0060271; P:cilium morphogenesis; ISS:UniProtKB.::GO:0046847; P:filopodium assembly; IEA:InterPro.::GO:0032312; P:regulation of ARF GTPase activity; IEA:InterPro.::GO:0007165; P:signal transduction; IEA:InterPro.
257Q8K3E5    1047   AHI1_MOUSE Jouberin OS=Mus musculus (Mouse). ...530.002     44.3     40     57GO:0005912; C:adherens junction; ISS:UniProtKB.::GO:0005911; C:cell-cell junction; ISS:UniProtKB.::GO:0005814; C:centriole; IDA:UniProtKB.::GO:0005932; C:microtubule basal body; IDA:UniProtKB.::GO:0036038; C:TCTN-B9D complex; IDA:UniProtKB.
GO:0005515; F:protein binding; IPI:UniProtKB.
GO:0042384; P:cilium assembly; IMP:UniProtKB.::GO:0035844; P:cloaca development; IGI:UniProtKB.::GO:0001947; P:heart looping; IGI:UniProtKB.::GO:0030902; P:hindbrain development; IGI:UniProtKB.::GO:0070121; P:Kupffer's vesicle development; ISS:UniProtKB.::GO:0070986; P:left/right axis specification; ISS:UniProtKB.::GO:0001738; P:morphogenesis of a polarized epithelium; IMP:UniProtKB.::GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB.::GO:0071599; P:otic vesicle development; IGI:UniProtKB.::GO:0035845; P:photoreceptor cell outer segment organization; IGI:UniProtKB.::GO:0030862; P:positive regulation of polarized epithelial cell differentiation; IMP:UniProtKB.::GO:0002092; P:positive regulation of receptor internalization; IMP:UniProtKB.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:UniProtKB.::GO:0039023; P:pronephric duct morphogenesis; ISS:UniProtKB.::GO:0039008; P:pronephric nephron tubule morphogenesis; IGI:UniProtKB.::GO:0033365; P:protein localization to organelle; IMP:UniProtKB.::GO:0050795; P:regulation of behavior; IMP:UniProtKB.::GO:0010842; P:retina layer formation; IGI:UniProtKB.::GO:0065001; P:specification of axis polarity; IGI:UniProtKB.::GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IMP:UniProtKB.::GO:0016192; P:vesicle-mediated transport; IMP:UniProtKB.
258Q9QWY8    1147   ASAP1_MOUSE Arf-GAP with SH3 domain, ANK repe...600.002     44.3     42     53GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0008060; F:ARF GTPase activator activity; IEA:InterPro.::GO:0008093; F:cytoskeletal adaptor activity; IEA:InterPro.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0017124; F:SH3 domain binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0060271; P:cilium morphogenesis; ISS:UniProtKB.::GO:0046847; P:filopodium assembly; IEA:InterPro.::GO:0032312; P:regulation of ARF GTPase activity; IEA:InterPro.::GO:0007165; P:signal transduction; IEA:InterPro.
259P15498    845   VAV_HUMAN Proto-oncogene vav OS=Homo sapiens ...760.002     44.3     33     47GO:0005829; C:cytosol; TAS:Reactome.::GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; TAS:ProtInc.
GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0030168; P:platelet activation; TAS:Reactome.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.::GO:0031295; P:T cell costimulation; TAS:Reactome.
260Q8TEC5    729   SH3R2_HUMAN Putative E3 ubiquitin-protein lig...793.7     33.9     28     44
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008157; F:protein phosphatase 1 binding; IDA:UniProtKB.::GO:0004864; F:protein phosphatase inhibitor activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0010923; P:negative regulation of phosphatase activity; IDA:UniProtKB.
261Q5I0D6    502   NOSTN_RAT Nostrin OS=Rattus norvegicus (Rat)....530.002     43.9     34     57GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
262Q96MF2    364   STAC3_HUMAN SH3 and cysteine-rich domain-cont...510.003     43.5     35     55
GO:0042802; F:identical protein binding; IPI:IntAct.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0035556; P:intracellular signal transduction; IEA:InterPro.
263Q8BYZ1    367   ABI3_MOUSE ABI gene family member 3 OS=Mus mu...560.003     43.5     41     52GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
264Q09746    642   BZZ1_SCHPO Protein BZZ1 OS=Schizosaccharomyce...520.003     43.9     44     54GO:0030479; C:actin cortical patch; ISS:PomBase.::GO:0032153; C:cell division site; IDA:PomBase.::GO:0051286; C:cell tip; IDA:PomBase.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0007015; P:actin filament organization; ISS:PomBase.::GO:0006897; P:endocytosis; ISS:PomBase.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.
265O43281    561   EFS_HUMAN Embryonal Fyn-associated substrate ...650.003     43.9     35     55GO:0005737; C:cytoplasm; TAS:ProtInc.
GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.::GO:0035556; P:intracellular signal transduction; TAS:ProtInc.
266Q05876    534   FYN_CHICK Tyrosine-protein kinase Fyn OS=Gall...580.003     43.9     40     52
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.::GO:0015631; F:tubulin binding; ISS:AgBase.
GO:0030900; P:forebrain development; ISS:AgBase.::GO:0001764; P:neuron migration; ISS:AgBase.::GO:0018108; P:peptidyl-tyrosine phosphorylation; ISS:AgBase.::GO:0008360; P:regulation of cell shape; ISS:AgBase.
267O13736    1420   SLA1_SCHPO Actin cytoskeleton-regulatory comp...570.003     43.9     35     60GO:0030479; C:actin cortical patch; IEA:UniProtKB-SubCell.::GO:0032153; C:cell division site; IDA:PomBase.::GO:0051286; C:cell tip; IDA:PomBase.::GO:0005829; C:cytosol; IDA:PomBase.::GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0042802; F:identical protein binding; IEA:InterPro.::GO:0030674; F:protein binding, bridging; IEA:InterPro.::GO:0043130; F:ubiquitin binding; IEA:InterPro.
GO:0000147; P:actin cortical patch assembly; ISS:PomBase.::GO:0007015; P:actin filament organization; ISS:PomBase.::GO:0006897; P:endocytosis; ISS:PomBase.::GO:0031505; P:fungal-type cell wall organization; ISS:PomBase.
268Q99469    402   STAC_HUMAN SH3 and cysteine-rich domain-conta...570.003     43.5     37     53GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005625; C:soluble fraction; TAS:ProtInc.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0035556; P:intracellular signal transduction; IEA:InterPro.
269Q5XHY7    523   STAM2_RAT Signal transducing adapter molecule...900.003     43.5     32     50GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
GO:0006886; P:intracellular protein transport; IEA:InterPro.
270Q5RDK0    564   ARHG9_PONAB Rho guanine nucleotide exchange f...660.003     43.5     27     58GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
271Q9UBW5    565   BIN2_HUMAN Bridging integrator 2 OS=Homo sapi...2430.003     43.5     25     42GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005515; F:protein binding; IPI:IntAct.
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