Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YDR388W
Length:
482
Number of sequences:
5887
Description:
YDR388W RVS167 SGDID:S000002796, Chr IV from 1250186-1251634, Genome Release 64-1-1, Verified ORF, "Actin-associated protein with roles in endocytosis and exocytosis; interacts with Rvs161p to regulate actin cytoskeleton, endocytosis, and viability following starvation or osmotic stress; recruited to bud tips by Gyl1p and Gyp5p during polarized growth; homolog of mammalian amphiphysin"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
151P98171    946   RHG04_HUMAN Rho GTPase-activating protein 4 O...580.0002     48.1     34     55GO:0005829; C:cytosol; TAS:Reactome.::GO:0005925; C:focal adhesion; IDA:HPA.::GO:0005634; C:nucleus; IDA:HPA.
GO:0005100; F:Rho GTPase activator activity; TAS:ProtInc.::GO:0005070; F:SH3/SH2 adaptor activity; TAS:ProtInc.
GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0007010; P:cytoskeleton organization; TAS:ProtInc.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0007266; P:Rho protein signal transduction; TAS:ProtInc.
152Q66HA1    850   M3K11_RAT Mitogen-activated protein kinase ki...700.0002     48.1     37     54GO:0005625; C:soluble fraction; IDA:RGD.
GO:0005524; F:ATP binding; IDA:RGD.::GO:0004706; F:JUN kinase kinase kinase activity; IDA:RGD.::GO:0031434; F:mitogen-activated protein kinase kinase binding; IPI:RGD.::GO:0004713; F:protein tyrosine kinase activity; IEA:InterPro.::GO:0048365; F:Rac GTPase binding; IPI:RGD.
GO:0008219; P:cell death; IMP:RGD.::GO:0043525; P:positive regulation of neuron apoptotic process; IMP:RGD.::GO:0046777; P:protein autophosphorylation; IDA:RGD.
153Q62421    347   SH3G3_MOUSE Endophilin-A3 OS=Mus musculus (Mo...950.0002     47.4     26     48GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
154P09324    541   YES_CHICK Tyrosine-protein kinase Yes OS=Gall...1150.0002     47.8     31     43GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.
155O75886    525   STAM2_HUMAN Signal transducing adapter molecu...570.0002     47.8     42     56GO:0005829; C:cytosol; TAS:Reactome.::GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IDA:HPA.
GO:0005515; F:protein binding; IPI:IntAct.
GO:0016044; P:cellular membrane organization; TAS:Reactome.::GO:0016197; P:endosome transport; TAS:Reactome.::GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome.::GO:0006886; P:intracellular protein transport; IEA:InterPro.::GO:0042059; P:negative regulation of epidermal growth factor receptor signaling pathway; TAS:Reactome.
156Q99962    352   SH3G2_HUMAN Endophilin-A1 OS=Homo sapiens (Hu...980.0002     47     30     45GO:0005829; C:cytosol; TAS:Reactome.::GO:0000139; C:Golgi membrane; TAS:Reactome.::GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0042802; F:identical protein binding; IPI:IntAct.::GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
GO:0007411; P:axon guidance; TAS:Reactome.::GO:0016044; P:cellular membrane organization; TAS:Reactome.::GO:0007417; P:central nervous system development; TAS:ProtInc.::GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome.::GO:0042059; P:negative regulation of epidermal growth factor receptor signaling pathway; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0006892; P:post-Golgi vesicle-mediated transport; TAS:Reactome.
157P49710    486   HCLS1_MOUSE Hematopoietic lineage cell-specif...520.0002     47.4     42     62GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0032403; F:protein complex binding; IPI:MGI.::GO:0017124; F:SH3 domain binding; IDA:MGI.
GO:0030218; P:erythrocyte differentiation; IMP:UniProtKB.::GO:0008284; P:positive regulation of cell proliferation; IMP:UniProtKB.::GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IMP:UniProtKB.::GO:0009725; P:response to hormone stimulus; IDA:UniProtKB.
158Q9UNF0    486   PACN2_HUMAN Protein kinase C and casein kinas...810.0002     47.4     38     52GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell.
GO:0005215; F:transporter activity; TAS:ProtInc.
GO:0030036; P:actin cytoskeleton organization; TAS:ProtInc.::GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
159Q8I1A6    366   SH3G3_DROWI Endophilin-A OS=Drosophila willis...520.0002     47     38     58GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0042171; F:lysophosphatidic acid acyltransferase activity; ISS:UniProtKB.
GO:0050803; P:regulation of synapse structure and activity; ISS:UniProtKB.::GO:0048488; P:synaptic vesicle endocytosis; ISS:UniProtKB.
160P35991    659   BTK_MOUSE Tyrosine-protein kinase BTK OS=Mus ...820.0002     47.8     34     45GO:0031410; C:cytoplasmic vesicle; IDA:MGI.::GO:0005634; C:nucleus; IDA:MGI.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0048469; P:cell maturation; IMP:MGI.::GO:0007249; P:I-kappaB kinase/NF-kappaB cascade; IMP:MGI.::GO:0045087; P:innate immune response; IEA:UniProtKB-KW.::GO:0018108; P:peptidyl-tyrosine phosphorylation; IDA:MGI.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
161O43295    1099   SRGP3_HUMAN SLIT-ROBO Rho GTPase-activating p...570.0002     47.8     35     58GO:0005829; C:cytosol; TAS:Reactome.
GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
GO:0051056; P:regulation of small GTPase mediated signal transduction; TAS:Reactome.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.
162Q5TCX8    1036   M3KL4_HUMAN Mitogen-activated protein kinase ...530.0003     47.4     38     60
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004709; F:MAP kinase kinase kinase activity; IEA:EC.::GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.::GO:0004713; F:protein tyrosine kinase activity; IEA:InterPro.
GO:0007257; P:activation of JUN kinase activity; ISS:UniProtKB.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.
163P07947    543   YES_HUMAN Tyrosine-protein kinase Yes OS=Homo...580.0003     47     41     52GO:0005829; C:cytosol; TAS:Reactome.::GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IDA:HPA.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0044325; F:ion channel binding; IPI:BHF-UCL.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; TAS:BHF-UCL.
GO:0007596; P:blood coagulation; TAS:Reactome.::GO:0050900; P:leukocyte migration; TAS:Reactome.::GO:0043114; P:regulation of vascular permeability; TAS:BHF-UCL.::GO:0031295; P:T cell costimulation; TAS:Reactome.
164Q28923    539   YES_CANFA Tyrosine-protein kinase Yes OS=Cani...580.0003     47     41     52GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.
165F1LM93    541   YES_RAT Tyrosine-protein kinase Yes OS=Rattus...580.0003     47     41     52GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0005624; C:membrane fraction; IDA:RGD.::GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005154; F:epidermal growth factor receptor binding; IPI:RGD.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.
GO:0046777; P:protein autophosphorylation; IDA:RGD.
166O76041    1014   NEBL_HUMAN Nebulette OS=Homo sapiens (Human)....1320.0003     47.4     26     41GO:0001725; C:stress fiber; IDA:UniProtKB.::GO:0030018; C:Z disc; IDA:UniProtKB.
GO:0051015; F:actin filament binding; IDA:UniProtKB.::GO:0031005; F:filamin binding; IPI:UniProtKB.::GO:0008307; F:structural constituent of muscle; NAS:UniProtKB.::GO:0005523; F:tropomyosin binding; IPI:UniProtKB.
GO:0071691; P:cardiac muscle thin filament assembly; IMP:UniProtKB.
167Q6GPD0    1940   RHG32_XENLA Rho GTPase-activating protein 32 ...610.0003     47.4     31     51GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
GO:0007165; P:signal transduction; IEA:InterPro.
168Q9CX99    217   GRAP_MOUSE GRB2-related adapter protein OS=Mu...530.1     38.1     32     55
169Q9NR80    690   ARHG4_HUMAN Rho guanine nucleotide exchange f...600.0003     47     38     53GO:0005829; C:cytosol; TAS:Reactome.::GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell.
GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0019904; F:protein domain specific binding; IPI:UniProtKB.::GO:0030676; F:Rac guanyl-nucleotide exchange factor activity; IMP:UniProtKB.
GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0046847; P:filopodium assembly; IMP:UniProtKB.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0030032; P:lamellipodium assembly; IMP:UniProtKB.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.
170Q04736    541   YES_MOUSE Tyrosine-protein kinase Yes OS=Mus ...580.0003     47     41     52GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.
GO:0015758; P:glucose transport; IDA:MGI.
171A5GFW5    784   CASS4_PIG Cas scaffolding protein family memb...610.0003     47     34     54GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.
GO:0000155; F:two-component sensor activity; IEA:InterPro.
GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
172Q9ES28    862   ARHG7_MOUSE Rho guanine nucleotide exchange f...550.0003     47     40     56GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.::GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.::GO:0001726; C:ruffle; IEA:UniProtKB-SubCell.
GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0019901; F:protein kinase binding; IPI:BHF-UCL.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0007399; P:nervous system development; IEA:UniProtKB-KW.::GO:0043065; P:positive regulation of apoptotic process; ISS:UniProtKB.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
173O55043    646   ARHG7_RAT Rho guanine nucleotide exchange fac...550.0003     47     40     56GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.::GO:0005925; C:focal adhesion; IDA:RGD.::GO:0030426; C:growth cone; IDA:RGD.::GO:0001726; C:ruffle; IEA:UniProtKB-SubCell.
GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
GO:0043615; P:astrocyte cell migration; IMP:RGD.::GO:0043065; P:positive regulation of apoptotic process; ISS:UniProtKB.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IDA:RGD.
174P87379    229   GRB2A_XENLA Growth factor receptor-bound prot...520.002     43.1     37     60GO:0005768; C:endosome; ISS:UniProtKB.::GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0005154; F:epidermal growth factor receptor binding; ISS:UniProtKB.::GO:0043560; F:insulin receptor substrate binding; ISS:UniProtKB.
GO:0007143; P:female meiosis; IDA:UniProtKB.::GO:0008286; P:insulin receptor signaling pathway; ISS:UniProtKB.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
175Q9QY53    687   NPHP1_MOUSE Nephrocystin-1 OS=Mus musculus (M...580.0003     47     41     60GO:0005912; C:adherens junction; IEA:UniProtKB-SubCell.::GO:0035085; C:cilium axoneme; IEA:UniProtKB-SubCell.::GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.::GO:0031514; C:motile cilium; ISS:UniProtKB.::GO:0032391; C:photoreceptor connecting cilium; IDA:UniProtKB.::GO:0005923; C:tight junction; IEA:UniProtKB-SubCell.
GO:0005515; F:protein binding; IPI:IntAct.
GO:0030030; P:cell projection organization; IMP:UniProtKB.::GO:0034613; P:cellular protein localization; IGI:UniProtKB.::GO:0035845; P:photoreceptor cell outer segment organization; IGI:UniProtKB.::GO:0060041; P:retina development in camera-type eye; IMP:UniProtKB.::GO:0048515; P:spermatid differentiation; IMP:UniProtKB.
176A2AAY5    908   SPD2B_MOUSE SH3 and PX domain-containing prot...570.0003     47     35     61GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0042995; C:cell projection; IEA:UniProtKB-KW.::GO:0005737; C:cytoplasm; IDA:UniProtKB.::GO:0002102; C:podosome; IDA:UniProtKB.
GO:0080025; F:phosphatidylinositol-3,5-bisphosphate binding; IDA:UniProtKB.::GO:0032266; F:phosphatidylinositol-3-phosphate binding; IMP:UniProtKB.::GO:0070273; F:phosphatidylinositol-4-phosphate binding; IDA:UniProtKB.::GO:0010314; F:phosphatidylinositol-5-phosphate binding; IDA:UniProtKB.::GO:0042169; F:SH2 domain binding; IDA:UniProtKB.
GO:0060612; P:adipose tissue development; IMP:UniProtKB.::GO:0060348; P:bone development; IMP:UniProtKB.::GO:0007154; P:cell communication; IEA:InterPro.::GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0001654; P:eye development; IMP:UniProtKB.::GO:0007507; P:heart development; IMP:UniProtKB.::GO:0071800; P:podosome assembly; IMP:UniProtKB.::GO:0045600; P:positive regulation of fat cell differentiation; IMP:UniProtKB.::GO:0072657; P:protein localization in membrane; ISS:UniProtKB.::GO:0006801; P:superoxide metabolic process; ISS:UniProtKB.
177Q8N157    1196   AHI1_HUMAN Jouberin OS=Homo sapiens (Human). ...620.0003     47     40     55GO:0005912; C:adherens junction; IDA:UniProtKB.::GO:0005911; C:cell-cell junction; IDA:UniProtKB.::GO:0005814; C:centriole; ISS:UniProtKB.::GO:0005932; C:microtubule basal body; IDA:UniProtKB.::GO:0036038; C:TCTN-B9D complex; ISS:UniProtKB.
GO:0005515; F:protein binding; IPI:UniProtKB.
GO:0042384; P:cilium assembly; ISS:UniProtKB.::GO:0035844; P:cloaca development; ISS:UniProtKB.::GO:0001947; P:heart looping; ISS:UniProtKB.::GO:0030902; P:hindbrain development; ISS:UniProtKB.::GO:0070121; P:Kupffer's vesicle development; ISS:UniProtKB.::GO:0070986; P:left/right axis specification; ISS:UniProtKB.::GO:0001738; P:morphogenesis of a polarized epithelium; ISS:UniProtKB.::GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.::GO:0071599; P:otic vesicle development; ISS:UniProtKB.::GO:0035845; P:photoreceptor cell outer segment organization; ISS:UniProtKB.::GO:0030862; P:positive regulation of polarized epithelial cell differentiation; ISS:UniProtKB.::GO:0002092; P:positive regulation of receptor internalization; ISS:UniProtKB.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.::GO:0039023; P:pronephric duct morphogenesis; ISS:UniProtKB.::GO:0039008; P:pronephric nephron tubule morphogenesis; ISS:UniProtKB.::GO:0050795; P:regulation of behavior; ISS:UniProtKB.::GO:0010842; P:retina layer formation; ISS:UniProtKB.::GO:0065001; P:specification of axis polarity; ISS:UniProtKB.::GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; ISS:UniProtKB.::GO:0016192; P:vesicle-mediated transport; ISS:UniProtKB.
178Q9V9J3    517   SRC42_DROME Tyrosine-protein kinase Src42A OS...980.0003     46.6     35     43
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.
GO:0051017; P:actin filament bundle assembly; IMP:FlyBase.::GO:0043277; P:apoptotic cell clearance; IMP:FlyBase.::GO:0048749; P:compound eye development; IMP:FlyBase.::GO:0007395; P:dorsal closure, spreading of leading edge cells; IMP:FlyBase.::GO:0046529; P:imaginal disc fusion, thorax closure; IMP:FlyBase.::GO:0007476; P:imaginal disc-derived wing morphogenesis; IMP:FlyBase.::GO:0007254; P:JNK cascade; TAS:FlyBase.::GO:0042059; P:negative regulation of epidermal growth factor receptor signaling pathway; IGI:FlyBase.::GO:0007424; P:open tracheal system development; IMP:FlyBase.::GO:0018108; P:peptidyl-tyrosine phosphorylation; IMP:FlyBase.::GO:0007435; P:salivary gland morphogenesis; IMP:FlyBase.::GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IGI:FlyBase.::GO:0006099; P:tricarboxylic acid cycle; IDA:FlyBase.
179O13154    448   PACN2_CHICK Protein kinase C and casein kinas...810.0003     46.6     38     53GO:0005829; C:cytosol; ISS:AgBase.::GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.
GO:0008092; F:cytoskeletal protein binding; ISS:AgBase.
GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0045806; P:negative regulation of endocytosis; ISS:AgBase.
180Q812A2    1099   SRGP3_MOUSE SLIT-ROBO Rho GTPase-activating p...570.0003     47     35     58GO:0005622; C:intracellular; IEA:InterPro.
GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:MGI.
GO:0007165; P:signal transduction; IEA:InterPro.
181Q5A895    498   HSE1_CANAL Class E vacuolar protein-sorting m...970.0004     46.6     34     47GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
GO:0006886; P:intracellular protein transport; IEA:InterPro.
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