Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YDR368W
Length:
312
Number of sequences:
5887
Description:
YDR368W YPR1 SGDID:S000002776, Chr IV from 1213904-1214842, Genome Release 64-1-1, Verified ORF, "NADPH-dependent aldo-keto reductase, reduces multiple substrates including 2-methylbutyraldehyde and D,L-glyceraldehyde, expression is induced by osmotic and oxidative stress; functionally redundant with other aldo-keto reductases"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
31P51652    323   AKC1H_RAT Aldo-keto reductase family 1 member...3033e-62     206     40     58GO:0005829; C:cytosol; IDA:MGI.::GO:0005625; C:soluble fraction; IDA:MGI.
GO:0047006; F:17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity; IDA:MGI.
GO:0050810; P:regulation of steroid biosynthetic process; IDA:RGD.
32A3PXS9    283   Y1918_MYCSJ Uncharacterized oxidoreductase Mj...2966e-62     204     40     56
GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
33Q5R7C9    323   AK1C3_PONAB Aldo-keto reductase family 1 memb...3109e-62     205     41     57GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0047020; F:15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity; ISS:UniProtKB.::GO:0004032; F:alditol:NADP+ 1-oxidoreductase activity; ISS:UniProtKB.::GO:0047026; F:androsterone dehydrogenase (A-specific) activity; IEA:EC.::GO:0047787; F:delta4-3-oxosteroid 5beta-reductase activity; ISS:UniProtKB.::GO:0035410; F:dihydrotestosterone 17-beta-dehydrogenase activity; ISS:UniProtKB.::GO:0045550; F:geranylgeranyl reductase activity; ISS:UniProtKB.::GO:0047718; F:indanol dehydrogenase activity; IEA:EC.::GO:0045703; F:ketoreductase activity; ISS:UniProtKB.::GO:0047086; F:ketosteroid monooxygenase activity; ISS:UniProtKB.::GO:0016655; F:oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor; ISS:UniProtKB.::GO:0018636; F:phenanthrene 9,10-monooxygenase activity; ISS:UniProtKB.::GO:0036131; F:prostaglandin D2 11-ketoreductase activity; IEA:EC.::GO:0004958; F:prostaglandin F receptor activity; ISS:UniProtKB.::GO:0047017; F:prostaglandin-F synthase activity; IEA:EC.::GO:0001758; F:retinal dehydrogenase activity; ISS:UniProtKB.::GO:0004745; F:retinol dehydrogenase activity; ISS:UniProtKB.::GO:0050327; F:testosterone 17-beta-dehydrogenase (NAD+) activity; IEA:EC.::GO:0047045; F:testosterone 17-beta-dehydrogenase (NADP+) activity; IEA:EC.::GO:0047115; F:trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity; IEA:EC.
GO:0016999; P:antibiotic metabolic process; ISS:UniProtKB.::GO:0071276; P:cellular response to cadmium ion; ISS:UniProtKB.::GO:0071277; P:cellular response to calcium ion; ISS:UniProtKB.::GO:0071384; P:cellular response to corticosteroid stimulus; ISS:UniProtKB.::GO:0071395; P:cellular response to jasmonic acid stimulus; ISS:UniProtKB.::GO:0071379; P:cellular response to prostaglandin stimulus; ISS:UniProtKB.::GO:0034614; P:cellular response to reactive oxygen species; ISS:UniProtKB.::GO:0016488; P:farnesol catabolic process; ISS:UniProtKB.::GO:1900053; P:negative regulation of retinoic acid biosynthetic process; ISS:UniProtKB.::GO:0008284; P:positive regulation of cell proliferation; ISS:UniProtKB.::GO:2000353; P:positive regulation of endothelial cell apoptotic process; ISS:UniProtKB.::GO:0051897; P:positive regulation of protein kinase B signaling cascade; ISS:UniProtKB.::GO:2000379; P:positive regulation of reactive oxygen species metabolic process; ISS:UniProtKB.::GO:0042448; P:progesterone metabolic process; ISS:UniProtKB.::GO:0000060; P:protein import into nucleus, translocation; ISS:UniProtKB.::GO:0048385; P:regulation of retinoic acid receptor signaling pathway; ISS:UniProtKB.::GO:2000224; P:regulation of testosterone biosynthetic process; ISS:UniProtKB.::GO:0042574; P:retinal metabolic process; ISS:UniProtKB.::GO:0061370; P:testosterone biosynthetic process; ISS:UniProtKB.
34A4TE41    279   Y4205_MYCGI Uncharacterized oxidoreductase Mf...2862e-61     203     41     57
GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
35P42330    323   AK1C3_HUMAN Aldo-keto reductase family 1 memb...3103e-61     204     41     56GO:0005737; C:cytoplasm; IDA:UniProtKB.::GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0047020; F:15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity; IDA:UniProtKB.::GO:0004032; F:alditol:NADP+ 1-oxidoreductase activity; IDA:UniProtKB.::GO:0047026; F:androsterone dehydrogenase (A-specific) activity; IEA:EC.::GO:0047787; F:delta4-3-oxosteroid 5beta-reductase activity; IDA:UniProtKB.::GO:0035410; F:dihydrotestosterone 17-beta-dehydrogenase activity; IDA:UniProtKB.::GO:0045550; F:geranylgeranyl reductase activity; IDA:UniProtKB.::GO:0047718; F:indanol dehydrogenase activity; IEA:EC.::GO:0045703; F:ketoreductase activity; IDA:UniProtKB.::GO:0047086; F:ketosteroid monooxygenase activity; IDA:UniProtKB.::GO:0016655; F:oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor; IDA:UniProtKB.::GO:0018636; F:phenanthrene 9,10-monooxygenase activity; IDA:UniProtKB.::GO:0036131; F:prostaglandin D2 11-ketoreductase activity; IEA:EC.::GO:0004958; F:prostaglandin F receptor activity; IDA:UniProtKB.::GO:0047017; F:prostaglandin-F synthase activity; IEA:EC.::GO:0001758; F:retinal dehydrogenase activity; IDA:UniProtKB.::GO:0004745; F:retinol dehydrogenase activity; IDA:UniProtKB.::GO:0050327; F:testosterone 17-beta-dehydrogenase (NAD+) activity; IEA:EC.::GO:0047045; F:testosterone 17-beta-dehydrogenase (NADP+) activity; IEA:EC.::GO:0047115; F:trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity; IEA:EC.
GO:0016999; P:antibiotic metabolic process; IMP:UniProtKB.::GO:0071276; P:cellular response to cadmium ion; IDA:UniProtKB.::GO:0071277; P:cellular response to calcium ion; IDA:UniProtKB.::GO:0071384; P:cellular response to corticosteroid stimulus; IDA:UniProtKB.::GO:0071395; P:cellular response to jasmonic acid stimulus; IDA:UniProtKB.::GO:0071379; P:cellular response to prostaglandin stimulus; IDA:UniProtKB.::GO:0034614; P:cellular response to reactive oxygen species; IDA:UniProtKB.::GO:0009267; P:cellular response to starvation; IEP:UniProtKB.::GO:0016488; P:farnesol catabolic process; IDA:UniProtKB.::GO:0030216; P:keratinocyte differentiation; IEP:UniProtKB.::GO:0008584; P:male gonad development; IEP:UniProtKB.::GO:0044259; P:multicellular organismal macromolecule metabolic process; IEP:UniProtKB.::GO:1900053; P:negative regulation of retinoic acid biosynthetic process; IDA:UniProtKB.::GO:0008284; P:positive regulation of cell proliferation; IDA:UniProtKB.::GO:2000353; P:positive regulation of endothelial cell apoptotic process; IDA:UniProtKB.::GO:0051897; P:positive regulation of protein kinase B signaling cascade; IDA:UniProtKB.::GO:2000379; P:positive regulation of reactive oxygen species metabolic process; IDA:UniProtKB.::GO:0042448; P:progesterone metabolic process; IDA:UniProtKB.::GO:0000060; P:protein import into nucleus, translocation; IDA:UniProtKB.::GO:0048385; P:regulation of retinoic acid receptor signaling pathway; IDA:UniProtKB.::GO:2000224; P:regulation of testosterone biosynthetic process; IMP:UniProtKB.::GO:0070293; P:renal absorption; NAS:UniProtKB.::GO:0007584; P:response to nutrient; IEP:UniProtKB.::GO:0042574; P:retinal metabolic process; IDA:UniProtKB.::GO:0061370; P:testosterone biosynthetic process; IMP:UniProtKB.
36Q95JH5    323   AK1C4_MACFA Aldo-keto reductase family 1 memb...3003e-61     204     41     58GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0047042; F:androsterone dehydrogenase (B-specific) activity; IEA:EC.::GO:0047743; F:chlordecone reductase activity; IEA:EC.
37P05980    323   PGFS1_BOVIN Prostaglandin F synthase 1 OS=Bos...3064e-61     203     40     58GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0036131; F:prostaglandin D2 11-ketoreductase activity; IEA:EC.::GO:0047017; F:prostaglandin-F synthase activity; IEA:EC.
GO:0001516; P:prostaglandin biosynthetic process; IEA:UniProtKB-KW.
38Q84TF0    314   AKRCA_ARATH Aldo-keto reductase family 4 memb...2965e-61     203     43     58GO:0005829; C:cytosol; IDA:TAIR.::GO:0005634; C:nucleus; IDA:TAIR.
GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
39P52897    323   PGFS2_BOVIN Prostaglandin F synthase 2 OS=Bos...3195e-61     203     39     56GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0036131; F:prostaglandin D2 11-ketoreductase activity; IEA:EC.::GO:0047017; F:prostaglandin-F synthase activity; IEA:EC.
GO:0001516; P:prostaglandin biosynthetic process; IEA:UniProtKB-KW.
40Q28FD1    327   AK1A1_XENTR Alcohol dehydrogenase [NADP(+)] O...2988e-61     202     43     59
GO:0008106; F:alcohol dehydrogenase (NADP+) activity; IEA:EC.
41Q95JH4    323   AK1C4_MACFU Aldo-keto reductase family 1 memb...3009e-61     202     41     58GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0047042; F:androsterone dehydrogenase (B-specific) activity; IEA:EC.::GO:0047743; F:chlordecone reductase activity; IEA:EC.
42Q9M338    315   AKRCB_ARATH Aldo-keto reductase family 4 memb...3051e-60     202     42     57GO:0005829; C:cytosol; IDA:TAIR.
GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
GO:0046686; P:response to cadmium ion; IEP:TAIR.
43P70694    323   DHB5_MOUSE Estradiol 17 beta-dehydrogenase 5 ...3102e-60     201     39     59
GO:0004033; F:aldo-keto reductase (NADP) activity; IDA:MGI.::GO:0004303; F:estradiol 17-beta-dehydrogenase activity; IDA:MGI.
GO:0006694; P:steroid biosynthetic process; IDA:MGI.
44Q8K023    323   AKC1H_MOUSE Aldo-keto reductase family 1 memb...3032e-60     201     40     56
GO:0047006; F:17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity; IDA:MGI.
GO:0007567; P:parturition; IMP:MGI.::GO:0006709; P:progesterone catabolic process; IDA:MGI.
45A1T726    279   Y2161_MYCVP Uncharacterized oxidoreductase Mv...2924e-60     199     40     55
GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
46Q6GMC7    327   AK1A1_XENLA Alcohol dehydrogenase [NADP(+)] O...2981e-59     199     42     59
GO:0008106; F:alcohol dehydrogenase (NADP+) activity; IEA:EC.
47Q6W8P9    323   AK1CO_HORSE Aldo-keto reductase family 1 memb...3042e-59     199     42     57GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
GO:0008202; P:steroid metabolic process; IEA:UniProtKB-KW.
48Q8VCX1    325   AK1D1_MOUSE 3-oxo-5-beta-steroid 4-dehydrogen...3272e-59     199     36     54
GO:0047787; F:delta4-3-oxosteroid 5beta-reductase activity; IEA:EC.
GO:0030573; P:bile acid catabolic process; IEA:UniProtKB-KW.
49Q8VC28    323   AK1CD_MOUSE Aldo-keto reductase family 1 memb...3102e-59     199     40     56
GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
GO:0006805; P:xenobiotic metabolic process; TAS:MGI.
50Q1XAA8    322   AK1CN_HORSE Aldo-keto reductase family 1 memb...3014e-59     198     40     56GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
GO:0008202; P:steroid metabolic process; IEA:UniProtKB-KW.
51Q6IMN8    297   ALRA_DICDI Aldose reductase A OS=Dictyosteliu...3101e-58     196     37     55GO:0005829; C:cytosol; IDA:dictyBase.::GO:0005615; C:extracellular space; IDA:dictyBase.::GO:0045335; C:phagocytic vesicle; IDA:dictyBase.
GO:0004032; F:alditol:NADP+ 1-oxidoreductase activity; IDA:dictyBase.
GO:0006928; P:cellular component movement; IMP:dictyBase.::GO:0042593; P:glucose homeostasis; IMP:dictyBase.::GO:0031158; P:negative regulation of aggregate size involved in sorocarp development; IMP:dictyBase.::GO:0009617; P:response to bacterium; IEP:dictyBase.::GO:0006979; P:response to oxidative stress; IMP:dictyBase.
52Q8ZI40    277   DKGA_YERPE 2,5-diketo-D-gluconic acid reducta...2751e-58     196     37     56GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0050580; F:2,5-didehydrogluconate reductase activity; IEA:EC.
GO:0019853; P:L-ascorbic acid biosynthetic process; IEA:UniProtKB-KW.
53Q568L5    324   A1A1B_DANRE Alcohol dehydrogenase [NADP(+)] B...2976e-58     195     40     58
GO:0008106; F:alcohol dehydrogenase (NADP+) activity; IEA:EC.
54P80276    316   ALDR_PIG Aldose reductase OS=Sus scrofa (Pig)...2927e-58     195     42     59GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004032; F:alditol:NADP+ 1-oxidoreductase activity; IEA:EC.
55O80944    311   AKRC8_ARATH Aldo-keto reductase family 4 memb...2939e-58     194     40     57GO:0005829; C:cytosol; IDA:TAIR.
GO:0004033; F:aldo-keto reductase (NADP) activity; IDA:UniProtKB.::GO:0070401; F:NADP+ binding; IDA:UniProtKB.::GO:0016229; F:steroid dehydrogenase activity; IDA:UniProtKB.
GO:0046686; P:response to cadmium ion; IEP:TAIR.::GO:0009409; P:response to cold; IEP:UniProtKB.::GO:0009651; P:response to salt stress; IEP:UniProtKB.::GO:0009636; P:response to toxin; IEA:UniProtKB-KW.::GO:0009414; P:response to water deprivation; IEP:UniProtKB.
56Q5BGA7    319   XYL1_EMENI Probable NAD(P)H-dependent D-xylos...3089e-58     194     39     56
GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
GO:0042732; P:D-xylose metabolic process; IEA:UniProtKB-KW.
57A0QV09    283   Y2407_MYCS2 Uncharacterized oxidoreductase MS...2851e-57     193     40     55
GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
58P15121    316   ALDR_HUMAN Aldose reductase OS=Homo sapiens (...3021e-57     194     43     57GO:0005829; C:cytosol; TAS:Reactome.::GO:0005615; C:extracellular space; TAS:ProtInc.::GO:0005634; C:nucleus; IDA:HPA.
GO:0004032; F:alditol:NADP+ 1-oxidoreductase activity; TAS:ProtInc.::GO:0009055; F:electron carrier activity; TAS:UniProtKB.::GO:0043795; F:glyceraldehyde oxidoreductase activity; IDA:UniProtKB.
GO:0016999; P:antibiotic metabolic process; IMP:UniProtKB.::GO:0006700; P:C21-steroid hormone biosynthetic process; TAS:Reactome.::GO:0005975; P:carbohydrate metabolic process; TAS:ProtInc.::GO:0006950; P:response to stress; TAS:UniProtKB.::GO:0044281; P:small molecule metabolic process; TAS:Reactome.
59Q54NZ7    311   ALRB_DICDI Aldose reductase B OS=Dictyosteliu...2931e-57     194     39     56
GO:0004032; F:alditol:NADP+ 1-oxidoreductase activity; ISS:dictyBase.
60O13283    324   XYL1_CANTR NAD(P)H-dependent D-xylose reducta...3231e-57     194     38     55
GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
GO:0042732; P:D-xylose metabolic process; IEA:UniProtKB-KW.
61Q96JD6    320   AKCL2_HUMAN 1,5-anhydro-D-fructose reductase ...3142e-57     194     37     54GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0050571; F:1,5-anhydro-D-fructose reductase activity; IEA:EC.
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