Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YDR323C
Length:
515
Number of sequences:
5887
Description:
YDR323C PEP7 SGDID:S000002731, Chr IV from 1114027-1112480, Genome Release 64-1-1, reverse complement, Verified ORF, "Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
31P40343    622   VPS27_YEAST Vacuolar protein sorting-associat...460.001     45.4     46     57GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.::GO:0033565; C:ESCRT-0 complex; IPI:SGD.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0032266; F:phosphatidylinositol-3-phosphate binding; IDA:SGD.::GO:0043130; F:ubiquitin binding; IDA:SGD.
GO:0045324; P:late endosome to vacuole transport; IMP:SGD.::GO:0045053; P:protein retention in Golgi apparatus; IMP:SGD.::GO:0006623; P:protein targeting to vacuole; IMP:SGD.
32A3LX75    732   VPS27_PICST Vacuolar protein sorting-associat...590.001     45.4     41     51GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0006886; P:intracellular protein transport; IEA:InterPro.
33Q96S99    279   PKHF1_HUMAN Pleckstrin homology domain-contai...440.001     44.7     41     57GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IDA:HPA.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
34Q6CL17    603   VPS27_KLULA Vacuolar protein sorting-associat...600.001     45.4     45     53GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0006886; P:intracellular protein transport; IEA:InterPro.
35Q8R4C2    606   RUFY2_MOUSE RUN and FYVE domain-containing pr...860.001     45.4     29     42GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
36Q0P4S0    951   LST2_XENTR Lateral signaling target protein 2...810.001     45.4     32     42GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0031901; C:early endosome membrane; ISS:UniProtKB.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0032266; F:phosphatidylinositol-3-phosphate binding; ISS:UniProtKB.
GO:0007175; P:negative regulation of epidermal growth factor-activated receptor activity; ISS:UniProtKB.
37Q6FQJ1    603   VPS27_CANGA Vacuolar protein sorting-associat...410.001     45.1     49     59GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0006886; P:intracellular protein transport; IEA:InterPro.
38Q15075    1411   EEA1_HUMAN Early endosome antigen 1 OS=Homo s...350.001     45.4     40     57GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.::GO:0019897; C:extrinsic to plasma membrane; IDA:UniProtKB.::GO:0005624; C:membrane fraction; TAS:ProtInc.
GO:0005545; F:1-phosphatidylinositol binding; IDA:UniProtKB.::GO:0005516; F:calmodulin binding; NAS:UniProtKB.::GO:0030742; F:GTP-dependent protein binding; IDA:UniProtKB.::GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.::GO:0008270; F:zinc ion binding; TAS:UniProtKB.
GO:0045022; P:early endosome to late endosome transport; NAS:UniProtKB.::GO:0016189; P:synaptic vesicle to endosome fusion; TAS:UniProtKB.::GO:0006906; P:vesicle fusion; IMP:UniProtKB.
39O14964    777   HGS_HUMAN Hepatocyte growth factor-regulated ...1050.001     45.1     28     43GO:0005829; C:cytosol; TAS:Reactome.::GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.::GO:0032585; C:multivesicular body membrane; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0019904; F:protein domain specific binding; IPI:UniProtKB.
GO:0016044; P:cellular membrane organization; TAS:Reactome.::GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome.::GO:0006886; P:intracellular protein transport; IEA:InterPro.::GO:0008285; P:negative regulation of cell proliferation; TAS:ProtInc.::GO:0042059; P:negative regulation of epidermal growth factor receptor signaling pathway; TAS:Reactome.::GO:0046426; P:negative regulation of JAK-STAT cascade; IDA:HGNC.::GO:0042176; P:regulation of protein catabolic process; TAS:HGNC.
40Q54CH1    580   ADCA_DICDI Arrestin domain-containing protein...1400.002     44.7     25     41GO:0005813; C:centrosome; IDA:dictyBase.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0007165; P:signal transduction; IEA:InterPro.
41Q9P2R3    1169   ANFY1_HUMAN Ankyrin repeat and FYVE domain-co...900.002     44.7     31     47GO:0010008; C:endosome membrane; ISS:UniProtKB.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
42Q99LI8    775   HGS_MOUSE Hepatocyte growth factor-regulated ...1050.002     44.7     28     43GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.::GO:0032585; C:multivesicular body membrane; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0006886; P:intracellular protein transport; IEA:InterPro.
43Q9JJ50    776   HGS_RAT Hepatocyte growth factor-regulated ty...1050.002     44.7     28     43GO:0005829; C:cytosol; IDA:RGD.::GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.::GO:0032585; C:multivesicular body membrane; IEA:UniProtKB-SubCell.::GO:0030141; C:secretory granule; IDA:RGD.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0019904; F:protein domain specific binding; NAS:RGD.
GO:0008333; P:endosome to lysosome transport; IMP:RGD.::GO:0006886; P:intracellular protein transport; IEA:InterPro.
44Q5UR69    701   YL615_MIMIV Putative phosphatidylinositol kin...470.002     44.3     43     55
GO:0016301; F:kinase activity; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0016773; F:phosphotransferase activity, alcohol group as acceptor; IEA:InterPro.
GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.::GO:0048015; P:phosphatidylinositol-mediated signaling; IEA:InterPro.
45O88387    766   FGD4_RAT FYVE, RhoGEF and PH domain-containin...710.002     44.3     31     48GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0030175; C:filopodium; IEA:UniProtKB-SubCell.
GO:0051015; F:actin filament binding; IMP:RGD.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
GO:0007257; P:activation of JUN kinase activity; IDA:MGI.::GO:0008360; P:regulation of cell shape; IMP:RGD.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
46P53191    635   PIB2_YEAST Phosphatidylinositol 3-phosphate-b...360.003     44.3     47     53GO:0005770; C:late endosome; TAS:SGD.::GO:0005739; C:mitochondrion; IDA:SGD.::GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
47Q91ZT5    766   FGD4_MOUSE FYVE, RhoGEF and PH domain-contain...710.003     44.3     31     48GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0030175; C:filopodium; IDA:MGI.::GO:0030027; C:lamellipodium; IDA:MGI.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
GO:0030032; P:lamellipodium assembly; IDA:MGI.::GO:0030035; P:microspike assembly; IDA:MGI.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
48O59722    1932   FAB1_SCHPO 1-phosphatidylinositol 3-phosphate...580.003     44.3     38     55GO:0000329; C:fungal-type vacuole membrane; ISS:PomBase.
GO:0000285; F:1-phosphatidylinositol-3-phosphate 5-kinase activity; IDA:PomBase.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0032266; F:phosphatidylinositol-3-phosphate binding; ISS:PomBase.
GO:0044267; P:cellular protein metabolic process; IEA:InterPro.::GO:0006995; P:cellular response to nitrogen starvation; IMP:PomBase.::GO:0006886; P:intracellular protein transport; IC:PomBase.::GO:0000750; P:pheromone-dependent signal transduction involved in conjugation with cellular fusion; IMP:PomBase.::GO:0007033; P:vacuole organization; ISS:PomBase.::GO:0016192; P:vesicle-mediated transport; IGI:PomBase.
49Q05B78    254   ZFY21_BOVIN Zinc finger FYVE domain-containin...480.004     42.7     38     50GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell.::GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
50Q9HGN5    279   YO45_SCHPO Putative E3 ubiquitin-protein liga...790.004     42.7     33     44GO:0005829; C:cytosol; IDA:PomBase.::GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.::GO:0000329; C:fungal-type vacuole membrane; ISS:PomBase.::GO:0005770; C:late endosome; ISS:PomBase.::GO:0005634; C:nucleus; IDA:PomBase.
GO:0032266; F:phosphatidylinositol-3-phosphate binding; ISS:PomBase.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:PomBase.::GO:0008270; F:zinc ion binding; IEA:InterPro.
51Q810B6    1169   ANFY1_MOUSE Ankyrin repeat and FYVE domain-co...900.004     43.5     31     47GO:0010008; C:endosome membrane; IDA:UniProtKB.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0006897; P:endocytosis; NAS:UniProtKB.
52B4JHI7    1115   LST2_DROGR Lateral signaling target protein 2...820.005     43.5     29     43
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
53Q9TZD0    661   LST2_CAEEL Lateral signaling target protein 2...530.006     43.1     43     49
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0032266; F:phosphatidylinositol-3-phosphate binding; ISS:WormBase.
GO:0040027; P:negative regulation of vulval development; IMP:WormBase.
54A8XJZ8    651   LST2_CAEBR Lateral signaling target protein 2...530.006     43.1     43     49
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
55Q8BL66    1411   EEA1_MOUSE Early endosome antigen 1 OS=Mus mu...350.006     43.1     40     57GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.::GO:0019897; C:extrinsic to plasma membrane; ISS:UniProtKB.::GO:0005969; C:serine-pyruvate aminotransferase complex; IDA:MGI.
GO:0005545; F:1-phosphatidylinositol binding; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006897; P:endocytosis; ISS:UniProtKB.
56A0JMD2    969   LST2_DANRE Lateral signaling target protein 2...810.007     42.7     32     43GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0031901; C:early endosome membrane; ISS:UniProtKB.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0032266; F:phosphatidylinositol-3-phosphate binding; ISS:UniProtKB.
GO:0007175; P:negative regulation of epidermal growth factor-activated receptor activity; ISS:UniProtKB.
57B3MT31    985   LST2_DROAN Lateral signaling target protein 2...810.008     42.7     32     42
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
58Q9HBF4    777   ZFYV1_HUMAN Zinc finger FYVE domain-containin...800.022     41.2     33     46GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.::GO:0005795; C:Golgi stack; IDA:UniProtKB.::GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0005545; F:1-phosphatidylinositol binding; IDA:UniProtKB.::GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IDA:UniProtKB.::GO:0043325; F:phosphatidylinositol-3,4-bisphosphate binding; IDA:UniProtKB.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0008270; F:zinc ion binding; NAS:UniProtKB.
GO:0010923; P:negative regulation of phosphatase activity; IDA:UniProtKB.
59Q6ZNL6    1462   FGD5_HUMAN FYVE, RhoGEF and PH domain-contain...450.009     42.7     47     58GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005794; C:Golgi apparatus; ISS:UniProtKB.::GO:0030027; C:lamellipodium; ISS:UniProtKB.::GO:0001726; C:ruffle; ISS:UniProtKB.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.::GO:0031267; F:small GTPase binding; ISS:UniProtKB.
GO:0030036; P:actin cytoskeleton organization; ISS:UniProtKB.::GO:0046847; P:filopodium assembly; ISS:UniProtKB.::GO:0043088; P:regulation of Cdc42 GTPase activity; ISS:UniProtKB.::GO:0008360; P:regulation of cell shape; ISS:UniProtKB.
60P34657    266   YOTB_CAEEL Uncharacterized protein ZK632.12 O...860.009     41.6     31     42
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0032266; F:phosphatidylinositol-3-phosphate binding; ISS:WormBase.::GO:0005515; F:protein binding; IPI:IntAct.
61Q5RFL4    789   ZFYV1_PONAB Zinc finger FYVE domain-containin...800.022     41.2     33     46GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.::GO:0005795; C:Golgi stack; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0010923; P:negative regulation of phosphatase activity; ISS:UniProtKB.
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