Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YDR323C
Length:
515
Number of sequences:
5887
Description:
YDR323C PEP7 SGDID:S000002731, Chr IV from 1114027-1112480, Genome Release 64-1-1, reverse complement, Verified ORF, "Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
1P32609    515   PEP7_YEAST Vacuolar segregation protein PEP7 ...5150     1058     100     100GO:0010009; C:external side of endosome membrane; IDA:SGD.::GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
GO:0032266; F:phosphatidylinositol-3-phosphate binding; IDA:SGD.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006895; P:Golgi to endosome transport; IMP:SGD.::GO:0006896; P:Golgi to vacuole transport; IPI:SGD.::GO:0000011; P:vacuole inheritance; IMP:SGD.::GO:0006904; P:vesicle docking involved in exocytosis; IMP:SGD.::GO:0006906; P:vesicle fusion; IMP:SGD.
2O13786    536   PEP7_SCHPO Vacuolar segregation protein pep7 ...5381e-45     172     30     46GO:0005794; C:Golgi apparatus; IDA:PomBase.
GO:0032266; F:phosphatidylinositol-3-phosphate binding; ISS:PomBase.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006896; P:Golgi to vacuole transport; ISS:PomBase.::GO:0006904; P:vesicle docking involved in exocytosis; ISS:PomBase.::GO:0006906; P:vesicle fusion; ISS:PomBase.
3Q80Y56    783   RBNS5_MOUSE Rabenosyn-5 OS=Mus musculus (Mous...2600.00000000001     70.9     26     44GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0017137; F:Rab GTPase binding; IPI:MGI.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0015031; P:protein transport; IEA:UniProtKB-KW.
4Q9H1K0    784   RBNS5_HUMAN Rabenosyn-5 OS=Homo sapiens (Huma...2600.0000000001     67.4     25     44GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0008270; F:zinc ion binding; NAS:UniProtKB.
GO:0007596; P:blood coagulation; TAS:Reactome.::GO:0016197; P:endosome transport; NAS:UniProtKB.::GO:0015031; P:protein transport; IEA:UniProtKB-KW.
5Q54TC3    585   SLOB1_DICDI Probable inactive serine/threonin...810.0000007     55.5     38     47
GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004672; F:protein kinase activity; IEA:InterPro.
6Q69ZL1    1399   FGD6_MOUSE FYVE, RhoGEF and PH domain-contain...730.000008     52.4     36     49GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
7Q96M96    766   FGD4_HUMAN FYVE, RhoGEF and PH domain-contain...710.00001     51.6     37     51GO:0015629; C:actin cytoskeleton; IDA:HPA.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0030175; C:filopodium; IEA:UniProtKB-SubCell.::GO:0005794; C:Golgi apparatus; ISS:UniProtKB.::GO:0030027; C:lamellipodium; ISS:UniProtKB.::GO:0001726; C:ruffle; ISS:UniProtKB.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.::GO:0031267; F:small GTPase binding; ISS:UniProtKB.
GO:0030036; P:actin cytoskeleton organization; ISS:UniProtKB.::GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0046847; P:filopodium assembly; ISS:UniProtKB.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0043088; P:regulation of Cdc42 GTPase activity; ISS:UniProtKB.::GO:0008360; P:regulation of cell shape; ISS:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.
8Q54LD5    785   ADCD_DICDI Arrestin domain-containing protein...1170.00004     50.1     26     39
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
9Q6ZV73    1430   FGD6_HUMAN FYVE, RhoGEF and PH domain-contain...960.00005     50.1     29     40GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005794; C:Golgi apparatus; ISS:UniProtKB.::GO:0030027; C:lamellipodium; ISS:UniProtKB.::GO:0001726; C:ruffle; ISS:UniProtKB.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.::GO:0031267; F:small GTPase binding; ISS:UniProtKB.
GO:0030036; P:actin cytoskeleton organization; ISS:UniProtKB.::GO:0046847; P:filopodium assembly; ISS:UniProtKB.::GO:0043088; P:regulation of Cdc42 GTPase activity; ISS:UniProtKB.::GO:0008360; P:regulation of cell shape; ISS:UniProtKB.
10Q9HCC9    887   LST2_HUMAN Lateral signaling target protein 2...810.0001     48.5     31     44GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0031901; C:early endosome membrane; IDA:UniProtKB.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0032266; F:phosphatidylinositol-3-phosphate binding; IDA:UniProtKB.::GO:0005515; F:protein binding; IPI:UniProtKB.
GO:0007175; P:negative regulation of epidermal growth factor-activated receptor activity; IMP:UniProtKB.
11Q6ZPK7    905   LST2_MOUSE Lateral signaling target protein 2...810.0001     48.5     31     44GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0031901; C:early endosome membrane; ISS:UniProtKB.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0032266; F:phosphatidylinositol-3-phosphate binding; ISS:UniProtKB.
GO:0007175; P:negative regulation of epidermal growth factor-activated receptor activity; ISS:UniProtKB.
12B0G126    2656   FYV1_DICDI 1-phosphatidylinositol 3-phosphate...680.0002     48.5     38     46GO:0005739; C:mitochondrion; ISS:dictyBase.
GO:0000285; F:1-phosphatidylinositol-3-phosphate 5-kinase activity; ISS:dictyBase.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0044267; P:cellular protein metabolic process; IEA:InterPro.
13O96838    1809   FYV1_DROME Putative 1-phosphatidylinositol 3-...570.0002     48.1     37     47GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.::GO:0012506; C:vesicle membrane; ISS:UniProtKB.
GO:0000285; F:1-phosphatidylinositol-3-phosphate 5-kinase activity; IMP:FlyBase.::GO:0016308; F:1-phosphatidylinositol-4-phosphate 5-kinase activity; ISS:UniProtKB.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; ISS:UniProtKB.
GO:0044267; P:cellular protein metabolic process; IEA:InterPro.::GO:0008333; P:endosome to lysosome transport; IMP:FlyBase.::GO:0035556; P:intracellular signal transduction; ISS:UniProtKB.
14Q9Y2I7    2098   FYV1_HUMAN 1-phosphatidylinositol 3-phosphate...570.0002     48.1     42     49GO:0031901; C:early endosome membrane; IDA:UniProtKB.::GO:0045121; C:membrane raft; IDA:HGNC.
GO:0000285; F:1-phosphatidylinositol-3-phosphate 5-kinase activity; IEA:EC.::GO:0016308; F:1-phosphatidylinositol-4-phosphate 5-kinase activity; TAS:HGNC.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB.
GO:0044267; P:cellular protein metabolic process; IEA:InterPro.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0034504; P:protein localization to nucleus; IMP:UniProtKB.::GO:0042147; P:retrograde transport, endosome to Golgi; IMP:UniProtKB.
15Q9Z1T6    2097   FYV1_MOUSE 1-phosphatidylinositol 3-phosphate...570.0002     47.8     42     49GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; IDA:MGI.::GO:0048471; C:perinuclear region of cytoplasm; IDA:MGI.
GO:0000285; F:1-phosphatidylinositol-3-phosphate 5-kinase activity; IEA:EC.::GO:0016308; F:1-phosphatidylinositol-4-phosphate 5-kinase activity; IDA:UniProtKB.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0008270; F:zinc ion binding; IDA:UniProtKB.
GO:0044267; P:cellular protein metabolic process; IEA:InterPro.::GO:0035556; P:intracellular signal transduction; IDA:UniProtKB.
16Q810J8    777   ZFYV1_MOUSE Zinc finger FYVE domain-containin...770.02     41.2     34     47GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.::GO:0005795; C:Golgi stack; ISS:UniProtKB.::GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.
GO:0005545; F:1-phosphatidylinositol binding; ISS:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0010923; P:negative regulation of phosphatase activity; ISS:UniProtKB.
17Q5R5R4    606   RUFY2_PONAB RUN and FYVE domain-containing pr...1580.0004     46.6     25     41GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
18Q8WXA3    655   RUFY2_HUMAN RUN and FYVE domain-containing pr...1580.0004     46.6     25     41GO:0005634; C:nucleus; IDA:HPA.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
19Q7Z6J4    655   FGD2_HUMAN FYVE, RhoGEF and PH domain-contain...350.0006     46.2     54     60GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.::GO:0005794; C:Golgi apparatus; ISS:UniProtKB.::GO:0030027; C:lamellipodium; ISS:UniProtKB.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.::GO:0031267; F:small GTPase binding; ISS:UniProtKB.
GO:0030036; P:actin cytoskeleton organization; ISS:UniProtKB.::GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0046847; P:filopodium assembly; ISS:UniProtKB.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0043088; P:regulation of Cdc42 GTPase activity; ISS:UniProtKB.::GO:0008360; P:regulation of cell shape; ISS:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.
20Q8BY35    655   FGD2_MOUSE FYVE, RhoGEF and PH domain-contain...350.0006     46.2     54     60GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
21B3P851    981   LST2_DROER Lateral signaling target protein 2...980.0006     46.2     31     43
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
22B4PRU6    984   LST2_DROYA Lateral signaling target protein 2...980.0006     46.2     31     43
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
23B4IC49    975   LST2_DROSE Lateral signaling target protein 2...980.0006     46.2     31     43
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
24Q9VB70    989   LST2_DROME Lateral signaling target protein 2...980.0007     46.2     31     43
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
25Q6BSD6    732   VPS27_DEBHA Vacuolar protein sorting-associat...500.0007     46.2     40     54GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0006886; P:intracellular protein transport; IEA:InterPro.
26Q5ABD9    841   VPS27_CANAL Vacuolar protein sorting-associat...580.0007     46.2     38     53GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0006886; P:intracellular protein transport; IEA:InterPro.::GO:0009405; P:pathogenesis; IMP:CGD.
27Q06651    286   PIB1_YEAST E3 ubiquitin-protein ligase PIB1 O...1670.0008     45.1     23     38GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.::GO:0000329; C:fungal-type vacuole membrane; IDA:SGD.::GO:0005770; C:late endosome; IDA:SGD.
GO:0032266; F:phosphatidylinositol-3-phosphate binding; IDA:SGD.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:SGD.::GO:0008270; F:zinc ion binding; IEA:InterPro.
28Q0V8S0    777   HGS_BOVIN Hepatocyte growth factor-regulated ...1050.0008     45.8     28     43GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.::GO:0032585; C:multivesicular body membrane; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0006886; P:intracellular protein transport; IEA:InterPro.
29Q68FU1    279   PKHF1_RAT Pleckstrin homology domain-containi...440.0009     45.1     41     57GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
30Q3TB82    279   PKHF1_MOUSE Pleckstrin homology domain-contai...440.001     44.7     41     57GO:0005764; C:lysosome; IDA:MGI.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0006917; P:induction of apoptosis; IDA:MGI.
31P40343    622   VPS27_YEAST Vacuolar protein sorting-associat...460.001     45.4     46     57GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.::GO:0033565; C:ESCRT-0 complex; IPI:SGD.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0032266; F:phosphatidylinositol-3-phosphate binding; IDA:SGD.::GO:0043130; F:ubiquitin binding; IDA:SGD.
GO:0045324; P:late endosome to vacuole transport; IMP:SGD.::GO:0045053; P:protein retention in Golgi apparatus; IMP:SGD.::GO:0006623; P:protein targeting to vacuole; IMP:SGD.
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