Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YDR313C
Length:
286
Number of sequences:
5887
Description:
YDR313C PIB1 SGDID:S000002721, Chr IV from 1090079-1089219, Genome Release 64-1-1, reverse complement, Verified ORF, "RING-type ubiquitin ligase of the endosomal and vacuolar membranes, binds phosphatidylinositol(3)-phosphate; contains a FYVE finger domain"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
61Q9Y2I7    2098   FYV1_HUMAN 1-phosphatidylinositol 3-phosphate...370.00001     50.4     49     59GO:0031901; C:early endosome membrane; IDA:UniProtKB.::GO:0045121; C:membrane raft; IDA:HGNC.
GO:0000285; F:1-phosphatidylinositol-3-phosphate 5-kinase activity; IEA:EC.::GO:0016308; F:1-phosphatidylinositol-4-phosphate 5-kinase activity; TAS:HGNC.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB.
GO:0044267; P:cellular protein metabolic process; IEA:InterPro.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0034504; P:protein localization to nucleus; IMP:UniProtKB.::GO:0042147; P:retrograde transport, endosome to Golgi; IMP:UniProtKB.
62Q9Z1T6    2097   FYV1_MOUSE 1-phosphatidylinositol 3-phosphate...370.00001     50.4     49     59GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; IDA:MGI.::GO:0048471; C:perinuclear region of cytoplasm; IDA:MGI.
GO:0000285; F:1-phosphatidylinositol-3-phosphate 5-kinase activity; IEA:EC.::GO:0016308; F:1-phosphatidylinositol-4-phosphate 5-kinase activity; IDA:UniProtKB.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0008270; F:zinc ion binding; IDA:UniProtKB.
GO:0044267; P:cellular protein metabolic process; IEA:InterPro.::GO:0035556; P:intracellular signal transduction; IDA:UniProtKB.
63Q9NYA4    1195   MTMR4_HUMAN Myotubularin-related protein 4 OS...770.00002     50.1     30     45GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004725; F:protein tyrosine phosphatase activity; TAS:ProtInc.
64Q7ZUV1    247   PKHF2_DANRE Pleckstrin homology domain-contai...770.00002     48.9     39     47
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.
65D3ZVP7    234   ZFY21_RAT Zinc finger FYVE domain-containing ...970.00002     48.5     31     43GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell.::GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
66Q71FD5    238   ZNRF2_MOUSE E3 ubiquitin-protein ligase ZNRF2...330.00002     48.1     48     67GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.::GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.::GO:0042734; C:presynaptic membrane; IEA:UniProtKB-SubCell.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
67Q6P4U6    215   ZNRF1_DANRE E3 ubiquitin-protein ligase znrf1...340.00002     48.1     47     68GO:0005768; C:endosome; IEA:UniProtKB-SubCell.::GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; ISS:UniProtKB.::GO:0070936; P:protein K48-linked ubiquitination; ISS:UniProtKB.
68O13821    610   VPS27_SCHPO Vacuolar protein sorting-associat...660.00002     48.9     30     52GO:0005829; C:cytosol; IDA:PomBase.::GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.::GO:0033565; C:ESCRT-0 complex; IPI:PomBase.::GO:0005634; C:nucleus; IDA:PomBase.::GO:0005628; C:prospore membrane; IDA:PomBase.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0035091; F:phosphatidylinositol binding; ISS:PomBase.::GO:0043130; F:ubiquitin binding; IMP:PomBase.
GO:0031321; P:ascospore-type prospore assembly; IGI:PomBase.::GO:0006897; P:endocytosis; IMP:PomBase.::GO:0006900; P:membrane budding; IC:PomBase.::GO:0045053; P:protein retention in Golgi apparatus; ISS:PomBase.::GO:0043328; P:protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; IMP:PomBase.
69Q8VCM3    234   ZFY21_MOUSE Zinc finger FYVE domain-containin...470.00003     48.1     40     53GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell.::GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
70O59722    1932   FAB1_SCHPO 1-phosphatidylinositol 3-phosphate...370.00003     48.9     46     62GO:0000329; C:fungal-type vacuole membrane; ISS:PomBase.
GO:0000285; F:1-phosphatidylinositol-3-phosphate 5-kinase activity; IDA:PomBase.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0032266; F:phosphatidylinositol-3-phosphate binding; ISS:PomBase.
GO:0044267; P:cellular protein metabolic process; IEA:InterPro.::GO:0006995; P:cellular response to nitrogen starvation; IMP:PomBase.::GO:0006886; P:intracellular protein transport; IC:PomBase.::GO:0000750; P:pheromone-dependent signal transduction involved in conjugation with cellular fusion; IMP:PomBase.::GO:0007033; P:vacuole organization; ISS:PomBase.::GO:0016192; P:vesicle-mediated transport; IGI:PomBase.
71Q9ZU51    147   RHA2B_ARATH Probable E3 ubiquitin-protein lig...510.00003     46.6     37     61
GO:0004842; F:ubiquitin-protein ligase activity; TAS:TAIR.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0080167; P:response to karrikin; IEP:TAIR.
72Q8NHG8    242   ZNRF2_HUMAN E3 ubiquitin-protein ligase ZNRF2...330.00003     47.8     48     67GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.::GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.::GO:0042734; C:presynaptic membrane; IEA:UniProtKB-SubCell.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
73Q755J9    604   VPS27_ASHGO Vacuolar protein sorting-associat...670.00004     48.5     36     49GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0006886; P:intracellular protein transport; IEA:InterPro.
74Q66KG7    195   ZNRF1_XENLA E3 ubiquitin-protein ligase znrf1...340.00005     47     47     65GO:0005768; C:endosome; IEA:UniProtKB-SubCell.::GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; ISS:UniProtKB.::GO:0070936; P:protein K48-linked ubiquitination; ISS:UniProtKB.
75F7EP40    195   ZNRF1_XENTR E3 ubiquitin-protein ligase znrf1...340.00005     46.6     47     65GO:0005768; C:endosome; IEA:UniProtKB-SubCell.::GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; ISS:UniProtKB.::GO:0070936; P:protein K48-linked ubiquitination; ISS:UniProtKB.
76Q0U4Z8    720   VPS27_PHANO Vacuolar protein sorting-associat...330.00006     47.8     45     70GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0006886; P:intracellular protein transport; IEA:InterPro.
77Q08CN9    217   ZNRF2_DANRE E3 ubiquitin-protein ligase ZNRF2...330.00006     46.6     48     64GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.::GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.::GO:0042734; C:presynaptic membrane; IEA:UniProtKB-SubCell.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
78Q810B6    1169   ANFY1_MOUSE Ankyrin repeat and FYVE domain-co...690.00007     47.8     30     46GO:0010008; C:endosome membrane; IDA:UniProtKB.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0006897; P:endocytosis; NAS:UniProtKB.
79F1MM41    227   ZNRF1_BOVIN E3 ubiquitin-protein ligase ZNRF1...340.00008     46.6     47     65GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005768; C:endosome; IEA:UniProtKB-SubCell.::GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.::GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; ISS:UniProtKB.::GO:0070936; P:protein K48-linked ubiquitination; ISS:UniProtKB.
80Q91V17    227   ZNRF1_MOUSE E3 ubiquitin-protein ligase ZNRF1...340.00008     46.6     47     65GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005768; C:endosome; IEA:UniProtKB-SubCell.::GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.::GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0007010; P:cytoskeleton organization; TAS:UniProtKB.::GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; IDA:UniProtKB.::GO:0070936; P:protein K48-linked ubiquitination; IDA:UniProtKB.
81Q3TB82    279   PKHF1_MOUSE Pleckstrin homology domain-contai...860.00008     47     34     48GO:0005764; C:lysosome; IDA:MGI.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0006917; P:induction of apoptosis; IDA:MGI.
82Q9P2R3    1169   ANFY1_HUMAN Ankyrin repeat and FYVE domain-co...650.00009     47.8     32     46GO:0010008; C:endosome membrane; ISS:UniProtKB.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
83Q8ND25    227   ZNRF1_HUMAN E3 ubiquitin-protein ligase ZNRF1...340.00009     46.6     47     65GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005768; C:endosome; IDA:LIFEdb.::GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.::GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
GO:0005515; F:protein binding; IPI:IntAct.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; ISS:UniProtKB.::GO:0070936; P:protein K48-linked ubiquitination; ISS:UniProtKB.
84Q91ZT5    766   FGD4_MOUSE FYVE, RhoGEF and PH domain-contain...410.00009     47.4     46     61GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0030175; C:filopodium; IDA:MGI.::GO:0030027; C:lamellipodium; IDA:MGI.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
GO:0030032; P:lamellipodium assembly; IDA:MGI.::GO:0030035; P:microspike assembly; IDA:MGI.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
85O88387    766   FGD4_RAT FYVE, RhoGEF and PH domain-containin...410.0001     47.4     46     61GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0030175; C:filopodium; IEA:UniProtKB-SubCell.
GO:0051015; F:actin filament binding; IMP:RGD.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
GO:0007257; P:activation of JUN kinase activity; IDA:MGI.::GO:0008360; P:regulation of cell shape; IMP:RGD.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
86Q68FU1    279   PKHF1_RAT Pleckstrin homology domain-containi...860.0001     46.6     31     45GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
87Q96S99    279   PKHF1_HUMAN Pleckstrin homology domain-contai...770.0001     46.2     32     44GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IDA:HPA.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
88Q96M96    766   FGD4_HUMAN FYVE, RhoGEF and PH domain-contain...410.0002     46.2     46     59GO:0015629; C:actin cytoskeleton; IDA:HPA.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0030175; C:filopodium; IEA:UniProtKB-SubCell.::GO:0005794; C:Golgi apparatus; ISS:UniProtKB.::GO:0030027; C:lamellipodium; ISS:UniProtKB.::GO:0001726; C:ruffle; ISS:UniProtKB.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.::GO:0031267; F:small GTPase binding; ISS:UniProtKB.
GO:0030036; P:actin cytoskeleton organization; ISS:UniProtKB.::GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0046847; P:filopodium assembly; ISS:UniProtKB.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0043088; P:regulation of Cdc42 GTPase activity; ISS:UniProtKB.::GO:0008360; P:regulation of cell shape; ISS:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.
89Q960X8    760   HRS_DROME Hepatocyte growth factor-regulated ...290.0002     46.2     52     72GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.::GO:0033565; C:ESCRT-0 complex; IDA:FlyBase.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.::GO:0008021; C:synaptic vesicle; NAS:FlyBase.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0007298; P:border follicle cell migration; IMP:FlyBase.::GO:0006897; P:endocytosis; IMP:FlyBase.::GO:0016197; P:endosome transport; TAS:FlyBase.::GO:0006886; P:intracellular protein transport; IEA:InterPro.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.::GO:0042059; P:negative regulation of epidermal growth factor receptor signaling pathway; NAS:FlyBase.::GO:0045752; P:positive regulation of Toll signaling pathway; IMP:FlyBase.::GO:0016082; P:synaptic vesicle priming; NAS:FlyBase.::GO:0008293; P:torso signaling pathway; NAS:FlyBase.::GO:0016050; P:vesicle organization; NAS:FlyBase.
90Q6CL17    603   VPS27_KLULA Vacuolar protein sorting-associat...680.0003     45.8     28     47GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0006886; P:intracellular protein transport; IEA:InterPro.
91Q7QAJ2    1161   LST2_ANOGA Lateral signaling target protein 2...390.0003     45.8     46     59
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
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