Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YDR313C
Length:
286
Number of sequences:
5887
Description:
YDR313C PIB1 SGDID:S000002721, Chr IV from 1090079-1089219, Genome Release 64-1-1, reverse complement, Verified ORF, "RING-type ubiquitin ligase of the endosomal and vacuolar membranes, binds phosphatidylinositol(3)-phosphate; contains a FYVE finger domain"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
1Q06651    286   PIB1_YEAST E3 ubiquitin-protein ligase PIB1 O...2860     595     100     100GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.::GO:0000329; C:fungal-type vacuole membrane; IDA:SGD.::GO:0005770; C:late endosome; IDA:SGD.
GO:0032266; F:phosphatidylinositol-3-phosphate binding; IDA:SGD.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:SGD.::GO:0008270; F:zinc ion binding; IEA:InterPro.
2Q9HGN5    279   YO45_SCHPO Putative E3 ubiquitin-protein liga...2741e-19     89.4     24     43GO:0005829; C:cytosol; IDA:PomBase.::GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.::GO:0000329; C:fungal-type vacuole membrane; ISS:PomBase.::GO:0005770; C:late endosome; ISS:PomBase.::GO:0005634; C:nucleus; IDA:PomBase.
GO:0032266; F:phosphatidylinositol-3-phosphate binding; ISS:PomBase.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:PomBase.::GO:0008270; F:zinc ion binding; IEA:InterPro.
3Q9BQS8    1478   FYCO1_HUMAN FYVE and coiled-coil domain-conta...750.00000000008     66.2     44     51GO:0005776; C:autophagic vacuole; IDA:UniProtKB.::GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.::GO:0016021; C:integral to membrane; IEA:InterPro.::GO:0005770; C:late endosome; IDA:UniProtKB.::GO:0005764; C:lysosome; IDA:UniProtKB.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB.
GO:0072383; P:plus-end-directed vesicle transport along microtubule; IMP:UniProtKB.
4Q15075    1411   EEA1_HUMAN Early endosome antigen 1 OS=Homo s...760.00000001     59.3     36     51GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.::GO:0019897; C:extrinsic to plasma membrane; IDA:UniProtKB.::GO:0005624; C:membrane fraction; TAS:ProtInc.
GO:0005545; F:1-phosphatidylinositol binding; IDA:UniProtKB.::GO:0005516; F:calmodulin binding; NAS:UniProtKB.::GO:0030742; F:GTP-dependent protein binding; IDA:UniProtKB.::GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.::GO:0008270; F:zinc ion binding; TAS:UniProtKB.
GO:0045022; P:early endosome to late endosome transport; NAS:UniProtKB.::GO:0016189; P:synaptic vesicle to endosome fusion; TAS:UniProtKB.::GO:0006906; P:vesicle fusion; IMP:UniProtKB.
5Q9TZD0    661   LST2_CAEEL Lateral signaling target protein 2...730.00000002     58.5     40     51
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0032266; F:phosphatidylinositol-3-phosphate binding; ISS:WormBase.
GO:0040027; P:negative regulation of vulval development; IMP:WormBase.
6Q8BL66    1411   EEA1_MOUSE Early endosome antigen 1 OS=Mus mu...760.00000002     58.5     37     51GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.::GO:0019897; C:extrinsic to plasma membrane; ISS:UniProtKB.::GO:0005969; C:serine-pyruvate aminotransferase complex; IDA:MGI.
GO:0005545; F:1-phosphatidylinositol binding; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006897; P:endocytosis; ISS:UniProtKB.
7A8XJZ8    651   LST2_CAEBR Lateral signaling target protein 2...730.00000003     58.2     40     51
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
8Q8IZQ1    3526   WDFY3_HUMAN WD repeat and FYVE domain-contain...760.00000005     57.8     37     45GO:0044444; C:cytoplasmic part; IDA:MGI.::GO:0019898; C:extrinsic to membrane; IDA:MGI.::GO:0005635; C:nuclear envelope; IDA:MGI.
GO:0005545; F:1-phosphatidylinositol binding; IDA:MGI.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.
9P34657    266   YOTB_CAEEL Uncharacterized protein ZK632.12 O...850.00000005     56.6     34     48
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0032266; F:phosphatidylinositol-3-phosphate binding; ISS:WormBase.::GO:0005515; F:protein binding; IPI:IntAct.
10Q8VDC1    1437   FYCO1_MOUSE FYVE and coiled-coil domain-conta...400.00000005     57.4     58     68GO:0005776; C:autophagic vacuole; ISS:UniProtKB.::GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.::GO:0016021; C:integral to membrane; IEA:InterPro.::GO:0005770; C:late endosome; ISS:UniProtKB.::GO:0005764; C:lysosome; ISS:UniProtKB.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0072383; P:plus-end-directed vesicle transport along microtubule; ISS:UniProtKB.
11P34756    2278   FAB1_YEAST 1-phosphatidylinositol 3-phosphate...380.00000008     57     55     66GO:0010008; C:endosome membrane; IDA:SGD.::GO:0000329; C:fungal-type vacuole membrane; IDA:SGD.::GO:0005739; C:mitochondrion; IDA:SGD.::GO:0070772; C:PAS complex; IDA:SGD.
GO:0000285; F:1-phosphatidylinositol-3-phosphate 5-kinase activity; IDA:SGD.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0032266; F:phosphatidylinositol-3-phosphate binding; IDA:SGD.
GO:0044267; P:cellular protein metabolic process; IEA:InterPro.
12Q6CFT4    565   VPS27_YARLI Vacuolar protein sorting-associat...1800.00000009     56.6     24     43GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0006886; P:intracellular protein transport; IEA:InterPro.
13O95405    1425   ZFYV9_HUMAN Zinc finger FYVE domain-containin...370.0000001     56.6     51     73GO:0031901; C:early endosome membrane; IDA:UniProtKB.
GO:0005545; F:1-phosphatidylinositol binding; IDA:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004872; F:receptor activity; IEA:UniProtKB-KW.::GO:0008236; F:serine-type peptidase activity; NAS:UniProtKB.
GO:0006897; P:endocytosis; NAS:UniProtKB.::GO:0007183; P:SMAD protein complex assembly; IDA:UniProtKB.::GO:0007184; P:SMAD protein import into nucleus; IMP:UniProtKB.::GO:0007179; P:transforming growth factor beta receptor signaling pathway; IMP:UniProtKB.
14Q8BIJ7    712   RUFY1_MOUSE RUN and FYVE domain-containing pr...790.0000001     56.2     37     49GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
GO:0008289; F:lipid binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:MGI.::GO:0008565; F:protein transporter activity; IDA:MGI.
GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0030100; P:regulation of endocytosis; IDA:MGI.
15A0JMD2    969   LST2_DANRE Lateral signaling target protein 2...740.0000001     56.2     35     47GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0031901; C:early endosome membrane; ISS:UniProtKB.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0032266; F:phosphatidylinositol-3-phosphate binding; ISS:UniProtKB.
GO:0007175; P:negative regulation of epidermal growth factor-activated receptor activity; ISS:UniProtKB.
16Q54CH1    580   ADCA_DICDI Arrestin domain-containing protein...710.0000001     55.8     38     46GO:0005813; C:centrosome; IDA:dictyBase.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0007165; P:signal transduction; IEA:InterPro.
17Q80U44    1528   ZFY16_MOUSE Zinc finger FYVE domain-containin...750.0000002     56.2     36     52GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
18Q7Z3T8    1539   ZFY16_HUMAN Zinc finger FYVE domain-containin...750.0000002     55.8     36     52GO:0031901; C:early endosome membrane; TAS:Reactome.
GO:0005545; F:1-phosphatidylinositol binding; IDA:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IDA:UniProtKB.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0008565; F:protein transporter activity; IMP:UniProtKB.
GO:0030509; P:BMP signaling pathway; TAS:Reactome.::GO:0016197; P:endosome transport; IMP:UniProtKB.::GO:0006622; P:protein targeting to lysosome; IMP:UniProtKB.::GO:0030100; P:regulation of endocytosis; TAS:UniProtKB.::GO:0016050; P:vesicle organization; NAS:UniProtKB.
19Q96T51    708   RUFY1_HUMAN RUN and FYVE domain-containing pr...790.0000002     55.8     37     48GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
GO:0008289; F:lipid binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0015031; P:protein transport; IEA:UniProtKB-KW.
20B0G126    2656   FYV1_DICDI 1-phosphatidylinositol 3-phosphate...710.0000002     55.8     35     46GO:0005739; C:mitochondrion; ISS:dictyBase.
GO:0000285; F:1-phosphatidylinositol-3-phosphate 5-kinase activity; ISS:dictyBase.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0044267; P:cellular protein metabolic process; IEA:InterPro.
21Q6VNB8    3508   WDFY3_MOUSE WD repeat and FYVE domain-contain...760.0000002     55.8     36     45
GO:0003831; F:beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity; IDA:MGI.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
22A8QCE4    619   LST2_BRUMA Lateral signaling target protein 2...420.0000005     54.3     50     60
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
23Q13615    1198   MTMR3_HUMAN Myotubularin-related protein 3 OS...770.0000006     54.3     34     45GO:0005737; C:cytoplasm; IDA:UniProtKB.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.::GO:0005624; C:membrane fraction; IDA:UniProtKB.::GO:0005634; C:nucleus; IDA:HPA.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004438; F:phosphatidylinositol-3-phosphatase activity; IDA:UniProtKB.::GO:0004722; F:protein serine/threonine phosphatase activity; IDA:UniProtKB.::GO:0004725; F:protein tyrosine phosphatase activity; IDA:UniProtKB.
GO:0046856; P:phosphatidylinositol dephosphorylation; IDA:UniProtKB.
24Q8K296    1196   MTMR3_MOUSE Myotubularin-related protein 3 OS...770.0000007     54.3     34     45
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004438; F:phosphatidylinositol-3-phosphatase activity; ISS:UniProtKB.::GO:0004725; F:protein tyrosine phosphatase activity; IEA:EC.
GO:0046856; P:phosphatidylinositol dephosphorylation; ISS:UniProtKB.
25Q5PQT2    1194   MTMR3_RAT Myotubularin-related protein 3 OS=R...770.0000007     53.9     34     45GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004438; F:phosphatidylinositol-3-phosphatase activity; ISS:UniProtKB.::GO:0004725; F:protein tyrosine phosphatase activity; IEA:EC.
GO:0046856; P:phosphatidylinositol dephosphorylation; ISS:UniProtKB.
26O14964    777   HGS_HUMAN Hepatocyte growth factor-regulated ...690.000001     53.5     32     49GO:0005829; C:cytosol; TAS:Reactome.::GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.::GO:0032585; C:multivesicular body membrane; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0019904; F:protein domain specific binding; IPI:UniProtKB.
GO:0016044; P:cellular membrane organization; TAS:Reactome.::GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome.::GO:0006886; P:intracellular protein transport; IEA:InterPro.::GO:0008285; P:negative regulation of cell proliferation; TAS:ProtInc.::GO:0042059; P:negative regulation of epidermal growth factor receptor signaling pathway; TAS:Reactome.::GO:0046426; P:negative regulation of JAK-STAT cascade; IDA:HGNC.::GO:0042176; P:regulation of protein catabolic process; TAS:HGNC.
27Q99LI8    775   HGS_MOUSE Hepatocyte growth factor-regulated ...690.000001     53.1     32     49GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.::GO:0032585; C:multivesicular body membrane; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0006886; P:intracellular protein transport; IEA:InterPro.
28Q5UR69    701   YL615_MIMIV Putative phosphatidylinositol kin...420.000001     53.1     48     57
GO:0016301; F:kinase activity; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0016773; F:phosphotransferase activity, alcohol group as acceptor; IEA:InterPro.
GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.::GO:0048015; P:phosphatidylinositol-mediated signaling; IEA:InterPro.
29Q54IL5    1697   UGT52_DICDI UDP-sugar-dependent glycosyltrans...700.000002     53.1     36     51
GO:0051507; F:beta-sitosterol UDP-glucosyltransferase activity; IDA:dictyBase.::GO:0030246; F:carbohydrate binding; IEA:InterPro.::GO:0051505; F:cholesterol UDP-glucosyltransferase activity; IDA:dictyBase.::GO:0051506; F:ergosterol UDP-glucosyltransferase activity; IDA:dictyBase.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0051508; F:stigmasterol UDP-glucosyltransferase activity; IDA:dictyBase.::GO:0051509; F:tomatidine UDP-glucosyltransferase activity; IDA:dictyBase.
GO:0030259; P:lipid glycosylation; IEA:InterPro.::GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW.
30O96838    1809   FYV1_DROME Putative 1-phosphatidylinositol 3-...370.000002     53.1     51     62GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.::GO:0012506; C:vesicle membrane; ISS:UniProtKB.
GO:0000285; F:1-phosphatidylinositol-3-phosphate 5-kinase activity; IMP:FlyBase.::GO:0016308; F:1-phosphatidylinositol-4-phosphate 5-kinase activity; ISS:UniProtKB.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; ISS:UniProtKB.
GO:0044267; P:cellular protein metabolic process; IEA:InterPro.::GO:0008333; P:endosome to lysosome transport; IMP:FlyBase.::GO:0035556; P:intracellular signal transduction; ISS:UniProtKB.
31Q9JJ50    776   HGS_RAT Hepatocyte growth factor-regulated ty...690.000002     52.8     32     49GO:0005829; C:cytosol; IDA:RGD.::GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.::GO:0032585; C:multivesicular body membrane; IEA:UniProtKB-SubCell.::GO:0030141; C:secretory granule; IDA:RGD.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0019904; F:protein domain specific binding; NAS:RGD.
GO:0008333; P:endosome to lysosome transport; IMP:RGD.::GO:0006886; P:intracellular protein transport; IEA:InterPro.
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