Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YDR308C
Length:
140
Number of sequences:
5887
Description:
YDR308C SRB7 SGDID:S000002716, Chr IV from 1078449-1078027, Genome Release 64-1-1, reverse complement, Verified ORF, "Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; target of the global repressor Tup1p"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
1P47822    140   MED21_YEAST Mediator of RNA polymerase II tra...1402e-97     283     100     100GO:0070847; C:core mediator complex; IDA:SGD.
GO:0001103; F:RNA polymerase II repressing transcription factor binding; IPI:SGD.::GO:0001105; F:RNA polymerase II transcription coactivator activity; IDA:SGD.::GO:0001106; F:RNA polymerase II transcription corepressor activity; IMP:SGD.
2Q6FNK3    219   MED21_CANGA Mediator of RNA polymerase II tra...1403e-64     201     72     81GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
3Q6CT76    143   MED21_KLULA Mediator of RNA polymerase II tra...1372e-55     176     65     77GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
4Q75EX7    142   MED21_ASHGO Mediator of RNA polymerase II tra...1381e-54     174     62     78GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
5Q6BQ63    173   MED21_DEBHA Mediator of RNA polymerase II tra...1737e-34     122     42     57GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
6A3LS24    164   MED21_PICST Mediator of RNA polymerase II tra...1631e-33     121     44     60GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
7Q5ACU4    178   MED21_CANAL Mediator of RNA polymerase II tra...1772e-29     110     36     56GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
8Q6C5U8    140   MED21_YARLI Mediator of RNA polymerase II tra...1269e-24     95.1     45     67GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
9Q7S8C2    137   MED21_NEUCR Mediator of RNA polymerase II tra...1281e-20     86.7     39     64GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
10A1C712    189   MED21_ASPCL Mediator of RNA polymerase II tra...1780.000000000004     63.9     29     43GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
11O94376    138   MED21_SCHPO Mediator of RNA polymerase II tra...1290.00000000001     62.4     32     52GO:0005829; C:cytosol; IDA:PomBase.::GO:0016592; C:mediator complex; IDA:PomBase.
GO:0001104; F:RNA polymerase II transcription cofactor activity; ISS:PomBase.
12Q0U499    155   MED21_PHANO Mediator of RNA polymerase II tra...1600.00000003     52.8     31     53GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
13Q16RX1    141   MED21_AEDAE Mediator of RNA polymerase II tra...1360.0000002     50.4     29     47GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
14Q2UF93    208   MED21_ASPOR Mediator of RNA polymerase II tra...300.0009     41.2     57     67GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
15A2QC41    196   MED21_ASPNC Mediator of RNA polymerase II tra...1610.0000003     50.4     30     38GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
16Q4X0I5    207   MED21_ASPFU Mediator of RNA polymerase II tra...300.0002     42.7     57     67GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
17Q7ZTI5    145   MED21_DANRE Mediator of RNA polymerase II tra...1450.000006     46.2     28     50GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
18Q1DXC2    192   MED21_COCIM Mediator of RNA polymerase II tra...1550.00002     45.8     27     35GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
19Q2TBU8    144   MED21_BOVIN Mediator of RNA polymerase II tra...1390.00005     43.5     28     45
GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
20Q9CQ39    144   MED21_MOUSE Mediator of RNA polymerase II tra...1390.0001     42.7     28     45GO:0016592; C:mediator complex; IDA:MGI.
GO:0005515; F:protein binding; IPI:MGI.
GO:0001824; P:blastocyst development; IMP:MGI.::GO:0006366; P:transcription from RNA polymerase II promoter; IC:MGI.
21Q4R6N3    144   MED21_MACFA Mediator of RNA polymerase II tra...1390.0001     42.7     28     45GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
22Q13503    144   MED21_HUMAN Mediator of RNA polymerase II tra...1410.0001     42.4     28     48GO:0016592; C:mediator complex; IDA:MGI.
GO:0003899; F:DNA-directed RNA polymerase activity; TAS:ProtInc.::GO:0003713; F:transcription coactivator activity; IDA:MGI.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI.
23Q5AZQ7    203   MED21_EMENI Mediator of RNA polymerase II tra...430.033     36.6     42     60GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
24A1DHP1    207   MED21_NEOFI Mediator of RNA polymerase II tra...820.002     40.4     33     62GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
25Q9W5P1    142   MED21_DROME Mediator of RNA polymerase II tra...1380.0003     41.6     29     44GO:0016592; C:mediator complex; IDA:UniProtKB.
GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0001104; F:RNA polymerase II transcription cofactor activity; IMP:UniProtKB.
26Q5RE46    144   MED21_PONAB Mediator of RNA polymerase II tra...1430.0005     40.8     27     46GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
27Q7PTL0    154   MED21_ANOGA Mediator of RNA polymerase II tra...1440.005     38.5     28     45GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
28A2VCL2    907   CC162_HUMAN Coiled-coil domain-containing pro...650.61     33.5     28     55
29P72525    823   PARC_STRPN DNA topoisomerase 4 subunit A OS=S...700.98     32.7     31     49GO:0005694; C:chromosome; IEA:InterPro.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:InterPro.::GO:0003918; F:DNA topoisomerase (ATP-hydrolyzing) activity; IEA:InterPro.
GO:0006265; P:DNA topological change; IEA:InterPro.
30P08775    1970   RPB1_MOUSE DNA-directed RNA polymerase II sub...1211.1     32.7     25     48GO:0005665; C:DNA-directed RNA polymerase II, core complex; ISS:UniProtKB.
GO:0003677; F:DNA binding; IDA:MGI.::GO:0003899; F:DNA-directed RNA polymerase activity; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0006366; P:transcription from RNA polymerase II promoter; ISS:UniProtKB.
31P24928    1970   RPB1_HUMAN DNA-directed RNA polymerase II sub...1211.1     32.7     25     48GO:0005665; C:DNA-directed RNA polymerase II, core complex; IDA:UniProtKB.
GO:0003677; F:DNA binding; NAS:UniProtKB.::GO:0003899; F:DNA-directed RNA polymerase activity; NAS:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0003968; F:RNA-directed RNA polymerase activity; IEA:UniProtKB-KW.::GO:0031625; F:ubiquitin protein ligase binding; IPI:BHF-UCL.
GO:0006370; P:mRNA capping; TAS:Reactome.::GO:0000398; P:nuclear mRNA splicing, via spliceosome; TAS:Reactome.::GO:0050434; P:positive regulation of viral transcription; TAS:Reactome.::GO:0006468; P:protein phosphorylation; IDA:GOC.::GO:0006355; P:regulation of transcription, DNA-dependent; NAS:UniProtKB.::GO:0006368; P:transcription elongation from RNA polymerase II promoter; TAS:Reactome.::GO:0006367; P:transcription initiation from RNA polymerase II promoter; TAS:Reactome.::GO:0006283; P:transcription-coupled nucleotide-excision repair; TAS:Reactome.::GO:0016032; P:viral reproduction; TAS:Reactome.
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