UniProt_SwissProt BLAST: Single locus

Species:

Saccharomyces cerevisiae S288C

Locus:

YDR280W

Length:

305

Number of sequences:

5887

Description:

YDR280W RRP45 SGDID:S000002688, Chr IV from 1020747-1021664, Genome Release 64-1-1, Verified ORF, "Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp45p (PM/SCL-75, EXOSC9)"

rec.	Subject	Hit Length	Description	Align.Len	E value	Bit score	% ident.	% pos.	GO associations
1	Q05636	305	RRP45_YEAST Exosome complex component RRP45 O...	305	0	628	100	100	GO:0000177; C:cytoplasmic exosome (RNase complex); IDA:SGD.::GO:0000176; C:nuclear exosome (RNase complex); IDA:SGD.::GO:0005730; C:nucleolus; IDA:SGD.
									GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
									GO:0000467; P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD.::GO:0070651; P:nonfunctional rRNA decay; IC:SGD.::GO:0071042; P:nuclear polyadenylation-dependent mRNA catabolic process; IC:SGD.::GO:0071035; P:nuclear polyadenylation-dependent rRNA catabolic process; IMP:SGD.::GO:0071038; P:nuclear polyadenylation-dependent tRNA catabolic process; IDA:SGD.::GO:0070478; P:nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay; IC:SGD.::GO:0070481; P:nuclear-transcribed mRNA catabolic process, non-stop decay; IC:SGD.::GO:0071051; P:polyadenylation-dependent snoRNA 3'-end processing; IC:SGD.::GO:0034473; P:U1 snRNA 3'-end processing; IMP:SGD.::GO:0034475; P:U4 snRNA 3'-end processing; IMP:SGD.::GO:0034476; P:U5 snRNA 3'-end processing; IMP:SGD.
2	O74918	291	RRP45_SCHPO Exosome complex component rrp45 O...	303	7e-105	315	50	69	GO:0000177; C:cytoplasmic exosome (RNase complex); ISS:PomBase.::GO:0005829; C:cytosol; IDA:PomBase.::GO:0000176; C:nuclear exosome (RNase complex); ISS:PomBase.::GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
									GO:0000175; F:3'-5'-exoribonuclease activity; ISS:PomBase.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
									GO:0000467; P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); ISS:PomBase.::GO:0070651; P:nonfunctional rRNA decay; ISS:PomBase.::GO:0071042; P:nuclear polyadenylation-dependent mRNA catabolic process; ISS:PomBase.::GO:0071035; P:nuclear polyadenylation-dependent rRNA catabolic process; ISS:PomBase.::GO:0071038; P:nuclear polyadenylation-dependent tRNA catabolic process; ISS:PomBase.::GO:0070478; P:nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay; ISS:PomBase.::GO:0070481; P:nuclear-transcribed mRNA catabolic process, non-stop decay; ISS:PomBase.
3	Q06265	439	EXOS9_HUMAN Exosome complex component RRP45 O...	290	1e-56	194	35	60	GO:0005829; C:cytosol; TAS:Reactome.::GO:0000176; C:nuclear exosome (RNase complex); IDA:UniProtKB.::GO:0005730; C:nucleolus; TAS:ProtInc.::GO:0005634; C:nucleus; IDA:UniProtKB.
									GO:0000175; F:3'-5'-exoribonuclease activity; NAS:UniProtKB.::GO:0017091; F:AU-rich element binding; IDA:UniProtKB.
									GO:0043928; P:exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay; IMP:UniProtKB.::GO:0006955; P:immune response; NAS:UniProtKB.::GO:0071028; P:nuclear mRNA surveillance; IMP:UniProtKB.::GO:0071035; P:nuclear polyadenylation-dependent rRNA catabolic process; IMP:UniProtKB.::GO:0030307; P:positive regulation of cell growth; IMP:UniProtKB.::GO:0006364; P:rRNA processing; NAS:UniProtKB.
4	Q3SWZ4	440	EXOS9_BOVIN Exosome complex component RRP45 O...	290	2e-56	194	34	60	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0000178; C:exosome (RNase complex); ISS:UniProtKB.::GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
									GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
									GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
5	Q4QR75	437	EXOS9_RAT Exosome complex component RRP45 OS=...	290	4e-56	193	35	59	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0000178; C:exosome (RNase complex); ISS:UniProtKB.::GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
									GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
									GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
6	Q9JHI7	438	EXOS9_MOUSE Exosome complex component RRP45 O...	290	5e-56	193	35	59	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0000178; C:exosome (RNase complex); ISS:UniProtKB.::GO:0005730; C:nucleolus; TAS:MGI.
									GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
									GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
7	B6YSE7	272	ECX2_THEON Probable exosome complex exonuclea...	270	2e-37	140	31	51	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0000178; C:exosome (RNase complex); IEA:UniProtKB-KW.
									GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.::GO:0003723; F:RNA binding; IEA:InterPro.
									GO:0006401; P:RNA catabolic process; IEA:InterPro.::GO:0006396; P:RNA processing; IEA:InterPro.
8	C5A2B8	273	ECX2_THEGJ Probable exosome complex exonuclea...	254	6e-37	138	35	53	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0000178; C:exosome (RNase complex); IEA:UniProtKB-KW.
									GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.::GO:0003723; F:RNA binding; IEA:InterPro.
									GO:0006401; P:RNA catabolic process; IEA:InterPro.::GO:0006396; P:RNA processing; IEA:InterPro.
9	Q5JIR7	272	ECX2_PYRKO Probable exosome complex exonuclea...	284	2e-36	137	32	53	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0000178; C:exosome (RNase complex); IEA:UniProtKB-KW.
									GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.::GO:0003723; F:RNA binding; IEA:InterPro.
									GO:0006401; P:RNA catabolic process; IEA:InterPro.::GO:0006396; P:RNA processing; IEA:InterPro.
10	O59224	274	ECX2_PYRHO Probable exosome complex exonuclea...	277	2e-36	137	32	51	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0000178; C:exosome (RNase complex); IEA:UniProtKB-KW.
									GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.::GO:0003723; F:RNA binding; IEA:InterPro.
									GO:0006401; P:RNA catabolic process; IEA:InterPro.::GO:0006396; P:RNA processing; IEA:InterPro.
11	Q8U0M0	277	ECX2_PYRFU Probable exosome complex exonuclea...	288	5e-36	136	30	49	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0000178; C:exosome (RNase complex); IEA:UniProtKB-KW.
									GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.::GO:0003723; F:RNA binding; IEA:InterPro.
									GO:0006401; P:RNA catabolic process; IEA:InterPro.::GO:0006396; P:RNA processing; IEA:InterPro.
12	Q8TYC2	267	ECX2_METKA Probable exosome complex exonuclea...	246	1e-35	134	33	51	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0000178; C:exosome (RNase complex); IEA:UniProtKB-KW.
									GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.::GO:0003723; F:RNA binding; IEA:InterPro.
									GO:0006401; P:RNA catabolic process; IEA:InterPro.::GO:0006396; P:RNA processing; IEA:InterPro.
13	Q8PTT7	266	ECX2_METMA Probable exosome complex exonuclea...	276	1e-32	126	30	49	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0000178; C:exosome (RNase complex); IEA:UniProtKB-KW.
									GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.::GO:0003723; F:RNA binding; IEA:InterPro.
									GO:0006401; P:RNA catabolic process; IEA:InterPro.::GO:0006396; P:RNA processing; IEA:InterPro.
14	Q0W2Y7	260	ECX2_UNCMA Probable exosome complex exonuclea...	255	2e-31	123	31	51	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0000178; C:exosome (RNase complex); IEA:UniProtKB-KW.
									GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.::GO:0003723; F:RNA binding; IEA:InterPro.
									GO:0006401; P:RNA catabolic process; IEA:InterPro.::GO:0006396; P:RNA processing; IEA:InterPro.
15	Q8TGX5	266	ECX2_METAC Probable exosome complex exonuclea...	264	1e-30	121	30	49	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0000178; C:exosome (RNase complex); IEA:UniProtKB-KW.
									GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.::GO:0003723; F:RNA binding; IEA:InterPro.
									GO:0006401; P:RNA catabolic process; IEA:InterPro.::GO:0006396; P:RNA processing; IEA:InterPro.
16	Q9V118	274	ECX2_PYRAB Probable exosome complex exonuclea...	270	1e-30	121	31	51	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0000178; C:exosome (RNase complex); IEA:UniProtKB-KW.
									GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.::GO:0000175; F:3'-5'-exoribonuclease activity; IEA:HAMAP.::GO:0003723; F:RNA binding; IEA:InterPro.
									GO:0006401; P:RNA catabolic process; IEA:HAMAP.::GO:0006396; P:RNA processing; IEA:InterPro.
17	Q96B26	276	EXOS8_HUMAN Exosome complex component RRP43 O...	272	6e-30	119	29	50	GO:0005829; C:cytosol; TAS:Reactome.::GO:0000178; C:exosome (RNase complex); IDA:UniProtKB.::GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
									GO:0017091; F:AU-rich element binding; IDA:UniProtKB.::GO:0005515; F:protein binding; IPI:IntAct.
									GO:0043928; P:exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay; TAS:Reactome.::GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
18	Q2KHU3	276	EXOS8_BOVIN Exosome complex component RRP43 O...	272	1e-29	119	29	50	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0000178; C:exosome (RNase complex); ISS:UniProtKB.::GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
									GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
19	Q9D753	276	EXOS8_MOUSE Exosome complex component RRP43 O...	272	3e-29	117	29	49	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0000178; C:exosome (RNase complex); ISS:UniProtKB.::GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
									GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
20	O29756	259	ECX2_ARCFU Probable exosome complex exonuclea...	260	2e-28	114	32	50	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0000178; C:exosome (RNase complex); IEA:UniProtKB-KW.
									GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.::GO:0003723; F:RNA binding; IEA:InterPro.
									GO:0006401; P:RNA catabolic process; IEA:InterPro.::GO:0006396; P:RNA processing; IEA:InterPro.
21	Q975G9	275	ECX2_SULTO Probable exosome complex exonuclea...	203	2e-26	109	30	51	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0000178; C:exosome (RNase complex); IEA:UniProtKB-KW.
									GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.::GO:0003723; F:RNA binding; IEA:InterPro.
									GO:0006401; P:RNA catabolic process; IEA:InterPro.::GO:0006396; P:RNA processing; IEA:InterPro.
22	O26778	271	ECX2_METTH Probable exosome complex exonuclea...	274	3e-26	108	29	51	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0000178; C:exosome (RNase complex); IEA:UniProtKB-KW.
									GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.::GO:0003723; F:RNA binding; IEA:InterPro.
									GO:0006401; P:RNA catabolic process; IEA:InterPro.::GO:0006396; P:RNA processing; IEA:InterPro.
23	Q9UXC0	275	ECX2_SULSO Probable exosome complex exonuclea...	241	6e-24	102	29	47	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0000178; C:exosome (RNase complex); IEA:UniProtKB-KW.
									GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.::GO:0003723; F:RNA binding; IEA:InterPro.
									GO:0006401; P:RNA catabolic process; IEA:InterPro.::GO:0006396; P:RNA processing; IEA:InterPro.
24	Q9YC05	276	ECX2_AERPE Probable exosome complex exonuclea...	153	3e-23	100	33	54	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0000178; C:exosome (RNase complex); IEA:UniProtKB-KW.
									GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.::GO:0003723; F:RNA binding; IEA:InterPro.
									GO:0006401; P:RNA catabolic process; IEA:InterPro.::GO:0006396; P:RNA processing; IEA:InterPro.
25	Q8ZVN0	274	ECX2_PYRAE Probable exosome complex exonuclea...	242	4e-23	100	28	48	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0000178; C:exosome (RNase complex); IEA:UniProtKB-KW.
									GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.::GO:0003723; F:RNA binding; IEA:InterPro.
									GO:0006401; P:RNA catabolic process; IEA:InterPro.::GO:0006396; P:RNA processing; IEA:InterPro.
26	Q10205	270	RRP43_SCHPO Exosome complex component rrp43 O...	264	2e-22	98.2	28	47	GO:0000177; C:cytoplasmic exosome (RNase complex); ISS:PomBase.::GO:0005829; C:cytosol; IDA:PomBase.::GO:0000176; C:nuclear exosome (RNase complex); ISS:PomBase.::GO:0005730; C:nucleolus; IDA:PomBase.
									GO:0000175; F:3'-5'-exoribonuclease activity; ISS:PomBase.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
									GO:0000467; P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); ISS:PomBase.::GO:0070651; P:nonfunctional rRNA decay; ISS:PomBase.::GO:0071042; P:nuclear polyadenylation-dependent mRNA catabolic process; ISS:PomBase.::GO:0071035; P:nuclear polyadenylation-dependent rRNA catabolic process; ISS:PomBase.::GO:0071038; P:nuclear polyadenylation-dependent tRNA catabolic process; ISS:PomBase.::GO:0070478; P:nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay; ISS:PomBase.::GO:0070481; P:nuclear-transcribed mRNA catabolic process, non-stop decay; ISS:PomBase.
27	C3NHC2	275	ECX2_SULIN Probable exosome complex exonuclea...	152	5e-22	97.1	34	52	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0000178; C:exosome (RNase complex); IEA:UniProtKB-KW.
									GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.::GO:0003723; F:RNA binding; IEA:InterPro.
									GO:0006401; P:RNA catabolic process; IEA:InterPro.::GO:0006396; P:RNA processing; IEA:InterPro.
28	Q9HIP1	260	ECX2_THEAC Probable exosome complex exonuclea...	174	7e-22	96.3	33	51	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0000178; C:exosome (RNase complex); IEA:UniProtKB-KW.
									GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.::GO:0003723; F:RNA binding; IEA:InterPro.
									GO:0006401; P:RNA catabolic process; IEA:InterPro.::GO:0006396; P:RNA processing; IEA:InterPro.
29	C3NED0	275	ECX2_SULIY Probable exosome complex exonuclea...	152	8e-22	96.7	34	52	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0000178; C:exosome (RNase complex); IEA:UniProtKB-KW.
									GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.::GO:0003723; F:RNA binding; IEA:InterPro.
									GO:0006401; P:RNA catabolic process; IEA:InterPro.::GO:0006396; P:RNA processing; IEA:InterPro.
30	C3MQ47	275	ECX2_SULIL Probable exosome complex exonuclea...	152	8e-22	96.7	34	52	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0000178; C:exosome (RNase complex); IEA:UniProtKB-KW.
									GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.::GO:0003723; F:RNA binding; IEA:InterPro.
									GO:0006401; P:RNA catabolic process; IEA:InterPro.::GO:0006396; P:RNA processing; IEA:InterPro.
31	C4KHE3	275	ECX2_SULIK Probable exosome complex exonuclea...	152	8e-22	96.7	34	52	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0000178; C:exosome (RNase complex); IEA:UniProtKB-KW.
									GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.::GO:0003723; F:RNA binding; IEA:InterPro.
									GO:0006401; P:RNA catabolic process; IEA:InterPro.::GO:0006396; P:RNA processing; IEA:InterPro.

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