UniProt_SwissProt BLAST: Single locus

Species:

Saccharomyces cerevisiae S288C

Locus:

YDR232W

Length:

548

Number of sequences:

5887

Description:

YDR232W HEM1 SGDID:S000002640, Chr IV from 927452-929098, Genome Release 64-1-1, Verified ORF, "5-aminolevulinate synthase, catalyzes the first step in the heme biosynthetic pathway; an N-terminal signal sequence is required for localization to the mitochondrial matrix; expression is regulated by Hap2p-Hap3p"

rec.	Subject	Hit Length	Description	Align.Len	E value	Bit score	% ident.	% pos.	GO associations
361	Q60HD1	473	SPTC1_MACFA Serine palmitoyltransferase 1 OS=...	264	2e-21	101	27	45	GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0035339; C:SPOTS complex; ISS:UniProtKB.
									GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.::GO:0004758; F:serine C-palmitoyltransferase activity; IEA:EC.::GO:0016769; F:transferase activity, transferring nitrogenous groups; IEA:InterPro.
									GO:0009058; P:biosynthetic process; IEA:InterPro.
362	A0QHJ9	381	BIKB_MYCA1 Putative 8-amino-7-oxononanoate sy...	391	2e-21	100	28	46
									GO:0008710; F:8-amino-7-oxononanoate synthase activity; IEA:EC.::GO:0008890; F:glycine C-acetyltransferase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.::GO:0016769; F:transferase activity, transferring nitrogenous groups; IEA:InterPro.
									GO:0009058; P:biosynthetic process; IEA:InterPro.
363	Q5R9T5	473	SPTC1_PONAB Serine palmitoyltransferase 1 OS=...	264	2e-21	101	27	45	GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0035339; C:SPOTS complex; ISS:UniProtKB.
									GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.::GO:0004758; F:serine C-palmitoyltransferase activity; IEA:EC.::GO:0016769; F:transferase activity, transferring nitrogenous groups; IEA:InterPro.
									GO:0009058; P:biosynthetic process; IEA:InterPro.
364	O35704	473	SPTC1_MOUSE Serine palmitoyltransferase 1 OS=...	264	2e-21	100	27	45	GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0035339; C:SPOTS complex; ISS:UniProtKB.
									GO:0005515; F:protein binding; IPI:MGI.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.::GO:0004758; F:serine C-palmitoyltransferase activity; IEA:EC.::GO:0016769; F:transferase activity, transferring nitrogenous groups; IEA:InterPro.
									GO:0046511; P:sphinganine biosynthetic process; IMP:MGI.::GO:0006686; P:sphingomyelin biosynthetic process; IMP:MGI.::GO:0046512; P:sphingosine biosynthetic process; IMP:MGI.
365	O54695	473	SPTC1_CRIGR Serine palmitoyltransferase 1 OS=...	264	4e-21	100	27	46	GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0035339; C:SPOTS complex; ISS:UniProtKB.
									GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.::GO:0004758; F:serine C-palmitoyltransferase activity; IEA:EC.::GO:0016769; F:transferase activity, transferring nitrogenous groups; IEA:InterPro.
									GO:0006686; P:sphingomyelin biosynthetic process; IDA:MGI.
366	A0PP02	389	BIKB_MYCUA Putative 8-amino-7-oxononanoate sy...	374	3e-20	96.3	30	47
									GO:0008710; F:8-amino-7-oxononanoate synthase activity; IEA:EC.::GO:0008890; F:glycine C-acetyltransferase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.::GO:0016769; F:transferase activity, transferring nitrogenous groups; IEA:InterPro.
									GO:0009058; P:biosynthetic process; IEA:InterPro.
367	B4SM82	407	BIOF_STRM5 8-amino-7-oxononanoate synthase OS...	375	2e-19	94.4	29	46
									GO:0008710; F:8-amino-7-oxononanoate synthase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.::GO:0016769; F:transferase activity, transferring nitrogenous groups; IEA:InterPro.
									GO:0009102; P:biotin biosynthetic process; IEA:UniProtKB-KW.
368	Q9KM65	389	CQSA_VIBCH CAI-1 autoinducer synthase OS=Vibr...	356	7e-19	92	23	45
									GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.::GO:0008483; F:transaminase activity; IEA:UniProtKB-KW.::GO:0016746; F:transferase activity, transferring acyl groups; IEA:UniProtKB-KW.
									GO:0009058; P:biosynthetic process; IEA:InterPro.
369	B2FLM5	407	BIOF_STRMK 8-amino-7-oxononanoate synthase OS...	366	1e-18	92	29	46
									GO:0008710; F:8-amino-7-oxononanoate synthase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.::GO:0016769; F:transferase activity, transferring nitrogenous groups; IEA:InterPro.
									GO:0009102; P:biotin biosynthetic process; IEA:UniProtKB-KW.
370	P25045	558	LCB1_YEAST Serine palmitoyltransferase 1 OS=S...	299	2e-18	92.4	24	44	GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005792; C:microsome; IPI:SGD.::GO:0035339; C:SPOTS complex; IDA:UniProtKB.
									GO:0005515; F:protein binding; IPI:IntAct.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.::GO:0004758; F:serine C-palmitoyltransferase activity; IMP:SGD.::GO:0016769; F:transferase activity, transferring nitrogenous groups; IEA:InterPro.
									GO:0030148; P:sphingolipid biosynthetic process; IMP:SGD.
371	A7N6R9	393	CQSA_VIBHB CAI-1 autoinducer synthase OS=Vibr...	405	3e-18	90.5	23	41
									GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.::GO:0008483; F:transaminase activity; IEA:UniProtKB-KW.::GO:0016746; F:transferase activity, transferring acyl groups; IEA:UniProtKB-KW.
									GO:0009058; P:biosynthetic process; IEA:InterPro.
372	Q9ZLN3	373	BIKB_HELPJ Putative 8-amino-7-oxononanoate sy...	361	2e-17	87.8	27	43
									GO:0008710; F:8-amino-7-oxononanoate synthase activity; IEA:EC.::GO:0008890; F:glycine C-acetyltransferase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.::GO:0016769; F:transferase activity, transferring nitrogenous groups; IEA:InterPro.
									GO:0009058; P:biosynthetic process; IEA:InterPro.
373	O25320	373	BIKB_HELPY Putative 8-amino-7-oxononanoate sy...	384	4e-17	86.7	27	43
									GO:0008710; F:8-amino-7-oxononanoate synthase activity; IEA:EC.::GO:0008890; F:glycine C-acetyltransferase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.::GO:0016769; F:transferase activity, transferring nitrogenous groups; IEA:InterPro.
									GO:0009058; P:biosynthetic process; IEA:InterPro.
374	O59682	509	LCB1_SCHPO Serine palmitoyltransferase 1 OS=S...	275	6e-17	87.4	25	44	GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0017059; C:serine C-palmitoyltransferase complex; ISS:PomBase.
									GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.::GO:0004758; F:serine C-palmitoyltransferase activity; IEA:EC.::GO:0016769; F:transferase activity, transferring nitrogenous groups; IEA:InterPro.
									GO:0030148; P:sphingolipid biosynthetic process; ISS:PomBase.
375	B2HQ90	389	BIKB_MYCMM Putative 8-amino-7-oxononanoate sy...	374	8e-17	85.9	30	47
									GO:0008710; F:8-amino-7-oxononanoate synthase activity; IEA:EC.::GO:0008890; F:glycine C-acetyltransferase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.::GO:0016769; F:transferase activity, transferring nitrogenous groups; IEA:InterPro.
									GO:0009058; P:biosynthetic process; IEA:InterPro.
376	Q8DLK8	437	GSA_THEEB Glutamate-1-semialdehyde 2,1-aminom...	182	0.034	40.4	26	41	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0042286; F:glutamate-1-semialdehyde 2,1-aminomutase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.::GO:0008483; F:transaminase activity; IEA:InterPro.
									GO:0015995; P:chlorophyll biosynthetic process; IEA:UniProtKB-KW.
377	Q2JS70	436	GSA_SYNJA Glutamate-1-semialdehyde 2,1-aminom...	181	0.047	40	25	41	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0042286; F:glutamate-1-semialdehyde 2,1-aminomutase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.::GO:0008483; F:transaminase activity; IEA:InterPro.
									GO:0015995; P:chlorophyll biosynthetic process; IEA:UniProtKB-KW.
378	P13254	398	MEGL_PSEPU Methionine gamma-lyase OS=Pseudomo...	130	0.071	39.3	30	47
									GO:0018826; F:methionine gamma-lyase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0006520; P:cellular amino acid metabolic process; IEA:InterPro.
379	Q2JMP7	436	GSA_SYNJB Glutamate-1-semialdehyde 2,1-aminom...	181	0.087	39.3	26	41	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0042286; F:glutamate-1-semialdehyde 2,1-aminomutase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.::GO:0008483; F:transaminase activity; IEA:InterPro.
									GO:0015995; P:chlorophyll biosynthetic process; IEA:UniProtKB-KW.
380	B4UKE6	430	GSA_ANASK Glutamate-1-semialdehyde 2,1-aminom...	124	0.14	38.5	31	44	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0042286; F:glutamate-1-semialdehyde 2,1-aminomutase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.::GO:0008483; F:transaminase activity; IEA:InterPro.
									GO:0006779; P:porphyrin-containing compound biosynthetic process; IEA:UniProtKB-KW.
381	P56990	416	GLYA_NEIMB Serine hydroxymethyltransferase OS...	214	0.27	37.7	28	43	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0008652; P:cellular amino acid biosynthetic process; IEA:UniProtKB-KW.::GO:0006544; P:glycine metabolic process; IEA:InterPro.::GO:0006563; P:L-serine metabolic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
382	B4SJB0	417	GLYA_STRM5 Serine hydroxymethyltransferase OS...	204	0.37	37	27	41	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0008652; P:cellular amino acid biosynthetic process; IEA:UniProtKB-KW.::GO:0006544; P:glycine metabolic process; IEA:InterPro.::GO:0006563; P:L-serine metabolic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
383	B2FNK2	417	GLYA_STRMK Serine hydroxymethyltransferase OS...	204	0.42	37	27	41	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0008652; P:cellular amino acid biosynthetic process; IEA:UniProtKB-KW.::GO:0006544; P:glycine metabolic process; IEA:InterPro.::GO:0006563; P:L-serine metabolic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
384	C1DEQ3	417	GLYA_AZOVD Serine hydroxymethyltransferase OS...	199	0.42	37	28	43	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0008652; P:cellular amino acid biosynthetic process; IEA:UniProtKB-KW.::GO:0006544; P:glycine metabolic process; IEA:InterPro.::GO:0006563; P:L-serine metabolic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
385	A8FSQ9	418	GLYA_SHESH Serine hydroxymethyltransferase OS...	202	0.5	36.6	26	41	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0008652; P:cellular amino acid biosynthetic process; IEA:UniProtKB-KW.::GO:0006544; P:glycine metabolic process; IEA:InterPro.::GO:0006563; P:L-serine metabolic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
386	Q2RJ31	437	GSA_MOOTA Glutamate-1-semialdehyde 2,1-aminom...	190	0.62	36.6	23	37	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0042286; F:glutamate-1-semialdehyde 2,1-aminomutase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.::GO:0008483; F:transaminase activity; IEA:InterPro.
									GO:0006779; P:porphyrin-containing compound biosynthetic process; IEA:UniProtKB-KW.
387	B0TJY5	418	GLYA_SHEHH Serine hydroxymethyltransferase OS...	202	0.7	36.2	26	41	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0008652; P:cellular amino acid biosynthetic process; IEA:UniProtKB-KW.::GO:0006544; P:glycine metabolic process; IEA:InterPro.::GO:0006563; P:L-serine metabolic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
388	Q9V0L2	389	AAT_PYRAB Aspartate aminotransferase OS=Pyroc...	278	0.84	35.8	22	41	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0016847; F:1-aminocyclopropane-1-carboxylate synthase activity; IEA:InterPro.::GO:0004069; F:L-aspartate:2-oxoglutarate aminotransferase activity; IEA:EC.::GO:0080130; F:L-phenylalanine:2-oxoglutarate aminotransferase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.::GO:0008483; F:transaminase activity; IEA:UniProtKB-KW.
389	A5WH82	418	GLYA_PSYWF Serine hydroxymethyltransferase OS...	59	0.85	35.8	36	54	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0008652; P:cellular amino acid biosynthetic process; IEA:UniProtKB-KW.::GO:0006544; P:glycine metabolic process; IEA:InterPro.::GO:0006563; P:L-serine metabolic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
390	Q0AFT6	416	GLYA_NITEC Serine hydroxymethyltransferase OS...	223	0.92	35.8	26	40	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0008652; P:cellular amino acid biosynthetic process; IEA:UniProtKB-KW.::GO:0006544; P:glycine metabolic process; IEA:InterPro.::GO:0006563; P:L-serine metabolic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
391	B2VI25	417	GLYA_ERWT9 Serine hydroxymethyltransferase OS...	59	0.95	35.8	36	53	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0008652; P:cellular amino acid biosynthetic process; IEA:UniProtKB-KW.::GO:0006544; P:glycine metabolic process; IEA:InterPro.::GO:0006563; P:L-serine metabolic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.

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