Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YDR129C
Length:
642
Number of sequences:
5887
Description:
YDR129C SAC6 SGDID:S000002536, Chr IV from 715247-713340,715379-715359, Genome Release 64-1-1, reverse complement, Verified ORF, "Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
31P15508    2128   SPTB1_MOUSE Spectrin beta chain, erythrocyte ...2370.000001     55.5     26     41GO:0008091; C:spectrin; IEA:InterPro.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0005200; F:structural constituent of cytoskeleton; IEA:InterPro.
GO:0051693; P:actin filament capping; IEA:UniProtKB-KW.
32P11277    2137   SPTB1_HUMAN Spectrin beta chain, erythrocyte ...2370.000003     54.7     27     42GO:0009986; C:cell surface; IDA:UniProtKB.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0031235; C:intrinsic to internal side of plasma membrane; TAS:BHF-UCL.::GO:0043234; C:protein complex; IDA:UniProtKB.::GO:0008091; C:spectrin; TAS:ProtInc.::GO:0014731; C:spectrin-associated cytoskeleton; IDA:BHF-UCL.
GO:0051015; F:actin filament binding; IDA:UniProtKB.::GO:0005200; F:structural constituent of cytoskeleton; IEA:InterPro.
GO:0051693; P:actin filament capping; IEA:UniProtKB-KW.::GO:0007411; P:axon guidance; TAS:Reactome.
33P30427    4687   PLEC_RAT Plectin OS=Rattus norvegicus (Rat). ...2260.0007     47     23     41GO:0016324; C:apical plasma membrane; IDA:RGD.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0030056; C:hemidesmosome; ISS:UniProtKB.::GO:0048471; C:perinuclear region of cytoplasm; IDA:RGD.::GO:0042383; C:sarcolemma; IDA:RGD.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0047485; F:protein N-terminus binding; IDA:RGD.::GO:0005200; F:structural constituent of cytoskeleton; IMP:RGD.
GO:0030855; P:epithelial cell differentiation; IEP:RGD.::GO:0007565; P:female pregnancy; IEP:RGD.::GO:0031581; P:hemidesmosome assembly; ISS:UniProtKB.::GO:0007584; P:response to nutrient; IDA:RGD.
34Q9H254    2564   SPTN4_HUMAN Spectrin beta chain, brain 3 OS=H...2520.00006     50.4     25     43GO:0005829; C:cytosol; TAS:Reactome.::GO:0016363; C:nuclear matrix; IDA:UniProtKB.::GO:0016605; C:PML body; IDA:UniProtKB.::GO:0008091; C:spectrin; IDA:UniProtKB.
GO:0003779; F:actin binding; TAS:UniProtKB.::GO:0030506; F:ankyrin binding; IDA:UniProtKB.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005200; F:structural constituent of cytoskeleton; TAS:UniProtKB.
GO:0051693; P:actin filament capping; IEA:UniProtKB-KW.::GO:0007411; P:axon guidance; TAS:Reactome.::GO:0007016; P:cytoskeletal anchoring at plasma membrane; TAS:UniProtKB.::GO:0016192; P:vesicle-mediated transport; TAS:UniProtKB.
35P11533    3660   DMD_CHICK Dystrophin OS=Gallus gallus (Chicke...2760.00005     50.4     27     41GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0042383; C:sarcolemma; IEA:UniProtKB-SubCell.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
36P46939    3433   UTRO_HUMAN Utrophin OS=Homo sapiens (Human). ...2610.00002     51.6     25     40GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005737; C:cytoplasm; IDA:UniProtKB.::GO:0005856; C:cytoskeleton; TAS:ProtInc.::GO:0005624; C:membrane fraction; TAS:ProtInc.::GO:0005634; C:nucleus; IDA:HPA.::GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006936; P:muscle contraction; TAS:ProtInc.::GO:0007517; P:muscle organ development; TAS:ProtInc.::GO:0001954; P:positive regulation of cell-matrix adhesion; IMP:UniProtKB.
37P11531    3678   DMD_MOUSE Dystrophin OS=Mus musculus (Mouse)....2710.0005     47.4     26     39GO:0030055; C:cell-substrate junction; IDA:MGI.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0016010; C:dystrophin-associated glycoprotein complex; IDA:MGI.::GO:0045121; C:membrane raft; IDA:MGI.::GO:0005792; C:microsome; IDA:MGI.::GO:0044306; C:neuron projection terminus; IDA:MGI.::GO:0042383; C:sarcolemma; IDA:MGI.::GO:0045202; C:synapse; IDA:MGI.::GO:0030018; C:Z disc; IDA:MGI.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0050998; F:nitric-oxide synthase binding; IPI:BHF-UCL.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0046716; P:muscle cell homeostasis; IMP:MGI.::GO:0045213; P:neurotransmitter receptor metabolic process; IMP:MGI.::GO:0021629; P:olfactory nerve structural organization; IMP:MGI.::GO:0006355; P:regulation of transcription, DNA-dependent; IMP:MGI.::GO:0007519; P:skeletal muscle tissue development; IMP:MGI.
38P11532    3685   DMD_HUMAN Dystrophin OS=Homo sapiens (Human)....2770.001     46.2     26     39GO:0009986; C:cell surface; IDA:UniProtKB.::GO:0043034; C:costamere; IDA:UniProtKB.::GO:0005856; C:cytoskeleton; TAS:ProtInc.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0016010; C:dystrophin-associated glycoprotein complex; IDA:UniProtKB.::GO:0042383; C:sarcolemma; IDA:BHF-UCL.
GO:0003779; F:actin binding; TAS:UniProtKB.::GO:0002162; F:dystroglycan binding; IPI:UniProtKB.::GO:0050998; F:nitric-oxide synthase binding; ISS:BHF-UCL.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0005200; F:structural constituent of cytoskeleton; TAS:ProtInc.::GO:0008307; F:structural constituent of muscle; IDA:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0030049; P:muscle filament sliding; TAS:Reactome.::GO:0043043; P:peptide biosynthetic process; IDA:UniProtKB.
39O76329    1738   ACTNB_DICDI Interaptin OS=Dictyostelium disco...303.6     34.7     53     67GO:0005813; C:centrosome; IDA:dictyBase.::GO:0005789; C:endoplasmic reticulum membrane; IDA:dictyBase.::GO:0032580; C:Golgi cisterna membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
GO:0003779; F:actin binding; ISS:dictyBase.
GO:0016337; P:cell-cell adhesion; IMP:dictyBase.::GO:0007275; P:multicellular organismal development; IMP:dictyBase.::GO:0009847; P:spore germination; IMP:dictyBase.
40Q6ZWQ0    6874   SYNE2_MOUSE Nesprin-2 OS=Mus musculus (Mouse)...1150.018     42.4     30     45GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005640; C:nuclear outer membrane; IEA:UniProtKB-SubCell.::GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.::GO:0033017; C:sarcoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO:0003779; F:actin binding; IDA:UniProtKB.
GO:0051642; P:centrosome localization; IMP:UniProtKB.::GO:0007163; P:establishment or maintenance of cell polarity; IMP:MGI.::GO:0010761; P:fibroblast migration; IMP:MGI.::GO:0006998; P:nuclear envelope organization; IMP:MGI.::GO:0031022; P:nuclear migration along microfilament; IMP:UniProtKB.::GO:0030335; P:positive regulation of cell migration; IMP:UniProtKB.::GO:0034504; P:protein localization to nucleus; IMP:MGI.
41Q8WXH0    6885   SYNE2_HUMAN Nesprin-2 OS=Homo sapiens (Human)...1150.089     40     30     45GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0031527; C:filopodium membrane; IDA:UniProtKB.::GO:0005925; C:focal adhesion; IDA:UniProtKB.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0031258; C:lamellipodium membrane; IDA:UniProtKB.::GO:0044429; C:mitochondrial part; IDA:UniProtKB.::GO:0005640; C:nuclear outer membrane; IEA:UniProtKB-SubCell.::GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.::GO:0033017; C:sarcoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0034993; C:SUN-KASH complex; IDA:UniProtKB.::GO:0030018; C:Z disc; IDA:UniProtKB.
GO:0003779; F:actin binding; ISS:UniProtKB.::GO:0005515; F:protein binding; IPI:UniProtKB.
GO:0051642; P:centrosome localization; IMP:UniProtKB.::GO:0090286; P:cytoskeletal anchoring at nuclear membrane; IDA:UniProtKB.::GO:0031022; P:nuclear migration along microfilament; ISS:UniProtKB.::GO:0030335; P:positive regulation of cell migration; ISS:UniProtKB.
42Q00963    2291   SPTCB_DROME Spectrin beta chain OS=Drosophila...2380.014     42.4     26     41GO:0016327; C:apicolateral plasma membrane; TAS:FlyBase.::GO:0030424; C:axon; IDA:FlyBase.::GO:0045169; C:fusome; IDA:FlyBase.::GO:0016328; C:lateral plasma membrane; IDA:FlyBase.::GO:0031594; C:neuromuscular junction; IDA:FlyBase.::GO:0008091; C:spectrin; IEA:InterPro.::GO:0045170; C:spectrosome; IDA:FlyBase.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0030506; F:ankyrin binding; IDA:FlyBase.::GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0008017; F:microtubule binding; IDA:FlyBase.::GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; IDA:FlyBase.::GO:0005200; F:structural constituent of cytoskeleton; IEA:InterPro.
GO:0051693; P:actin filament capping; IEA:UniProtKB-KW.::GO:0016199; P:axon midline choice point recognition; IMP:FlyBase.::GO:0045478; P:fusome organization; TAS:FlyBase.::GO:0042062; P:long-term strengthening of neuromuscular junction; IMP:FlyBase.::GO:0048790; P:maintenance of presynaptic active zone structure; IDA:FlyBase.::GO:0007026; P:negative regulation of microtubule depolymerization; IMP:FlyBase.::GO:0007274; P:neuromuscular synaptic transmission; IMP:FlyBase.::GO:0072499; P:photoreceptor cell axon guidance; IMP:FlyBase.::GO:0007009; P:plasma membrane organization; TAS:FlyBase.::GO:0030721; P:spectrosome organization; TAS:FlyBase.
43Q9JI91    894   ACTN2_MOUSE Alpha-actinin-2 OS=Mus musculus (...2630.005     43.9     25     41GO:0005865; C:striated muscle thin filament; TAS:MGI.::GO:0030018; C:Z disc; IDA:UniProtKB.
GO:0051015; F:actin filament binding; IDA:MGI.::GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0030674; F:protein binding, bridging; TAS:MGI.::GO:0042803; F:protein homodimerization activity; TAS:UniProtKB.::GO:0030375; F:thyroid hormone receptor coactivator activity; IDA:MGI.::GO:0051370; F:ZASP binding; IDA:UniProtKB.
GO:0006936; P:muscle contraction; IPI:MGI.
44Q3ZC55    894   ACTN2_BOVIN Alpha-actinin-2 OS=Bos taurus (Bo...2630.005     43.5     25     41GO:0030018; C:Z disc; IEA:UniProtKB-SubCell.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0005509; F:calcium ion binding; IEA:InterPro.
45P35609    894   ACTN2_HUMAN Alpha-actinin-2 OS=Homo sapiens (...2630.005     43.9     25     41GO:0005884; C:actin filament; TAS:ProtInc.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0043197; C:dendritic spine; TAS:UniProtKB.::GO:0005576; C:extracellular region; TAS:Reactome.::GO:0030175; C:filopodium; IDA:UniProtKB.::GO:0005925; C:focal adhesion; IMP:UniProtKB.::GO:0031093; C:platelet alpha granule lumen; TAS:Reactome.::GO:0031143; C:pseudopodium; TAS:UniProtKB.::GO:0030018; C:Z disc; IDA:UniProtKB.
GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0051373; F:FATZ binding; IDA:UniProtKB.::GO:0042802; F:identical protein binding; IPI:IntAct.::GO:0005178; F:integrin binding; TAS:UniProtKB.::GO:0044325; F:ion channel binding; IPI:BHF-UCL.::GO:0046983; F:protein dimerization activity; IDA:UniProtKB.::GO:0008307; F:structural constituent of muscle; TAS:ProtInc.::GO:0031432; F:titin binding; IDA:BHF-UCL.::GO:0070080; F:titin Z domain binding; IPI:BHF-UCL.::GO:0051370; F:ZASP binding; IDA:UniProtKB.
GO:0048041; P:focal adhesion assembly; IMP:UniProtKB.::GO:0030035; P:microspike assembly; IDA:UniProtKB.::GO:0030049; P:muscle filament sliding; TAS:Reactome.::GO:0030168; P:platelet activation; TAS:Reactome.::GO:0002576; P:platelet degranulation; TAS:Reactome.::GO:0051289; P:protein homotetramerization; IDA:UniProtKB.::GO:0042981; P:regulation of apoptotic process; NAS:UniProtKB.::GO:0007268; P:synaptic transmission; TAS:Reactome.
46O97592    3680   DMD_CANFA Dystrophin OS=Canis familiaris (Dog...2770.0002     48.5     26     39GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0042383; C:sarcolemma; IEA:UniProtKB-SubCell.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
47Q5GN48    3674   DMD_PIG Dystrophin OS=Sus scrofa (Pig). GN=DM...2770.0001     48.9     26     39GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0042383; C:sarcolemma; IEA:UniProtKB-SubCell.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
48Q9JI55    4473   PLEC_CRIGR Plectin OS=Cricetulus griseus (Chi...1840.013     42.7     22     41GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0030496; C:midbody; IDA:UniProtKB.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.
49Q7PKQ5    922   ACTN_ANOGA Alpha-actinin, sarcomeric OS=Anoph...2240.00006     50.1     25     42
GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0005509; F:calcium ion binding; IEA:InterPro.
50Q6ZWR6    8799   SYNE1_MOUSE Nesprin-1 OS=Mus musculus (Mouse)...1190.011     43.1     29     47GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005640; C:nuclear outer membrane; IEA:UniProtKB-SubCell.::GO:0030017; C:sarcomere; IEA:UniProtKB-SubCell.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.
GO:0040023; P:establishment of nucleus localization; IMP:MGI.
51Q9VDW6    3598   DMDA_DROME Dystrophin, isoforms A/C/F/G/H OS=...1140.015     42.4     32     45GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0005856; C:cytoskeleton; IDA:UniProtKB.::GO:0016010; C:dystrophin-associated glycoprotein complex; IPI:FlyBase.::GO:0042383; C:sarcolemma; IEA:UniProtKB-SubCell.::GO:0045202; C:synapse; IDA:UniProtKB.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0050699; F:WW domain binding; IPI:FlyBase.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0030010; P:establishment of cell polarity; IMP:FlyBase.::GO:0008586; P:imaginal disc-derived wing vein morphogenesis; IMP:FlyBase.::GO:0007474; P:imaginal disc-derived wing vein specification; IMP:UniProtKB.::GO:0046716; P:muscle cell homeostasis; IMP:FlyBase.::GO:0007274; P:neuromuscular synaptic transmission; IDA:FlyBase.::GO:0046928; P:regulation of neurotransmitter secretion; IMP:UniProtKB.::GO:0048172; P:regulation of short-term neuronal synaptic plasticity; IDA:FlyBase.
52P20111    897   ACTN2_CHICK Alpha-actinin-2 OS=Gallus gallus ...2630.01     42.7     25     41GO:0030175; C:filopodium; IDA:UniProtKB.::GO:0030018; C:Z disc; ISS:UniProtKB.
GO:0005509; F:calcium ion binding; IEA:InterPro.
GO:0030035; P:microspike assembly; IDA:UniProtKB.
53Q8NF91    8797   SYNE1_HUMAN Nesprin-1 OS=Homo sapiens (Human)...1190.002     45.4     30     48GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005794; C:Golgi apparatus; IDA:UniProtKB.::GO:0016021; C:integral to membrane; IDA:UniProtKB.::GO:0005640; C:nuclear outer membrane; IEA:UniProtKB-SubCell.::GO:0045211; C:postsynaptic membrane; IDA:UniProtKB.::GO:0030017; C:sarcomere; IDA:MGI.::GO:0034993; C:SUN-KASH complex; IDA:UniProtKB.
GO:0003779; F:actin binding; IDA:UniProtKB.::GO:0005521; F:lamin binding; IPI:UniProtKB.
GO:0008219; P:cell death; IEA:UniProtKB-KW.::GO:0090286; P:cytoskeletal anchoring at nuclear membrane; IDA:UniProtKB.::GO:0007030; P:Golgi organization; IDA:UniProtKB.::GO:0042692; P:muscle cell differentiation; IDA:UniProtKB.::GO:0090292; P:nuclear matrix anchoring at nuclear membrane; IDA:UniProtKB.
54P18091    924   ACTN_DROME Alpha-actinin, sarcomeric OS=Droso...2280.00009     49.7     24     42GO:0030018; C:Z disc; IDA:FlyBase.
GO:0003779; F:actin binding; IPI:UniProtKB.::GO:0005509; F:calcium ion binding; IEA:InterPro.
GO:0031532; P:actin cytoskeleton reorganization; IMP:FlyBase.::GO:0007629; P:flight behavior; IMP:FlyBase.::GO:0045214; P:sarcomere organization; IMP:FlyBase.
55Q8BTM8    2647   FLNA_MOUSE Filamin-A OS=Mus musculus (Mouse)....1620.0004     47.8     27     44GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; ISS:UniProtKB.::GO:0005886; C:plasma membrane; ISS:UniProtKB.::GO:0005802; C:trans-Golgi network; IDA:MGI.
GO:0051015; F:actin filament binding; ISS:UniProtKB.::GO:0034988; F:Fc-gamma receptor I complex binding; ISS:UniProtKB.::GO:0001948; F:glycoprotein binding; ISS:UniProtKB.::GO:0005080; F:protein kinase C binding; IDA:MGI.::GO:0048365; F:Rac GTPase binding; ISS:UniProtKB.::GO:0004871; F:signal transducer activity; ISS:UniProtKB.::GO:0008134; F:transcription factor binding; ISS:UniProtKB.
GO:0051764; P:actin crosslink formation; ISS:UniProtKB.::GO:0031532; P:actin cytoskeleton reorganization; ISS:UniProtKB.::GO:0051220; P:cytoplasmic sequestering of protein; ISS:UniProtKB.::GO:0045022; P:early endosome to late endosome transport; IDA:MGI.::GO:0001837; P:epithelial to mesenchymal transition; IGI:MGI.::GO:0045184; P:establishment of protein localization; ISS:UniProtKB.::GO:0007195; P:inhibition of adenylate cyclase activity by dopamine receptor signaling pathway; ISS:UniProtKB.::GO:0042177; P:negative regulation of protein catabolic process; ISS:UniProtKB.::GO:0043433; P:negative regulation of sequence-specific DNA binding transcription factor activity; ISS:UniProtKB.::GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; ISS:UniProtKB.::GO:0042993; P:positive regulation of transcription factor import into nucleus; ISS:UniProtKB.::GO:0034394; P:protein localization at cell surface; ISS:UniProtKB.::GO:0050821; P:protein stabilization; ISS:UniProtKB.::GO:0043113; P:receptor clustering; ISS:UniProtKB.
56A5D7D1    911   ACTN4_BOVIN Alpha-actinin-4 OS=Bos taurus (Bo...2600.004     43.9     25     41GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0030529; C:ribonucleoprotein complex; ISS:UniProtKB.
GO:0005509; F:calcium ion binding; IEA:InterPro.
GO:0015031; P:protein transport; IEA:UniProtKB-KW.
57Q5RCS6    911   ACTN4_PONAB Alpha-actinin-4 OS=Pongo abelii (...2600.005     43.9     25     41GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0030529; C:ribonucleoprotein complex; ISS:UniProtKB.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0005509; F:calcium ion binding; IEA:InterPro.
GO:0015031; P:protein transport; IEA:UniProtKB-KW.
58O43707    911   ACTN4_HUMAN Alpha-actinin-4 OS=Homo sapiens (...2600.005     43.9     25     41GO:0005576; C:extracellular region; TAS:Reactome.::GO:0005634; C:nucleus; IDA:UniProtKB.::GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.::GO:0031093; C:platelet alpha granule lumen; TAS:Reactome.::GO:0043234; C:protein complex; IDA:UniProtKB.::GO:0031143; C:pseudopodium; TAS:UniProtKB.::GO:0030529; C:ribonucleoprotein complex; IDA:UniProtKB.
GO:0051015; F:actin filament binding; IDA:UniProtKB.::GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005178; F:integrin binding; TAS:UniProtKB.::GO:0001882; F:nucleoside binding; IDA:UniProtKB.::GO:0042803; F:protein homodimerization activity; TAS:UniProtKB.
GO:0030168; P:platelet activation; TAS:Reactome.::GO:0002576; P:platelet degranulation; TAS:Reactome.::GO:0051272; P:positive regulation of cellular component movement; IDA:UniProtKB.::GO:0032417; P:positive regulation of sodium:hydrogen antiporter activity; NAS:UniProtKB.::GO:0015031; P:protein transport; IEA:UniProtKB-KW.::GO:0042981; P:regulation of apoptotic process; NAS:UniProtKB.
59Q9QXQ0    911   ACTN4_RAT Alpha-actinin-4 OS=Rattus norvegicu...2600.005     43.9     25     41GO:0005829; C:cytosol; TAS:Reactome.::GO:0005634; C:nucleus; IDA:RGD.::GO:0043234; C:protein complex; IDA:RGD.::GO:0030529; C:ribonucleoprotein complex; ISS:UniProtKB.
GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0032403; F:protein complex binding; IPI:RGD.::GO:0047485; F:protein N-terminus binding; IPI:RGD.
GO:0015031; P:protein transport; IEA:UniProtKB-KW.::GO:0042981; P:regulation of apoptotic process; IMP:RGD.::GO:0001666; P:response to hypoxia; IEP:RGD.
60P57780    912   ACTN4_MOUSE Alpha-actinin-4 OS=Mus musculus (...2600.004     43.9     25     41GO:0030863; C:cortical cytoskeleton; IDA:MGI.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0031143; C:pseudopodium; IDA:UniProtKB.::GO:0030529; C:ribonucleoprotein complex; ISS:UniProtKB.::GO:0001725; C:stress fiber; IDA:UniProtKB.
GO:0051015; F:actin filament binding; IDA:MGI.::GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0042803; F:protein homodimerization activity; TAS:UniProtKB.
GO:0051017; P:actin filament bundle assembly; IDA:UniProtKB.::GO:0051271; P:negative regulation of cellular component movement; IDA:UniProtKB.::GO:0051272; P:positive regulation of cellular component movement; IDA:UniProtKB.::GO:0048549; P:positive regulation of pinocytosis; IMP:UniProtKB.::GO:0015031; P:protein transport; IEA:UniProtKB-KW.
61Q08043    901   ACTN3_HUMAN Alpha-actinin-3 OS=Homo sapiens (...2630.0006     47     26     41GO:0005884; C:actin filament; TAS:ProtInc.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0005925; C:focal adhesion; IMP:UniProtKB.::GO:0031143; C:pseudopodium; TAS:UniProtKB.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005178; F:integrin binding; TAS:UniProtKB.::GO:0042803; F:protein homodimerization activity; TAS:UniProtKB.::GO:0008307; F:structural constituent of muscle; TAS:ProtInc.
GO:0048041; P:focal adhesion assembly; IMP:UniProtKB.::GO:0030049; P:muscle filament sliding; TAS:Reactome.::GO:0042981; P:regulation of apoptotic process; NAS:UniProtKB.
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