rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
1 | P52490 | 153 | UBC13_YEAST Ubiquitin-conjugating enzyme E2 1... | 153 | 8e-109 | 313 | 100 | 100 | GO:0005737; C:cytoplasm; IDA:SGD.::GO:0005634; C:nucleus; IDA:SGD.::GO:0031371; C:ubiquitin conjugating enzyme complex; IPI:SGD. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004842; F:ubiquitin-protein ligase activity; IEA:EC. | | | | | | | | | | GO:0010994; P:free ubiquitin chain polymerization; IDA:SGD.::GO:0006301; P:postreplication repair; IMP:SGD.::GO:0006513; P:protein monoubiquitination; TAS:SGD.::GO:0000209; P:protein polyubiquitination; IDA:SGD. | 2 | Q86K32 | 154 | UBE2N_DICDI Probable ubiquitin-conjugating en... | 149 | 8e-79 | 237 | 73 | 87 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004842; F:ubiquitin-protein ligase activity; IEA:EC. | | | | | | | | | | GO:0006281; P:DNA repair; IEA:UniProtKB-KW. | 3 | Q9EQX9 | 152 | UBE2N_RAT Ubiquitin-conjugating enzyme E2 N O... | 148 | 2e-75 | 228 | 70 | 84 | GO:0035370; C:UBC13-UEV1A complex; ISS:UniProtKB.::GO:0000151; C:ubiquitin ligase complex; ISS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB. | | | | | | | | | | GO:0006281; P:DNA repair; IEA:UniProtKB-KW.::GO:0070534; P:protein K63-linked ubiquitination; ISS:UniProtKB.::GO:0006511; P:ubiquitin-dependent protein catabolic process; TAS:RGD. | 4 | Q5R7J6 | 152 | UBE2N_PONAB Ubiquitin-conjugating enzyme E2 N... | 148 | 3e-75 | 228 | 70 | 84 | GO:0035370; C:UBC13-UEV1A complex; ISS:UniProtKB.::GO:0000151; C:ubiquitin ligase complex; ISS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB. | | | | | | | | | | GO:0070534; P:protein K63-linked ubiquitination; ISS:UniProtKB. | 5 | P61089 | 152 | UBE2N_MOUSE Ubiquitin-conjugating enzyme E2 N... | 148 | 3e-75 | 228 | 70 | 84 | GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0005634; C:nucleus; ISS:UniProtKB.::GO:0031372; C:UBC13-MMS2 complex; ISS:HGNC.::GO:0035370; C:UBC13-UEV1A complex; ISS:UniProtKB.::GO:0000151; C:ubiquitin ligase complex; ISS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0043130; F:ubiquitin binding; ISS:HGNC.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB. | | | | | | | | | | GO:0000729; P:DNA double-strand break processing; ISS:HGNC.::GO:0000724; P:double-strand break repair via homologous recombination; ISS:HGNC.::GO:0016574; P:histone ubiquitination; ISS:HGNC.::GO:0045739; P:positive regulation of DNA repair; ISS:HGNC.::GO:0031058; P:positive regulation of histone modification; ISS:HGNC.::GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; ISS:HGNC.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISS:HGNC.::GO:0051443; P:positive regulation of ubiquitin-protein ligase activity; ISS:HGNC.::GO:0006301; P:postreplication repair; ISS:HGNC.::GO:0070534; P:protein K63-linked ubiquitination; ISS:UniProtKB.::GO:0033182; P:regulation of histone ubiquitination; ISS:HGNC.::GO:0050852; P:T cell receptor signaling pathway; ISS:HGNC.::GO:0006511; P:ubiquitin-dependent protein catabolic process; IDA:MGI. | 6 | P61088 | 152 | UBE2N_HUMAN Ubiquitin-conjugating enzyme E2 N... | 148 | 3e-75 | 228 | 70 | 84 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005634; C:nucleus; IDA:UniProtKB.::GO:0031372; C:UBC13-MMS2 complex; IDA:HGNC.::GO:0035370; C:UBC13-UEV1A complex; IDA:UniProtKB.::GO:0000151; C:ubiquitin ligase complex; IDA:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0043130; F:ubiquitin binding; IDA:HGNC.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB. | | | | | | | | | | GO:0019221; P:cytokine-mediated signaling pathway; TAS:Reactome.::GO:0000729; P:DNA double-strand break processing; IMP:HGNC.::GO:0000724; P:double-strand break repair via homologous recombination; IMP:HGNC.::GO:0016574; P:histone ubiquitination; IMP:HGNC.::GO:0045087; P:innate immune response; TAS:Reactome.::GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; TAS:Reactome.::GO:0070423; P:nucleotide-binding oligomerization domain containing signaling pathway; TAS:Reactome.::GO:0045739; P:positive regulation of DNA repair; IMP:HGNC.::GO:0031058; P:positive regulation of histone modification; IMP:HGNC.::GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IMP:HGNC.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IMP:UniProtKB.::GO:0051443; P:positive regulation of ubiquitin-protein ligase activity; IMP:HGNC.::GO:0006301; P:postreplication repair; IMP:HGNC.::GO:0070534; P:protein K63-linked ubiquitination; IDA:UniProtKB.::GO:0033182; P:regulation of histone ubiquitination; IMP:HGNC.::GO:0050852; P:T cell receptor signaling pathway; IMP:UniProtKB.::GO:0008063; P:Toll signaling pathway; TAS:Reactome.::GO:0034130; P:toll-like receptor 1 signaling pathway; TAS:Reactome.::GO:0034134; P:toll-like receptor 2 signaling pathway; TAS:Reactome.::GO:0034142; P:toll-like receptor 4 signaling pathway; TAS:Reactome. | 7 | Q0P5K3 | 152 | UBE2N_BOVIN Ubiquitin-conjugating enzyme E2 N... | 148 | 3e-75 | 228 | 70 | 84 | GO:0035370; C:UBC13-UEV1A complex; ISS:UniProtKB.::GO:0000151; C:ubiquitin ligase complex; ISS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB. | | | | | | | | | | GO:0070534; P:protein K63-linked ubiquitination; ISS:UniProtKB. | 8 | Q4R4I1 | 152 | UBE2N_MACFA Ubiquitin-conjugating enzyme E2 N... | 148 | 2e-74 | 225 | 70 | 84 | GO:0035370; C:UBC13-UEV1A complex; ISS:UniProtKB.::GO:0000151; C:ubiquitin ligase complex; ISS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB. | | | | | | | | | | GO:0006281; P:DNA repair; IEA:UniProtKB-KW.::GO:0070534; P:protein K63-linked ubiquitination; ISS:UniProtKB. | 9 | P35128 | 151 | UBE2N_DROME Ubiquitin-conjugating enzyme E2 N... | 148 | 2e-74 | 225 | 71 | 84 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004842; F:ubiquitin-protein ligase activity; IEA:EC. | | | | | | | | | | GO:0007412; P:axon target recognition; IMP:FlyBase.::GO:0007629; P:flight behavior; IMP:FlyBase.::GO:0007625; P:grooming behavior; IMP:FlyBase.::GO:0007630; P:jump response; IMP:FlyBase.::GO:0008594; P:photoreceptor cell morphogenesis; IMP:FlyBase.::GO:0072347; P:response to anesthetic; IMP:FlyBase. | 10 | Q94A97 | 153 | UBC35_ARATH Ubiquitin-conjugating enzyme E2 3... | 147 | 7e-74 | 224 | 69 | 86 | GO:0031372; C:UBC13-MMS2 complex; IPI:TAIR. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:TAIR. | | | | | | | | | | GO:0006301; P:postreplication repair; IGI:TAIR.::GO:0046686; P:response to cadmium ion; IEP:TAIR.::GO:0010039; P:response to iron ion; IMP:TAIR.::GO:0010053; P:root epidermal cell differentiation; IGI:TAIR.::GO:0006511; P:ubiquitin-dependent protein catabolic process; IDA:TAIR. | 11 | Q9FZ48 | 153 | UBC36_ARATH Ubiquitin-conjugating enzyme E2 3... | 147 | 1e-73 | 224 | 68 | 86 | GO:0005829; C:cytosol; IDA:TAIR.::GO:0005886; C:plasma membrane; IDA:TAIR.::GO:0031372; C:UBC13-MMS2 complex; IPI:TAIR. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:TAIR.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:TAIR. | | | | | | | | | | GO:0010039; P:response to iron ion; IMP:TAIR.::GO:0010053; P:root epidermal cell differentiation; IGI:TAIR.::GO:0006511; P:ubiquitin-dependent protein catabolic process; IDA:TAIR. | 12 | O13685 | 148 | UBC13_SCHPO Ubiquitin-conjugating enzyme E2 1... | 146 | 9e-71 | 216 | 71 | 82 | GO:0005829; C:cytosol; IDA:PomBase.::GO:0005634; C:nucleus; IDA:PomBase. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0042803; F:protein homodimerization activity; IDA:PomBase.::GO:0004842; F:ubiquitin-protein ligase activity; IEA:EC. | | | | | | | | | | GO:0071479; P:cellular response to ionizing radiation; IDA:PomBase.::GO:0006301; P:postreplication repair; IMP:PomBase.::GO:0070534; P:protein K63-linked ubiquitination; IDA:PomBase. | 13 | Q5JXB2 | 153 | UE2NL_HUMAN Putative ubiquitin-conjugating en... | 149 | 2e-65 | 203 | 66 | 78 | | | | | | | | | | | GO:0016881; F:acid-amino acid ligase activity; IEA:InterPro. | | | | | | | | | | | 14 | P15732 | 148 | UBC5_YEAST Ubiquitin-conjugating enzyme E2-16... | 146 | 1e-43 | 147 | 49 | 64 | GO:0000502; C:proteasome complex; IPI:SGD. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:SGD. | | | | | | | | | | GO:0000209; P:protein polyubiquitination; IDA:SGD.::GO:0006950; P:response to stress; IDA:SGD. | 15 | Q9Y2X8 | 147 | UB2D4_HUMAN Ubiquitin-conjugating enzyme E2 D... | 143 | 2e-43 | 146 | 50 | 65 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB. | | | | | | | | | | GO:0070979; P:protein K11-linked ubiquitination; IDA:UniProtKB.::GO:0044314; P:protein K27-linked ubiquitination; IDA:UniProtKB.::GO:0035519; P:protein K29-linked ubiquitination; IDA:UniProtKB.::GO:0070936; P:protein K48-linked ubiquitination; IDA:UniProtKB.::GO:0085020; P:protein K6-linked ubiquitination; IDA:UniProtKB.::GO:0070534; P:protein K63-linked ubiquitination; IDA:UniProtKB. | 16 | P35129 | 147 | UBC2_CAEEL Ubiquitin-conjugating enzyme E2 2 ... | 143 | 2e-43 | 146 | 50 | 66 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0031625; F:ubiquitin protein ligase binding; IPI:WormBase.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:WormBase. | | | | | | | | | | GO:0006915; P:apoptotic process; IMP:WormBase.::GO:0016477; P:cell migration; IMP:WormBase.::GO:0008340; P:determination of adult lifespan; IMP:WormBase.::GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.::GO:0007281; P:germ cell development; IMP:WormBase.::GO:0008406; P:gonad development; IMP:WormBase.::GO:0040007; P:growth; IMP:WormBase.::GO:0040035; P:hermaphrodite genitalia development; IMP:WormBase.::GO:0007126; P:meiosis; IMP:WormBase.::GO:0002119; P:nematode larval development; IMP:WormBase.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IDA:WormBase. | 17 | D3ZDK2 | 147 | UB2D1_RAT Ubiquitin-conjugating enzyme E2 D1 ... | 143 | 3e-43 | 145 | 49 | 66 | GO:0005737; C:cytoplasm; ISS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB. | | | | | | | | | | GO:0070936; P:protein K48-linked ubiquitination; ISS:UniProtKB. | 18 | P61080 | 147 | UB2D1_MOUSE Ubiquitin-conjugating enzyme E2 D... | 143 | 3e-43 | 145 | 49 | 66 | GO:0005737; C:cytoplasm; ISS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:MGI.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB. | | | | | | | | | | GO:0031398; P:positive regulation of protein ubiquitination; ISS:UniProtKB.::GO:0006511; P:ubiquitin-dependent protein catabolic process; ISS:UniProtKB. | 19 | P51668 | 147 | UB2D1_HUMAN Ubiquitin-conjugating enzyme E2 D... | 143 | 3e-43 | 145 | 49 | 66 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005654; C:nucleoplasm; TAS:Reactome. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB. | | | | | | | | | | GO:0031145; P:anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; TAS:Reactome.::GO:0030509; P:BMP signaling pathway; TAS:Reactome.::GO:0007094; P:mitotic cell cycle spindle assembly checkpoint; TAS:Reactome.::GO:0051436; P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; TAS:Reactome.::GO:0051437; P:positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; TAS:Reactome.::GO:0070936; P:protein K48-linked ubiquitination; IDA:UniProtKB.::GO:0007179; P:transforming growth factor beta receptor signaling pathway; TAS:Reactome. | 20 | Q2TA10 | 147 | UB2D1_BOVIN Ubiquitin-conjugating enzyme E2 D... | 143 | 3e-43 | 145 | 49 | 66 | GO:0005737; C:cytoplasm; ISS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB. | | | | | | | | | | GO:0070936; P:protein K48-linked ubiquitination; ISS:UniProtKB. | 21 | P25867 | 147 | UBCD1_DROME Ubiquitin-conjugating enzyme E2-1... | 143 | 4e-43 | 145 | 50 | 66 | GO:0005875; C:microtubule associated complex; IDA:FlyBase. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; IGI:FlyBase. | | | | | | | | | | GO:0051276; P:chromosome organization; IMP:FlyBase.::GO:0001751; P:compound eye photoreceptor cell differentiation; IMP:FlyBase.::GO:0008054; P:cyclin catabolic process; IMP:FlyBase.::GO:0048132; P:female germ-line stem cell division; IMP:FlyBase.::GO:0030718; P:germ-line stem cell maintenance; IMP:FlyBase.::GO:0007140; P:male meiosis; IMP:FlyBase.::GO:0007067; P:mitosis; IMP:FlyBase.::GO:0016322; P:neuron remodeling; IDA:FlyBase.::GO:0031647; P:regulation of protein stability; IMP:FlyBase.::GO:0045676; P:regulation of R7 cell differentiation; IGI:FlyBase.::GO:0007286; P:spermatid development; IMP:FlyBase. | 22 | P62840 | 147 | UB2D2_XENLA Ubiquitin-conjugating enzyme E2 D... | 143 | 5e-43 | 145 | 49 | 65 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004842; F:ubiquitin-protein ligase activity; IEA:EC. | | | | | | | | | | | 23 | P62839 | 147 | UB2D2_RAT Ubiquitin-conjugating enzyme E2 D2 ... | 143 | 5e-43 | 145 | 49 | 65 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB. | | | | | | | | | | GO:0070936; P:protein K48-linked ubiquitination; ISS:UniProtKB. | 24 | P62838 | 147 | UB2D2_MOUSE Ubiquitin-conjugating enzyme E2 D... | 143 | 5e-43 | 145 | 49 | 65 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB. | | | | | | | | | | | 25 | P62837 | 147 | UB2D2_HUMAN Ubiquitin-conjugating enzyme E2 D... | 143 | 5e-43 | 145 | 49 | 65 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB. | | | | | | | | | | GO:0070936; P:protein K48-linked ubiquitination; IDA:UniProtKB.::GO:0006511; P:ubiquitin-dependent protein catabolic process; TAS:ProtInc. | 26 | Q1RMX2 | 147 | UB2D2_BOVIN Ubiquitin-conjugating enzyme E2 D... | 143 | 5e-43 | 145 | 49 | 65 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB. | | | | | | | | | | GO:0070936; P:protein K48-linked ubiquitination; ISS:UniProtKB. | 27 | P15731 | 148 | UBC4_YEAST Ubiquitin-conjugating enzyme E2 4 ... | 146 | 1e-42 | 144 | 49 | 63 | GO:0000502; C:proteasome complex; IPI:SGD. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0043130; F:ubiquitin binding; IDA:SGD.::GO:0004842; F:ubiquitin-protein ligase activity; IMP:UniProtKB. | | | | | | | | | | GO:0006513; P:protein monoubiquitination; IDA:SGD.::GO:0000209; P:protein polyubiquitination; IMP:UniProtKB.::GO:0006950; P:response to stress; IDA:SGD.::GO:0043162; P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; IMP:SGD. | 28 | P46595 | 147 | UBC4_SCHPO Ubiquitin-conjugating enzyme E2 4 ... | 143 | 1e-42 | 144 | 49 | 64 | GO:0005829; C:cytosol; IDA:PomBase.::GO:0005634; C:nucleus; IDA:PomBase. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB. | | | | | | | | | | GO:0008054; P:cyclin catabolic process; IGI:PomBase.::GO:0000070; P:mitotic sister chromatid segregation; IMP:PomBase.::GO:0000209; P:protein polyubiquitination; ISS:UniProtKB. | 29 | Q06AA9 | 147 | UB2D2_PIG Ubiquitin-conjugating enzyme E2 D2 ... | 143 | 2e-42 | 144 | 48 | 64 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB. | | | | | | | | | | GO:0070936; P:protein K48-linked ubiquitination; ISS:UniProtKB. | 30 | P35134 | 148 | UBC11_ARATH Ubiquitin-conjugating enzyme E2 1... | 148 | 2e-42 | 144 | 48 | 66 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:TAIR. | | | | | | | | | | GO:0006511; P:ubiquitin-dependent protein catabolic process; IDA:TAIR. | 31 | P61078 | 147 | UB2D3_RAT Ubiquitin-conjugating enzyme E2 D3 ... | 143 | 2e-42 | 144 | 48 | 64 | GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB. | | | | | | | | | | GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0006281; P:DNA repair; IEA:UniProtKB-KW.::GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; ISS:UniProtKB.::GO:0070979; P:protein K11-linked ubiquitination; ISS:UniProtKB.::GO:0070936; P:protein K48-linked ubiquitination; ISS:UniProtKB. |