Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YDR049W
Length:
632
Number of sequences:
5887
Description:
YDR049W VMS1 SGDID:S000002456, Chr IV from 553254-555152, Genome Release 64-1-1, Verified ORF, "Component of a Cdc48p-complex involved in protein quality control; exhibits cytosolic and ER-membrane localization, with Cdc48p, during normal growth, and contributes to ER-associated degradation (ERAD) of specific substrates at a step after their ubiquitination; forms a mitochondrially-associated complex with Cdc48p and Npl4p under oxidative stress that is required for ubiquitin-mediated mitochondria-associated protein degradation (MAD); conserved in C. elegans and humans"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
1Q04311    632   VMS1_YEAST Protein VMS1 OS=Saccharomyces cere...6320     1308     100     100GO:0005829; C:cytosol; IDA:SGD.::GO:0005789; C:endoplasmic reticulum membrane; IDA:SGD.::GO:0005739; C:mitochondrion; IDA:SGD.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0030433; P:ER-associated protein catabolic process; IMP:SGD.::GO:0072671; P:mitochondria-associated protein catabolic process; IMP:SGD.
2O74977    600   VMS1_SCHPO VMS1 homolog C1827.04 OS=Schizosac...6471e-73     254     32     51GO:0005829; C:cytosol; IDA:PomBase.::GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.::GO:0043234; C:protein complex; NAS:PomBase.
3Q9H8Y5    726   ANKZ1_HUMAN Ankyrin repeat and zinc finger do...3901e-29     128     28     42GO:0005622; C:intracellular; IEA:InterPro.
GO:0008270; F:zinc ion binding; IEA:InterPro.
4Q66H85    722   ANKZ1_RAT Ankyrin repeat and zinc finger doma...3766e-27     119     27     42GO:0005622; C:intracellular; IEA:InterPro.
GO:0008270; F:zinc ion binding; IEA:InterPro.
5Q80UU1    748   ANKZ1_MOUSE Ankyrin repeat and zinc finger do...3757e-25     113     27     40GO:0005622; C:intracellular; IEA:InterPro.
GO:0008270; F:zinc ion binding; IEA:InterPro.
6P34511    618   VMS1_CAEEL Protein vms-1 OS=Caenorhabditis el...1450.11     39.3     23     44GO:0030425; C:dendrite; IDA:WormBase.::GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
GO:0008270; F:zinc ion binding; IEA:InterPro.
7Q58CQ5    728   ANKZ1_BOVIN Ankyrin repeat and zinc finger do...3974e-21     101     28     41GO:0005622; C:intracellular; IEA:InterPro.
GO:0008270; F:zinc ion binding; IEA:InterPro.
8P38344    393   REI1_YEAST Pre-60S factor REI1 OS=Saccharomyc...490.00003     50.4     43     67GO:0005737; C:cytoplasm; IDA:SGD.
GO:0005515; F:protein binding; IPI:IntAct.::GO:0043565; F:sequence-specific DNA binding; IDA:SGD.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0007117; P:budding cell bud growth; IGI:SGD.::GO:0000278; P:mitotic cell cycle; IGI:SGD.::GO:0006913; P:nucleocytoplasmic transport; IMP:SGD.::GO:0042273; P:ribosomal large subunit biogenesis; IMP:SGD.
9Q91VY9    476   ZN622_MOUSE Zinc finger protein 622 OS=Mus mu...670.001     45.4     27     51
GO:0003676; F:nucleic acid binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
10O95271    1327   TNKS1_HUMAN Tankyrase-1 OS=Homo sapiens (Huma...520.002     45.1     44     67GO:0000775; C:chromosome, centromeric region; IEA:UniProtKB-SubCell.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0005792; C:microsome; IDA:BHF-UCL.::GO:0000784; C:nuclear chromosome, telomeric region; IDA:BHF-UCL.::GO:0031965; C:nuclear membrane; TAS:BHF-UCL.::GO:0005643; C:nuclear pore; TAS:BHF-UCL.::GO:0000242; C:pericentriolar material; TAS:BHF-UCL.
GO:0003950; F:NAD+ ADP-ribosyltransferase activity; IDA:UniProtKB.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0008270; F:zinc ion binding; IDA:BHF-UCL.
GO:0007052; P:mitotic spindle organization; TAS:BHF-UCL.::GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.::GO:0043392; P:negative regulation of DNA binding; IDA:BHF-UCL.::GO:0018105; P:peptidyl-serine phosphorylation; IDA:MGI.::GO:0018107; P:peptidyl-threonine phosphorylation; IDA:MGI.::GO:0090263; P:positive regulation of canonical Wnt receptor signaling pathway; IMP:UniProtKB.::GO:0032212; P:positive regulation of telomere maintenance via telomerase; IDA:BHF-UCL.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.::GO:0070213; P:protein auto-ADP-ribosylation; IDA:UniProtKB.::GO:0070198; P:protein localization to chromosome, telomeric region; IMP:BHF-UCL.::GO:0070212; P:protein poly-ADP-ribosylation; IDA:BHF-UCL.::GO:0000209; P:protein polyubiquitination; IDA:UniProtKB.::GO:0015031; P:protein transport; IEA:UniProtKB-KW.::GO:0051225; P:spindle assembly; TAS:BHF-UCL.::GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW.
11Q6PFX9    1320   TNKS1_MOUSE Tankyrase-1 OS=Mus musculus (Mous...520.002     45.1     44     67GO:0000775; C:chromosome, centromeric region; IEA:UniProtKB-SubCell.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0005643; C:nuclear pore; IEA:UniProtKB-SubCell.
GO:0003950; F:NAD+ ADP-ribosyltransferase activity; ISS:UniProtKB.
GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.::GO:0090263; P:positive regulation of canonical Wnt receptor signaling pathway; ISS:UniProtKB.::GO:0070213; P:protein auto-ADP-ribosylation; ISS:UniProtKB.::GO:0000209; P:protein polyubiquitination; ISS:UniProtKB.::GO:0015031; P:protein transport; IEA:UniProtKB-KW.::GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW.
12Q969S3    477   ZN622_HUMAN Zinc finger protein 622 OS=Homo s...600.006     43.1     28     60GO:0005794; C:Golgi apparatus; IDA:HPA.::GO:0005730; C:nucleolus; IDA:HPA.
GO:0003676; F:nucleic acid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0008631; P:induction of apoptosis by oxidative stress; IDA:UniProtKB.::GO:0046330; P:positive regulation of JNK cascade; IMP:UniProtKB.::GO:0033674; P:positive regulation of kinase activity; IDA:UniProtKB.
13Q3UES3    1166   TNKS2_MOUSE Tankyrase-2 OS=Mus musculus (Mous...740.006     43.5     38     55GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0003950; F:NAD+ ADP-ribosyltransferase activity; ISS:UniProtKB.
GO:0035264; P:multicellular organism growth; IMP:MGI.::GO:0090263; P:positive regulation of canonical Wnt receptor signaling pathway; ISS:UniProtKB.::GO:0070213; P:protein auto-ADP-ribosylation; ISS:UniProtKB.::GO:0000209; P:protein polyubiquitination; ISS:UniProtKB.::GO:0040014; P:regulation of multicellular organism growth; IMP:MGI.::GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW.
14Q9H2K2    1166   TNKS2_HUMAN Tankyrase-2 OS=Homo sapiens (Huma...740.007     43.1     38     55GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0005792; C:microsome; IDA:BHF-UCL.::GO:0000784; C:nuclear chromosome, telomeric region; IC:BHF-UCL.::GO:0005635; C:nuclear envelope; IDA:BHF-UCL.::GO:0000242; C:pericentriolar material; IDA:BHF-UCL.::GO:0048471; C:perinuclear region of cytoplasm; IDA:BHF-UCL.
GO:0019899; F:enzyme binding; IPI:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0003950; F:NAD+ ADP-ribosyltransferase activity; IDA:UniProtKB.
GO:0090263; P:positive regulation of canonical Wnt receptor signaling pathway; IMP:UniProtKB.::GO:0032212; P:positive regulation of telomere maintenance via telomerase; IC:BHF-UCL.::GO:0070213; P:protein auto-ADP-ribosylation; IDA:UniProtKB.::GO:0070198; P:protein localization to chromosome, telomeric region; IMP:BHF-UCL.::GO:0000209; P:protein polyubiquitination; IDA:UniProtKB.::GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW.
15O59811    463   YJVF_SCHPO Zinc finger protein C550.15c OS=Sc...510.008     42.7     35     57GO:0005829; C:cytosol; IDA:PomBase.
GO:0003676; F:nucleic acid binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006913; P:nucleocytoplasmic transport; ISS:PomBase.::GO:0042273; P:ribosomal large subunit biogenesis; ISS:PomBase.
16Q90Y35    405   ZN622_CHICK Zinc finger protein 622 OS=Gallus...550.011     42.4     29     56GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0003676; F:nucleic acid binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
17Q7TM96    386   ZN622_RAT Zinc finger protein 622 OS=Rattus n...600.011     42.4     28     58GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0003676; F:nucleic acid binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
18Q96PM9    366   Z385A_HUMAN Zinc finger protein 385A OS=Homo ...360.31     37.4     36     67GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
19Q06709    432   REH1_YEAST Zinc finger protein REH1 OS=Saccha...490.32     37.7     29     57GO:0005737; C:cytoplasm; IDA:SGD.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0042273; P:ribosomal large subunit biogenesis; IGI:SGD.
20Q8BG95    976   MYPT2_MOUSE Protein phosphatase 1 regulatory ...471.4     35.8     38     57GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
21A2RV29    301   ZN346_DANRE Zinc finger protein 346 OS=Danio ...841.4     35.4     31     45GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0003725; F:double-stranded RNA binding; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
22Q8BXJ8    482   Z385B_MOUSE Zinc finger protein 385B OS=Mus m...311.7     35.4     42     68GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0003676; F:nucleic acid binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
23O60237    982   MYPT2_HUMAN Protein phosphatase 1 regulatory ...471.7     35.4     38     57GO:0015629; C:actin cytoskeleton; IDA:HPA.::GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IDA:HPA.
GO:0008047; F:enzyme activator activity; TAS:ProtInc.
GO:0006937; P:regulation of muscle contraction; TAS:ProtInc.::GO:0007165; P:signal transduction; TAS:ProtInc.
24Q569K4    471   Z385B_HUMAN Zinc finger protein 385B OS=Homo ...312     35     42     68GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0003676; F:nucleic acid binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
25Q5VYY1    191   ANR22_HUMAN Ankyrin repeat domain-containing ...642.2     34.3     38     52
26O14974    1030   MYPT1_HUMAN Protein phosphatase 1 regulatory ...434.9     33.9     37     63GO:0005813; C:centrosome; IDA:UniProtKB.::GO:0043292; C:contractile fiber; IDA:UniProtKB.::GO:0000776; C:kinetochore; IDA:UniProtKB.::GO:0072357; C:PTW/PP1 phosphatase complex; IDA:UniProtKB.
GO:0071889; F:14-3-3 protein binding; IDA:UniProtKB.::GO:0004857; F:enzyme inhibitor activity; IDA:UniProtKB.::GO:0019208; F:phosphatase regulator activity; IDA:UniProtKB.::GO:0019901; F:protein kinase binding; IPI:UniProtKB.::GO:0004871; F:signal transducer activity; NAS:ProtInc.
GO:0051297; P:centrosome organization; IMP:UniProtKB.::GO:0007067; P:mitosis; IMP:UniProtKB.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.::GO:0006470; P:protein dephosphorylation; IMP:UniProtKB.::GO:0030155; P:regulation of cell adhesion; IDA:UniProtKB.::GO:0035507; P:regulation of myosin-light-chain-phosphatase activity; IDA:UniProtKB.
27Q91ZK0    452   AP2D_MOUSE Transcription factor AP-2-delta OS...555     33.9     36     60GO:0005667; C:transcription factor complex; IPI:MGI.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:MGI.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:MGI.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
28Q7Z6R9    452   AP2D_HUMAN Transcription factor AP-2-delta OS...555.1     33.9     36     60
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
29Q10728    1032   MYPT1_RAT Protein phosphatase 1 regulatory su...438.4     33.1     37     60GO:0005813; C:centrosome; ISS:UniProtKB.::GO:0000776; C:kinetochore; ISS:UniProtKB.::GO:0072357; C:PTW/PP1 phosphatase complex; ISS:UniProtKB.
GO:0071889; F:14-3-3 protein binding; ISS:UniProtKB.::GO:0004857; F:enzyme inhibitor activity; ISS:UniProtKB.::GO:0019208; F:phosphatase regulator activity; ISS:UniProtKB.::GO:0004721; F:phosphoprotein phosphatase activity; IDA:RGD.
GO:0051297; P:centrosome organization; ISS:UniProtKB.::GO:0007067; P:mitosis; ISS:UniProtKB.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.::GO:0006470; P:protein dephosphorylation; ISS:UniProtKB.::GO:0030155; P:regulation of cell adhesion; ISS:UniProtKB.::GO:0035507; P:regulation of myosin-light-chain-phosphatase activity; ISS:UniProtKB.
30Q9DBR7    1029   MYPT1_MOUSE Protein phosphatase 1 regulatory ...438.6     33.1     37     60GO:0005813; C:centrosome; ISS:UniProtKB.::GO:0000776; C:kinetochore; ISS:UniProtKB.::GO:0072357; C:PTW/PP1 phosphatase complex; ISS:UniProtKB.
GO:0071889; F:14-3-3 protein binding; ISS:UniProtKB.::GO:0004857; F:enzyme inhibitor activity; ISS:UniProtKB.::GO:0019208; F:phosphatase regulator activity; ISS:UniProtKB.
GO:0051297; P:centrosome organization; ISS:UniProtKB.::GO:0007067; P:mitosis; ISS:UniProtKB.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.::GO:0006470; P:protein dephosphorylation; IMP:MGI.::GO:0030155; P:regulation of cell adhesion; ISS:UniProtKB.::GO:0035507; P:regulation of myosin-light-chain-phosphatase activity; ISS:UniProtKB.::GO:0046822; P:regulation of nucleocytoplasmic transport; IMP:MGI.
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