Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YDR043C
Length:
231
Number of sequences:
5887
Description:
YDR043C NRG1 SGDID:S000002450, Chr IV from 543369-542674, Genome Release 64-1-1, reverse complement, Verified ORF, "Transcriptional repressor that recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
31Q8SUR9    449   Z856_ENCCU Zinc finger C2H2 protein ECU08_056...570.000000001     61.2     47     61GO:0005622; C:intracellular; IEA:InterPro.
GO:0003676; F:nucleic acid binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
32P39956    796   RPH1_YEAST DNA damage-responsive transcriptio...750.000000002     60.5     40     60GO:0005634; C:nucleus; IC:SGD.
GO:0051864; F:histone demethylase activity (H3-K36 specific); IDA:SGD.::GO:0032454; F:histone demethylase activity (H3-K9 specific); IDA:SGD.::GO:0001078; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; IDA:SGD.::GO:0043565; F:sequence-specific DNA binding; IDA:SGD.::GO:0008270; F:zinc ion binding; IEA:InterPro.
33O08876    480   KLF10_RAT Krueppel-like factor 10 OS=Rattus n...510.000002     51.6     49     57GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006917; P:induction of apoptosis; IDA:RGD.::GO:0042127; P:regulation of cell proliferation; IDA:RGD.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
34Q13118    480   KLF10_HUMAN Krueppel-like factor 10 OS=Homo s...510.000002     51.6     49     57GO:0005634; C:nucleus; TAS:ProtInc.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; TAS:ProtInc.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0008283; P:cell proliferation; TAS:ProtInc.::GO:0007267; P:cell-cell signaling; TAS:ProtInc.::GO:0008285; P:negative regulation of cell proliferation; TAS:ProtInc.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; TAS:ProtInc.::GO:0001501; P:skeletal system development; TAS:ProtInc.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0007179; P:transforming growth factor beta receptor signaling pathway; TAS:ProtInc.
35Q3TTC2    378   TYY2_MOUSE Transcription factor YY2 OS=Mus mu...600.000006     49.7     37     53GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
36Q8K1S5    502   KLF11_MOUSE Krueppel-like factor 11 OS=Mus mu...293.2     32.3     41     59GO:0005634; C:nucleus; IC:UniProtKB.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
37O89091    479   KLF10_MOUSE Krueppel-like factor 10 OS=Mus mu...510.000002     51.6     49     57GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0030282; P:bone mineralization; IMP:MGI.::GO:0045672; P:positive regulation of osteoclast differentiation; IMP:MGI.::GO:0006355; P:regulation of transcription, DNA-dependent; IMP:MGI.::GO:0035019; P:somatic stem cell maintenance; IDA:MGI.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
38Q13351    362   KLF1_HUMAN Krueppel-like factor 1 OS=Homo sap...580.19     36.2     36     48GO:0000790; C:nuclear chromatin; IDA:BHF-UCL.
GO:0000987; F:core promoter proximal region sequence-specific DNA binding; IDA:BHF-UCL.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; TAS:ProtInc.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
39P33749    630   MSN4_YEAST Zinc finger protein MSN4 OS=Saccha...880.00000003     56.6     34     56GO:0005829; C:cytosol; IDA:SGD.::GO:0005634; C:nucleus; IDA:SGD.
GO:0000987; F:core promoter proximal region sequence-specific DNA binding; IDA:SGD.::GO:0000982; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity; IMP:SGD.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006338; P:chromatin remodeling; IGI:SGD.::GO:0061401; P:positive regulation of transcription from RNA polymerase II promoter in response to a hypotonic environment; IGI:SGD.::GO:0061402; P:positive regulation of transcription from RNA polymerase II promoter in response to acidity; IMP:SGD.::GO:0061422; P:positive regulation of transcription from RNA polymerase II promoter in response to alkalinity; IGI:SGD.::GO:0061412; P:positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation; IGI:SGD.::GO:0061395; P:positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance; IGI:SGD.::GO:0061410; P:positive regulation of transcription from RNA polymerase II promoter in response to ethanol; IGI:SGD.::GO:0061409; P:positive regulation of transcription from RNA polymerase II promoter in response to freezing; IGI:SGD.::GO:0061406; P:positive regulation of transcription from RNA polymerase II promoter in response to glucose starvation; IGI:SGD.::GO:0061408; P:positive regulation of transcription from RNA polymerase II promoter in response to heat stress; IMP:SGD.::GO:0061407; P:positive regulation of transcription from RNA polymerase II promoter in response to hydrogen peroxide; IMP:SGD.::GO:0061405; P:positive regulation of transcription from RNA polymerase II promoter in response to hydrostatic pressure; IGI:SGD.::GO:0061404; P:positive regulation of transcription from RNA polymerase II promoter in response to increased salt; IGI:SGD.::GO:0061403; P:positive regulation of transcription from RNA polymerase II promoter in response to nitrosative stress; IGI:SGD.::GO:0097236; P:positive regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation; IGI:SGD.::GO:0001302; P:replicative cell aging; IGI:SGD.
40P22227    288   ZFP42_MOUSE Zinc finger protein 42 OS=Mus mus...530.00006     46.6     40     57GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0007286; P:spermatid development; IMP:MGI.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
41P57682    345   KLF3_HUMAN Krueppel-like factor 3 OS=Homo sap...490.043     38.1     41     49GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; NAS:ProtInc.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0007275; P:multicellular organismal development; TAS:ProtInc.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
42O14901    512   KLF11_HUMAN Krueppel-like factor 11 OS=Homo s...293.1     32.3     41     59GO:0005634; C:nucleus; TAS:ProtInc.
GO:0000981; F:sequence-specific DNA binding RNA polymerase II transcription factor activity; IDA:BHF-UCL.::GO:0044212; F:transcription regulatory region DNA binding; IDA:BHF-UCL.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0008285; P:negative regulation of cell proliferation; IDA:BHF-UCL.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.::GO:0043065; P:positive regulation of apoptotic process; IDA:BHF-UCL.::GO:0000115; P:regulation of transcription involved in S phase of mitotic cell cycle; IDA:BHF-UCL.
43Q03833    894   GIS1_YEAST Transcriptional activator/represso...520.00000004     56.6     48     65GO:0005739; C:mitochondrion; IDA:SGD.::GO:0005634; C:nucleus; IDA:SGD.
GO:0051864; F:histone demethylase activity (H3-K36 specific); IMP:SGD.::GO:0000978; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding; IDA:SGD.::GO:0001078; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; IMP:SGD.::GO:0001077; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; IC:SGD.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0001300; P:chronological cell aging; IMP:SGD.::GO:0060275; P:maintenance of stationary phase in response to starvation; IMP:SGD.::GO:0071071; P:regulation of phospholipid biosynthetic process; IMP:SGD.
44O74252    692   STE12_EMENI Transcription factor steA OS=194 ...320.56     35     41     63GO:0005634; C:nucleus; IC:UniProtKB.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:UniProtKB.::GO:0019953; P:sexual reproduction; IMP:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
45Q60980    344   KLF3_MOUSE Krueppel-like factor 3 OS=Mus musc...490.047     38.1     41     49GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
46Q8CJ78    1038   ZN628_MOUSE Zinc finger protein 628 OS=Mus mu...582.5     33.1     31     45GO:0005634; C:nucleus; IDA:MGI.
GO:0003677; F:DNA binding; IDA:MGI.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:MGI.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
47Q2FAY8    376   TYY2_RATRT Transcription factor YY2 OS=Rattus...600.000009     49.3     37     53GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
48P0C6P6    376   TYY2_RAT Transcription factor YY2 OS=Rattus n...600.000009     49.3     37     53GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
49Q98T94    492   GLIS2_XENLA Zinc finger protein GLIS2 OS=Xeno...510.009     40.4     41     51GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016607; C:nuclear speck; ISS:UniProtKB.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0045892; P:negative regulation of transcription, DNA-dependent; ISS:UniProtKB.::GO:0007399; P:nervous system development; IEA:UniProtKB-KW.::GO:0045893; P:positive regulation of transcription, DNA-dependent; ISS:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
50Q96SZ4    725   ZSC10_HUMAN Zinc finger and SCAN domain-conta...551     34.3     31     45GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0045892; P:negative regulation of transcription, DNA-dependent; ISS:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0016032; P:viral reproduction; IEA:InterPro.
51O75840    302   KLF7_HUMAN Krueppel-like factor 7 OS=Homo sap...512.8     32.3     39     49GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; TAS:ProtInc.::GO:0003713; F:transcription coactivator activity; TAS:ProtInc.::GO:0008270; F:zinc ion binding; TAS:ProtInc.
GO:0006357; P:regulation of transcription from RNA polymerase II promoter; TAS:ProtInc.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
52Q02447    781   SP3_HUMAN Transcription factor Sp3 OS=Homo sa...759.5     31.2     29     45GO:0016605; C:PML body; IEA:UniProtKB-SubCell.
GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:UniProtKB.
53Q99JB0    301   KLF7_MOUSE Krueppel-like factor 7 OS=Mus musc...513.4     32.3     39     49GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0003677; F:DNA binding; IDA:MGI.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:MGI.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0007411; P:axon guidance; IMP:MGI.::GO:0048813; P:dendrite morphogenesis; IMP:MGI.::GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:MGI.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
54Q9NQV7    894   PRDM9_HUMAN Histone-lysine N-methyltransferas...480.61     35     38     52GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.::GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:EC.::GO:0003676; F:nucleic acid binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006311; P:meiotic gene conversion; IDA:MGI.::GO:0010845; P:positive regulation of reciprocal meiotic recombination; IMP:MGI.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
55A1YG26    473   ZSC21_PANPA Zinc finger and SCAN domain-conta...551.2     33.9     29     51GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0016032; P:viral reproduction; IEA:InterPro.
56Q9Y5A6    473   ZSC21_HUMAN Zinc finger and SCAN domain-conta...551.2     33.9     29     51GO:0005634; C:nucleus; NAS:UniProtKB.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0045893; P:positive regulation of transcription, DNA-dependent; NAS:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0016032; P:viral reproduction; IEA:InterPro.
57A1YEV9    473   ZSC21_GORGO Zinc finger and SCAN domain-conta...551.2     33.9     29     51GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0016032; P:viral reproduction; IEA:InterPro.
58Q00899    414   TYY1_MOUSE Transcriptional repressor protein ...500.00002     48.5     38     60GO:0016363; C:nuclear matrix; IEA:UniProtKB-SubCell.::GO:0031519; C:PcG protein complex; IDA:MGI.::GO:0005667; C:transcription factor complex; IDA:MGI.
GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:MGI.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0009952; P:anterior/posterior pattern specification; IMP:MGI.::GO:0048593; P:camera-type eye morphogenesis; IGI:MGI.::GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0051276; P:chromosome organization; IMP:UniProtKB.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:MGI.::GO:0010225; P:response to UV-C; IMP:UniProtKB.::GO:0006403; P:RNA localization; IMP:MGI.::GO:0007283; P:spermatogenesis; IMP:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
59P25490    414   TYY1_HUMAN Transcriptional repressor protein ...500.00002     48.5     38     60GO:0031011; C:Ino80 complex; IDA:UniProtKB.::GO:0016363; C:nuclear matrix; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IDA:HPA.
GO:0000400; F:four-way junction DNA binding; IDA:UniProtKB.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0003723; F:RNA binding; IDA:MGI.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; TAS:ProtInc.::GO:0003713; F:transcription coactivator activity; TAS:ProtInc.::GO:0003714; F:transcription corepressor activity; TAS:ProtInc.::GO:0044212; F:transcription regulatory region DNA binding; IDA:MGI.::GO:0008270; F:zinc ion binding; TAS:ProtInc.
GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0034644; P:cellular response to UV; IMP:UniProtKB.::GO:0000724; P:double-strand break repair via homologous recombination; IMP:UniProtKB.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:MGI.::GO:0010225; P:response to UV-C; IMP:UniProtKB.::GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
60Q9BZE0    524   GLIS2_HUMAN Zinc finger protein GLIS2 OS=Homo...510.088     37.4     41     51GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016607; C:nuclear speck; ISS:UniProtKB.
GO:0001077; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; ISS:BHF-UCL.::GO:0044212; F:transcription regulatory region DNA binding; ISS:BHF-UCL.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0043433; P:negative regulation of sequence-specific DNA binding transcription factor activity; ISS:BHF-UCL.::GO:0045879; P:negative regulation of smoothened signaling pathway; ISS:UniProtKB.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISS:BHF-UCL.::GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
61P43300    387   EGR3_MOUSE Early growth response protein 3 OS...360.044     38.1     42     58GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0007274; P:neuromuscular synaptic transmission; IMP:MGI.::GO:0007422; P:peripheral nervous system development; IMP:MGI.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
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